YOL046C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data;almost completely overlaps the verified gene PSK2/YOL045W

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL046C / YOL046C

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:3.00|P-value:7.25E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.06|P-value:5.89E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.34|P-value:2.02E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.22|P-value:4.21E-6 ID:SGTC_91|Compound:0417-1751|FD-Score:4.28|P-value:3.07E-6 ID:SGTC_136|Compound:0097-0015|FD-Score:4.01|P-value:1.15E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:3.83|P-value:2.58E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:4.88|P-value:1.35E-7 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.09|P-value:8.31E-8 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.47|P-value:1.18E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:4.51|P-value:9.91E-7 ID:SGTC_544|Compound:k015-0020|FD-Score:3.13|P-value:4.49E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.59|P-value:7.36E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:-3.33|P-value:3.31E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:-4.06|P-value:1.55E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:3.05|P-value:6.05E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.30|P-value:2.32E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-5.26|P-value:3.14E-8 ID:SGTC_950|Compound:1165-0508|FD-Score:3.56|P-value:8.34E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:-5.37|P-value:1.62E-8 ID:SGTC_955|Compound:1216-0110|FD-Score:2.94|P-value:9.07E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.35|P-value:1.91E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.22|P-value:3.18E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.24|P-value:2.98E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:-3.25|P-value:4.47E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:2.92|P-value:9.69E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.36|P-value:1.83E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.69|P-value:4.84E-5 ID:SGTC_1602|Compound:st001878|FD-Score:3.51|P-value:1.01E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.35|P-value:3.03E-4 ID:SGTC_1653|Compound:st012112|FD-Score:-3.18|P-value:5.70E-4 ID:SGTC_1655|Compound:st012546|FD-Score:-3.12|P-value:7.05E-4 ID:SGTC_1923|Compound:st058458|FD-Score:-3.49|P-value:1.77E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-3.84|P-value:4.18E-5 ID:SGTC_2001|Compound:4023502|FD-Score:-3.05|P-value:9.23E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.45|P-value:1.28E-4 ID:SGTC_2323|Compound:6148992|FD-Score:4.32|P-value:2.63E-6 ID:SGTC_2330|Compound:7979373|FD-Score:-3.62|P-value:1.04E-4 ID:SGTC_2415|Compound:st077333|FD-Score:7.34|P-value:6.47E-15 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:2.97|P-value:8.16E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.20|P-value:8.07E-6 ID:SGTC_2887|Compound:9044784|FD-Score:-3.45|P-value:2.05E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.03|P-value:6.62E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-3.29|P-value:3.79E-4 ID:SGTC_3094|Compound:9117742|FD-Score:-4.53|P-value:1.62E-6 ID:SGTC_3143|Compound:9086658|FD-Score:-5.09|P-value:8.18E-8 ID:SGTC_3200|Compound:9114385|FD-Score:4.54|P-value:8.52E-7 ID:SGTC_25|Compound:0118-0223|FD-Score:3.00|P-value:7.25E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.06|P-value:5.89E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.34|P-value:2.02E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.22|P-value:4.21E-6 ID:SGTC_91|Compound:0417-1751|FD-Score:4.28|P-value:3.07E-6 ID:SGTC_136|Compound:0097-0015|FD-Score:4.01|P-value:1.15E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:3.83|P-value:2.58E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:4.88|P-value:1.35E-7 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.09|P-value:8.31E-8 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.47|P-value:1.18E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:4.51|P-value:9.91E-7 ID:SGTC_544|Compound:k015-0020|FD-Score:3.13|P-value:4.49E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.59|P-value:7.36E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:-3.33|P-value:3.31E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:-4.06|P-value:1.55E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:3.05|P-value:6.05E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.30|P-value:2.32E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-5.26|P-value:3.14E-8 ID:SGTC_950|Compound:1165-0508|FD-Score:3.56|P-value:8.34E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:-5.37|P-value:1.62E-8 ID:SGTC_955|Compound:1216-0110|FD-Score:2.94|P-value:9.07E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.35|P-value:1.91E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.22|P-value:3.18E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.24|P-value:2.98E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:-3.25|P-value:4.47E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:2.92|P-value:9.69E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.36|P-value:1.83E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.69|P-value:4.84E-5 ID:SGTC_1602|Compound:st001878|FD-Score:3.51|P-value:1.01E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.35|P-value:3.03E-4 ID:SGTC_1653|Compound:st012112|FD-Score:-3.18|P-value:5.70E-4 ID:SGTC_1655|Compound:st012546|FD-Score:-3.12|P-value:7.05E-4 ID:SGTC_1923|Compound:st058458|FD-Score:-3.49|P-value:1.77E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-3.84|P-value:4.18E-5 ID:SGTC_2001|Compound:4023502|FD-Score:-3.05|P-value:9.23E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.45|P-value:1.28E-4 ID:SGTC_2323|Compound:6148992|FD-Score:4.32|P-value:2.63E-6 ID:SGTC_2330|Compound:7979373|FD-Score:-3.62|P-value:1.04E-4 ID:SGTC_2415|Compound:st077333|FD-Score:7.34|P-value:6.47E-15 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:2.97|P-value:8.16E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.20|P-value:8.07E-6 ID:SGTC_2887|Compound:9044784|FD-Score:-3.45|P-value:2.05E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.03|P-value:6.62E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-3.29|P-value:3.79E-4 ID:SGTC_3094|Compound:9117742|FD-Score:-4.53|P-value:1.62E-6 ID:SGTC_3143|Compound:9086658|FD-Score:-5.09|P-value:8.18E-8 ID:SGTC_3200|Compound:9114385|FD-Score:4.54|P-value:8.52E-7

Top fitness defect scores for YOL046C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2415 st077333 7.34 57.7 µM 6.47E-15 6 1.04E-13
2 SGTC_303 1348-1668 4.88 34.2 µM 1.35E-7 1 5.28E-7
3 SGTC_3200 9114385 4.54 49.5 µM 8.52E-7 21 2.84E-6
4 SGTC_475 α-linolenic acid 4.51 10.0 µM 9.91E-7 excess fatty acid 14 3.26E-6
5 SGTC_2323 6148992 4.32 148.3 µM 2.63E-6 24 7.95E-6
6 SGTC_91 0417-1751 4.28 58.4 µM 3.07E-6 Golgi 41 9.16E-6
7 SGTC_87 0100-0052 4.22 35.5 µM 4.21E-6 91 1.22E-5
8 SGTC_136 0097-0015 4.01 404.5 µM 1.15E-5 60S ribosome export 16 3.06E-5
9 SGTC_137 0438-0332 3.83 85.4 µM 2.58E-5 ubiquinone biosynthesis & proteasome 132 6.41E-5
10 SGTC_1514 1189-1591 3.69 158.0 µM 4.84E-5 44 1.14E-4
11 SGTC_574 1315-0397 3.59 40.0 µM 7.36E-5 53 1.67E-4
12 SGTC_950 1165-0508 3.56 94.1 µM 8.34E-5 40 1.87E-4
13 SGTC_1602 st001878 3.51 87.6 µM 1.01E-4 31 2.24E-4
14 SGTC_436 n,n-dimethylsphingosine 3.47 3.3 µM 1.18E-4 42 2.57E-4
15 SGTC_2263 7948595 3.45 193.3 µM 1.28E-4 16 2.78E-4
16 SGTC_1351 1496-0003 3.36 46.5 µM 1.83E-4 35 3.85E-4
17 SGTC_986 1493-0483 3.35 84.0 µM 1.91E-4 30 3.99E-4
18 SGTC_69 0096-0274 3.34 206.7 µM 2.02E-4 mitochondrial processes 77 4.19E-4
19 SGTC_745 0469-0705 3.30 296.0 µM 2.32E-4 mitochondrial processes 40 4.76E-4
20 SGTC_1245 0418-0076 3.24 17.2 µM 2.98E-4 ERG2 57 5.99E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.64E-11 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.114 3.56E-11 YJR116W_p TDA4_p hom Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele
0.109 2.36E-10 YGR189C CRH1 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress
0.101 4.98E-9 YOL048C RRT8 hom Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress
0.100 5.60E-9 YHR065C RRP3 het Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity
0.098 1.14E-8 YEL058W PCM1 het Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
0.094 4.22E-8 YLR272C YCS4 het Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.091 1.26E-7 YDR151C CTH1 hom Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis
0.088 3.79E-7 YDR295C HDA2 hom Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance
0.086 6.67E-7 YOR062C_p YOR062C_p hom Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.085 7.59E-7 YMR285C NGL2 hom Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication
0.081 2.43E-6 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.081 2.44E-6 YJL026W RNR2 het Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
0.081 2.68E-6 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.079 4.39E-6 YBR087W RFC5 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon