YNR053C / NOG2

Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNR053C / NOG2

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:5.10|P-value:1.72E-7 ID:SGTC_135|Compound:0933-0004|FD-Score:3.15|P-value:7.47E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.27|P-value:4.97E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:5.41|P-value:3.24E-8 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.84|P-value:9.05E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.43|P-value:4.24E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.30|P-value:6.76E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:4.06|P-value:2.36E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:5.24|P-value:8.22E-8 ID:SGTC_1045|Compound:1348-1485|FD-Score:-4.13|P-value:2.87E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.46|P-value:2.54E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:4.18|P-value:1.40E-5 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.94|P-value:3.87E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:-3.48|P-value:3.56E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:-3.65|P-value:1.90E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.97|P-value:3.37E-5 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.56|P-value:1.74E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.20|P-value:6.31E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.67|P-value:1.12E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.37|P-value:5.25E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.91|P-value:4.31E-5 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:4.88|P-value:5.14E-7 ID:SGTC_1768|Compound:st044301|FD-Score:3.38|P-value:3.34E-4 ID:SGTC_1807|Compound:st050092|FD-Score:3.98|P-value:3.33E-5 ID:SGTC_1832|Compound:st054113|FD-Score:4.06|P-value:2.32E-5 ID:SGTC_1840|Compound:st055363|FD-Score:-3.59|P-value:2.36E-4 ID:SGTC_1859|Compound:st055998|FD-Score:3.45|P-value:2.59E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-4.18|P-value:2.29E-5 ID:SGTC_1955|Compound:wogonin|FD-Score:-4.26|P-value:1.60E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.65|P-value:1.21E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.25|P-value:5.28E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.19|P-value:6.64E-4 ID:SGTC_2481|Compound:5478948|FD-Score:4.72|P-value:1.17E-6 ID:SGTC_2517|Compound:totarol|FD-Score:3.07|P-value:9.88E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-3.40|P-value:4.77E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.90|P-value:7.34E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:6.15|P-value:4.07E-10 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:-3.53|P-value:2.95E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.18|P-value:9.98E-4 ID:SGTC_2710|Compound:st078562|FD-Score:4.50|P-value:3.28E-6 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:4.00|P-value:2.96E-5 ID:SGTC_2809|Compound:7964133|FD-Score:4.25|P-value:1.03E-5 ID:SGTC_2880|Compound:9042983|FD-Score:4.49|P-value:3.48E-6 ID:SGTC_2887|Compound:9044784|FD-Score:7.75|P-value:5.91E-15 ID:SGTC_2893|Compound:9048488|FD-Score:3.35|P-value:3.78E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-3.64|P-value:1.99E-4 ID:SGTC_2963|Compound:9082507|FD-Score:3.61|P-value:1.41E-4 ID:SGTC_3000|Compound:9075062|FD-Score:5.24|P-value:8.23E-8 ID:SGTC_3027|Compound:9089541|FD-Score:3.60|P-value:1.47E-4 ID:SGTC_3044|Compound:9093193|FD-Score:4.48|P-value:3.52E-6 ID:SGTC_3054|Compound:9094397|FD-Score:5.28|P-value:6.37E-8 ID:SGTC_3081|Compound:9117243|FD-Score:3.93|P-value:4.05E-5 ID:SGTC_3093|Compound:9117344|FD-Score:4.76|P-value:9.58E-7 ID:SGTC_3095|Compound:9117207|FD-Score:3.52|P-value:2.03E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.69|P-value:1.63E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.46|P-value:2.52E-4 ID:SGTC_3260|Compound:9137109|FD-Score:3.09|P-value:9.14E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.85|P-value:8.77E-5 ID:SGTC_3326|Compound:9140064|FD-Score:4.86|P-value:5.84E-7 ID:SGTC_3327|Compound:9140648|FD-Score:-4.00|P-value:4.91E-5 ID:SGTC_3331|Compound:9141060|FD-Score:-4.19|P-value:2.22E-5 ID:SGTC_49|Compound:0717-0965|FD-Score:5.10|P-value:1.72E-7 ID:SGTC_135|Compound:0933-0004|FD-Score:3.15|P-value:7.47E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.27|P-value:4.97E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:5.41|P-value:3.24E-8 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.84|P-value:9.05E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.43|P-value:4.24E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.30|P-value:6.76E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:4.06|P-value:2.36E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:5.24|P-value:8.22E-8 ID:SGTC_1045|Compound:1348-1485|FD-Score:-4.13|P-value:2.87E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.46|P-value:2.54E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:4.18|P-value:1.40E-5 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.94|P-value:3.87E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:-3.48|P-value:3.56E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:-3.65|P-value:1.90E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.97|P-value:3.37E-5 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.56|P-value:1.74E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.20|P-value:6.31E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.67|P-value:1.12E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.37|P-value:5.25E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.91|P-value:4.31E-5 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:4.88|P-value:5.14E-7 ID:SGTC_1768|Compound:st044301|FD-Score:3.38|P-value:3.34E-4 ID:SGTC_1807|Compound:st050092|FD-Score:3.98|P-value:3.33E-5 ID:SGTC_1832|Compound:st054113|FD-Score:4.06|P-value:2.32E-5 ID:SGTC_1840|Compound:st055363|FD-Score:-3.59|P-value:2.36E-4 ID:SGTC_1859|Compound:st055998|FD-Score:3.45|P-value:2.59E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-4.18|P-value:2.29E-5 ID:SGTC_1955|Compound:wogonin|FD-Score:-4.26|P-value:1.60E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.65|P-value:1.21E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.25|P-value:5.28E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.19|P-value:6.64E-4 ID:SGTC_2481|Compound:5478948|FD-Score:4.72|P-value:1.17E-6 ID:SGTC_2517|Compound:totarol|FD-Score:3.07|P-value:9.88E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-3.40|P-value:4.77E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.90|P-value:7.34E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:6.15|P-value:4.07E-10 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:-3.53|P-value:2.95E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.18|P-value:9.98E-4 ID:SGTC_2710|Compound:st078562|FD-Score:4.50|P-value:3.28E-6 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:4.00|P-value:2.96E-5 ID:SGTC_2809|Compound:7964133|FD-Score:4.25|P-value:1.03E-5 ID:SGTC_2880|Compound:9042983|FD-Score:4.49|P-value:3.48E-6 ID:SGTC_2887|Compound:9044784|FD-Score:7.75|P-value:5.91E-15 ID:SGTC_2893|Compound:9048488|FD-Score:3.35|P-value:3.78E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-3.64|P-value:1.99E-4 ID:SGTC_2963|Compound:9082507|FD-Score:3.61|P-value:1.41E-4 ID:SGTC_3000|Compound:9075062|FD-Score:5.24|P-value:8.23E-8 ID:SGTC_3027|Compound:9089541|FD-Score:3.60|P-value:1.47E-4 ID:SGTC_3044|Compound:9093193|FD-Score:4.48|P-value:3.52E-6 ID:SGTC_3054|Compound:9094397|FD-Score:5.28|P-value:6.37E-8 ID:SGTC_3081|Compound:9117243|FD-Score:3.93|P-value:4.05E-5 ID:SGTC_3093|Compound:9117344|FD-Score:4.76|P-value:9.58E-7 ID:SGTC_3095|Compound:9117207|FD-Score:3.52|P-value:2.03E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.69|P-value:1.63E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.46|P-value:2.52E-4 ID:SGTC_3260|Compound:9137109|FD-Score:3.09|P-value:9.14E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.85|P-value:8.77E-5 ID:SGTC_3326|Compound:9140064|FD-Score:4.86|P-value:5.84E-7 ID:SGTC_3327|Compound:9140648|FD-Score:-4.00|P-value:4.91E-5 ID:SGTC_3331|Compound:9141060|FD-Score:-4.19|P-value:2.22E-5

Top fitness defect scores for YNR053C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2887 9044784 7.75 58.4 µM 5.91E-15 fatty acid desaturase (OLE1) 4 4.72E-15 0.61
2 SGTC_2536 dehydroabietamide 6.15 32.0 µM 4.07E-10 1 3.80E-10 0.59
3 SGTC_297 0986-0032 5.41 24.0 µM 3.24E-8 60S ribosome export 2 3.19E-8 1.49
4 SGTC_3054 9094397 5.28 49.5 µM 6.37E-8 fatty acid desaturase (OLE1) 3 6.32E-8 0.86
5 SGTC_997 3996-0078 5.24 137.0 µM 8.22E-8 1 8.18E-8 0.40
6 SGTC_3000 9075062 5.24 71.4 µM 8.23E-8 3 8.19E-8 0.93
7 SGTC_49 0717-0965 5.10 32.1 µM 1.72E-7 60S ribosome export 4 1.73E-7 0.03
8 SGTC_1582 3',3',6'-trihydroxyflavone 4.88 74.0 µM 5.14E-7 2 5.22E-7 0.26
9 SGTC_3326 9140064 4.86 16.4 µM 5.84E-7 2 5.94E-7 0.36
10 SGTC_3093 9117344 4.76 49.5 µM 9.58E-7 60S ribosome export 2 9.79E-7 0.05
11 SGTC_2481 5478948 4.72 45.2 µM 1.17E-6 PDR1 5 1.20E-6 0.34
12 SGTC_2710 st078562 4.50 53.7 µM 3.28E-6 2 3.39E-6 0.18
13 SGTC_2880 9042983 4.49 58.4 µM 3.48E-6 fatty acid desaturase (OLE1) 8 3.60E-6 0.16
14 SGTC_3044 9093193 4.48 49.5 µM 3.52E-6 2 3.65E-6 0.46
15 SGTC_2809 7964133 4.25 13.0 µM 1.03E-5 60S ribosome export 9 1.07E-5 0.14
16 SGTC_1256 0570-0116 4.18 285.0 µM 1.40E-5 4 1.47E-5 0.06
17 SGTC_1832 st054113 4.06 55.0 µM 2.32E-5 4 2.44E-5 0.64
18 SGTC_788 1182-0090 4.06 188.0 µM 2.36E-5 endomembrane recycling 12 2.49E-5 0.07
19 SGTC_2768 sulfasalazine 4.00 50.2 µM 2.96E-5 8 3.12E-5 0.03
20 SGTC_1807 st050092 3.98 58.9 µM 3.33E-5 60S ribosome export 4 3.51E-5 0.16

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 1.06E-14 YGL055W OLE1 het Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
0.128 1.13E-13 YBR190W_d YBR190W_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W
0.123 7.15E-13 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.121 2.22E-12 YBR232C_d YBR232C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.121 2.38E-12 YLR009W RLP24 het Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp
0.111 1.16E-10 YHR170W NMD3 het Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
0.101 4.86E-9 YOL115W PAP2 hom Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p
0.095 3.93E-8 YGL030W RPL30 het Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog
0.089 2.80E-7 YDR288W NSE3 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress
0.088 3.11E-7 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.084 1.25E-6 YML018C YML018C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene; relative distribution to the vacuolar membrane decreases upon DNA replication stress; YML018C has a paralog, THI74, that arose from the whole genome duplication
0.083 1.68E-6 YHR150W PEX28 hom Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p
0.082 1.97E-6 YCR094W CDC50 hom Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication
0.081 2.37E-6 YDL154W MSH5 hom Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans
0.081 2.75E-6 YOL120C RPL18A het Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication