YNR042W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR042W / YNR042W

Click on Significant Values for Screen Details ID:SGTC_32|Compound:0928-0142|FD-Score:3.18|P-value:2.83E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:24.10|P-value:1.60E-152 ID:SGTC_64|Compound:000l-0018|FD-Score:19.60|P-value:1.48E-101 ID:SGTC_67|Compound:0335-0847|FD-Score:20.00|P-value:2.65E-106 ID:SGTC_86|Compound:0417-1630|FD-Score:14.20|P-value:2.11E-54 ID:SGTC_134|Compound:0269-0018|FD-Score:3.38|P-value:1.20E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:6.10|P-value:1.51E-11 ID:SGTC_142|Compound:0335-0849|FD-Score:14.80|P-value:8.88E-59 ID:SGTC_158|Compound:k038-0087|FD-Score:20.60|P-value:2.27E-112 ID:SGTC_165|Compound:k038-0023|FD-Score:4.74|P-value:1.29E-7 ID:SGTC_200|Compound:k038-0079|FD-Score:6.45|P-value:1.10E-12 ID:SGTC_216|Compound:k038-0035|FD-Score:4.75|P-value:1.18E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:14.10|P-value:2.69E-53 ID:SGTC_294|Compound:k038-0071|FD-Score:6.79|P-value:6.95E-14 ID:SGTC_314|Compound:1671-0008|FD-Score:4.25|P-value:1.95E-6 ID:SGTC_331|Compound:k048-0133|FD-Score:3.27|P-value:1.93E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:4.37|P-value:9.87E-7 ID:SGTC_335|Compound:4077-0256|FD-Score:4.55|P-value:3.83E-7 ID:SGTC_340|Compound:k038-0059|FD-Score:14.50|P-value:1.85E-56 ID:SGTC_367|Compound:0335-0881|FD-Score:4.26|P-value:1.82E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:10.90|P-value:9.76E-33 ID:SGTC_635|Compound:k038-0028|FD-Score:3.90|P-value:1.12E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:7.67|P-value:3.14E-17 ID:SGTC_846|Compound:0335-0850|FD-Score:4.92|P-value:4.24E-8 ID:SGTC_996|Compound:3970-0799|FD-Score:3.55|P-value:5.90E-5 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.30|P-value:1.72E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.18|P-value:6.92E-9 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.16|P-value:3.04E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:-3.54|P-value:4.99E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-3.38|P-value:1.03E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.03|P-value:5.05E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-2.89|P-value:7.51E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.10|P-value:3.32E-4 ID:SGTC_1635|Compound:st007035|FD-Score:23.20|P-value:1.10E-141 ID:SGTC_1750|Compound:st081859|FD-Score:-2.95|P-value:5.95E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.06|P-value:4.56E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.04|P-value:1.63E-8 ID:SGTC_2105|Compound:5350118|FD-Score:-2.98|P-value:5.22E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.62|P-value:4.26E-5 ID:SGTC_2359|Compound:9039622|FD-Score:3.13|P-value:3.39E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.14|P-value:3.24E-4 ID:SGTC_2429|Compound:5902844|FD-Score:2.87|P-value:9.30E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.13|P-value:3.61E-6 ID:SGTC_2605|Compound:digitonin|FD-Score:3.15|P-value:3.18E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.21|P-value:2.47E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.08|P-value:4.15E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.69|P-value:3.06E-5 ID:SGTC_2641|Compound:levomentholum|FD-Score:4.03|P-value:5.79E-6 ID:SGTC_2644|Compound:guaiazulene|FD-Score:3.55|P-value:5.75E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.21|P-value:2.07E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.03|P-value:5.09E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.46|P-value:8.70E-5 ID:SGTC_2976|Compound:9009005|FD-Score:4.26|P-value:1.79E-6 ID:SGTC_2978|Compound:9011784|FD-Score:6.08|P-value:1.79E-11 ID:SGTC_2980|Compound:9014342|FD-Score:4.09|P-value:4.32E-6 ID:SGTC_2981|Compound:9013952|FD-Score:-3.05|P-value:3.98E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-3.32|P-value:1.31E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.08|P-value:3.58E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:3.18|P-value:2.83E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:24.10|P-value:1.60E-152 ID:SGTC_64|Compound:000l-0018|FD-Score:19.60|P-value:1.48E-101 ID:SGTC_67|Compound:0335-0847|FD-Score:20.00|P-value:2.65E-106 ID:SGTC_86|Compound:0417-1630|FD-Score:14.20|P-value:2.11E-54 ID:SGTC_134|Compound:0269-0018|FD-Score:3.38|P-value:1.20E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:6.10|P-value:1.51E-11 ID:SGTC_142|Compound:0335-0849|FD-Score:14.80|P-value:8.88E-59 ID:SGTC_158|Compound:k038-0087|FD-Score:20.60|P-value:2.27E-112 ID:SGTC_165|Compound:k038-0023|FD-Score:4.74|P-value:1.29E-7 ID:SGTC_200|Compound:k038-0079|FD-Score:6.45|P-value:1.10E-12 ID:SGTC_216|Compound:k038-0035|FD-Score:4.75|P-value:1.18E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:14.10|P-value:2.69E-53 ID:SGTC_294|Compound:k038-0071|FD-Score:6.79|P-value:6.95E-14 ID:SGTC_314|Compound:1671-0008|FD-Score:4.25|P-value:1.95E-6 ID:SGTC_331|Compound:k048-0133|FD-Score:3.27|P-value:1.93E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:4.37|P-value:9.87E-7 ID:SGTC_335|Compound:4077-0256|FD-Score:4.55|P-value:3.83E-7 ID:SGTC_340|Compound:k038-0059|FD-Score:14.50|P-value:1.85E-56 ID:SGTC_367|Compound:0335-0881|FD-Score:4.26|P-value:1.82E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:10.90|P-value:9.76E-33 ID:SGTC_635|Compound:k038-0028|FD-Score:3.90|P-value:1.12E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:7.67|P-value:3.14E-17 ID:SGTC_846|Compound:0335-0850|FD-Score:4.92|P-value:4.24E-8 ID:SGTC_996|Compound:3970-0799|FD-Score:3.55|P-value:5.90E-5 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.30|P-value:1.72E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.18|P-value:6.92E-9 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.16|P-value:3.04E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:-3.54|P-value:4.99E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-3.38|P-value:1.03E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.03|P-value:5.05E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-2.89|P-value:7.51E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.10|P-value:3.32E-4 ID:SGTC_1635|Compound:st007035|FD-Score:23.20|P-value:1.10E-141 ID:SGTC_1750|Compound:st081859|FD-Score:-2.95|P-value:5.95E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.06|P-value:4.56E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.04|P-value:1.63E-8 ID:SGTC_2105|Compound:5350118|FD-Score:-2.98|P-value:5.22E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.62|P-value:4.26E-5 ID:SGTC_2359|Compound:9039622|FD-Score:3.13|P-value:3.39E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.14|P-value:3.24E-4 ID:SGTC_2429|Compound:5902844|FD-Score:2.87|P-value:9.30E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.13|P-value:3.61E-6 ID:SGTC_2605|Compound:digitonin|FD-Score:3.15|P-value:3.18E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.21|P-value:2.47E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.08|P-value:4.15E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.69|P-value:3.06E-5 ID:SGTC_2641|Compound:levomentholum|FD-Score:4.03|P-value:5.79E-6 ID:SGTC_2644|Compound:guaiazulene|FD-Score:3.55|P-value:5.75E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.21|P-value:2.07E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.03|P-value:5.09E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.46|P-value:8.70E-5 ID:SGTC_2976|Compound:9009005|FD-Score:4.26|P-value:1.79E-6 ID:SGTC_2978|Compound:9011784|FD-Score:6.08|P-value:1.79E-11 ID:SGTC_2980|Compound:9014342|FD-Score:4.09|P-value:4.32E-6 ID:SGTC_2981|Compound:9013952|FD-Score:-3.05|P-value:3.98E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-3.32|P-value:1.31E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.08|P-value:3.58E-4

Top fitness defect scores for YNR042W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_36 0335-0881 24.10 14.2 µM 1.60E-152 ubiquinone biosynthesis & proteasome 2 1.77E-128
2 SGTC_1635 st007035 23.20 42.4 µM 1.10E-141 14 2.21E-119
3 SGTC_158 k038-0087 20.60 26.4 µM 2.27E-112 ubiquinone biosynthesis & proteasome 5 9.09E-95
4 SGTC_67 0335-0847 20.00 266.0 µM 2.65E-106 ubiquinone biosynthesis & proteasome 4 1.13E-89
5 SGTC_64 000l-0018 19.60 272.1 µM 1.48E-101 ubiquinone biosynthesis & proteasome 11 1.09E-85
6 SGTC_142 0335-0849 14.80 62.7 µM 8.88E-59 ubiquinone biosynthesis & proteasome 16 9.39E-50
7 SGTC_340 k038-0059 14.50 454.0 µM 1.85E-56 ubiquinone biosynthesis & proteasome 1 8.33E-48
8 SGTC_86 0417-1630 14.20 471.9 µM 2.11E-54 ubiquinone biosynthesis & proteasome 19 4.46E-46
9 SGTC_236 1509-0011 14.10 5.3 µM 2.69E-53 116 3.80E-45
10 SGTC_386 1509-0011 10.90 3.1 µM 9.76E-33 40 7.31E-28
11 SGTC_794 k038-0031 7.67 316.0 µM 3.14E-17 ubiquinone biosynthesis & proteasome 35 8.28E-15
12 SGTC_294 k038-0071 6.79 157.0 µM 6.95E-14 ubiquinone biosynthesis & proteasome 7 5.48E-12
13 SGTC_200 k038-0079 6.45 37.5 µM 1.10E-12 ubiquinone biosynthesis & proteasome 24 5.65E-11
14 SGTC_137 0438-0332 6.10 85.4 µM 1.51E-11 ubiquinone biosynthesis & proteasome 61 5.15E-10
15 SGTC_2978 9011784 6.08 43.0 µM 1.79E-11 6 5.92E-10
16 SGTC_846 0335-0850 4.92 148.0 µM 4.24E-8 ubiquinone biosynthesis & proteasome 20 4.23E-7
17 SGTC_216 k038-0035 4.75 28.4 µM 1.18E-7 ubiquinone biosynthesis & proteasome 35 1.01E-6
18 SGTC_165 k038-0023 4.74 64.4 µM 1.29E-7 ubiquinone biosynthesis & proteasome 52 1.09E-6
19 SGTC_335 4077-0256 4.55 27.6 µM 3.83E-7 10 2.73E-6
20 SGTC_332 4112-0506 4.37 40.9 µM 9.87E-7 19 6.08E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.804 0 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.803 0 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.788 0 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.787 0 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.752 0 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.711 0 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.698 0 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.635 0 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.634 0 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.631 0 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.596 5.63E-322 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.582 1.16E-302 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.573 9.44E-292 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.565 9.83E-282 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.559 3.79E-275 YOL008W COQ10 hom Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes