HIPHOP chemogenomics database
YOL043C / NTG2 
DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YOL043C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.133 | 1.06E-14 | YNL209W | SSB2 | hom | Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication |
| 0.131 | 2.47E-14 | YDR022C | ATG31 | hom | Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion |
| 0.113 | 4.97E-11 | YJL125C | GCD14 | het | Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression |
| 0.112 | 8.89E-11 | YNL254C | RTC4 | hom | Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus |
| 0.093 | 5.95E-8 | YDL219W | DTD1 | hom | D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes |
| 0.093 | 7.45E-8 | YGR182C_d | YGR182C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W |
| 0.088 | 3.80E-7 | YKL059C | MPE1 | het | Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif |
| 0.085 | 8.43E-7 | YPR112C | MRD1 | het | Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region |
| 0.083 | 1.52E-6 | YBR153W | RIB7 | het | Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway |
| 0.082 | 1.81E-6 | YDL241W_p | YDL241W_p | hom | Putative protein of unknown function; YDL241W is not an essential gene |
| 0.081 | 2.39E-6 | YMR235C | RNA1 | het | GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport |
| 0.081 | 2.46E-6 | YOR291W | YPK9 | hom | Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome |
| 0.079 | 4.13E-6 | YER091C | MET6 | hom | Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs |
| 0.078 | 5.69E-6 | YJL200C | ACO2 | hom | Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol |
| 0.077 | 8.52E-6 | YBR108W | AIM3 | hom | Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss |