YNR044W / AGA1

Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR044W / AGA1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.33|P-value:1.37E-7 ID:SGTC_304|Compound:1310-0298|FD-Score:2.71|P-value:6.30E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:2.65|P-value:8.02E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-2.64|P-value:9.89E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:2.89|P-value:2.94E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.27|P-value:2.73E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:7.15|P-value:1.24E-17 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:-3.36|P-value:4.08E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:3.19|P-value:7.22E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:2.84|P-value:3.60E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.69|P-value:8.15E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.88|P-value:4.76E-9 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.02|P-value:1.98E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.80|P-value:5.97E-9 ID:SGTC_708|Compound:3448-5400|FD-Score:-2.80|P-value:5.31E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.10|P-value:1.42E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.91|P-value:3.30E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:2.85|P-value:3.45E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:-2.69|P-value:8.05E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.01|P-value:1.98E-9 ID:SGTC_1125|Compound:tnp00248|FD-Score:2.82|P-value:3.96E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:2.77|P-value:4.89E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.59|P-value:9.98E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:2.81|P-value:4.09E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.78|P-value:3.44E-6 ID:SGTC_1283|Compound:0922-0125|FD-Score:4.10|P-value:5.67E-7 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:2.74|P-value:5.56E-4 ID:SGTC_1590|Compound:st077108|FD-Score:3.29|P-value:4.55E-5 ID:SGTC_1779|Compound:st039427|FD-Score:2.93|P-value:2.41E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-2.84|P-value:4.49E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.75|P-value:6.48E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.06|P-value:1.35E-4 ID:SGTC_2014|Compound:4013930|FD-Score:2.79|P-value:4.52E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.20|P-value:6.94E-5 ID:SGTC_2103|Compound:5378138|FD-Score:2.84|P-value:3.66E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.56|P-value:1.14E-5 ID:SGTC_2366|Compound:9070441|FD-Score:-3.06|P-value:1.72E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.65|P-value:7.15E-6 ID:SGTC_2369|Compound:9071472|FD-Score:-3.73|P-value:5.87E-6 ID:SGTC_2398|Compound:5228213|FD-Score:4.38|P-value:9.68E-8 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.07|P-value:1.64E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.34|P-value:4.42E-14 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.08|P-value:6.31E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:3.50|P-value:1.58E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:3.39|P-value:2.72E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:4.01|P-value:9.34E-7 ID:SGTC_2608|Compound:thymoquinone|FD-Score:2.62|P-value:9.12E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:4.06|P-value:7.00E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.71|P-value:5.20E-6 ID:SGTC_2693|Compound:st077581|FD-Score:3.15|P-value:8.76E-5 ID:SGTC_2829|Compound:7992743|FD-Score:2.76|P-value:5.08E-4 ID:SGTC_2849|Compound:9019321|FD-Score:2.60|P-value:9.82E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.51|P-value:1.49E-5 ID:SGTC_3297|Compound:9117502|FD-Score:2.89|P-value:2.95E-4 ID:SGTC_3336|Compound:9143619|FD-Score:3.44|P-value:2.11E-5 ID:SGTC_3338|Compound:9144300|FD-Score:-2.79|P-value:5.49E-4 ID:SGTC_3355|Compound:9151058|FD-Score:-2.80|P-value:5.22E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.33|P-value:1.37E-7 ID:SGTC_304|Compound:1310-0298|FD-Score:2.71|P-value:6.30E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:2.65|P-value:8.02E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-2.64|P-value:9.89E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:2.89|P-value:2.94E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.27|P-value:2.73E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:7.15|P-value:1.24E-17 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:-3.36|P-value:4.08E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:3.19|P-value:7.22E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:2.84|P-value:3.60E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.69|P-value:8.15E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.88|P-value:4.76E-9 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.02|P-value:1.98E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.80|P-value:5.97E-9 ID:SGTC_708|Compound:3448-5400|FD-Score:-2.80|P-value:5.31E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.10|P-value:1.42E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.91|P-value:3.30E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:2.85|P-value:3.45E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:-2.69|P-value:8.05E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.01|P-value:1.98E-9 ID:SGTC_1125|Compound:tnp00248|FD-Score:2.82|P-value:3.96E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:2.77|P-value:4.89E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.59|P-value:9.98E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:2.81|P-value:4.09E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.78|P-value:3.44E-6 ID:SGTC_1283|Compound:0922-0125|FD-Score:4.10|P-value:5.67E-7 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:2.74|P-value:5.56E-4 ID:SGTC_1590|Compound:st077108|FD-Score:3.29|P-value:4.55E-5 ID:SGTC_1779|Compound:st039427|FD-Score:2.93|P-value:2.41E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-2.84|P-value:4.49E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.75|P-value:6.48E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.06|P-value:1.35E-4 ID:SGTC_2014|Compound:4013930|FD-Score:2.79|P-value:4.52E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.20|P-value:6.94E-5 ID:SGTC_2103|Compound:5378138|FD-Score:2.84|P-value:3.66E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.56|P-value:1.14E-5 ID:SGTC_2366|Compound:9070441|FD-Score:-3.06|P-value:1.72E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.65|P-value:7.15E-6 ID:SGTC_2369|Compound:9071472|FD-Score:-3.73|P-value:5.87E-6 ID:SGTC_2398|Compound:5228213|FD-Score:4.38|P-value:9.68E-8 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.07|P-value:1.64E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.34|P-value:4.42E-14 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.08|P-value:6.31E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:3.50|P-value:1.58E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:3.39|P-value:2.72E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:4.01|P-value:9.34E-7 ID:SGTC_2608|Compound:thymoquinone|FD-Score:2.62|P-value:9.12E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:4.06|P-value:7.00E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.71|P-value:5.20E-6 ID:SGTC_2693|Compound:st077581|FD-Score:3.15|P-value:8.76E-5 ID:SGTC_2829|Compound:7992743|FD-Score:2.76|P-value:5.08E-4 ID:SGTC_2849|Compound:9019321|FD-Score:2.60|P-value:9.82E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.51|P-value:1.49E-5 ID:SGTC_3297|Compound:9117502|FD-Score:2.89|P-value:2.95E-4 ID:SGTC_3336|Compound:9143619|FD-Score:3.44|P-value:2.11E-5 ID:SGTC_3338|Compound:9144300|FD-Score:-2.79|P-value:5.49E-4 ID:SGTC_3355|Compound:9151058|FD-Score:-2.80|P-value:5.22E-4

Top fitness defect scores for YNR044W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_457 grayanotoxin iii 7.15 135.0 µM 1.24E-17 13 4.45E-13
2 SGTC_669 0108-0021 4.80 26.2 µM 5.97E-9 fatty acid desaturase (OLE1) 43 7.83E-7
3 SGTC_2398 5228213 4.38 48.8 µM 9.68E-8 iron homeostasis 26 5.85E-6
4 SGTC_58 0957-0393 4.33 9.0 µM 1.37E-7 cell wall 339 7.52E-6
5 SGTC_1283 0922-0125 4.10 16.4 µM 5.67E-7 17 2.10E-5
6 SGTC_2583 asiatic acid 4.08 100.0 µM 6.31E-7 35 2.26E-5
7 SGTC_2616 abietic acid 4.06 100.0 µM 7.00E-7 27 2.44E-5
8 SGTC_2605 digitonin 4.01 300.0 nM 9.34E-7 25 3.01E-5
9 SGTC_1270 0831-1170 3.78 17.3 µM 3.44E-6 13 7.72E-5
10 SGTC_2688 kanamycin b 3.71 96.7 µM 5.20E-6 calcium & mitochondrial duress 405 1.04E-4
11 SGTC_2367 9070478 3.65 135.4 µM 7.15E-6 cell wall 44 1.31E-4
12 SGTC_2359 9039622 3.56 200.0 µM 1.14E-5 endomembrane recycling 32 1.84E-4
13 SGTC_2856 9022925 3.51 19.5 µM 1.49E-5 34 2.24E-4
14 SGTC_2584 androsterone 3.50 48.7 µM 1.58E-5 cell wall 159 2.33E-4
15 SGTC_3336 9143619 3.44 71.4 µM 2.11E-5 33 2.88E-4
16 SGTC_2586 curcumin 3.39 80.0 µM 2.72E-5 iron homeostasis 85 3.45E-4
17 SGTC_1590 st077108 3.29 57.8 µM 4.55E-5 17 5.02E-4
18 SGTC_2021 4019055 3.20 173.0 µM 6.94E-5 endomembrane recycling 192 6.82E-4
19 SGTC_549 1661-1316 3.19 519.0 µM 7.22E-5 44 7.02E-4
20 SGTC_2693 st077581 3.15 40.7 µM 8.76E-5 80 8.08E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.279 6.81E-61 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.264 1.46E-54 YDR317W HIM1 hom Protein of unknown function involved in DNA repair
0.253 2.42E-50 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.250 5.21E-49 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.226 4.32E-40 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.224 1.58E-39 YDL037C BSC1 hom Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.223 3.23E-39 YFL056C AAD6 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.217 3.60E-37 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.199 2.49E-31 YNL115C_p YNL115C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.199 3.34E-31 YML021C UNG1 hom Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
0.196 1.91E-30 YDL025C RTK1 hom Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress
0.195 3.22E-30 YNL077W APJ1 hom Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress
0.182 2.08E-26 YBR292C_d YBR292C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
0.180 9.69E-26 YBR084W MIS1 hom Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
0.179 1.19E-25 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]