YNR058W / BIO3

7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR058W / BIO3

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:4.19|P-value:2.23E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:4.68|P-value:2.57E-6 ID:SGTC_125|Compound:0133-0007|FD-Score:3.20|P-value:9.33E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.55|P-value:2.71E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:3.62|P-value:2.07E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:-3.73|P-value:1.21E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:5.44|P-value:5.62E-8 ID:SGTC_438|Compound:sphingosine|FD-Score:3.78|P-value:1.14E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.62|P-value:2.09E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:4.55|P-value:4.67E-6 ID:SGTC_497|Compound:capsazepine|FD-Score:3.82|P-value:9.91E-5 ID:SGTC_595|Compound:3909-8003|FD-Score:3.30|P-value:6.66E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:4.01|P-value:4.57E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:3.19|P-value:9.47E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.56|P-value:2.61E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.13|P-value:2.38E-7 ID:SGTC_904|Compound:1141-0088|FD-Score:3.24|P-value:7.97E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.53|P-value:2.97E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.45|P-value:3.93E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:6.54|P-value:8.65E-11 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.67|P-value:1.77E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.64|P-value:1.97E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.19|P-value:2.22E-5 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.42|P-value:4.28E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.36|P-value:5.37E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.49|P-value:6.02E-6 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.77|P-value:1.21E-4 ID:SGTC_1726|Compound:st035556|FD-Score:4.67|P-value:2.69E-6 ID:SGTC_1746|Compound:st038117|FD-Score:5.63|P-value:2.00E-8 ID:SGTC_1757|Compound:st041620|FD-Score:4.02|P-value:4.49E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.93|P-value:6.44E-5 ID:SGTC_1814|Compound:st052110|FD-Score:4.99|P-value:5.68E-7 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.11|P-value:3.08E-5 ID:SGTC_2135|Compound:5326629|FD-Score:4.53|P-value:4.99E-6 ID:SGTC_2151|Compound:5563267|FD-Score:3.67|P-value:1.73E-4 ID:SGTC_2164|Compound:5685496|FD-Score:6.04|P-value:1.92E-9 ID:SGTC_2173|Compound:5763948|FD-Score:3.89|P-value:7.50E-5 ID:SGTC_2442|Compound:5158906|FD-Score:15.50|P-value:6.56E-52 ID:SGTC_2451|Compound:5856223|FD-Score:3.88|P-value:7.74E-5 ID:SGTC_2455|Compound:5377712|FD-Score:-7.48|P-value:1.09E-13 ID:SGTC_2456|Compound:5770359|FD-Score:-3.28|P-value:6.24E-4 ID:SGTC_2461|Compound:5755302|FD-Score:6.60|P-value:6.00E-11 ID:SGTC_2462|Compound:5162487|FD-Score:-5.17|P-value:1.85E-7 ID:SGTC_2464|Compound:5717415|FD-Score:-4.74|P-value:1.62E-6 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.82|P-value:9.98E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-3.68|P-value:1.48E-4 ID:SGTC_2717|Compound:st081029|FD-Score:3.38|P-value:5.06E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.64|P-value:1.95E-4 ID:SGTC_2744|Compound:captopril|FD-Score:3.66|P-value:1.80E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.45|P-value:3.92E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.32|P-value:6.12E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-3.36|P-value:4.65E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-4.28|P-value:1.30E-5 ID:SGTC_2907|Compound:7721985|FD-Score:4.01|P-value:4.65E-5 ID:SGTC_2911|Compound:7942208|FD-Score:-3.65|P-value:1.62E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.26|P-value:7.52E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.34|P-value:5.05E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.31|P-value:6.44E-4 ID:SGTC_3049|Compound:9092223|FD-Score:4.06|P-value:3.86E-5 ID:SGTC_3055|Compound:9094636|FD-Score:3.27|P-value:7.35E-4 ID:SGTC_3124|Compound:9127567|FD-Score:4.15|P-value:2.65E-5 ID:SGTC_3125|Compound:9127534|FD-Score:3.45|P-value:3.89E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.93|P-value:6.43E-5 ID:SGTC_3182|Compound:9108849|FD-Score:3.53|P-value:2.93E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:4.19|P-value:2.23E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:4.68|P-value:2.57E-6 ID:SGTC_125|Compound:0133-0007|FD-Score:3.20|P-value:9.33E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.55|P-value:2.71E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:3.62|P-value:2.07E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:-3.73|P-value:1.21E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:5.44|P-value:5.62E-8 ID:SGTC_438|Compound:sphingosine|FD-Score:3.78|P-value:1.14E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.62|P-value:2.09E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:4.55|P-value:4.67E-6 ID:SGTC_497|Compound:capsazepine|FD-Score:3.82|P-value:9.91E-5 ID:SGTC_595|Compound:3909-8003|FD-Score:3.30|P-value:6.66E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:4.01|P-value:4.57E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:3.19|P-value:9.47E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.56|P-value:2.61E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.13|P-value:2.38E-7 ID:SGTC_904|Compound:1141-0088|FD-Score:3.24|P-value:7.97E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.53|P-value:2.97E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.45|P-value:3.93E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:6.54|P-value:8.65E-11 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.67|P-value:1.77E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.64|P-value:1.97E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.19|P-value:2.22E-5 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.42|P-value:4.28E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.36|P-value:5.37E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.49|P-value:6.02E-6 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.77|P-value:1.21E-4 ID:SGTC_1726|Compound:st035556|FD-Score:4.67|P-value:2.69E-6 ID:SGTC_1746|Compound:st038117|FD-Score:5.63|P-value:2.00E-8 ID:SGTC_1757|Compound:st041620|FD-Score:4.02|P-value:4.49E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.93|P-value:6.44E-5 ID:SGTC_1814|Compound:st052110|FD-Score:4.99|P-value:5.68E-7 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.11|P-value:3.08E-5 ID:SGTC_2135|Compound:5326629|FD-Score:4.53|P-value:4.99E-6 ID:SGTC_2151|Compound:5563267|FD-Score:3.67|P-value:1.73E-4 ID:SGTC_2164|Compound:5685496|FD-Score:6.04|P-value:1.92E-9 ID:SGTC_2173|Compound:5763948|FD-Score:3.89|P-value:7.50E-5 ID:SGTC_2442|Compound:5158906|FD-Score:15.50|P-value:6.56E-52 ID:SGTC_2451|Compound:5856223|FD-Score:3.88|P-value:7.74E-5 ID:SGTC_2455|Compound:5377712|FD-Score:-7.48|P-value:1.09E-13 ID:SGTC_2456|Compound:5770359|FD-Score:-3.28|P-value:6.24E-4 ID:SGTC_2461|Compound:5755302|FD-Score:6.60|P-value:6.00E-11 ID:SGTC_2462|Compound:5162487|FD-Score:-5.17|P-value:1.85E-7 ID:SGTC_2464|Compound:5717415|FD-Score:-4.74|P-value:1.62E-6 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.82|P-value:9.98E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-3.68|P-value:1.48E-4 ID:SGTC_2717|Compound:st081029|FD-Score:3.38|P-value:5.06E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.64|P-value:1.95E-4 ID:SGTC_2744|Compound:captopril|FD-Score:3.66|P-value:1.80E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.45|P-value:3.92E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.32|P-value:6.12E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-3.36|P-value:4.65E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-4.28|P-value:1.30E-5 ID:SGTC_2907|Compound:7721985|FD-Score:4.01|P-value:4.65E-5 ID:SGTC_2911|Compound:7942208|FD-Score:-3.65|P-value:1.62E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.26|P-value:7.52E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.34|P-value:5.05E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.31|P-value:6.44E-4 ID:SGTC_3049|Compound:9092223|FD-Score:4.06|P-value:3.86E-5 ID:SGTC_3055|Compound:9094636|FD-Score:3.27|P-value:7.35E-4 ID:SGTC_3124|Compound:9127567|FD-Score:4.15|P-value:2.65E-5 ID:SGTC_3125|Compound:9127534|FD-Score:3.45|P-value:3.89E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.93|P-value:6.43E-5 ID:SGTC_3182|Compound:9108849|FD-Score:3.53|P-value:2.93E-4

Top fitness defect scores for YNR058W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2442 5158906 15.50 48.5 µM 6.56E-52 1 3.44E-54
2 SGTC_2461 5755302 6.60 26.1 µM 6.00E-11 10 2.12E-11
3 SGTC_1064 honokiol 6.54 6.8 µM 8.65E-11 2 3.10E-11
4 SGTC_2164 5685496 6.04 200.0 µM 1.92E-9 4 7.92E-10
5 SGTC_1746 st038117 5.63 42.0 µM 2.00E-8 9 9.19E-9
6 SGTC_337 1315-0038 5.44 354.0 µM 5.62E-8 amide catabolism 11 2.70E-8
7 SGTC_1814 st052110 4.99 31.5 µM 5.68E-7 RNA processing & uracil transport 6 3.03E-7
8 SGTC_115 0527-0192 4.68 112.0 µM 2.57E-6 42 1.47E-6
9 SGTC_1726 st035556 4.67 14.6 µM 2.69E-6 22 1.54E-6
10 SGTC_481 bay k-8644 4.55 50.0 µM 4.67E-6 16 2.74E-6
11 SGTC_2135 5326629 4.53 150.4 µM 4.99E-6 RPP1 & pyrimidine depletion 13 2.94E-6
12 SGTC_1576 erythromycin ethylsuccinate 4.49 23.2 µM 6.02E-6 15 3.58E-6
13 SGTC_1248 0469-0687 4.19 58.6 µM 2.22E-5 20 1.40E-5
14 SGTC_68 0986-0284 4.19 82.8 µM 2.23E-5 59 1.41E-5
15 SGTC_3124 9127567 4.15 49.5 µM 2.65E-5 DNA damage response 13 1.68E-5
16 SGTC_2131 toluylene red 4.11 5.3 µM 3.08E-5 60S ribosome export 20 1.97E-5
17 SGTC_3049 9092223 4.06 49.5 µM 3.86E-5 21 2.50E-5
18 SGTC_1757 st041620 4.02 31.8 µM 4.49E-5 30 2.92E-5
19 SGTC_693 4161-2696 4.01 114.0 µM 4.57E-5 9 2.98E-5
20 SGTC_2907 7721985 4.01 69.9 µM 4.65E-5 19 3.03E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 7.70E-10 YBR022W POA1 hom Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing
0.094 4.40E-8 YDL008W APC11 het Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity
0.091 1.27E-7 YKL185W ASH1 hom Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
0.088 3.17E-7 YLL001W DNM1 hom Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
0.084 1.03E-6 YDR284C DPP1 hom Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism
0.084 1.08E-6 YPL062W_d YPL062W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
0.082 2.22E-6 YDR294C DPL1 hom Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
0.078 5.91E-6 YML082W_p YML082W_p hom Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene
0.077 7.45E-6 YBR034C HMT1 hom Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region.
0.076 1.01E-5 YGR010W NMA2 hom Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication
0.076 1.13E-5 YIL046W-A_p YIL046W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.073 2.30E-5 YMR273C ZDS1 hom Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication
0.072 3.13E-5 YDR077W SED1 hom Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites
0.071 3.85E-5 YDR506C GMC1 hom Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-localized protein
0.070 4.87E-5 YPR088C SRP54 het Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain