HIPHOP chemogenomics database
YOL093W / TRM10 
tRNA methyltransferase; methylates the N-1 position of guanosine in tRNAs; protein abundance increases in response to DNA replication stress
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YOL093W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.119 | 4.61E-12 | YNL039W | BDP1 | het | Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs |
| 0.106 | 7.32E-10 | YPL092W | SSU1 | hom | Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein |
| 0.092 | 8.48E-8 | YGL215W | CLG1 | hom | Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2 |
| 0.087 | 4.90E-7 | YOL052C-A | DDR2 | hom | Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication |
| 0.086 | 6.77E-7 | YMR026C | PEX12 | hom | C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder |
| 0.083 | 1.44E-6 | YPR022C_p | YPR022C_p | hom | Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS |
| 0.082 | 2.25E-6 | YMR086C-A_d | YMR086C-A_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.081 | 2.95E-6 | YNR020C | ATP23 | hom | Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p |
| 0.078 | 5.41E-6 | YLR306W | UBC12 | hom | Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes |
| 0.077 | 7.67E-6 | YDR524C | AGE1 | hom | ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif |
| 0.076 | 1.02E-5 | YDR100W | TVP15 | hom | Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p |
| 0.074 | 2.01E-5 | YOR249C | APC5 | het | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress |
| 0.072 | 3.12E-5 | YLR211C_p | YLR211C_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron |
| 0.072 | 3.13E-5 | YML038C | YMD8 | hom | Putative nucleotide sugar transporter, has similarity to Vrg4p |
| 0.069 | 5.62E-5 | YOR124C | UBP2 | hom | Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity |