YOL065C / INP54

Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL065C / INP54

Click on Significant Values for Screen Details ID:SGTC_5|Compound:0352-0601|FD-Score:-2.88|P-value:6.98E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.31|P-value:6.91E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:11.70|P-value:3.83E-39 ID:SGTC_129|Compound:0088-0017|FD-Score:2.86|P-value:6.63E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:5.92|P-value:1.84E-11 ID:SGTC_132|Compound:0417-1715|FD-Score:6.28|P-value:1.10E-12 ID:SGTC_135|Compound:0933-0004|FD-Score:3.65|P-value:2.18E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:-2.85|P-value:7.94E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.53|P-value:3.90E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:-4.15|P-value:1.99E-6 ID:SGTC_206|Compound:4546-0025|FD-Score:-2.90|P-value:6.51E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:3.34|P-value:8.98E-5 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.37|P-value:7.78E-5 ID:SGTC_232|Compound:clozapine|FD-Score:-2.85|P-value:7.80E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:4.30|P-value:7.25E-7 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.20|P-value:1.90E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:-3.74|P-value:1.68E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:3.25|P-value:1.35E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:10.80|P-value:9.10E-34 ID:SGTC_571|Compound:k831-0106|FD-Score:3.15|P-value:2.06E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.04|P-value:3.26E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.10|P-value:2.51E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.95|P-value:5.30E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:2.85|P-value:6.90E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.50|P-value:4.47E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:5.31|P-value:1.41E-9 ID:SGTC_940|Compound:3232-1287|FD-Score:2.94|P-value:4.89E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:-2.96|P-value:5.16E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:10.10|P-value:1.27E-29 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.77|P-value:1.22E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:2.84|P-value:7.27E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.13|P-value:2.26E-4 ID:SGTC_1626|Compound:st003712|FD-Score:2.82|P-value:7.94E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-3.54|P-value:4.34E-5 ID:SGTC_1633|Compound:st005664|FD-Score:-4.03|P-value:3.82E-6 ID:SGTC_1764|Compound:st044502|FD-Score:-3.97|P-value:5.24E-6 ID:SGTC_2019|Compound:4016004|FD-Score:2.98|P-value:4.21E-4 ID:SGTC_2057|Compound:5236571|FD-Score:4.39|P-value:4.39E-7 ID:SGTC_2060|Compound:5238662|FD-Score:-2.79|P-value:9.81E-4 ID:SGTC_2338|Compound:7999974|FD-Score:2.92|P-value:5.33E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.15|P-value:2.03E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.03|P-value:3.34E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:4.09|P-value:2.32E-6 ID:SGTC_2700|Compound:st077718|FD-Score:-2.81|P-value:9.08E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.55|P-value:3.42E-5 ID:SGTC_2818|Compound:7996756|FD-Score:-2.83|P-value:8.38E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.41|P-value:6.66E-5 ID:SGTC_3298|Compound:9116858|FD-Score:3.16|P-value:2.00E-4 ID:SGTC_5|Compound:0352-0601|FD-Score:-2.88|P-value:6.98E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.31|P-value:6.91E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:11.70|P-value:3.83E-39 ID:SGTC_129|Compound:0088-0017|FD-Score:2.86|P-value:6.63E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:5.92|P-value:1.84E-11 ID:SGTC_132|Compound:0417-1715|FD-Score:6.28|P-value:1.10E-12 ID:SGTC_135|Compound:0933-0004|FD-Score:3.65|P-value:2.18E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:-2.85|P-value:7.94E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.53|P-value:3.90E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:-4.15|P-value:1.99E-6 ID:SGTC_206|Compound:4546-0025|FD-Score:-2.90|P-value:6.51E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:3.34|P-value:8.98E-5 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.37|P-value:7.78E-5 ID:SGTC_232|Compound:clozapine|FD-Score:-2.85|P-value:7.80E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:4.30|P-value:7.25E-7 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.20|P-value:1.90E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:-3.74|P-value:1.68E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:3.25|P-value:1.35E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:10.80|P-value:9.10E-34 ID:SGTC_571|Compound:k831-0106|FD-Score:3.15|P-value:2.06E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.04|P-value:3.26E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.10|P-value:2.51E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.95|P-value:5.30E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:2.85|P-value:6.90E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.50|P-value:4.47E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:5.31|P-value:1.41E-9 ID:SGTC_940|Compound:3232-1287|FD-Score:2.94|P-value:4.89E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:-2.96|P-value:5.16E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:10.10|P-value:1.27E-29 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.77|P-value:1.22E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:2.84|P-value:7.27E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.13|P-value:2.26E-4 ID:SGTC_1626|Compound:st003712|FD-Score:2.82|P-value:7.94E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-3.54|P-value:4.34E-5 ID:SGTC_1633|Compound:st005664|FD-Score:-4.03|P-value:3.82E-6 ID:SGTC_1764|Compound:st044502|FD-Score:-3.97|P-value:5.24E-6 ID:SGTC_2019|Compound:4016004|FD-Score:2.98|P-value:4.21E-4 ID:SGTC_2057|Compound:5236571|FD-Score:4.39|P-value:4.39E-7 ID:SGTC_2060|Compound:5238662|FD-Score:-2.79|P-value:9.81E-4 ID:SGTC_2338|Compound:7999974|FD-Score:2.92|P-value:5.33E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.15|P-value:2.03E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.03|P-value:3.34E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:4.09|P-value:2.32E-6 ID:SGTC_2700|Compound:st077718|FD-Score:-2.81|P-value:9.08E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.55|P-value:3.42E-5 ID:SGTC_2818|Compound:7996756|FD-Score:-2.83|P-value:8.38E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.41|P-value:6.66E-5 ID:SGTC_3298|Compound:9116858|FD-Score:3.16|P-value:2.00E-4

Top fitness defect scores for YOL065C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_103 0844-0104 11.70 51.8 µM 3.83E-39 ERAD & cell cycle 19 8.73E-32
2 SGTC_568 1193-0097 10.80 7.5 µM 9.10E-34 ERAD & cell cycle 18 1.84E-27
3 SGTC_1161 k007-0610 10.10 110.0 µM 1.27E-29 ERAD & cell cycle 15 3.97E-24
4 SGTC_132 0417-1715 6.28 25.8 µM 1.10E-12 RPP1 & pyrimidine depletion 3 1.70E-10
5 SGTC_130 0136-0219 5.92 337.7 µM 1.84E-11 4 1.65E-9
6 SGTC_764 1951-2361 5.31 146.0 µM 1.41E-9 14 5.45E-8
7 SGTC_2057 5236571 4.39 38.3 µM 4.39E-7 RPP1 & pyrimidine depletion 19 5.59E-6
8 SGTC_64 000l-0018 4.31 272.1 µM 6.91E-7 ubiquinone biosynthesis & proteasome 133 8.07E-6
9 SGTC_437 s-farnesyl-l-cysteine methyl ester 4.30 6.7 µM 7.25E-7 9 8.39E-6
10 SGTC_2665 lovastatin 4.09 100.0 µM 2.32E-6 9 2.15E-5
11 SGTC_1202 1988-0068 3.77 29.6 µM 1.22E-5 RNA processing & uracil transport 33 8.22E-5
12 SGTC_135 0933-0004 3.65 26.4 µM 2.18E-5 60S ribosome export 32 1.32E-4
13 SGTC_2701 st077767 3.55 14.7 µM 3.42E-5 61 1.90E-4
14 SGTC_188 3229-0966 3.53 278.5 µM 3.90E-5 40 2.11E-4
15 SGTC_757 1066-0008 3.50 322.0 µM 4.47E-5 Golgi 34 2.36E-4
16 SGTC_2932 9016711 3.41 44.5 µM 6.66E-5 66 3.26E-4
17 SGTC_220 paclitaxel 3.37 373.4 µM 7.78E-5 20 3.69E-4
18 SGTC_216 k038-0035 3.34 28.4 µM 8.98E-5 ubiquinone biosynthesis & proteasome 64 4.15E-4
19 SGTC_549 1661-1316 3.25 519.0 µM 1.35E-4 39 5.78E-4
20 SGTC_3298 9116858 3.16 71.4 µM 2.00E-4 35 7.94E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.477 1.79E-190 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.344 1.50E-93 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.341 6.95E-92 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.328 5.26E-85 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.327 2.76E-84 YDL126C CDC48 het AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP
0.312 8.73E-77 YOR363C PIP2 hom Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication
0.308 7.87E-75 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.301 1.73E-71 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.298 1.39E-69 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.297 4.16E-69 YDL122W UBP1 hom Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains
0.295 1.86E-68 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.288 4.62E-65 YFR008W FAR7 hom Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress
0.283 5.47E-63 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.283 1.36E-62 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.276 1.65E-59 YMR116C ASC1 hom G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation