YOL132W / GAS4

1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL132W / GAS4

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:2.97|P-value:9.14E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:2.97|P-value:9.34E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.57|P-value:9.04E-5 ID:SGTC_398|Compound:bronopol|FD-Score:3.24|P-value:3.47E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.16|P-value:4.71E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.74|P-value:4.37E-5 ID:SGTC_602|Compound:3130-1533|FD-Score:3.25|P-value:3.36E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.79|P-value:3.56E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:-2.98|P-value:9.59E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.85|P-value:2.81E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.69|P-value:5.46E-5 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.13|P-value:5.20E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.29|P-value:2.85E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.88|P-value:2.61E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.59|P-value:8.29E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:-3.95|P-value:1.88E-5 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.22|P-value:3.98E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:4.27|P-value:3.97E-6 ID:SGTC_1444|Compound:4112-3581|FD-Score:-3.14|P-value:5.31E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.83|P-value:3.06E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:5.60|P-value:2.24E-9 ID:SGTC_1520|Compound:flindersine|FD-Score:2.98|P-value:8.83E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.70|P-value:5.31E-5 ID:SGTC_1990|Compound:st072050|FD-Score:2.95|P-value:9.78E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.34|P-value:2.32E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.30|P-value:2.71E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-3.39|P-value:2.07E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.20|P-value:3.97E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.45|P-value:1.47E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.26|P-value:3.36E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.56|P-value:1.02E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.53|P-value:1.07E-6 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.95|P-value:1.75E-5 ID:SGTC_2705|Compound:st078069|FD-Score:3.21|P-value:3.80E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.54|P-value:1.04E-4 ID:SGTC_3000|Compound:9075062|FD-Score:3.04|P-value:7.09E-4 ID:SGTC_3131|Compound:9127911|FD-Score:4.25|P-value:4.29E-6 ID:SGTC_3245|Compound:9134821|FD-Score:3.24|P-value:3.48E-4 ID:SGTC_3329|Compound:9141233|FD-Score:3.12|P-value:5.33E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:2.97|P-value:9.14E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:2.97|P-value:9.34E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.57|P-value:9.04E-5 ID:SGTC_398|Compound:bronopol|FD-Score:3.24|P-value:3.47E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.16|P-value:4.71E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.74|P-value:4.37E-5 ID:SGTC_602|Compound:3130-1533|FD-Score:3.25|P-value:3.36E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.79|P-value:3.56E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:-2.98|P-value:9.59E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.85|P-value:2.81E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.69|P-value:5.46E-5 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.13|P-value:5.20E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.29|P-value:2.85E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.88|P-value:2.61E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.59|P-value:8.29E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:-3.95|P-value:1.88E-5 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.22|P-value:3.98E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:4.27|P-value:3.97E-6 ID:SGTC_1444|Compound:4112-3581|FD-Score:-3.14|P-value:5.31E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.83|P-value:3.06E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:5.60|P-value:2.24E-9 ID:SGTC_1520|Compound:flindersine|FD-Score:2.98|P-value:8.83E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.70|P-value:5.31E-5 ID:SGTC_1990|Compound:st072050|FD-Score:2.95|P-value:9.78E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.34|P-value:2.32E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.30|P-value:2.71E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-3.39|P-value:2.07E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.20|P-value:3.97E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.45|P-value:1.47E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.26|P-value:3.36E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.56|P-value:1.02E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.53|P-value:1.07E-6 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.95|P-value:1.75E-5 ID:SGTC_2705|Compound:st078069|FD-Score:3.21|P-value:3.80E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.54|P-value:1.04E-4 ID:SGTC_3000|Compound:9075062|FD-Score:3.04|P-value:7.09E-4 ID:SGTC_3131|Compound:9127911|FD-Score:4.25|P-value:4.29E-6 ID:SGTC_3245|Compound:9134821|FD-Score:3.24|P-value:3.48E-4 ID:SGTC_3329|Compound:9141233|FD-Score:3.12|P-value:5.33E-4

Top fitness defect scores for YOL132W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1513 0337-0559 5.60 19.0 µM 2.24E-9 1 1.05E-8
2 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 4.53 70.0 µM 1.07E-6 redox potentiating 59 3.01E-6
3 SGTC_1408 3909-7976 4.27 48.8 µM 3.97E-6 Golgi 16 9.99E-6
4 SGTC_3131 9127911 4.25 49.5 µM 4.29E-6 22 1.07E-5
5 SGTC_2675 theaflavin digallate 3.95 100.0 µM 1.75E-5 iron homeostasis 32 3.90E-5
6 SGTC_972 1319-0219 3.85 195.0 µM 2.81E-5 30 6.02E-5
7 SGTC_1503 4585-0012 3.83 61.3 µM 3.06E-5 17 6.51E-5
8 SGTC_814 3342-0569 3.79 96.0 µM 3.56E-5 21 7.48E-5
9 SGTC_597 k018-0003 3.74 82.8 µM 4.37E-5 RNA pol III & RNase P/MRP 15 9.03E-5
10 SGTC_1676 st018489 3.70 23.4 µM 5.31E-5 60S ribosome export 44 1.08E-4
11 SGTC_1082 camptothecin 3.69 424.9 nM 5.46E-5 DNA damage response 51 1.11E-4
12 SGTC_1287 0971-0001 3.59 34.6 µM 8.29E-5 sphingolipid biosynthesis & PDR1 57 1.62E-4
13 SGTC_344 k064-0035 3.57 6.4 µM 9.04E-5 60S ribosome export 32 1.76E-4
14 SGTC_2997 9067075 3.54 71.4 µM 1.04E-4 unfolded protein response 69 2.00E-4
15 SGTC_2454 5-benzylidenerhodanine 3.45 10.4 µM 1.47E-4 TRP & mitochondrial translation 63 2.75E-4
16 SGTC_2149 5554786 3.34 194.8 µM 2.32E-4 cell wall signaling 60 4.18E-4
17 SGTC_2288 7946289 3.30 167.3 µM 2.71E-4 60 4.82E-4
18 SGTC_1119 parthenolide 3.29 318.5 nM 2.85E-4 TSC3-RPN4 75 5.05E-4
19 SGTC_602 3130-1533 3.25 38.1 µM 3.36E-4 42 5.87E-4
20 SGTC_398 bronopol 3.24 33.3 µM 3.47E-4 RNA processing & uracil transport 45 6.05E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.80E-11 YER121W_p YER121W_p hom Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
0.108 4.15E-10 YDL135C RDI1 hom Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress
0.106 7.34E-10 YOL162W_p YOL162W_p hom Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family
0.100 7.83E-9 YMR101C SRT1 hom Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
0.095 4.04E-8 YDR336W_p YDR336W_p hom Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene
0.093 5.76E-8 YIL034C CAP2 hom Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress
0.091 1.38E-7 YBR151W APD1 hom Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus
0.090 2.01E-7 YDR267C CIA1 het Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein
0.088 2.89E-7 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.088 3.35E-7 YNL322C KRE1 hom Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.083 1.33E-6 YPR111W DBF20 hom Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs
0.083 1.55E-6 YDL037C BSC1 hom Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.082 1.86E-6 YOR214C_p YOR214C_p hom Putative protein of unknown function; YOR214C is not an essential gene
0.081 2.58E-6 YHL025W SNF6 hom Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions
0.081 2.81E-6 YJL070C_p YJL070C_p hom Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication