YOL130W / ALR1

Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOL130W / ALR1

Click on Significant Values for Screen Details ID:SGTC_19|Compound:0279-0214|FD-Score:-3.36|P-value:4.22E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.18|P-value:9.14E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.16|P-value:9.85E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.03|P-value:3.17E-5 ID:SGTC_823|Compound:0417-1665|FD-Score:3.24|P-value:7.40E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.44|P-value:3.72E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:-4.63|P-value:2.21E-6 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.81|P-value:9.25E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.42|P-value:3.91E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.15|P-value:9.99E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-3.17|P-value:8.17E-4 ID:SGTC_2458|Compound:5808907|FD-Score:3.25|P-value:7.10E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.69|P-value:1.49E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.52|P-value:2.78E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:3.98|P-value:4.64E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.75|P-value:1.17E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-3.41|P-value:3.57E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:-3.36|P-value:4.22E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.18|P-value:9.14E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.16|P-value:9.85E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.03|P-value:3.17E-5 ID:SGTC_823|Compound:0417-1665|FD-Score:3.24|P-value:7.40E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.44|P-value:3.72E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:-4.63|P-value:2.21E-6 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.81|P-value:9.25E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.42|P-value:3.91E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.15|P-value:9.99E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-3.17|P-value:8.17E-4 ID:SGTC_2458|Compound:5808907|FD-Score:3.25|P-value:7.10E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.69|P-value:1.49E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.52|P-value:2.78E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:3.98|P-value:4.64E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.75|P-value:1.17E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-3.41|P-value:3.57E-4

Top fitness defect scores for YOL130W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2559 tetrahydrosappanone a trimethyl ether 3.98 100.0 µM 4.64E-5 1 3.42E-5 0.48
2 SGTC_1292 0kpi-0043 3.81 232.0 µM 9.25E-5 3 6.97E-5 0.26
3 SGTC_2595 hexamethylquercetagetin 3.75 100.0 µM 1.17E-4 8 8.90E-5 0.08
4 SGTC_2540 epiandrosterone 3.69 100.0 µM 1.49E-4 5 1.14E-4 0.12
5 SGTC_2553 4-methylesculetin 3.52 85.1 µM 2.78E-4 7 2.17E-4 0.02
6 SGTC_841 0251-0215 3.44 91.2 µM 3.72E-4 5 2.93E-4 1.37E-4
7 SGTC_1427 4048-4900 3.42 550.0 nM 3.91E-4 2 3.08E-4 0.07
8 SGTC_2458 5808907 3.25 16.4 µM 7.10E-4 11 5.70E-4 0.06
9 SGTC_823 0417-1665 3.24 178.0 µM 7.40E-4 10 5.95E-4 0.23
10 SGTC_377 3970-0964 3.18 33.1 µM 9.14E-4 14 7.39E-4 0.02
11 SGTC_445 e6 berbamine 3.16 66.0 µM 9.85E-4 NEO1-PIK1 42 7.99E-4 8.58E-4
12 SGTC_1953 st076800 3.15 12.1 µM 9.99E-4 24 8.11E-4 0.06
13 SGTC_6 0844-0013 3.08 19.8 µM 0.00127 26 0.00104 0.04
14 SGTC_1264 0783-0040 3.06 158.0 µM 0.00135 9 0.00111 0.10
15 SGTC_2117 5521686 3.03 200.0 µM 0.00148 10 0.00121 0.04
16 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 3.03 66.7 µM 0.00149 7 0.00122 0.08
17 SGTC_1995 st072814 2.90 61.1 µM 0.00221 8 0.00184 3.14E-4
18 SGTC_1975 st070967 2.87 30.8 µM 0.00245 31 0.00204 0.00
19 SGTC_756 0508-1999 2.86 28.3 µM 0.00251 RPP1 & pyrimidine depletion 29 0.00210 0.03
20 SGTC_1796 st049173 2.86 110.4 µM 0.00252 11 0.00210 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.156 9.26E-20 YEL065W SIT1 hom Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
0.105 1.25E-9 YPL195W APL5 hom Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function
0.104 1.31E-9 YCR054C CTR86 het Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress
0.104 1.63E-9 YLR313C SPH1 hom Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p
0.100 5.77E-9 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.100 8.05E-9 YDL209C CWC2 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2
0.099 9.50E-9 YNL132W KRE33 het Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
0.099 1.02E-8 YOR103C OST2 het Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
0.097 1.58E-8 YBR174C_d YBR174C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective
0.097 1.68E-8 YBL093C ROX3 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme
0.096 2.78E-8 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.093 6.15E-8 YPR043W RPL43A hom Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication
0.092 9.27E-8 YOR148C SPP2 het Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction
0.092 1.03E-7 YLR143W DPH6 hom Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene
0.091 1.23E-7 YER136W GDI1 het GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins