YOL019W-A_p

Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL019W-A / YOL019W-A

Click on Significant Values for Screen Details ID:SGTC_236|Compound:1509-0011|FD-Score:4.15|P-value:2.08E-6 ID:SGTC_458|Compound:nppb|FD-Score:2.81|P-value:9.59E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.74|P-value:1.26E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:2.86|P-value:7.67E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:2.84|P-value:8.56E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:4.82|P-value:4.14E-8 ID:SGTC_844|Compound:0330-0132|FD-Score:2.93|P-value:5.85E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.46|P-value:6.32E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:2.99|P-value:4.65E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:2.90|P-value:6.55E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-2.97|P-value:3.99E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.50|P-value:5.19E-5 ID:SGTC_1289|Compound:0976-0073|FD-Score:4.19|P-value:1.69E-6 ID:SGTC_1303|Compound:1160-0052|FD-Score:-4.29|P-value:6.78E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.92|P-value:4.82E-4 ID:SGTC_1618|Compound:st003135|FD-Score:3.13|P-value:2.65E-4 ID:SGTC_1813|Compound:st051246|FD-Score:2.81|P-value:9.31E-4 ID:SGTC_1946|Compound:st076057|FD-Score:3.88|P-value:8.50E-6 ID:SGTC_1948|Compound:st076329|FD-Score:4.10|P-value:2.68E-6 ID:SGTC_1975|Compound:st070967|FD-Score:2.93|P-value:5.83E-4 ID:SGTC_1976|Compound:st070609|FD-Score:4.02|P-value:4.13E-6 ID:SGTC_2028|Compound:5153890|FD-Score:-3.73|P-value:1.26E-5 ID:SGTC_2029|Compound:5175081|FD-Score:-3.55|P-value:3.10E-5 ID:SGTC_2297|Compound:7971671|FD-Score:2.82|P-value:9.12E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-5.21|P-value:2.23E-9 ID:SGTC_2355|Compound:9061122|FD-Score:3.20|P-value:2.00E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.11|P-value:2.87E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.09|P-value:3.12E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.09|P-value:3.10E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:2.92|P-value:6.09E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-3.17|P-value:1.75E-4 ID:SGTC_2705|Compound:st078069|FD-Score:-2.96|P-value:4.08E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.44|P-value:6.88E-5 ID:SGTC_2955|Compound:9076254|FD-Score:6.82|P-value:1.60E-14 ID:SGTC_2960|Compound:9079389|FD-Score:-4.57|P-value:1.30E-7 ID:SGTC_2964|Compound:9083345|FD-Score:-10.30|P-value:5.25E-31 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.02|P-value:4.08E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.26|P-value:1.52E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.03|P-value:3.12E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.68|P-value:2.19E-5 ID:SGTC_3166|Compound:9102297|FD-Score:-2.89|P-value:5.38E-4 ID:SGTC_3218|Compound:9131285|FD-Score:2.91|P-value:6.36E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.15|P-value:2.08E-6 ID:SGTC_458|Compound:nppb|FD-Score:2.81|P-value:9.59E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.74|P-value:1.26E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:2.86|P-value:7.67E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:2.84|P-value:8.56E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:4.82|P-value:4.14E-8 ID:SGTC_844|Compound:0330-0132|FD-Score:2.93|P-value:5.85E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.46|P-value:6.32E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:2.99|P-value:4.65E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:2.90|P-value:6.55E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-2.97|P-value:3.99E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.50|P-value:5.19E-5 ID:SGTC_1289|Compound:0976-0073|FD-Score:4.19|P-value:1.69E-6 ID:SGTC_1303|Compound:1160-0052|FD-Score:-4.29|P-value:6.78E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.92|P-value:4.82E-4 ID:SGTC_1618|Compound:st003135|FD-Score:3.13|P-value:2.65E-4 ID:SGTC_1813|Compound:st051246|FD-Score:2.81|P-value:9.31E-4 ID:SGTC_1946|Compound:st076057|FD-Score:3.88|P-value:8.50E-6 ID:SGTC_1948|Compound:st076329|FD-Score:4.10|P-value:2.68E-6 ID:SGTC_1975|Compound:st070967|FD-Score:2.93|P-value:5.83E-4 ID:SGTC_1976|Compound:st070609|FD-Score:4.02|P-value:4.13E-6 ID:SGTC_2028|Compound:5153890|FD-Score:-3.73|P-value:1.26E-5 ID:SGTC_2029|Compound:5175081|FD-Score:-3.55|P-value:3.10E-5 ID:SGTC_2297|Compound:7971671|FD-Score:2.82|P-value:9.12E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-5.21|P-value:2.23E-9 ID:SGTC_2355|Compound:9061122|FD-Score:3.20|P-value:2.00E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.11|P-value:2.87E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.09|P-value:3.12E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.09|P-value:3.10E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:2.92|P-value:6.09E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-3.17|P-value:1.75E-4 ID:SGTC_2705|Compound:st078069|FD-Score:-2.96|P-value:4.08E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.44|P-value:6.88E-5 ID:SGTC_2955|Compound:9076254|FD-Score:6.82|P-value:1.60E-14 ID:SGTC_2960|Compound:9079389|FD-Score:-4.57|P-value:1.30E-7 ID:SGTC_2964|Compound:9083345|FD-Score:-10.30|P-value:5.25E-31 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.02|P-value:4.08E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.26|P-value:1.52E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.03|P-value:3.12E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.68|P-value:2.19E-5 ID:SGTC_3166|Compound:9102297|FD-Score:-2.89|P-value:5.38E-4 ID:SGTC_3218|Compound:9131285|FD-Score:2.91|P-value:6.36E-4

Top fitness defect scores for YOL019W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2955 9076254 6.82 12.2 µM 1.60E-14 1 4.66E-12
2 SGTC_827 3253-0474 4.82 693.0 µM 4.14E-8 7 7.03E-7
3 SGTC_1289 0976-0073 4.19 69.1 µM 1.69E-6 10 1.42E-5
4 SGTC_236 1509-0011 4.15 5.3 µM 2.08E-6 372 1.68E-5
5 SGTC_1948 st076329 4.10 66.6 µM 2.68E-6 23 2.07E-5
6 SGTC_1976 st070609 4.02 63.5 µM 4.13E-6 11 2.94E-5
7 SGTC_1946 st076057 3.88 65.1 µM 8.50E-6 5 5.29E-5
8 SGTC_3145 9085516 3.68 49.5 µM 2.19E-5 fatty acid desaturase (OLE1) 37 1.14E-4
9 SGTC_1141 3253-0389 3.50 52.6 µM 5.19E-5 15 2.31E-4
10 SGTC_852 0418-0143 3.46 439.0 µM 6.32E-5 calcium & mitochondrial duress 94 2.72E-4
11 SGTC_2810 7959871 3.44 45.5 µM 6.88E-5 copper-dependent oxidative stress 60 2.91E-4
12 SGTC_3066 9117245 3.26 49.5 µM 1.52E-4 29 5.56E-4
13 SGTC_2355 9061122 3.20 103.1 µM 2.00E-4 29 6.97E-4
14 SGTC_1618 st003135 3.13 44.5 µM 2.65E-4 42 8.77E-4
15 SGTC_2481 5478948 3.11 45.2 µM 2.87E-4 PDR1 80 9.36E-4
16 SGTC_2568 diosmetin 3.09 100.0 µM 3.10E-4 63 9.97E-4
17 SGTC_2483 5729050 3.09 27.2 µM 3.12E-4 61 0.00100
18 SGTC_3060 1327-0027 3.02 12.5 µM 4.08E-4 62 0.00125
19 SGTC_922 1866-0035 2.99 480.0 µM 4.65E-4 excess fatty acid 125 0.00139
20 SGTC_1975 st070967 2.93 30.8 µM 5.83E-4 91 0.00167

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.215 2.18E-36 YJR052W RAD7 hom Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
0.167 2.32E-22 YER057C HMF1 hom Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro
0.154 3.33E-19 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.146 2.31E-17 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.145 3.23E-17 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.143 7.26E-17 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.137 1.54E-15 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.136 2.56E-15 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.135 3.70E-15 YGR112W SHY1 hom Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome
0.135 5.17E-15 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.134 5.81E-15 YJL146W IDS2 hom Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation
0.133 1.08E-14 YLR203C MSS51 hom Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis
0.132 1.49E-14 YBL021C HAP3 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding
0.130 4.39E-14 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.129 5.54E-14 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex