YOL120C / RPL18A

Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOL120C / RPL18A

Click on Significant Values for Screen Details ID:SGTC_152|Compound:4469-0003|FD-Score:4.89|P-value:2.26E-5 ID:SGTC_154|Compound:3389-1638|FD-Score:4.08|P-value:3.34E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:4.30|P-value:1.66E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:4.57|P-value:6.88E-5 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.79|P-value:7.83E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:-3.93|P-value:5.88E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:7.04|P-value:2.35E-9 ID:SGTC_280|Compound:3448-3607|FD-Score:-3.79|P-value:8.67E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.74|P-value:9.90E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:3.86|P-value:6.36E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-5.26|P-value:6.66E-6 ID:SGTC_586|Compound:0957-0265|FD-Score:-4.25|P-value:2.23E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:-4.73|P-value:4.64E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:6.26|P-value:9.44E-8 ID:SGTC_809|Compound:3998-0021|FD-Score:4.42|P-value:1.13E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:6.04|P-value:2.47E-7 ID:SGTC_941|Compound:3237-0776|FD-Score:5.64|P-value:1.29E-6 ID:SGTC_946|Compound:3434-1334|FD-Score:4.07|P-value:3.41E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-4.11|P-value:3.42E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:5.31|P-value:4.82E-6 ID:SGTC_959|Compound:1222-0044|FD-Score:7.18|P-value:1.12E-9 ID:SGTC_966|Compound:1300-0360|FD-Score:-4.09|P-value:3.57E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:-3.80|P-value:8.54E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:5.63|P-value:1.40E-6 ID:SGTC_1033|Compound:k072-0102|FD-Score:-4.49|P-value:1.02E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:5.73|P-value:9.19E-7 ID:SGTC_1036|Compound:k216-0215|FD-Score:-4.06|P-value:3.99E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:4.46|P-value:1.01E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-6.14|P-value:1.84E-7 ID:SGTC_1060|Compound:3448-7350|FD-Score:4.41|P-value:1.19E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.27|P-value:1.88E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.57|P-value:6.89E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.86|P-value:6.47E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-4.95|P-value:2.13E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:-4.04|P-value:4.16E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.25|P-value:1.95E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.86|P-value:7.02E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:-4.54|P-value:8.75E-5 ID:SGTC_1405|Compound:3909-7894|FD-Score:-4.35|P-value:1.62E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:-3.98|P-value:4.99E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:5.49|P-value:2.36E-6 ID:SGTC_1465|Compound:k213-0056|FD-Score:5.26|P-value:5.87E-6 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.81|P-value:7.37E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:6.83|P-value:6.41E-9 ID:SGTC_1678|Compound:st019265|FD-Score:-5.37|P-value:4.41E-6 ID:SGTC_1750|Compound:st081859|FD-Score:4.56|P-value:7.22E-5 ID:SGTC_1761|Compound:st044296|FD-Score:6.37|P-value:5.74E-8 ID:SGTC_1775|Compound:st081588|FD-Score:-3.99|P-value:4.91E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.68|P-value:5.40E-5 ID:SGTC_1827|Compound:berberine|FD-Score:-4.19|P-value:2.68E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-4.67|P-value:5.56E-5 ID:SGTC_1930|Compound:st074634|FD-Score:-5.62|P-value:1.64E-6 ID:SGTC_2055|Compound:5235184|FD-Score:-3.96|P-value:5.36E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.89|P-value:5.90E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-4.87|P-value:2.79E-5 ID:SGTC_2077|Compound:5212015|FD-Score:-4.22|P-value:2.41E-4 ID:SGTC_2105|Compound:5350118|FD-Score:4.87|P-value:2.43E-5 ID:SGTC_2126|Compound:5251174|FD-Score:4.06|P-value:3.50E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:6.97|P-value:3.24E-9 ID:SGTC_2166|Compound:5933061|FD-Score:-5.26|P-value:6.76E-6 ID:SGTC_2178|Compound:5812956|FD-Score:4.62|P-value:5.98E-5 ID:SGTC_2179|Compound:6298986|FD-Score:-4.95|P-value:2.11E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:-4.67|P-value:5.71E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.77|P-value:9.14E-4 ID:SGTC_2263|Compound:7948595|FD-Score:4.26|P-value:1.94E-4 ID:SGTC_2265|Compound:7929201|FD-Score:4.00|P-value:4.31E-4 ID:SGTC_2320|Compound:7373003|FD-Score:5.24|P-value:6.35E-6 ID:SGTC_2369|Compound:9071472|FD-Score:4.21|P-value:2.21E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.01|P-value:4.66E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.84|P-value:7.53E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.79|P-value:7.95E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.81|P-value:7.39E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.42|P-value:1.31E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.70|P-value:9.98E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-5.69|P-value:1.26E-6 ID:SGTC_2721|Compound:ifenprodil|FD-Score:6.03|P-value:2.59E-7 ID:SGTC_2725|Compound:haloperidol|FD-Score:6.44|P-value:4.17E-8 ID:SGTC_2730|Compound:imipramine|FD-Score:7.80|P-value:4.19E-11 ID:SGTC_2739|Compound:tacrine|FD-Score:-6.00|P-value:3.43E-7 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.80|P-value:8.34E-4 ID:SGTC_2792|Compound:7535235|FD-Score:5.45|P-value:2.77E-6 ID:SGTC_2887|Compound:9044784|FD-Score:3.83|P-value:7.08E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.92|P-value:5.38E-4 ID:SGTC_2977|Compound:9011197|FD-Score:3.89|P-value:5.83E-4 ID:SGTC_2980|Compound:9014342|FD-Score:-3.98|P-value:4.95E-4 ID:SGTC_2993|Compound:9054257|FD-Score:7.17|P-value:1.20E-9 ID:SGTC_3007|Compound:9078383|FD-Score:6.86|P-value:5.55E-9 ID:SGTC_3081|Compound:9117243|FD-Score:5.86|P-value:5.35E-7 ID:SGTC_3126|Compound:9127922|FD-Score:4.85|P-value:2.66E-5 ID:SGTC_3150|Compound:9097574|FD-Score:3.76|P-value:8.56E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-5.35|P-value:4.80E-6 ID:SGTC_3296|Compound:9122258|FD-Score:-3.76|P-value:9.40E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.79|P-value:8.74E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:4.89|P-value:2.26E-5 ID:SGTC_154|Compound:3389-1638|FD-Score:4.08|P-value:3.34E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:4.30|P-value:1.66E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:4.57|P-value:6.88E-5 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.79|P-value:7.83E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:-3.93|P-value:5.88E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:7.04|P-value:2.35E-9 ID:SGTC_280|Compound:3448-3607|FD-Score:-3.79|P-value:8.67E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.74|P-value:9.90E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:3.86|P-value:6.36E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-5.26|P-value:6.66E-6 ID:SGTC_586|Compound:0957-0265|FD-Score:-4.25|P-value:2.23E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:-4.73|P-value:4.64E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:6.26|P-value:9.44E-8 ID:SGTC_809|Compound:3998-0021|FD-Score:4.42|P-value:1.13E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:6.04|P-value:2.47E-7 ID:SGTC_941|Compound:3237-0776|FD-Score:5.64|P-value:1.29E-6 ID:SGTC_946|Compound:3434-1334|FD-Score:4.07|P-value:3.41E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-4.11|P-value:3.42E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:5.31|P-value:4.82E-6 ID:SGTC_959|Compound:1222-0044|FD-Score:7.18|P-value:1.12E-9 ID:SGTC_966|Compound:1300-0360|FD-Score:-4.09|P-value:3.57E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:-3.80|P-value:8.54E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:5.63|P-value:1.40E-6 ID:SGTC_1033|Compound:k072-0102|FD-Score:-4.49|P-value:1.02E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:5.73|P-value:9.19E-7 ID:SGTC_1036|Compound:k216-0215|FD-Score:-4.06|P-value:3.99E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:4.46|P-value:1.01E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-6.14|P-value:1.84E-7 ID:SGTC_1060|Compound:3448-7350|FD-Score:4.41|P-value:1.19E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.27|P-value:1.88E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.57|P-value:6.89E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.86|P-value:6.47E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-4.95|P-value:2.13E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:-4.04|P-value:4.16E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.25|P-value:1.95E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.86|P-value:7.02E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:-4.54|P-value:8.75E-5 ID:SGTC_1405|Compound:3909-7894|FD-Score:-4.35|P-value:1.62E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:-3.98|P-value:4.99E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:5.49|P-value:2.36E-6 ID:SGTC_1465|Compound:k213-0056|FD-Score:5.26|P-value:5.87E-6 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.81|P-value:7.37E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:6.83|P-value:6.41E-9 ID:SGTC_1678|Compound:st019265|FD-Score:-5.37|P-value:4.41E-6 ID:SGTC_1750|Compound:st081859|FD-Score:4.56|P-value:7.22E-5 ID:SGTC_1761|Compound:st044296|FD-Score:6.37|P-value:5.74E-8 ID:SGTC_1775|Compound:st081588|FD-Score:-3.99|P-value:4.91E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.68|P-value:5.40E-5 ID:SGTC_1827|Compound:berberine|FD-Score:-4.19|P-value:2.68E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-4.67|P-value:5.56E-5 ID:SGTC_1930|Compound:st074634|FD-Score:-5.62|P-value:1.64E-6 ID:SGTC_2055|Compound:5235184|FD-Score:-3.96|P-value:5.36E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.89|P-value:5.90E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-4.87|P-value:2.79E-5 ID:SGTC_2077|Compound:5212015|FD-Score:-4.22|P-value:2.41E-4 ID:SGTC_2105|Compound:5350118|FD-Score:4.87|P-value:2.43E-5 ID:SGTC_2126|Compound:5251174|FD-Score:4.06|P-value:3.50E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:6.97|P-value:3.24E-9 ID:SGTC_2166|Compound:5933061|FD-Score:-5.26|P-value:6.76E-6 ID:SGTC_2178|Compound:5812956|FD-Score:4.62|P-value:5.98E-5 ID:SGTC_2179|Compound:6298986|FD-Score:-4.95|P-value:2.11E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:-4.67|P-value:5.71E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.77|P-value:9.14E-4 ID:SGTC_2263|Compound:7948595|FD-Score:4.26|P-value:1.94E-4 ID:SGTC_2265|Compound:7929201|FD-Score:4.00|P-value:4.31E-4 ID:SGTC_2320|Compound:7373003|FD-Score:5.24|P-value:6.35E-6 ID:SGTC_2369|Compound:9071472|FD-Score:4.21|P-value:2.21E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.01|P-value:4.66E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.84|P-value:7.53E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.79|P-value:7.95E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.81|P-value:7.39E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.42|P-value:1.31E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.70|P-value:9.98E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-5.69|P-value:1.26E-6 ID:SGTC_2721|Compound:ifenprodil|FD-Score:6.03|P-value:2.59E-7 ID:SGTC_2725|Compound:haloperidol|FD-Score:6.44|P-value:4.17E-8 ID:SGTC_2730|Compound:imipramine|FD-Score:7.80|P-value:4.19E-11 ID:SGTC_2739|Compound:tacrine|FD-Score:-6.00|P-value:3.43E-7 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.80|P-value:8.34E-4 ID:SGTC_2792|Compound:7535235|FD-Score:5.45|P-value:2.77E-6 ID:SGTC_2887|Compound:9044784|FD-Score:3.83|P-value:7.08E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.92|P-value:5.38E-4 ID:SGTC_2977|Compound:9011197|FD-Score:3.89|P-value:5.83E-4 ID:SGTC_2980|Compound:9014342|FD-Score:-3.98|P-value:4.95E-4 ID:SGTC_2993|Compound:9054257|FD-Score:7.17|P-value:1.20E-9 ID:SGTC_3007|Compound:9078383|FD-Score:6.86|P-value:5.55E-9 ID:SGTC_3081|Compound:9117243|FD-Score:5.86|P-value:5.35E-7 ID:SGTC_3126|Compound:9127922|FD-Score:4.85|P-value:2.66E-5 ID:SGTC_3150|Compound:9097574|FD-Score:3.76|P-value:8.56E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-5.35|P-value:4.80E-6 ID:SGTC_3296|Compound:9122258|FD-Score:-3.76|P-value:9.40E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.79|P-value:8.74E-4

Top fitness defect scores for YOL120C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2730 imipramine 7.80 71.3 µM 4.19E-11 1 3.02E-15 1.65
2 SGTC_959 1222-0044 7.18 107.0 µM 1.12E-9 1 3.37E-13 2.65
3 SGTC_2993 9054257 7.17 71.4 µM 1.20E-9 fatty acid desaturase (OLE1) 5 3.74E-13 0.25
4 SGTC_258 haloperidol 7.04 50.8 µM 2.35E-9 fatty acid desaturase (OLE1) 3 9.85E-13 1.33
5 SGTC_2129 girgensonine 6.97 121.0 µM 3.24E-9 heme biosynthesis & mitochondrial translocase 8 1.56E-12 0.12
6 SGTC_3007 9078383 6.86 71.4 µM 5.55E-9 1 3.37E-12 1.46
7 SGTC_1506 4226-2149 6.83 212.0 µM 6.41E-9 1 4.15E-12 2.38
8 SGTC_2725 haloperidol 6.44 53.2 µM 4.17E-8 plasma membrane duress 6 6.08E-11 0.30
9 SGTC_1761 st044296 6.37 37.0 µM 5.74E-8 1 9.61E-11 1.33
10 SGTC_800 3448-7362 6.26 155.0 µM 9.44E-8 translation 20 1.96E-10 0.02
11 SGTC_832 4083-0019 6.04 164.0 µM 2.47E-7 translation 9 7.78E-10 0.12
12 SGTC_2721 ifenprodil 6.03 61.4 µM 2.59E-7 plasma membrane duress 2 8.31E-10 1.62
13 SGTC_3081 9117243 5.86 49.5 µM 5.35E-7 fatty acid desaturase (OLE1) 13 2.35E-9 0.20
14 SGTC_1035 k081-0041 5.73 55.2 µM 9.19E-7 Golgi 3 5.09E-9 0.51
15 SGTC_941 3237-0776 5.64 460.0 µM 1.29E-6 2 8.31E-9 0.93
16 SGTC_1009 4106-0057 5.63 9.9 µM 1.40E-6 3 9.27E-9 0.37
17 SGTC_1415 3966-0071 5.49 78.1 µM 2.36E-6 DNA intercalators 1 1.96E-8 0.46
18 SGTC_2792 7535235 5.45 81.8 µM 2.77E-6 fatty acid desaturase (OLE1) 4 2.47E-8 0.77
19 SGTC_957 1187-1561 5.31 14.1 µM 4.82E-6 2 5.43E-8 0.55
20 SGTC_1465 k213-0056 5.26 144.0 µM 5.87E-6 DNA intercalators 3 7.19E-8 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.304 2.68E-72 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly
0.251 1.99E-49 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.237 4.38E-44 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.229 6.03E-41 YLR076C_d YLR076C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10
0.227 2.22E-40 YGL055W OLE1 het Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
0.221 2.19E-38 YBR190W_d YBR190W_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W
0.212 2.94E-35 YLR009W RLP24 het Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp
0.199 3.56E-31 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.192 3.05E-29 YOR206W NOC2 het Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors
0.189 2.92E-28 YPR136C_d YPR136C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.185 2.88E-27 YPL142C_d YPL142C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit
0.184 5.48E-27 YPL143W RPL33A het Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication
0.177 3.62E-25 YOL040C RPS15 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
0.174 2.53E-24 YKL180W RPL17A het Ribosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.172 1.37E-23 YGR095C RRP46 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)