YOL121C / RPS19A

Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL121C / RPS19A

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:3.55|P-value:1.71E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.04|P-value:9.35E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.93|P-value:3.05E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.19|P-value:6.54E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:3.96|P-value:3.21E-5 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.16|P-value:7.32E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:4.05|P-value:2.25E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:-4.59|P-value:1.46E-6 ID:SGTC_620|Compound:0109-0052|FD-Score:3.11|P-value:8.60E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:-3.05|P-value:9.17E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:9.26|P-value:3.86E-21 ID:SGTC_643|Compound:k048-0106|FD-Score:5.24|P-value:6.08E-8 ID:SGTC_647|Compound:0140-0236|FD-Score:-3.65|P-value:9.80E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:-4.23|P-value:7.96E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:-5.80|P-value:1.80E-9 ID:SGTC_735|Compound:3076-0345|FD-Score:3.35|P-value:3.77E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:-7.48|P-value:1.38E-14 ID:SGTC_738|Compound:1315-0003|FD-Score:3.37|P-value:3.49E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:4.59|P-value:1.86E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:3.45|P-value:2.57E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:-3.09|P-value:7.86E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:-4.32|P-value:5.42E-6 ID:SGTC_969|Compound:1313-0238|FD-Score:3.25|P-value:5.30E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.52|P-value:1.95E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.82|P-value:5.98E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:-3.10|P-value:7.79E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.25|P-value:5.28E-4 ID:SGTC_1781|Compound:st038725|FD-Score:9.13|P-value:1.33E-20 ID:SGTC_1783|Compound:st039459|FD-Score:5.54|P-value:1.14E-8 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.83|P-value:5.56E-5 ID:SGTC_1793|Compound:st048256|FD-Score:-6.04|P-value:3.86E-10 ID:SGTC_1827|Compound:berberine|FD-Score:-3.82|P-value:4.89E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.23|P-value:5.80E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.35|P-value:3.75E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.11|P-value:8.84E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-3.83|P-value:4.60E-5 ID:SGTC_2367|Compound:9070478|FD-Score:-3.41|P-value:2.51E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.12|P-value:7.14E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.30|P-value:4.40E-4 ID:SGTC_2402|Compound:5553605|FD-Score:6.44|P-value:3.73E-11 ID:SGTC_2403|Compound:6032726|FD-Score:4.69|P-value:1.09E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.33|P-value:3.68E-8 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.48|P-value:1.91E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.28|P-value:4.76E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:-3.04|P-value:9.34E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.58|P-value:1.56E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.85|P-value:5.18E-5 ID:SGTC_2505|Compound:galangin|FD-Score:3.78|P-value:6.88E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.56|P-value:1.65E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-7.86|P-value:6.30E-16 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:4.85|P-value:4.87E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.55|P-value:1.76E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.15|P-value:7.67E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:4.35|P-value:5.75E-6 ID:SGTC_2783|Compound:7738165|FD-Score:3.46|P-value:2.42E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.12|P-value:8.42E-4 ID:SGTC_2810|Compound:7959871|FD-Score:-3.63|P-value:1.04E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.47|P-value:2.41E-4 ID:SGTC_2906|Compound:7926292|FD-Score:-3.16|P-value:6.18E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.30|P-value:4.47E-4 ID:SGTC_3069|Compound:9117009|FD-Score:3.40|P-value:3.07E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.41|P-value:2.94E-4 ID:SGTC_3192|Compound:9110362|FD-Score:5.05|P-value:1.74E-7 ID:SGTC_3197|Compound:9113331|FD-Score:-5.23|P-value:5.00E-8 ID:SGTC_3200|Compound:9114385|FD-Score:3.59|P-value:1.50E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.11|P-value:7.49E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.55|P-value:1.71E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.04|P-value:9.35E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.93|P-value:3.05E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.19|P-value:6.54E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:3.96|P-value:3.21E-5 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.16|P-value:7.32E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:4.05|P-value:2.25E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:-4.59|P-value:1.46E-6 ID:SGTC_620|Compound:0109-0052|FD-Score:3.11|P-value:8.60E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:-3.05|P-value:9.17E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:9.26|P-value:3.86E-21 ID:SGTC_643|Compound:k048-0106|FD-Score:5.24|P-value:6.08E-8 ID:SGTC_647|Compound:0140-0236|FD-Score:-3.65|P-value:9.80E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:-4.23|P-value:7.96E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:-5.80|P-value:1.80E-9 ID:SGTC_735|Compound:3076-0345|FD-Score:3.35|P-value:3.77E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:-7.48|P-value:1.38E-14 ID:SGTC_738|Compound:1315-0003|FD-Score:3.37|P-value:3.49E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:4.59|P-value:1.86E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:3.45|P-value:2.57E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:-3.09|P-value:7.86E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:-4.32|P-value:5.42E-6 ID:SGTC_969|Compound:1313-0238|FD-Score:3.25|P-value:5.30E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.52|P-value:1.95E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.82|P-value:5.98E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:-3.10|P-value:7.79E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.25|P-value:5.28E-4 ID:SGTC_1781|Compound:st038725|FD-Score:9.13|P-value:1.33E-20 ID:SGTC_1783|Compound:st039459|FD-Score:5.54|P-value:1.14E-8 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.83|P-value:5.56E-5 ID:SGTC_1793|Compound:st048256|FD-Score:-6.04|P-value:3.86E-10 ID:SGTC_1827|Compound:berberine|FD-Score:-3.82|P-value:4.89E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.23|P-value:5.80E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.35|P-value:3.75E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.11|P-value:8.84E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-3.83|P-value:4.60E-5 ID:SGTC_2367|Compound:9070478|FD-Score:-3.41|P-value:2.51E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.12|P-value:7.14E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.30|P-value:4.40E-4 ID:SGTC_2402|Compound:5553605|FD-Score:6.44|P-value:3.73E-11 ID:SGTC_2403|Compound:6032726|FD-Score:4.69|P-value:1.09E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.33|P-value:3.68E-8 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.48|P-value:1.91E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.28|P-value:4.76E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:-3.04|P-value:9.34E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.58|P-value:1.56E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.85|P-value:5.18E-5 ID:SGTC_2505|Compound:galangin|FD-Score:3.78|P-value:6.88E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.56|P-value:1.65E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-7.86|P-value:6.30E-16 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:4.85|P-value:4.87E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.55|P-value:1.76E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.15|P-value:7.67E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:4.35|P-value:5.75E-6 ID:SGTC_2783|Compound:7738165|FD-Score:3.46|P-value:2.42E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.12|P-value:8.42E-4 ID:SGTC_2810|Compound:7959871|FD-Score:-3.63|P-value:1.04E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.47|P-value:2.41E-4 ID:SGTC_2906|Compound:7926292|FD-Score:-3.16|P-value:6.18E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.30|P-value:4.47E-4 ID:SGTC_3069|Compound:9117009|FD-Score:3.40|P-value:3.07E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.41|P-value:2.94E-4 ID:SGTC_3192|Compound:9110362|FD-Score:5.05|P-value:1.74E-7 ID:SGTC_3197|Compound:9113331|FD-Score:-5.23|P-value:5.00E-8 ID:SGTC_3200|Compound:9114385|FD-Score:3.59|P-value:1.50E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.11|P-value:7.49E-4

Top fitness defect scores for YOL121C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_625 k213-0058 9.26 121.0 µM 3.86E-21 translation 5 1.05E-20
2 SGTC_1781 st038725 9.13 66.3 µM 1.33E-20 NEO1 22 3.51E-20
3 SGTC_2402 5553605 6.44 200.0 µM 3.73E-11 3 5.81E-11
4 SGTC_1783 st039459 5.54 87.5 µM 1.14E-8 Golgi 7 1.56E-8
5 SGTC_2405 ticlatone 5.33 3.5 µM 3.68E-8 35 4.89E-8
6 SGTC_643 k048-0106 5.24 28.4 µM 6.08E-8 RSC & ERG11 5 7.99E-8
7 SGTC_3192 9110362 5.05 49.5 µM 1.74E-7 mitochondrial processes 2 2.23E-7
8 SGTC_2595 hexamethylquercetagetin 4.85 100.0 µM 4.87E-7 10 6.10E-7
9 SGTC_2403 6032726 4.69 181.2 µM 1.09E-6 23 1.34E-6
10 SGTC_739 1486-1183 4.59 203.0 µM 1.86E-6 11 2.26E-6
11 SGTC_2772 vinpocetine 4.35 57.1 µM 5.75E-6 17 6.83E-6
12 SGTC_411 enrofloxacin 4.05 100.0 µM 2.25E-5 DNA damage response 13 2.60E-5
13 SGTC_368 fentichlor 3.96 4.6 µM 3.21E-5 27 3.67E-5
14 SGTC_2502 avocadyne acetate 3.85 18.6 µM 5.18E-5 24 5.87E-5
15 SGTC_1787 fluconazole 3.83 80.0 µM 5.56E-5 iron homeostasis 27 6.30E-5
16 SGTC_1391 3442-0225 3.82 151.0 µM 5.98E-5 19 6.76E-5
17 SGTC_2505 galangin 3.78 7.9 µM 6.88E-5 RPP1 & pyrimidine depletion 10 7.75E-5
18 SGTC_3200 9114385 3.59 49.5 µM 1.50E-4 48 1.66E-4
19 SGTC_2495 cafestol 3.58 54.5 µM 1.56E-4 Golgi 32 1.73E-4
20 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 3.56 66.7 µM 1.65E-4 38 1.82E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.212 2.33E-35 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.161 7.21E-21 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.142 1.40E-16 YOR078W BUD21 hom Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern
0.138 1.00E-15 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.134 6.62E-15 YER127W LCP5 het Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus
0.132 1.39E-14 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.131 2.80E-14 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.129 7.72E-14 YLR264W RPS28B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication
0.117 1.31E-11 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.113 5.37E-11 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.111 1.05E-10 YLR435W TSR2 hom Protein with a potential role in pre-rRNA processing
0.111 1.24E-10 YGR271C-A EFG1 hom Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
0.108 3.58E-10 YJR145C RPS4A hom Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication
0.108 3.93E-10 YDR174W HMO1 hom Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase
0.106 7.15E-10 YMR230W RPS10B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication