YOL028C / YAP7

Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL028C / YAP7

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:3.22|P-value:8.19E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:4.17|P-value:2.26E-5 ID:SGTC_233|Compound:rapamycin|FD-Score:3.46|P-value:3.58E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-4.19|P-value:1.94E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:3.78|P-value:1.08E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.58|P-value:2.30E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:5.55|P-value:2.72E-8 ID:SGTC_916|Compound:4466-0038|FD-Score:-3.25|P-value:6.96E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:5.34|P-value:8.67E-8 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.18|P-value:9.36E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.58|P-value:2.35E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.42|P-value:4.10E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.27|P-value:6.95E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.21|P-value:8.36E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.68|P-value:1.61E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.43|P-value:4.03E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.58|P-value:2.34E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.51|P-value:2.94E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.50|P-value:3.04E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.83|P-value:8.80E-5 ID:SGTC_2700|Compound:st077718|FD-Score:3.82|P-value:9.44E-5 ID:SGTC_3140|Compound:9094243|FD-Score:3.69|P-value:1.53E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:3.22|P-value:8.19E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:4.17|P-value:2.26E-5 ID:SGTC_233|Compound:rapamycin|FD-Score:3.46|P-value:3.58E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-4.19|P-value:1.94E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:3.78|P-value:1.08E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.58|P-value:2.30E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:5.55|P-value:2.72E-8 ID:SGTC_916|Compound:4466-0038|FD-Score:-3.25|P-value:6.96E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:5.34|P-value:8.67E-8 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.18|P-value:9.36E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.58|P-value:2.35E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.42|P-value:4.10E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.27|P-value:6.95E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.21|P-value:8.36E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.68|P-value:1.61E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.43|P-value:4.03E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.58|P-value:2.34E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.51|P-value:2.94E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.50|P-value:3.04E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.83|P-value:8.80E-5 ID:SGTC_2700|Compound:st077718|FD-Score:3.82|P-value:9.44E-5 ID:SGTC_3140|Compound:9094243|FD-Score:3.69|P-value:1.53E-4

Top fitness defect scores for YOL028C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_913 3487-1245 5.55 167.0 µM 2.72E-8 4 1.40E-8
2 SGTC_919 tnp00227 5.34 403.6 nM 8.67E-8 RNA pol III & RNase P/MRP 10 4.69E-8
3 SGTC_61 0978-8327 4.17 98.6 µM 2.26E-5 ergosterol biosynthesis 28 1.53E-5
4 SGTC_2423 st077119 3.83 87.2 µM 8.80E-5 13 6.30E-5
5 SGTC_2700 st077718 3.82 96.8 µM 9.44E-5 15 6.78E-5
6 SGTC_561 1550-0330 3.78 72.9 µM 1.08E-4 11 7.76E-5
7 SGTC_3140 9094243 3.69 49.5 µM 1.53E-4 30 1.12E-4
8 SGTC_2011 4012611 3.68 177.0 µM 1.61E-4 mitochondrial processes 39 1.18E-4
9 SGTC_910 3454-3003 3.58 490.0 µM 2.30E-4 27 1.71E-4
10 SGTC_2150 5556613 3.58 200.0 µM 2.34E-4 25 1.74E-4
11 SGTC_1339 1486-1321 3.58 22.7 µM 2.35E-4 ERG2 36 1.75E-4
12 SGTC_2325 6158266 3.51 200.0 µM 2.94E-4 39 2.21E-4
13 SGTC_2418 pentamidine 3.50 31.7 µM 3.04E-4 mitochondrial processes 62 2.29E-4
14 SGTC_233 rapamycin 3.46 362.0 pM 3.58E-4 22 2.71E-4
15 SGTC_2130 NSC 7 3.43 2.5 µM 4.03E-4 copper-dependent oxidative stress 52 3.07E-4
16 SGTC_1363 1636-0063 3.42 10.4 µM 4.10E-4 Golgi 48 3.12E-4
17 SGTC_1407 3909-7909 3.27 12.3 µM 6.95E-4 60S ribosome export 38 5.41E-4
18 SGTC_24 0417-1663 3.22 219.0 µM 8.19E-4 40 6.41E-4
19 SGTC_1524 corynanthine 3.21 62.1 µM 8.36E-4 46 6.55E-4
20 SGTC_1045 1348-1485 3.18 165.0 µM 9.36E-4 75 7.37E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.180 9.85E-26 YLR018C POM34 hom Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication
0.148 7.57E-18 YJL213W YJL213W hom Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
0.121 2.26E-12 YCL024W KCC4 hom Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication
0.116 1.42E-11 YKR018C YKR018C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
0.110 1.52E-10 YIL145C PAN6 hom Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC
0.099 7.73E-9 YDR373W FRQ1 het N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily
0.097 1.83E-8 YCL048W SPS22 hom Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
0.097 1.99E-8 YER143W DDI1 hom DNA damage-inducible v-SNARE binding protein with a role in suppression of protein secretion; may play a role in S-phase checkpoint control; has ubiquitin-associated (UBA), ubiquitin-like (UBL), and retroviral-like proteinase (RVP) domains
0.093 7.29E-8 YNL006W LST8 het Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat
0.090 1.71E-7 YNL039W BDP1 het Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs
0.089 2.26E-7 YFL010W-A AUA1 hom Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease
0.086 6.94E-7 YOR324C FRT1 hom Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication
0.081 2.34E-6 YBR204C LDH1 hom Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)
0.078 5.42E-6 YHR076W PTC7 hom Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope
0.077 8.53E-6 YPL085W SEC16 het COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p