YOL110W / SHR5

Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL110W / SHR5

Click on Significant Values for Screen Details ID:SGTC_172|Compound:1112-0046|FD-Score:3.15|P-value:7.72E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:-3.19|P-value:6.60E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:3.78|P-value:7.42E-5 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.52|P-value:1.96E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.20|P-value:6.64E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-5.56|P-value:1.12E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.81|P-value:6.40E-7 ID:SGTC_544|Compound:k015-0020|FD-Score:4.03|P-value:2.57E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:3.64|P-value:1.26E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.15|P-value:7.75E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.13|P-value:8.36E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:4.00|P-value:2.91E-5 ID:SGTC_892|Compound:0929-0076|FD-Score:3.79|P-value:7.14E-5 ID:SGTC_918|Compound:glabranin|FD-Score:3.15|P-value:7.67E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:4.81|P-value:6.68E-7 ID:SGTC_924|Compound:2046-0044|FD-Score:4.35|P-value:6.13E-6 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.12|P-value:8.70E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.85|P-value:5.49E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:-3.38|P-value:3.39E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:-4.46|P-value:3.55E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:-3.35|P-value:3.79E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.14|P-value:8.02E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.86|P-value:5.32E-5 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.89|P-value:4.70E-5 ID:SGTC_1190|Compound:1486-1332|FD-Score:-4.45|P-value:3.76E-6 ID:SGTC_1191|Compound:1487-1166|FD-Score:-3.53|P-value:1.94E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:6.91|P-value:1.92E-12 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.93|P-value:3.86E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.12|P-value:8.75E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.29|P-value:4.78E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-3.50|P-value:2.14E-4 ID:SGTC_1932|Compound:st074806|FD-Score:4.96|P-value:3.08E-7 ID:SGTC_2113|Compound:5491891|FD-Score:3.17|P-value:7.16E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.81|P-value:6.39E-5 ID:SGTC_2276|Compound:7947513|FD-Score:3.46|P-value:2.54E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.75|P-value:8.19E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.70|P-value:9.87E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:5.01|P-value:2.45E-7 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.87|P-value:4.96E-5 ID:SGTC_2769|Compound:toremifene|FD-Score:3.39|P-value:3.25E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.49|P-value:2.30E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.88|P-value:4.78E-5 ID:SGTC_2870|Compound:9038528|FD-Score:3.35|P-value:3.81E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.93|P-value:3.85E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:3.15|P-value:7.72E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:-3.19|P-value:6.60E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:3.78|P-value:7.42E-5 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.52|P-value:1.96E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.20|P-value:6.64E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-5.56|P-value:1.12E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.81|P-value:6.40E-7 ID:SGTC_544|Compound:k015-0020|FD-Score:4.03|P-value:2.57E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:3.64|P-value:1.26E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.15|P-value:7.75E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.13|P-value:8.36E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:4.00|P-value:2.91E-5 ID:SGTC_892|Compound:0929-0076|FD-Score:3.79|P-value:7.14E-5 ID:SGTC_918|Compound:glabranin|FD-Score:3.15|P-value:7.67E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:4.81|P-value:6.68E-7 ID:SGTC_924|Compound:2046-0044|FD-Score:4.35|P-value:6.13E-6 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.12|P-value:8.70E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.85|P-value:5.49E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:-3.38|P-value:3.39E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:-4.46|P-value:3.55E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:-3.35|P-value:3.79E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.14|P-value:8.02E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.86|P-value:5.32E-5 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.89|P-value:4.70E-5 ID:SGTC_1190|Compound:1486-1332|FD-Score:-4.45|P-value:3.76E-6 ID:SGTC_1191|Compound:1487-1166|FD-Score:-3.53|P-value:1.94E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:6.91|P-value:1.92E-12 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.93|P-value:3.86E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.12|P-value:8.75E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.29|P-value:4.78E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-3.50|P-value:2.14E-4 ID:SGTC_1932|Compound:st074806|FD-Score:4.96|P-value:3.08E-7 ID:SGTC_2113|Compound:5491891|FD-Score:3.17|P-value:7.16E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.81|P-value:6.39E-5 ID:SGTC_2276|Compound:7947513|FD-Score:3.46|P-value:2.54E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.75|P-value:8.19E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.70|P-value:9.87E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:5.01|P-value:2.45E-7 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.87|P-value:4.96E-5 ID:SGTC_2769|Compound:toremifene|FD-Score:3.39|P-value:3.25E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.49|P-value:2.30E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.88|P-value:4.78E-5 ID:SGTC_2870|Compound:9038528|FD-Score:3.35|P-value:3.81E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.93|P-value:3.85E-5

Top fitness defect scores for YOL110W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1193 1488-0126 6.91 41.5 µM 1.92E-12 4 2.45E-12
2 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 5.01 100.0 µM 2.45E-7 7 2.78E-7
3 SGTC_1932 st074806 4.96 40.9 µM 3.08E-7 5 3.49E-7
4 SGTC_923 1900-2434 4.81 73.3 µM 6.68E-7 RNA processing & uracil transport 16 7.50E-7
5 SGTC_924 2046-0044 4.35 21.3 µM 6.13E-6 9 6.74E-6
6 SGTC_544 k015-0020 4.03 52.4 µM 2.57E-5 10 2.79E-5
7 SGTC_681 1642-0006 4.00 26.6 µM 2.91E-5 4 3.15E-5
8 SGTC_3181 9108277 3.93 49.5 µM 3.85E-5 iron homeostasis 16 4.16E-5
9 SGTC_1257 0669-0121 3.93 16.0 µM 3.86E-5 30 4.17E-5
10 SGTC_1151 3909-8316 3.89 15.3 µM 4.70E-5 17 5.07E-5
11 SGTC_2721 ifenprodil 3.87 61.4 µM 4.96E-5 plasma membrane duress 21 5.34E-5
12 SGTC_1100 amiodarone 3.86 5.1 µM 5.32E-5 17 5.73E-5
13 SGTC_1042 0350-0096 3.85 82.0 µM 5.49E-5 TSC3-RPN4 29 5.91E-5
14 SGTC_2117 5521686 3.81 200.0 µM 6.39E-5 16 6.87E-5
15 SGTC_892 0929-0076 3.79 29.0 µM 7.14E-5 TRP & mitochondrial translation 47 7.67E-5
16 SGTC_174 3553-0389 3.78 74.3 µM 7.42E-5 26 7.96E-5
17 SGTC_2433 5607874 3.75 27.8 µM 8.19E-5 21 8.78E-5
18 SGTC_556 4058-0063 3.64 51.5 µM 1.26E-4 35 1.35E-4
19 SGTC_2791 5663188 3.49 71.4 µM 2.30E-4 RPP1 & pyrimidine depletion 36 2.44E-4
20 SGTC_2276 7947513 3.46 42.1 µM 2.54E-4 37 2.70E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 3.22E-10 YOR008C-A_p YOR008C-A_p hom Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres
0.099 9.84E-9 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.096 2.80E-8 YNR032W PPG1 hom Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases
0.088 3.50E-7 YLR143W DPH6 hom Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene
0.083 1.37E-6 YBR097W VPS15 hom Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized, with Vps34p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery
0.075 1.33E-5 YDR280W RRP45 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
0.074 1.66E-5 YLR121C YPS3 hom Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
0.074 1.83E-5 YMR233W TRI1 hom Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication
0.073 2.20E-5 YNL339C YRF1-6 hom Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
0.073 2.33E-5 YGR187C HGH1 hom Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress
0.072 2.96E-5 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.071 3.42E-5 YCL039W GID7 hom Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions
0.071 3.81E-5 YNL002C RLP7 het Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs
0.070 5.28E-5 YGL223C COG1 hom Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.069 6.18E-5 YBR205W KTR3 hom Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress