YOL127W / RPL25

Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOL127W / RPL25

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:6.65|P-value:1.38E-8 ID:SGTC_20|Compound:0481-0013|FD-Score:3.79|P-value:7.81E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.79|P-value:3.12E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:-4.32|P-value:1.53E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:4.40|P-value:1.19E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:7.22|P-value:8.19E-10 ID:SGTC_104|Compound:0074-0074|FD-Score:4.55|P-value:7.15E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:10.70|P-value:2.13E-19 ID:SGTC_115|Compound:0527-0192|FD-Score:8.61|P-value:3.23E-13 ID:SGTC_134|Compound:0269-0018|FD-Score:9.48|P-value:1.16E-15 ID:SGTC_159|Compound:3970-0959|FD-Score:4.12|P-value:2.88E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:4.50|P-value:8.56E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:10.80|P-value:1.11E-19 ID:SGTC_236|Compound:1509-0011|FD-Score:11.90|P-value:1.17E-23 ID:SGTC_246|Compound:cycloheximide|FD-Score:4.91|P-value:2.03E-5 ID:SGTC_263|Compound:alizarin|FD-Score:5.03|P-value:1.32E-5 ID:SGTC_302|Compound:1094-0063|FD-Score:3.82|P-value:7.08E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.65|P-value:5.16E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:-4.14|P-value:2.73E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:10.30|P-value:3.33E-18 ID:SGTC_339|Compound:3091-4833|FD-Score:3.80|P-value:7.59E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:8.85|P-value:7.36E-14 ID:SGTC_386|Compound:1509-0011|FD-Score:4.34|P-value:1.46E-4 ID:SGTC_398|Compound:bronopol|FD-Score:-5.75|P-value:7.93E-7 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.73|P-value:9.11E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-6.27|P-value:8.32E-8 ID:SGTC_431|Compound:k089-0097|FD-Score:5.45|P-value:2.61E-6 ID:SGTC_444|Compound:curcumin|FD-Score:5.23|P-value:6.13E-6 ID:SGTC_490|Compound:phenamil|FD-Score:-4.47|P-value:9.34E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:5.37|P-value:3.62E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:5.33|P-value:4.21E-6 ID:SGTC_539|Compound:4859-0462|FD-Score:-4.54|P-value:7.59E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:7.23|P-value:7.76E-10 ID:SGTC_586|Compound:0957-0265|FD-Score:-4.49|P-value:8.77E-5 ID:SGTC_641|Compound:4092-0595|FD-Score:4.45|P-value:9.91E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.74|P-value:8.96E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.91|P-value:5.41E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:3.84|P-value:6.64E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:3.89|P-value:5.75E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:8.28|P-value:2.24E-12 ID:SGTC_768|Compound:0384-0033|FD-Score:-4.09|P-value:3.13E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:5.78|P-value:6.74E-7 ID:SGTC_829|Compound:1635-0120|FD-Score:-4.32|P-value:1.53E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:-3.93|P-value:5.11E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-5.50|P-value:2.17E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:3.84|P-value:6.74E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:4.25|P-value:1.92E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-4.02|P-value:3.88E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:7.03|P-value:2.19E-9 ID:SGTC_957|Compound:1187-1561|FD-Score:4.08|P-value:3.30E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:-5.70|P-value:9.54E-7 ID:SGTC_987|Compound:1497-1013|FD-Score:3.91|P-value:5.43E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-5.02|P-value:1.39E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.76|P-value:3.53E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:-3.91|P-value:5.50E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-5.25|P-value:5.90E-6 ID:SGTC_1131|Compound:3454-3128|FD-Score:-4.23|P-value:2.03E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-4.01|P-value:4.04E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:-3.93|P-value:5.13E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:-3.77|P-value:8.13E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:5.57|P-value:1.61E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.22|P-value:8.04E-10 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.75|P-value:8.64E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:5.22|P-value:6.59E-6 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.86|P-value:6.32E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.74|P-value:3.78E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.86|P-value:2.50E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:-3.86|P-value:6.32E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-4.99|P-value:1.53E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:-5.18|P-value:7.60E-6 ID:SGTC_1588|Compound:farnesol|FD-Score:4.26|P-value:1.84E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-5.22|P-value:6.56E-6 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.02|P-value:3.94E-4 ID:SGTC_1704|Compound:st028805|FD-Score:4.02|P-value:3.90E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.13|P-value:2.81E-4 ID:SGTC_1723|Compound:st034307|FD-Score:4.59|P-value:6.37E-5 ID:SGTC_1750|Compound:st081859|FD-Score:7.06|P-value:1.85E-9 ID:SGTC_1754|Compound:st042065|FD-Score:-4.16|P-value:2.59E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.84|P-value:2.64E-5 ID:SGTC_1886|Compound:st057356|FD-Score:-3.99|P-value:4.36E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.80|P-value:7.55E-4 ID:SGTC_1949|Compound:st076024|FD-Score:6.79|P-value:7.05E-9 ID:SGTC_2021|Compound:4019055|FD-Score:-5.04|P-value:1.29E-5 ID:SGTC_2038|Compound:4100038|FD-Score:-3.94|P-value:5.03E-4 ID:SGTC_2046|Compound:4110841|FD-Score:8.37|P-value:1.38E-12 ID:SGTC_2054|Compound:5233173|FD-Score:-3.81|P-value:7.32E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-4.47|P-value:9.29E-5 ID:SGTC_2111|Compound:5486399|FD-Score:-4.82|P-value:2.84E-5 ID:SGTC_2116|Compound:5511452|FD-Score:4.26|P-value:1.86E-4 ID:SGTC_2139|Compound:5578692|FD-Score:-4.17|P-value:2.44E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-5.25|P-value:5.88E-6 ID:SGTC_2225|Compound:6654152|FD-Score:-3.77|P-value:8.24E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:-5.88|P-value:4.54E-7 ID:SGTC_2242|Compound:6630449|FD-Score:4.45|P-value:9.94E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.18|P-value:2.44E-4 ID:SGTC_2275|Compound:7947463|FD-Score:4.21|P-value:2.17E-4 ID:SGTC_2291|Compound:7917025|FD-Score:4.90|P-value:2.10E-5 ID:SGTC_2322|Compound:7413319|FD-Score:10.80|P-value:6.35E-20 ID:SGTC_2338|Compound:7999974|FD-Score:-4.42|P-value:1.13E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-4.02|P-value:3.94E-4 ID:SGTC_2377|Compound:9073351|FD-Score:5.73|P-value:8.49E-7 ID:SGTC_2389|Compound:9091542|FD-Score:10.70|P-value:2.75E-19 ID:SGTC_2396|Compound:5342950|FD-Score:-3.77|P-value:8.25E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.79|P-value:3.17E-5 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-3.94|P-value:4.96E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:4.15|P-value:2.67E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.72|P-value:9.57E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:8.68|P-value:2.03E-13 ID:SGTC_2651|Compound:1327-0036|FD-Score:7.92|P-value:1.79E-11 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:5.75|P-value:7.77E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.80|P-value:6.72E-9 ID:SGTC_2756|Compound:carbadox|FD-Score:-4.83|P-value:2.77E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-7.07|P-value:1.80E-9 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-4.52|P-value:8.07E-5 ID:SGTC_2797|Compound:7859098|FD-Score:-4.37|P-value:1.32E-4 ID:SGTC_2799|Compound:7812892|FD-Score:-3.95|P-value:4.82E-4 ID:SGTC_3009|Compound:9080819|FD-Score:4.41|P-value:1.13E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.62|P-value:5.72E-5 ID:SGTC_3142|Compound:9086498|FD-Score:10.80|P-value:1.29E-19 ID:SGTC_3249|Compound:9135183|FD-Score:-4.97|P-value:1.67E-5 ID:SGTC_3337|Compound:9144342|FD-Score:4.01|P-value:4.09E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-4.64|P-value:5.40E-5 ID:SGTC_3343|Compound:9148379|FD-Score:-4.43|P-value:1.09E-4 ID:SGTC_3347|Compound:9188721|FD-Score:4.34|P-value:1.42E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:6.65|P-value:1.38E-8 ID:SGTC_20|Compound:0481-0013|FD-Score:3.79|P-value:7.81E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.79|P-value:3.12E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:-4.32|P-value:1.53E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:4.40|P-value:1.19E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:7.22|P-value:8.19E-10 ID:SGTC_104|Compound:0074-0074|FD-Score:4.55|P-value:7.15E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:10.70|P-value:2.13E-19 ID:SGTC_115|Compound:0527-0192|FD-Score:8.61|P-value:3.23E-13 ID:SGTC_134|Compound:0269-0018|FD-Score:9.48|P-value:1.16E-15 ID:SGTC_159|Compound:3970-0959|FD-Score:4.12|P-value:2.88E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:4.50|P-value:8.56E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:10.80|P-value:1.11E-19 ID:SGTC_236|Compound:1509-0011|FD-Score:11.90|P-value:1.17E-23 ID:SGTC_246|Compound:cycloheximide|FD-Score:4.91|P-value:2.03E-5 ID:SGTC_263|Compound:alizarin|FD-Score:5.03|P-value:1.32E-5 ID:SGTC_302|Compound:1094-0063|FD-Score:3.82|P-value:7.08E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.65|P-value:5.16E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:-4.14|P-value:2.73E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:10.30|P-value:3.33E-18 ID:SGTC_339|Compound:3091-4833|FD-Score:3.80|P-value:7.59E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:8.85|P-value:7.36E-14 ID:SGTC_386|Compound:1509-0011|FD-Score:4.34|P-value:1.46E-4 ID:SGTC_398|Compound:bronopol|FD-Score:-5.75|P-value:7.93E-7 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.73|P-value:9.11E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-6.27|P-value:8.32E-8 ID:SGTC_431|Compound:k089-0097|FD-Score:5.45|P-value:2.61E-6 ID:SGTC_444|Compound:curcumin|FD-Score:5.23|P-value:6.13E-6 ID:SGTC_490|Compound:phenamil|FD-Score:-4.47|P-value:9.34E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:5.37|P-value:3.62E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:5.33|P-value:4.21E-6 ID:SGTC_539|Compound:4859-0462|FD-Score:-4.54|P-value:7.59E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:7.23|P-value:7.76E-10 ID:SGTC_586|Compound:0957-0265|FD-Score:-4.49|P-value:8.77E-5 ID:SGTC_641|Compound:4092-0595|FD-Score:4.45|P-value:9.91E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.74|P-value:8.96E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.91|P-value:5.41E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:3.84|P-value:6.64E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:3.89|P-value:5.75E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:8.28|P-value:2.24E-12 ID:SGTC_768|Compound:0384-0033|FD-Score:-4.09|P-value:3.13E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:5.78|P-value:6.74E-7 ID:SGTC_829|Compound:1635-0120|FD-Score:-4.32|P-value:1.53E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:-3.93|P-value:5.11E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-5.50|P-value:2.17E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:3.84|P-value:6.74E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:4.25|P-value:1.92E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-4.02|P-value:3.88E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:7.03|P-value:2.19E-9 ID:SGTC_957|Compound:1187-1561|FD-Score:4.08|P-value:3.30E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:-5.70|P-value:9.54E-7 ID:SGTC_987|Compound:1497-1013|FD-Score:3.91|P-value:5.43E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-5.02|P-value:1.39E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.76|P-value:3.53E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:-3.91|P-value:5.50E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-5.25|P-value:5.90E-6 ID:SGTC_1131|Compound:3454-3128|FD-Score:-4.23|P-value:2.03E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-4.01|P-value:4.04E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:-3.93|P-value:5.13E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:-3.77|P-value:8.13E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:5.57|P-value:1.61E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.22|P-value:8.04E-10 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.75|P-value:8.64E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:5.22|P-value:6.59E-6 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.86|P-value:6.32E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.74|P-value:3.78E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.86|P-value:2.50E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:-3.86|P-value:6.32E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-4.99|P-value:1.53E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:-5.18|P-value:7.60E-6 ID:SGTC_1588|Compound:farnesol|FD-Score:4.26|P-value:1.84E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-5.22|P-value:6.56E-6 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.02|P-value:3.94E-4 ID:SGTC_1704|Compound:st028805|FD-Score:4.02|P-value:3.90E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.13|P-value:2.81E-4 ID:SGTC_1723|Compound:st034307|FD-Score:4.59|P-value:6.37E-5 ID:SGTC_1750|Compound:st081859|FD-Score:7.06|P-value:1.85E-9 ID:SGTC_1754|Compound:st042065|FD-Score:-4.16|P-value:2.59E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.84|P-value:2.64E-5 ID:SGTC_1886|Compound:st057356|FD-Score:-3.99|P-value:4.36E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.80|P-value:7.55E-4 ID:SGTC_1949|Compound:st076024|FD-Score:6.79|P-value:7.05E-9 ID:SGTC_2021|Compound:4019055|FD-Score:-5.04|P-value:1.29E-5 ID:SGTC_2038|Compound:4100038|FD-Score:-3.94|P-value:5.03E-4 ID:SGTC_2046|Compound:4110841|FD-Score:8.37|P-value:1.38E-12 ID:SGTC_2054|Compound:5233173|FD-Score:-3.81|P-value:7.32E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-4.47|P-value:9.29E-5 ID:SGTC_2111|Compound:5486399|FD-Score:-4.82|P-value:2.84E-5 ID:SGTC_2116|Compound:5511452|FD-Score:4.26|P-value:1.86E-4 ID:SGTC_2139|Compound:5578692|FD-Score:-4.17|P-value:2.44E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-5.25|P-value:5.88E-6 ID:SGTC_2225|Compound:6654152|FD-Score:-3.77|P-value:8.24E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:-5.88|P-value:4.54E-7 ID:SGTC_2242|Compound:6630449|FD-Score:4.45|P-value:9.94E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.18|P-value:2.44E-4 ID:SGTC_2275|Compound:7947463|FD-Score:4.21|P-value:2.17E-4 ID:SGTC_2291|Compound:7917025|FD-Score:4.90|P-value:2.10E-5 ID:SGTC_2322|Compound:7413319|FD-Score:10.80|P-value:6.35E-20 ID:SGTC_2338|Compound:7999974|FD-Score:-4.42|P-value:1.13E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-4.02|P-value:3.94E-4 ID:SGTC_2377|Compound:9073351|FD-Score:5.73|P-value:8.49E-7 ID:SGTC_2389|Compound:9091542|FD-Score:10.70|P-value:2.75E-19 ID:SGTC_2396|Compound:5342950|FD-Score:-3.77|P-value:8.25E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.79|P-value:3.17E-5 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-3.94|P-value:4.96E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:4.15|P-value:2.67E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.72|P-value:9.57E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:8.68|P-value:2.03E-13 ID:SGTC_2651|Compound:1327-0036|FD-Score:7.92|P-value:1.79E-11 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:5.75|P-value:7.77E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.80|P-value:6.72E-9 ID:SGTC_2756|Compound:carbadox|FD-Score:-4.83|P-value:2.77E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-7.07|P-value:1.80E-9 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-4.52|P-value:8.07E-5 ID:SGTC_2797|Compound:7859098|FD-Score:-4.37|P-value:1.32E-4 ID:SGTC_2799|Compound:7812892|FD-Score:-3.95|P-value:4.82E-4 ID:SGTC_3009|Compound:9080819|FD-Score:4.41|P-value:1.13E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.62|P-value:5.72E-5 ID:SGTC_3142|Compound:9086498|FD-Score:10.80|P-value:1.29E-19 ID:SGTC_3249|Compound:9135183|FD-Score:-4.97|P-value:1.67E-5 ID:SGTC_3337|Compound:9144342|FD-Score:4.01|P-value:4.09E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-4.64|P-value:5.40E-5 ID:SGTC_3343|Compound:9148379|FD-Score:-4.43|P-value:1.09E-4 ID:SGTC_3347|Compound:9188721|FD-Score:4.34|P-value:1.42E-4

Top fitness defect scores for YOL127W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_236 1509-0011 11.90 5.3 µM 1.17E-23 1 4.68E-33 1.76
2 SGTC_2322 7413319 10.80 38.2 µM 6.35E-20 ERAD & cell cycle 4 1.02E-27 1.81
3 SGTC_227 fluconazole 10.80 33.5 µM 1.11E-19 azole & statin 11 2.25E-27 0.23
4 SGTC_3142 9086498 10.80 49.5 µM 1.29E-19 iron homeostasis 7 2.79E-27 1.27
5 SGTC_108 0509-0257 10.70 621.1 µM 2.13E-19 1 5.72E-27 3.00
6 SGTC_2389 9091542 10.70 195.5 µM 2.75E-19 iron homeostasis 1 8.21E-27 5.80
7 SGTC_335 4077-0256 10.30 27.6 µM 3.33E-18 1 2.89E-25 5.11
8 SGTC_134 0269-0018 9.48 6.9 µM 1.16E-15 2 1.23E-21 1.27
9 SGTC_371 0195-0006 8.85 7.4 µM 7.36E-14 1 4.56E-19 2.51
10 SGTC_2612 dictamnine 8.68 15.5 µM 2.03E-13 RNA pol III & RNase P/MRP 10 1.93E-18 0.45
11 SGTC_115 0527-0192 8.61 112.0 µM 3.23E-13 1 3.75E-18 1.68
12 SGTC_2046 4110841 8.37 106.0 µM 1.38E-12 iron homeostasis 2 2.98E-17 1.14
13 SGTC_733 4069-0007 8.28 56.1 µM 2.24E-12 ERAD & cell cycle 5 5.92E-17 0.35
14 SGTC_2651 1327-0036 7.92 5.0 µM 1.79E-11 22 1.14E-15 0.53
15 SGTC_568 1193-0097 7.23 7.5 µM 7.76E-10 ERAD & cell cycle 9 2.44E-13 0.23
16 SGTC_1161 k007-0610 7.22 110.0 µM 8.04E-10 ERAD & cell cycle 12 2.57E-13 0.18
17 SGTC_103 0844-0104 7.22 51.8 µM 8.19E-10 ERAD & cell cycle 17 2.64E-13 0.20
18 SGTC_1750 st081859 7.06 2.4 µM 1.85E-9 endomembrane recycling 12 8.43E-13 0.21
19 SGTC_955 1216-0110 7.03 33.0 µM 2.19E-9 sphingolipid biosynthesis & PDR1 1 1.07E-12 1.83
20 SGTC_2679 rapamycin 6.80 1.0 nM 6.72E-9 21 5.26E-12 0.12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.232 2.10E-42 YGL116W CDC20 het Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.222 6.91E-39 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.209 1.50E-34 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.191 8.61E-29 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.190 1.02E-28 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.181 3.96E-26 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.178 2.32E-25 YJL209W CBP1 hom Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress
0.177 4.07E-25 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.176 1.15E-24 YMR116C ASC1 hom G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation
0.173 6.52E-24 YDL107W MSS2 hom Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p
0.172 9.12E-24 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.172 1.06E-23 YDL165W CDC36 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.172 1.27E-23 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.172 1.41E-23 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.169 7.98E-23 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes