YOL083W / ATG34

Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL083W / ATG34

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.94|P-value:6.74E-6 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.14|P-value:2.38E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:4.34|P-value:7.85E-7 ID:SGTC_67|Compound:0335-0847|FD-Score:7.23|P-value:6.14E-16 ID:SGTC_71|Compound:0417-1750|FD-Score:4.20|P-value:1.71E-6 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.19|P-value:1.94E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.17|P-value:2.31E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:4.65|P-value:1.41E-7 ID:SGTC_448|Compound:monastrol|FD-Score:-2.86|P-value:7.30E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.04|P-value:3.60E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.54|P-value:4.65E-5 ID:SGTC_818|Compound:4072-2707|FD-Score:3.04|P-value:3.91E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.18|P-value:2.27E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.75|P-value:1.69E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.15|P-value:2.52E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.21|P-value:2.00E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.66|P-value:2.58E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:2.95|P-value:5.65E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.43|P-value:7.69E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:2.84|P-value:8.67E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-2.95|P-value:5.17E-4 ID:SGTC_1853|Compound:st056710|FD-Score:2.88|P-value:7.50E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.74|P-value:1.78E-5 ID:SGTC_1958|Compound:st076513|FD-Score:-2.85|P-value:7.45E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.08|P-value:2.99E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-2.98|P-value:4.57E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-3.30|P-value:1.20E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.99|P-value:1.67E-8 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.42|P-value:7.85E-5 ID:SGTC_2133|Compound:5320837|FD-Score:-5.62|P-value:2.07E-10 ID:SGTC_2135|Compound:5326629|FD-Score:-3.80|P-value:1.19E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.54|P-value:2.22E-7 ID:SGTC_2258|Compound:7960471|FD-Score:-4.20|P-value:1.46E-6 ID:SGTC_2333|Compound:9017922|FD-Score:3.07|P-value:3.49E-4 ID:SGTC_2336|Compound:9001819|FD-Score:6.42|P-value:6.34E-13 ID:SGTC_2355|Compound:9061122|FD-Score:3.36|P-value:1.04E-4 ID:SGTC_2437|Compound:5741531|FD-Score:4.05|P-value:3.84E-6 ID:SGTC_2449|Compound:5812982|FD-Score:-3.04|P-value:3.59E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.00|P-value:4.61E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-2.82|P-value:8.55E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:2.81|P-value:9.63E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-4.36|P-value:6.06E-7 ID:SGTC_2865|Compound:9030313|FD-Score:-4.63|P-value:1.31E-7 ID:SGTC_2868|Compound:9035608|FD-Score:-4.55|P-value:2.11E-7 ID:SGTC_2869|Compound:9037858|FD-Score:-3.94|P-value:5.75E-6 ID:SGTC_2876|Compound:9059903|FD-Score:3.18|P-value:2.24E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-2.84|P-value:7.87E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-2.89|P-value:6.36E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.00|P-value:4.61E-4 ID:SGTC_3341|Compound:9147222|FD-Score:3.74|P-value:1.81E-5 ID:SGTC_3352|Compound:9151559|FD-Score:3.87|P-value:9.61E-6 ID:SGTC_8|Compound:0354-0001|FD-Score:3.94|P-value:6.74E-6 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.14|P-value:2.38E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:4.34|P-value:7.85E-7 ID:SGTC_67|Compound:0335-0847|FD-Score:7.23|P-value:6.14E-16 ID:SGTC_71|Compound:0417-1750|FD-Score:4.20|P-value:1.71E-6 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.19|P-value:1.94E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.17|P-value:2.31E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:4.65|P-value:1.41E-7 ID:SGTC_448|Compound:monastrol|FD-Score:-2.86|P-value:7.30E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.04|P-value:3.60E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.54|P-value:4.65E-5 ID:SGTC_818|Compound:4072-2707|FD-Score:3.04|P-value:3.91E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.18|P-value:2.27E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.75|P-value:1.69E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.15|P-value:2.52E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.21|P-value:2.00E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.66|P-value:2.58E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:2.95|P-value:5.65E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.43|P-value:7.69E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:2.84|P-value:8.67E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-2.95|P-value:5.17E-4 ID:SGTC_1853|Compound:st056710|FD-Score:2.88|P-value:7.50E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.74|P-value:1.78E-5 ID:SGTC_1958|Compound:st076513|FD-Score:-2.85|P-value:7.45E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.08|P-value:2.99E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-2.98|P-value:4.57E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-3.30|P-value:1.20E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.99|P-value:1.67E-8 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.42|P-value:7.85E-5 ID:SGTC_2133|Compound:5320837|FD-Score:-5.62|P-value:2.07E-10 ID:SGTC_2135|Compound:5326629|FD-Score:-3.80|P-value:1.19E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.54|P-value:2.22E-7 ID:SGTC_2258|Compound:7960471|FD-Score:-4.20|P-value:1.46E-6 ID:SGTC_2333|Compound:9017922|FD-Score:3.07|P-value:3.49E-4 ID:SGTC_2336|Compound:9001819|FD-Score:6.42|P-value:6.34E-13 ID:SGTC_2355|Compound:9061122|FD-Score:3.36|P-value:1.04E-4 ID:SGTC_2437|Compound:5741531|FD-Score:4.05|P-value:3.84E-6 ID:SGTC_2449|Compound:5812982|FD-Score:-3.04|P-value:3.59E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.00|P-value:4.61E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-2.82|P-value:8.55E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:2.81|P-value:9.63E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-4.36|P-value:6.06E-7 ID:SGTC_2865|Compound:9030313|FD-Score:-4.63|P-value:1.31E-7 ID:SGTC_2868|Compound:9035608|FD-Score:-4.55|P-value:2.11E-7 ID:SGTC_2869|Compound:9037858|FD-Score:-3.94|P-value:5.75E-6 ID:SGTC_2876|Compound:9059903|FD-Score:3.18|P-value:2.24E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-2.84|P-value:7.87E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-2.89|P-value:6.36E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.00|P-value:4.61E-4 ID:SGTC_3341|Compound:9147222|FD-Score:3.74|P-value:1.81E-5 ID:SGTC_3352|Compound:9151559|FD-Score:3.87|P-value:9.61E-6

Top fitness defect scores for YOL083W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_67 0335-0847 7.23 266.0 µM 6.14E-16 ubiquinone biosynthesis & proteasome 47 2.40E-13
2 SGTC_2336 9001819 6.42 198.7 µM 6.34E-13 heme biosynthesis & mitochondrial translocase 4 7.02E-11
3 SGTC_2126 5251174 4.99 33.9 µM 1.67E-8 8 2.95E-7
4 SGTC_364 0083-0097 4.65 67.7 µM 1.41E-7 14 1.70E-6
5 SGTC_64 000l-0018 4.34 272.1 µM 7.85E-7 ubiquinone biosynthesis & proteasome 131 6.97E-6
6 SGTC_71 0417-1750 4.20 47.8 µM 1.71E-6 Golgi 37 1.32E-5
7 SGTC_46 0329-0187a 4.14 2.2 µM 2.38E-6 67 1.74E-5
8 SGTC_2437 5741531 4.05 144.2 µM 3.84E-6 34 2.57E-5
9 SGTC_8 0354-0001 3.94 70.0 µM 6.74E-6 77 4.09E-5
10 SGTC_3352 9151559 3.87 45.6 µM 9.61E-6 14 5.48E-5
11 SGTC_996 3970-0799 3.75 1.8 µM 1.69E-5 91 8.74E-5
12 SGTC_1917 st066507 3.74 28.5 µM 1.78E-5 Golgi 47 9.10E-5
13 SGTC_3341 9147222 3.74 25.9 µM 1.81E-5 RNA processing & uracil transport 19 9.24E-5
14 SGTC_1184 1269-1718 3.66 139.0 µM 2.58E-5 40 1.24E-4
15 SGTC_808 0711-0032 3.54 135.0 µM 4.65E-5 24 2.01E-4
16 SGTC_1327 1436-0082 3.43 2.2 µM 7.69E-5 37 3.05E-4
17 SGTC_2131 toluylene red 3.42 5.3 µM 7.85E-5 60S ribosome export 44 3.10E-4
18 SGTC_2355 9061122 3.36 103.1 µM 1.04E-4 26 3.92E-4
19 SGTC_1174 0739-0097 3.21 51.1 µM 2.00E-4 redox potentiating 62 6.73E-4
20 SGTC_2876 9059903 3.18 26.0 µM 2.24E-4 38 7.37E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.217 4.60E-37 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.207 6.34E-34 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.191 7.49E-29 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.184 7.60E-27 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.184 7.73E-27 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.163 2.21E-21 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.158 2.85E-20 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.152 6.76E-19 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.151 1.17E-18 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.151 1.68E-18 YPL153C RAD53 het Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication
0.150 2.78E-18 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.149 4.60E-18 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.144 4.11E-17 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.141 2.22E-16 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.139 7.29E-16 YNL130C CPT1 hom Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication