HIPHOP chemogenomics database

YOL002C / IZH2

Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc

Zygosity: Homozygous strain

fixedexpanded
Profile for YOL002C / IZH2

Click on Significant Values for Screen Details

Top fitness defect scores for YOL002C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1026	k007-1105	19.50	30.6 µM	1.93E-89	ERAD & cell cycle	2	3.13E-85
2	SGTC_733	4069-0007	18.50	56.1 µM	6.82E-81	ERAD & cell cycle	4	4.25E-77
3	SGTC_103	0844-0104	14.00	51.8 µM	6.87E-47	ERAD & cell cycle	11	9.64E-45
4	SGTC_568	1193-0097	13.40	7.5 µM	4.96E-43	ERAD & cell cycle	7	4.53E-41
5	SGTC_384	k007-0144	13.00	5.2 µM	1.32E-40	ERAD & cell cycle	5	9.22E-39
6	SGTC_2322	7413319	12.70	38.2 µM	6.78E-39	ERAD & cell cycle	8	3.91E-37
7	SGTC_2597	laccaic acid a	12.30	100.0 µM	1.40E-36		1	6.27E-35
8	SGTC_1161	k007-0610	10.40	110.0 µM	7.67E-27	ERAD & cell cycle	12	1.17E-25
9	SGTC_373	0844-0104	10.30	25.9 µM	1.87E-26	ERAD & cell cycle	7	2.73E-25
10	SGTC_352	k048-0007	10.00	5.1 µM	5.89E-25	ERAD & cell cycle	9	7.28E-24
11	SGTC_805	3852-0218	8.59	479.0 µM	6.94E-19	ERAD & cell cycle	7	4.40E-18
12	SGTC_1165	k072-0275	7.10	30.3 µM	1.77E-13		6	6.24E-13
13	SGTC_637	1181-0519	6.18	7.3 µM	1.22E-10	fatty acid desaturase (OLE1)	50	3.15E-10
14	SGTC_1658	st012944	5.97	20.0 µM	4.79E-10	iron homeostasis	29	1.16E-9
15	SGTC_603	3794-0023	5.54	45.9 µM	6.98E-9		4	1.50E-8
16	SGTC_444	curcumin	5.27	90.4 µM	3.38E-8	iron homeostasis	9	6.73E-8
17	SGTC_660	4031-1742	5.05	102.0 µM	1.18E-7	redox potentiating	20	2.21E-7
18	SGTC_1110	3-hydroxy-3'-methoxyflavone	4.91	1.2 µM	2.45E-7	iron homeostasis	26	4.45E-7
19	SGTC_1024	4507-0395	4.77	26.0 µM	5.27E-7	TSC3-RPN4	14	9.25E-7
20	SGTC_157	1348-1695	4.51	65.8 µM	1.94E-6	iron homeostasis	44	3.22E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.676	0	YIL030C	SSM4	hom	Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.538	1.06E-250	YDR199W_d	YDR199W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.530	4.65E-243	YMR022W	UBC7	hom	Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.518	6.56E-230	YDR186C	YDR186C	hom	Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.513	3.34E-225	YER084W_p	YER084W_p	hom	Protein of unknown function; expressed at both mRNA and protein levels
0.441	6.06E-160	YMR029C	FAR8	hom	Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.423	1.06E-145	YMR052C-A_d	YMR052C-A_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.412	4.61E-138	YKR014C	YPT52	hom	Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress
0.402	1.33E-130	YML014W	TRM9	hom	tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.387	4.52E-120	YDL100C	GET3	hom	Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress
0.374	5.35E-112	YMR052W	FAR3	hom	Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.354	1.11E-99	YMR116C	ASC1	hom	G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation
0.345	1.31E-94	YDR200C	VPS64	hom	Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance
0.343	5.80E-93	YOR246C	ENV9	hom	Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.338	1.55E-90	YLR380W	CSR1	hom	Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress