YOL096C / COQ3

O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL096C / COQ3

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:19.70|P-value:7.63E-88 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.41|P-value:2.94E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:4.66|P-value:1.28E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:11.50|P-value:2.77E-31 ID:SGTC_67|Compound:0335-0847|FD-Score:9.28|P-value:3.93E-21 ID:SGTC_70|Compound:0141-0289|FD-Score:3.13|P-value:7.83E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:9.27|P-value:4.44E-21 ID:SGTC_108|Compound:0509-0257|FD-Score:3.73|P-value:8.46E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.04|P-value:2.26E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:4.88|P-value:4.24E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:7.70|P-value:4.07E-15 ID:SGTC_137|Compound:0438-0332|FD-Score:4.74|P-value:8.74E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:14.20|P-value:3.80E-47 ID:SGTC_158|Compound:k038-0087|FD-Score:7.99|P-value:3.73E-16 ID:SGTC_168|Compound:3970-0862|FD-Score:3.32|P-value:4.00E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.42|P-value:2.85E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:7.00|P-value:8.08E-13 ID:SGTC_216|Compound:k038-0035|FD-Score:6.90|P-value:1.73E-12 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.72|P-value:8.87E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:22.10|P-value:5.21E-110 ID:SGTC_245|Compound:methotrexate|FD-Score:-3.14|P-value:7.56E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.15|P-value:7.40E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.32|P-value:4.06E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:3.99|P-value:2.87E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:4.89|P-value:4.04E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:7.98|P-value:4.13E-16 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.15|P-value:7.31E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.89|P-value:4.28E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:3.57|P-value:1.57E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:5.29|P-value:4.77E-8 ID:SGTC_716|Compound:1683-5115|FD-Score:-4.81|P-value:6.11E-7 ID:SGTC_717|Compound:1532-0246|FD-Score:3.14|P-value:7.56E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:-4.51|P-value:2.72E-6 ID:SGTC_719|Compound:2810-4230|FD-Score:4.29|P-value:7.61E-6 ID:SGTC_722|Compound:3534-0461|FD-Score:-5.59|P-value:8.63E-9 ID:SGTC_794|Compound:k038-0031|FD-Score:8.92|P-value:1.12E-19 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.36|P-value:3.53E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.92|P-value:3.81E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.26|P-value:8.57E-6 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.57|P-value:1.56E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:-4.76|P-value:7.89E-7 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.46|P-value:3.39E-6 ID:SGTC_1635|Compound:st007035|FD-Score:6.46|P-value:3.60E-11 ID:SGTC_1840|Compound:st055363|FD-Score:3.59|P-value:1.44E-4 ID:SGTC_1859|Compound:st055998|FD-Score:4.87|P-value:4.44E-7 ID:SGTC_1871|Compound:st057448|FD-Score:4.83|P-value:5.57E-7 ID:SGTC_1881|Compound:5652484|FD-Score:-3.23|P-value:5.58E-4 ID:SGTC_2061|Compound:5245884|FD-Score:4.13|P-value:1.54E-5 ID:SGTC_2101|Compound:5377231|FD-Score:-3.46|P-value:2.42E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-3.10|P-value:8.80E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-3.15|P-value:7.41E-4 ID:SGTC_2327|Compound:6189656|FD-Score:6.02|P-value:6.32E-10 ID:SGTC_2358|Compound:9037157|FD-Score:4.41|P-value:4.40E-6 ID:SGTC_2432|Compound:5630864|FD-Score:-3.40|P-value:3.04E-4 ID:SGTC_2436|Compound:5633522|FD-Score:-3.39|P-value:3.17E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.34|P-value:3.73E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.23|P-value:5.68E-4 ID:SGTC_2840|Compound:9008771|FD-Score:3.76|P-value:7.55E-5 ID:SGTC_2849|Compound:9019321|FD-Score:4.07|P-value:2.02E-5 ID:SGTC_2856|Compound:9022925|FD-Score:3.79|P-value:6.66E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-3.53|P-value:1.83E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.44|P-value:2.57E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.36|P-value:3.51E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.64|P-value:1.21E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.09|P-value:9.03E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-3.57|P-value:1.58E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.08|P-value:9.59E-4 ID:SGTC_3231|Compound:9132313|FD-Score:3.23|P-value:5.68E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.75|P-value:7.69E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:19.70|P-value:7.63E-88 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.41|P-value:2.94E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:4.66|P-value:1.28E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:11.50|P-value:2.77E-31 ID:SGTC_67|Compound:0335-0847|FD-Score:9.28|P-value:3.93E-21 ID:SGTC_70|Compound:0141-0289|FD-Score:3.13|P-value:7.83E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:9.27|P-value:4.44E-21 ID:SGTC_108|Compound:0509-0257|FD-Score:3.73|P-value:8.46E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.04|P-value:2.26E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:4.88|P-value:4.24E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:7.70|P-value:4.07E-15 ID:SGTC_137|Compound:0438-0332|FD-Score:4.74|P-value:8.74E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:14.20|P-value:3.80E-47 ID:SGTC_158|Compound:k038-0087|FD-Score:7.99|P-value:3.73E-16 ID:SGTC_168|Compound:3970-0862|FD-Score:3.32|P-value:4.00E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.42|P-value:2.85E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:7.00|P-value:8.08E-13 ID:SGTC_216|Compound:k038-0035|FD-Score:6.90|P-value:1.73E-12 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.72|P-value:8.87E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:22.10|P-value:5.21E-110 ID:SGTC_245|Compound:methotrexate|FD-Score:-3.14|P-value:7.56E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.15|P-value:7.40E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.32|P-value:4.06E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:3.99|P-value:2.87E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:4.89|P-value:4.04E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:7.98|P-value:4.13E-16 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.15|P-value:7.31E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.89|P-value:4.28E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:3.57|P-value:1.57E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:5.29|P-value:4.77E-8 ID:SGTC_716|Compound:1683-5115|FD-Score:-4.81|P-value:6.11E-7 ID:SGTC_717|Compound:1532-0246|FD-Score:3.14|P-value:7.56E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:-4.51|P-value:2.72E-6 ID:SGTC_719|Compound:2810-4230|FD-Score:4.29|P-value:7.61E-6 ID:SGTC_722|Compound:3534-0461|FD-Score:-5.59|P-value:8.63E-9 ID:SGTC_794|Compound:k038-0031|FD-Score:8.92|P-value:1.12E-19 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.36|P-value:3.53E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.92|P-value:3.81E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.26|P-value:8.57E-6 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.57|P-value:1.56E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:-4.76|P-value:7.89E-7 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.46|P-value:3.39E-6 ID:SGTC_1635|Compound:st007035|FD-Score:6.46|P-value:3.60E-11 ID:SGTC_1840|Compound:st055363|FD-Score:3.59|P-value:1.44E-4 ID:SGTC_1859|Compound:st055998|FD-Score:4.87|P-value:4.44E-7 ID:SGTC_1871|Compound:st057448|FD-Score:4.83|P-value:5.57E-7 ID:SGTC_1881|Compound:5652484|FD-Score:-3.23|P-value:5.58E-4 ID:SGTC_2061|Compound:5245884|FD-Score:4.13|P-value:1.54E-5 ID:SGTC_2101|Compound:5377231|FD-Score:-3.46|P-value:2.42E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-3.10|P-value:8.80E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-3.15|P-value:7.41E-4 ID:SGTC_2327|Compound:6189656|FD-Score:6.02|P-value:6.32E-10 ID:SGTC_2358|Compound:9037157|FD-Score:4.41|P-value:4.40E-6 ID:SGTC_2432|Compound:5630864|FD-Score:-3.40|P-value:3.04E-4 ID:SGTC_2436|Compound:5633522|FD-Score:-3.39|P-value:3.17E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.34|P-value:3.73E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.23|P-value:5.68E-4 ID:SGTC_2840|Compound:9008771|FD-Score:3.76|P-value:7.55E-5 ID:SGTC_2849|Compound:9019321|FD-Score:4.07|P-value:2.02E-5 ID:SGTC_2856|Compound:9022925|FD-Score:3.79|P-value:6.66E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-3.53|P-value:1.83E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.44|P-value:2.57E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.36|P-value:3.51E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.64|P-value:1.21E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.09|P-value:9.03E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-3.57|P-value:1.58E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.08|P-value:9.59E-4 ID:SGTC_3231|Compound:9132313|FD-Score:3.23|P-value:5.68E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.75|P-value:7.69E-5

Top fitness defect scores for YOL096C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 22.10 5.3 µM 5.21E-110 44 4.17E-108
2 SGTC_36 0335-0881 19.70 14.2 µM 7.63E-88 ubiquinone biosynthesis & proteasome 3 2.48E-86
3 SGTC_142 0335-0849 14.20 62.7 µM 3.80E-47 ubiquinone biosynthesis & proteasome 17 2.37E-46
4 SGTC_64 000l-0018 11.50 272.1 µM 2.77E-31 ubiquinone biosynthesis & proteasome 33 9.09E-31
5 SGTC_67 0335-0847 9.28 266.0 µM 3.93E-21 ubiquinone biosynthesis & proteasome 26 8.56E-21
6 SGTC_86 0417-1630 9.27 471.9 µM 4.44E-21 ubiquinone biosynthesis & proteasome 46 9.66E-21
7 SGTC_794 k038-0031 8.92 316.0 µM 1.12E-19 ubiquinone biosynthesis & proteasome 23 2.30E-19
8 SGTC_158 k038-0087 7.99 26.4 µM 3.73E-16 ubiquinone biosynthesis & proteasome 49 6.66E-16
9 SGTC_386 1509-0011 7.98 3.1 µM 4.13E-16 64 7.36E-16
10 SGTC_134 0269-0018 7.70 6.9 µM 4.07E-15 62 6.96E-15
11 SGTC_200 k038-0079 7.00 37.5 µM 8.08E-13 ubiquinone biosynthesis & proteasome 20 1.26E-12
12 SGTC_216 k038-0035 6.90 28.4 µM 1.73E-12 ubiquinone biosynthesis & proteasome 17 2.67E-12
13 SGTC_1635 st007035 6.46 42.4 µM 3.60E-11 128 5.27E-11
14 SGTC_2327 6189656 6.02 200.0 µM 6.32E-10 3 8.80E-10
15 SGTC_635 k038-0028 5.29 24.7 µM 4.77E-8 ubiquinone biosynthesis & proteasome 24 6.17E-8
16 SGTC_340 k038-0059 4.89 454.0 µM 4.04E-7 ubiquinone biosynthesis & proteasome 30 5.03E-7
17 SGTC_119 0121-0043 4.88 24.8 µM 4.24E-7 mitochondrial stress 62 5.28E-7
18 SGTC_1859 st055998 4.87 20.0 µM 4.44E-7 11 5.53E-7
19 SGTC_1871 st057448 4.83 67.3 µM 5.57E-7 8 6.90E-7
20 SGTC_137 0438-0332 4.74 85.4 µM 8.74E-7 ubiquinone biosynthesis & proteasome 86 1.08E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.750 0 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.720 0 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.715 0 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.698 0 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.676 0 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.657 0 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.620 0 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.570 7.74E-288 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.549 7.63E-264 YML110C COQ5 hom 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
0.545 2.47E-259 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.534 1.20E-246 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.488 1.35E-200 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.476 3.08E-189 YOL008W COQ10 hom Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
0.472 6.37E-186 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.471 1.33E-184 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover