YNR071C_p

Putative aldose 1-epimerase

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR071C / YNR071C

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:3.04|P-value:7.11E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.16|P-value:4.06E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.11|P-value:5.00E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:4.12|P-value:7.68E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.46|P-value:1.23E-6 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.23|P-value:3.52E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.04|P-value:7.29E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.05|P-value:6.27E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.26|P-value:3.19E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:5.82|P-value:4.87E-10 ID:SGTC_530|Compound:4358-1714|FD-Score:3.04|P-value:7.19E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.16|P-value:4.55E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.02|P-value:7.67E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:3.25|P-value:3.24E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:4.24|P-value:4.17E-6 ID:SGTC_1359|Compound:1582-0056|FD-Score:5.29|P-value:1.36E-8 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.05|P-value:6.18E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:-4.26|P-value:3.32E-6 ID:SGTC_1454|Compound:4239-0054|FD-Score:5.93|P-value:2.27E-10 ID:SGTC_1636|Compound:st007707|FD-Score:4.25|P-value:4.02E-6 ID:SGTC_1653|Compound:st012112|FD-Score:4.35|P-value:2.51E-6 ID:SGTC_1765|Compound:st044815|FD-Score:3.06|P-value:6.72E-4 ID:SGTC_1820|Compound:st053765|FD-Score:4.47|P-value:1.31E-6 ID:SGTC_1848|Compound:st056003|FD-Score:3.73|P-value:4.52E-5 ID:SGTC_1868|Compound:st057644|FD-Score:3.55|P-value:9.84E-5 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.46|P-value:1.43E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.31|P-value:2.27E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.49|P-value:1.27E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.11|P-value:5.46E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.21|P-value:3.79E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:2.99|P-value:8.53E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.52|P-value:1.11E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.82|P-value:3.03E-5 ID:SGTC_2957|Compound:9076800|FD-Score:-4.59|P-value:6.22E-7 ID:SGTC_2962|Compound:9082311|FD-Score:-2.99|P-value:7.81E-4 ID:SGTC_3106|Compound:9121286|FD-Score:4.02|P-value:1.21E-5 ID:SGTC_3111|Compound:9122088|FD-Score:3.36|P-value:2.15E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.87|P-value:2.47E-5 ID:SGTC_3122|Compound:9126309|FD-Score:-3.66|P-value:5.41E-5 ID:SGTC_3287|Compound:9117173|FD-Score:3.39|P-value:1.86E-4 ID:SGTC_3293|Compound:9120939|FD-Score:4.17|P-value:6.02E-6 ID:SGTC_41|Compound:0478-0632|FD-Score:3.04|P-value:7.11E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.16|P-value:4.06E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.11|P-value:5.00E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:4.12|P-value:7.68E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.46|P-value:1.23E-6 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.23|P-value:3.52E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.04|P-value:7.29E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.05|P-value:6.27E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.26|P-value:3.19E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:5.82|P-value:4.87E-10 ID:SGTC_530|Compound:4358-1714|FD-Score:3.04|P-value:7.19E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.16|P-value:4.55E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.02|P-value:7.67E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:3.25|P-value:3.24E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:4.24|P-value:4.17E-6 ID:SGTC_1359|Compound:1582-0056|FD-Score:5.29|P-value:1.36E-8 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.05|P-value:6.18E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:-4.26|P-value:3.32E-6 ID:SGTC_1454|Compound:4239-0054|FD-Score:5.93|P-value:2.27E-10 ID:SGTC_1636|Compound:st007707|FD-Score:4.25|P-value:4.02E-6 ID:SGTC_1653|Compound:st012112|FD-Score:4.35|P-value:2.51E-6 ID:SGTC_1765|Compound:st044815|FD-Score:3.06|P-value:6.72E-4 ID:SGTC_1820|Compound:st053765|FD-Score:4.47|P-value:1.31E-6 ID:SGTC_1848|Compound:st056003|FD-Score:3.73|P-value:4.52E-5 ID:SGTC_1868|Compound:st057644|FD-Score:3.55|P-value:9.84E-5 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.46|P-value:1.43E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.31|P-value:2.27E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.49|P-value:1.27E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.11|P-value:5.46E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.21|P-value:3.79E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:2.99|P-value:8.53E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.52|P-value:1.11E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.82|P-value:3.03E-5 ID:SGTC_2957|Compound:9076800|FD-Score:-4.59|P-value:6.22E-7 ID:SGTC_2962|Compound:9082311|FD-Score:-2.99|P-value:7.81E-4 ID:SGTC_3106|Compound:9121286|FD-Score:4.02|P-value:1.21E-5 ID:SGTC_3111|Compound:9122088|FD-Score:3.36|P-value:2.15E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.87|P-value:2.47E-5 ID:SGTC_3122|Compound:9126309|FD-Score:-3.66|P-value:5.41E-5 ID:SGTC_3287|Compound:9117173|FD-Score:3.39|P-value:1.86E-4 ID:SGTC_3293|Compound:9120939|FD-Score:4.17|P-value:6.02E-6

Top fitness defect scores for YNR071C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1454 4239-0054 5.93 42.6 µM 2.27E-10 5 1.50E-9
2 SGTC_507 nimesulide 5.82 162.0 µM 4.87E-10 7 2.99E-9
3 SGTC_1359 1582-0056 5.29 520.0 nM 1.36E-8 4 6.11E-8
4 SGTC_1820 st053765 4.47 18.6 µM 1.31E-6 RPP1 & pyrimidine depletion 10 3.84E-6
5 SGTC_1653 st012112 4.35 65.0 µM 2.51E-6 7 6.91E-6
6 SGTC_1636 st007707 4.25 68.9 µM 4.02E-6 43 1.06E-5
7 SGTC_1355 1499-0035 4.24 1.7 µM 4.17E-6 12 1.10E-5
8 SGTC_3293 9120939 4.17 62.0 µM 6.02E-6 16 1.53E-5
9 SGTC_139 0099-0334 4.12 718.6 µM 7.68E-6 24 1.91E-5
10 SGTC_3106 9121286 4.02 49.5 µM 1.21E-5 9 2.89E-5
11 SGTC_3114 9122766 3.87 49.5 µM 2.47E-5 17 5.52E-5
12 SGTC_2588 indole-3-carbinol 3.82 100.0 µM 3.03E-5 50 6.64E-5
13 SGTC_1848 st056003 3.73 16.4 µM 4.52E-5 23 9.54E-5
14 SGTC_1868 st057644 3.55 42.7 µM 9.84E-5 49 1.94E-4
15 SGTC_2586 curcumin 3.52 80.0 µM 1.11E-4 iron homeostasis 76 2.17E-4
16 SGTC_2289 7946404 3.49 165.1 µM 1.27E-4 111 2.43E-4
17 SGTC_2039 Aminomethylbenzodioxan 3.46 200.0 µM 1.43E-4 12 2.72E-4
18 SGTC_3287 9117173 3.39 37.1 µM 1.86E-4 60S ribosome export 12 3.46E-4
19 SGTC_3111 9122088 3.36 49.5 µM 2.15E-4 9 3.95E-4
20 SGTC_505 gw-5074 3.26 63.9 µM 3.19E-4 85 5.66E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 1.78E-12 YLR290C_p YLR290C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene
0.121 1.90E-12 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.121 2.13E-12 YIR024C YIR024C hom Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect
0.115 2.33E-11 YMR317W_p YMR317W_p hom Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene
0.096 2.23E-8 YGR140W CBF2 het Essential kinetochore protein; component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; relative distribution to the spindle pole body decreases upon DNA replication stress
0.091 1.18E-7 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.091 1.43E-7 YDR504C SPG3 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.090 1.66E-7 YGR232W NAS6 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6
0.089 2.27E-7 YGR087C PDC6 hom Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
0.089 2.30E-7 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.086 5.67E-7 YDL117W CYK3 hom SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants
0.085 7.89E-7 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
0.079 4.89E-6 YMR117C SPC24 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
0.078 6.24E-6 YOR343C_d YOR343C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.078 6.28E-6 YBR153W RIB7 het Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway