YOL082W / ATG19

Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL082W / ATG19

Click on Significant Values for Screen Details ID:SGTC_2|Compound:0422-0095|FD-Score:3.23|P-value:1.65E-4 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:3.08|P-value:3.13E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:-4.43|P-value:5.76E-7 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.91|P-value:8.92E-6 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.22|P-value:1.73E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:2.79|P-value:9.46E-4 ID:SGTC_269|Compound:exalamide|FD-Score:3.24|P-value:1.62E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:-3.36|P-value:1.16E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:-3.11|P-value:3.22E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.19|P-value:1.99E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-2.96|P-value:6.00E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.04|P-value:3.59E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:-2.92|P-value:6.85E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.50|P-value:5.02E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:5.13|P-value:6.44E-9 ID:SGTC_746|Compound:1095-0025|FD-Score:2.84|P-value:7.92E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:-5.35|P-value:2.01E-9 ID:SGTC_798|Compound:1287-0182|FD-Score:3.05|P-value:3.49E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.57|P-value:3.70E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:4.41|P-value:5.03E-7 ID:SGTC_996|Compound:3970-0799|FD-Score:3.86|P-value:9.19E-6 ID:SGTC_1005|Compound:4092-0690|FD-Score:-4.30|P-value:1.19E-6 ID:SGTC_1101|Compound:ebselen|FD-Score:2.94|P-value:5.45E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.41|P-value:7.61E-5 ID:SGTC_1140|Compound:3229-1848|FD-Score:2.86|P-value:7.25E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.09|P-value:3.48E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.89|P-value:6.60E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:2.90|P-value:6.28E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.90|P-value:7.48E-4 ID:SGTC_1815|Compound:st051655|FD-Score:3.59|P-value:3.43E-5 ID:SGTC_1904|Compound:st060225|FD-Score:-2.92|P-value:6.78E-4 ID:SGTC_2004|Compound:4023728|FD-Score:2.88|P-value:6.83E-4 ID:SGTC_2030|Compound:5175110|FD-Score:2.95|P-value:5.15E-4 ID:SGTC_2046|Compound:4110841|FD-Score:3.14|P-value:2.43E-4 ID:SGTC_2102|Compound:5377816|FD-Score:2.93|P-value:5.63E-4 ID:SGTC_2319|Compound:6033012|FD-Score:-2.91|P-value:7.20E-4 ID:SGTC_2324|Compound:6149169|FD-Score:3.82|P-value:1.12E-5 ID:SGTC_2332|Compound:7982454|FD-Score:-2.84|P-value:9.35E-4 ID:SGTC_2339|Compound:9000433|FD-Score:2.84|P-value:8.01E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.22|P-value:1.70E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-2.82|P-value:9.90E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-6.56|P-value:2.62E-13 ID:SGTC_2833|Compound:9001315|FD-Score:-2.85|P-value:9.05E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-4.24|P-value:1.60E-6 ID:SGTC_2849|Compound:9019321|FD-Score:-3.00|P-value:5.05E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-4.51|P-value:3.70E-7 ID:SGTC_3163|Compound:9099914|FD-Score:-2.91|P-value:7.01E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-3.00|P-value:5.04E-4 ID:SGTC_3198|Compound:9112019|FD-Score:-2.91|P-value:7.03E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.50|P-value:6.24E-5 ID:SGTC_2|Compound:0422-0095|FD-Score:3.23|P-value:1.65E-4 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:3.08|P-value:3.13E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:-4.43|P-value:5.76E-7 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.91|P-value:8.92E-6 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.22|P-value:1.73E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:2.79|P-value:9.46E-4 ID:SGTC_269|Compound:exalamide|FD-Score:3.24|P-value:1.62E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:-3.36|P-value:1.16E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:-3.11|P-value:3.22E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.19|P-value:1.99E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-2.96|P-value:6.00E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.04|P-value:3.59E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:-2.92|P-value:6.85E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.50|P-value:5.02E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:5.13|P-value:6.44E-9 ID:SGTC_746|Compound:1095-0025|FD-Score:2.84|P-value:7.92E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:-5.35|P-value:2.01E-9 ID:SGTC_798|Compound:1287-0182|FD-Score:3.05|P-value:3.49E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.57|P-value:3.70E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:4.41|P-value:5.03E-7 ID:SGTC_996|Compound:3970-0799|FD-Score:3.86|P-value:9.19E-6 ID:SGTC_1005|Compound:4092-0690|FD-Score:-4.30|P-value:1.19E-6 ID:SGTC_1101|Compound:ebselen|FD-Score:2.94|P-value:5.45E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.41|P-value:7.61E-5 ID:SGTC_1140|Compound:3229-1848|FD-Score:2.86|P-value:7.25E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.09|P-value:3.48E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.89|P-value:6.60E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:2.90|P-value:6.28E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.90|P-value:7.48E-4 ID:SGTC_1815|Compound:st051655|FD-Score:3.59|P-value:3.43E-5 ID:SGTC_1904|Compound:st060225|FD-Score:-2.92|P-value:6.78E-4 ID:SGTC_2004|Compound:4023728|FD-Score:2.88|P-value:6.83E-4 ID:SGTC_2030|Compound:5175110|FD-Score:2.95|P-value:5.15E-4 ID:SGTC_2046|Compound:4110841|FD-Score:3.14|P-value:2.43E-4 ID:SGTC_2102|Compound:5377816|FD-Score:2.93|P-value:5.63E-4 ID:SGTC_2319|Compound:6033012|FD-Score:-2.91|P-value:7.20E-4 ID:SGTC_2324|Compound:6149169|FD-Score:3.82|P-value:1.12E-5 ID:SGTC_2332|Compound:7982454|FD-Score:-2.84|P-value:9.35E-4 ID:SGTC_2339|Compound:9000433|FD-Score:2.84|P-value:8.01E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.22|P-value:1.70E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-2.82|P-value:9.90E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-6.56|P-value:2.62E-13 ID:SGTC_2833|Compound:9001315|FD-Score:-2.85|P-value:9.05E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-4.24|P-value:1.60E-6 ID:SGTC_2849|Compound:9019321|FD-Score:-3.00|P-value:5.05E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-4.51|P-value:3.70E-7 ID:SGTC_3163|Compound:9099914|FD-Score:-2.91|P-value:7.01E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-3.00|P-value:5.04E-4 ID:SGTC_3198|Compound:9112019|FD-Score:-2.91|P-value:7.03E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.50|P-value:6.24E-5

Top fitness defect scores for YOL082W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_739 1486-1183 5.13 203.0 µM 6.44E-9 7 1.43E-7
2 SGTC_991 3996-0057 4.41 64.7 µM 5.03E-7 11 5.17E-6
3 SGTC_996 3970-0799 3.86 1.8 µM 9.19E-6 87 5.66E-5
4 SGTC_2324 6149169 3.82 200.0 µM 1.12E-5 21 6.66E-5
5 SGTC_1815 st051655 3.59 58.2 µM 3.43E-5 TSC3-RPN4 12 1.68E-4
6 SGTC_891 0929-0073 3.57 133.0 µM 3.70E-5 35 1.78E-4
7 SGTC_737 1950-0117 3.50 57.9 µM 5.02E-5 34 2.30E-4
8 SGTC_1138 3761-0006 3.41 1.0 µM 7.61E-5 15 3.24E-4
9 SGTC_269 exalamide 3.24 29.0 µM 1.62E-4 ergosterol biosynthesis 33 6.04E-4
10 SGTC_2 0422-0095 3.23 29.0 µM 1.65E-4 redox potentiating 16 6.15E-4
11 SGTC_2605 digitonin 3.22 300.0 nM 1.70E-4 63 6.31E-4
12 SGTC_46 0329-0187a 3.22 2.2 µM 1.73E-4 112 6.37E-4
13 SGTC_357 1325-0123 3.19 420.0 µM 1.99E-4 28 7.15E-4
14 SGTC_2046 4110841 3.14 106.0 µM 2.43E-4 iron homeostasis 55 8.47E-4
15 SGTC_30 5-(2-thienylidene)-Rhodanine 3.08 28.7 µM 3.13E-4 18 0.00104
16 SGTC_798 1287-0182 3.05 476.0 µM 3.49E-4 62 0.00114
17 SGTC_515 4092-1064 3.04 102.0 µM 3.59E-4 plasma membrane duress 106 0.00117
18 SGTC_2030 5175110 2.95 200.0 µM 5.15E-4 Golgi 63 0.00157
19 SGTC_1101 ebselen 2.94 5.3 µM 5.45E-4 69 0.00165
20 SGTC_2102 5377816 2.93 72.8 µM 5.63E-4 68 0.00169

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.173 6.47E-24 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.164 1.73E-21 YPL163C SVS1 hom Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication
0.163 2.79E-21 YDR330W UBX5 hom UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
0.145 3.05E-17 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.138 1.21E-15 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.129 6.81E-14 YJR014W TMA22 hom Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress
0.127 1.84E-13 YOR084W LPX1 hom Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
0.124 6.41E-13 YDR046C BAP3 hom Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication
0.123 7.67E-13 YGR001C_p YGR001C_p hom Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae
0.122 1.35E-12 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.117 1.39E-11 YMR105C PGM2 hom Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress
0.115 3.02E-11 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.112 7.14E-11 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.110 1.97E-10 YBL043W ECM13 hom Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication
0.110 1.94E-10 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)