HIPHOP chemogenomics database

YNR074C / AIF1

Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase

Zygosity: Homozygous strain

fixedexpanded
Profile for YNR074C / AIF1

Click on Significant Values for Screen Details

Top fitness defect scores for YNR074C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1916	st067606	5.84	49.2 µM	2.52E-9		8	2.66E-9
2	SGTC_2030	5175110	5.77	200.0 µM	3.68E-9	Golgi	6	3.88E-9
3	SGTC_142	0335-0849	5.32	62.7 µM	5.02E-8	ubiquinone biosynthesis & proteasome	79	5.22E-8
4	SGTC_541	4513-1321	4.89	94.0 µM	4.87E-7		10	5.00E-7
5	SGTC_1936	st074407	4.85	74.3 µM	5.93E-7	DNA damage response	15	6.08E-7
6	SGTC_137	0438-0332	4.79	85.4 µM	8.12E-7	ubiquinone biosynthesis & proteasome	81	8.32E-7
7	SGTC_158	k038-0087	4.71	26.4 µM	1.18E-6	ubiquinone biosynthesis & proteasome	98	1.21E-6
8	SGTC_1633	st005664	4.53	67.9 µM	2.90E-6		19	2.95E-6
9	SGTC_2693	st077581	4.52	40.7 µM	3.00E-6		18	3.06E-6
10	SGTC_1638	st008370	4.34	60.6 µM	6.95E-6	ergosterol biosynthesis	25	7.05E-6
11	SGTC_1908	st060353	4.18	56.5 µM	1.47E-5	RPP1 & pyrimidine depletion	30	1.48E-5
12	SGTC_259	usnic acid	4.13	108.9 µM	1.82E-5		14	1.83E-5
13	SGTC_2000	st075254	4.08	36.4 µM	2.24E-5		6	2.26E-5
14	SGTC_86	0417-1630	3.93	471.9 µM	4.15E-5	ubiquinone biosynthesis & proteasome	151	4.18E-5
15	SGTC_2367	9070478	3.65	135.4 µM	1.33E-4	cell wall	45	1.33E-4
16	SGTC_3212	9128307	3.64	49.5 µM	1.34E-4		60	1.34E-4
17	SGTC_1688	st021091	3.58	57.6 µM	1.69E-4		12	1.69E-4
18	SGTC_1324	1418-0026	3.57	34.4 µM	1.77E-4		21	1.76E-4
19	SGTC_1153	4055-0057	3.49	267.0 µM	2.40E-4		45	2.39E-4
20	SGTC_1148	3909-7663	3.44	27.7 µM	2.89E-4		27	2.89E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.233	1.90E-42	YOR254C	SEC63	het	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.224	1.38E-39	YML034C-A_d	YML034C-A_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.220	3.39E-38	YPR064W_d	YPR064W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.218	2.84E-37	YJL193W_p	YJL193W_p	hom	Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.202	4.40E-32	YDL183C	YDL183C	hom	Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.183	9.73E-27	YJL155C	FBP26	hom	Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.176	1.03E-24	YOL008W	COQ10	hom	Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q₆ to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
0.174	2.74E-24	YLR201C	COQ9	hom	Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.174	4.23E-24	YML034W	SRC1	hom	Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.171	1.74E-23	YER019C-A	SBH2	hom	Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.169	8.52E-23	YPR065W	ROX1	hom	Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.167	2.12E-22	YER012W	PRE1	het	Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
0.166	3.23E-22	YGL119W	COQ8	hom	Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.166	4.84E-22	YNR041C	COQ2	hom	Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.164	1.26E-21	YCL014W	BUD3	hom	Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding