YOL053W / AIM39

Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL053W / AIM39

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:3.01|P-value:4.22E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:2.99|P-value:4.48E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:2.90|P-value:6.45E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:2.84|P-value:8.05E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:13.50|P-value:3.15E-50 ID:SGTC_342|Compound:k048-0088|FD-Score:-3.05|P-value:4.83E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.06|P-value:3.46E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:2.88|P-value:6.83E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:-3.30|P-value:1.77E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:2.91|P-value:6.23E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.89|P-value:1.21E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.67|P-value:3.39E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:3.19|P-value:2.00E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:-3.05|P-value:4.76E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.21|P-value:2.40E-6 ID:SGTC_1192|Compound:1488-0095|FD-Score:2.98|P-value:4.62E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.77|P-value:1.47E-5 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.45|P-value:9.27E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.26|P-value:1.46E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.30|P-value:1.25E-4 ID:SGTC_1716|Compound:st033144|FD-Score:3.21|P-value:1.88E-4 ID:SGTC_1904|Compound:st060225|FD-Score:-3.03|P-value:5.24E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.37|P-value:9.25E-5 ID:SGTC_2107|Compound:5363541|FD-Score:3.03|P-value:3.79E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.47|P-value:6.07E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.46|P-value:6.28E-5 ID:SGTC_2788|Compound:5282734|FD-Score:3.75|P-value:1.67E-5 ID:SGTC_2791|Compound:5663188|FD-Score:2.91|P-value:6.25E-4 ID:SGTC_2814|Compound:7977482|FD-Score:4.78|P-value:6.31E-8 ID:SGTC_2815|Compound:7968870|FD-Score:-4.78|P-value:9.78E-8 ID:SGTC_2829|Compound:7992743|FD-Score:3.03|P-value:3.85E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.47|P-value:5.99E-5 ID:SGTC_2934|Compound:9036370|FD-Score:2.78|P-value:9.93E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.25|P-value:1.56E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.01|P-value:4.22E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:2.99|P-value:4.48E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:2.90|P-value:6.45E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:2.84|P-value:8.05E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:13.50|P-value:3.15E-50 ID:SGTC_342|Compound:k048-0088|FD-Score:-3.05|P-value:4.83E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.06|P-value:3.46E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:2.88|P-value:6.83E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:-3.30|P-value:1.77E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:2.91|P-value:6.23E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.89|P-value:1.21E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.67|P-value:3.39E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:3.19|P-value:2.00E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:-3.05|P-value:4.76E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.21|P-value:2.40E-6 ID:SGTC_1192|Compound:1488-0095|FD-Score:2.98|P-value:4.62E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.77|P-value:1.47E-5 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.45|P-value:9.27E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.26|P-value:1.46E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.30|P-value:1.25E-4 ID:SGTC_1716|Compound:st033144|FD-Score:3.21|P-value:1.88E-4 ID:SGTC_1904|Compound:st060225|FD-Score:-3.03|P-value:5.24E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.37|P-value:9.25E-5 ID:SGTC_2107|Compound:5363541|FD-Score:3.03|P-value:3.79E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.47|P-value:6.07E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.46|P-value:6.28E-5 ID:SGTC_2788|Compound:5282734|FD-Score:3.75|P-value:1.67E-5 ID:SGTC_2791|Compound:5663188|FD-Score:2.91|P-value:6.25E-4 ID:SGTC_2814|Compound:7977482|FD-Score:4.78|P-value:6.31E-8 ID:SGTC_2815|Compound:7968870|FD-Score:-4.78|P-value:9.78E-8 ID:SGTC_2829|Compound:7992743|FD-Score:3.03|P-value:3.85E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.47|P-value:5.99E-5 ID:SGTC_2934|Compound:9036370|FD-Score:2.78|P-value:9.93E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.25|P-value:1.56E-4

Top fitness defect scores for YOL053W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_309 k408-0051 13.50 1.5 µM 3.15E-50 3 6.65E-42
2 SGTC_2814 7977482 4.78 43.0 µM 6.31E-8 27 8.71E-7
3 SGTC_1234 0326-0494 3.77 15.5 µM 1.47E-5 19 8.08E-5
4 SGTC_2788 5282734 3.75 71.4 µM 1.67E-5 58 9.00E-5
5 SGTC_2831 7999036 3.47 19.5 µM 5.99E-5 69 2.60E-4
6 SGTC_2693 st077581 3.47 40.7 µM 6.07E-5 58 2.63E-4
7 SGTC_2752 diclazuril 3.46 33.1 µM 6.28E-5 159 2.71E-4
8 SGTC_1988 st071872 3.37 53.4 µM 9.25E-5 18 3.74E-4
9 SGTC_1346 1488-2224 3.30 62.4 µM 1.25E-4 34 4.80E-4
10 SGTC_1270 0831-1170 3.26 17.3 µM 1.46E-4 29 5.48E-4
11 SGTC_2935 9038016 3.25 30.0 µM 1.56E-4 47 5.77E-4
12 SGTC_1716 st033144 3.21 30.6 µM 1.88E-4 42 6.75E-4
13 SGTC_968 1309-0633 3.19 340.0 µM 2.00E-4 35 7.10E-4
14 SGTC_353 1988-1175 3.06 58.3 µM 3.46E-4 unfolded protein response 58 0.00112
15 SGTC_2107 5363541 3.03 170.2 µM 3.79E-4 32 0.00121
16 SGTC_2829 7992743 3.03 58.4 µM 3.85E-4 89 0.00123
17 SGTC_41 0478-0632 3.01 82.6 µM 4.22E-4 77 0.00132
18 SGTC_114 0364-0001 2.99 490.3 µM 4.48E-4 110 0.00139
19 SGTC_1192 1488-0095 2.98 21.4 µM 4.62E-4 57 0.00143
20 SGTC_607 4491-0986 2.91 66.8 µM 6.23E-4 heme requiring 74 0.00183

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.502 6.14E-213 YJL153C INO1 hom Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
0.249 1.33E-48 YKL175W ZRT3 hom Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency
0.223 3.65E-39 YGR100W MDR1 hom Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function
0.211 5.44E-35 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.195 5.00E-30 YMR229C RRP5 het RNA binding protein involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome; has binding preference for single stranded tracts of U's; relocalizes from nucleolus to nucleus upon DNA replication stress
0.188 3.50E-28 YNL042W-B_p YNL042W-B_p hom Putative protein of unknown function
0.184 5.57E-27 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.184 6.68E-27 YOR093C_p YOR093C_p hom Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
0.178 2.70E-25 YDR020C_p DAS2_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases
0.171 1.63E-23 YDL224C WHI4 hom Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication
0.169 7.28E-23 YIR004W DJP1 hom Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ
0.165 8.73E-22 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.165 9.10E-22 YJL084C ALY2 hom Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins; ALY2 has a paralog, ALY1, that arose from the whole genome duplication
0.163 2.35E-21 YNL023C FAP1 hom Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1
0.159 1.61E-20 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress