| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|
| 0.121 |
1.78E-12 |
YLR290C_p |
YLR290C_p |
hom |
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene |
| 0.121 |
1.90E-12 |
YOR159C |
SME1 |
het |
Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E |
| 0.121 |
2.13E-12 |
YIR024C |
YIR024C |
hom |
Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect |
| 0.115 |
2.33E-11 |
YMR317W_p |
YMR317W_p |
hom |
Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene |
| 0.096 |
2.23E-8 |
YGR140W |
CBF2 |
het |
Essential kinetochore protein; component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; relative distribution to the spindle pole body decreases upon DNA replication stress |
| 0.091 |
1.18E-7 |
YLR117C |
CLF1 |
het |
Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins |
| 0.091 |
1.43E-7 |
YDR504C |
SPG3 |
hom |
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources |
| 0.090 |
1.66E-7 |
YGR232W |
NAS6 |
hom |
Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6 |
| 0.089 |
2.27E-7 |
YGR087C |
PDC6 |
hom |
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation |
| 0.089 |
2.30E-7 |
YER013W |
PRP22 |
het |
DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes |
| 0.086 |
5.67E-7 |
YDL117W |
CYK3 |
hom |
SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants |
| 0.085 |
7.89E-7 |
YKL024C |
URA6 |
het |
Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP) |
| 0.079 |
4.89E-6 |
YMR117C |
SPC24 |
het |
Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering |
| 0.078 |
6.24E-6 |
YOR343C_d |
YOR343C_d |
hom |
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.078 |
6.28E-6 |
YBR153W |
RIB7 |
het |
Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway |
