YOL144W / NOP8

Nucleolar protein required for 60S ribosomal subunit biogenesis

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOL144W / NOP8

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:5.54|P-value:5.55E-6 ID:SGTC_15|Compound:0266-0086|FD-Score:5.84|P-value:1.80E-6 ID:SGTC_50|Compound:0929-0078|FD-Score:-4.88|P-value:4.56E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:10.10|P-value:4.59E-16 ID:SGTC_63|Compound:0099-0242|FD-Score:8.22|P-value:3.36E-11 ID:SGTC_64|Compound:000l-0018|FD-Score:4.06|P-value:6.65E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:12.30|P-value:4.81E-23 ID:SGTC_70|Compound:0141-0289|FD-Score:6.69|P-value:5.39E-8 ID:SGTC_86|Compound:0417-1630|FD-Score:5.11|P-value:2.58E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:7.02|P-value:1.23E-8 ID:SGTC_116|Compound:0155-0182|FD-Score:-5.50|P-value:5.15E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:-3.88|P-value:9.05E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:8.05|P-value:7.90E-11 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:5.74|P-value:2.66E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:9.00|P-value:4.17E-13 ID:SGTC_150|Compound:3970-0969|FD-Score:4.44|P-value:2.17E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-5.89|P-value:1.19E-6 ID:SGTC_194|Compound:1486-1323|FD-Score:4.21|P-value:4.32E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:4.96|P-value:4.28E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:13.10|P-value:8.59E-26 ID:SGTC_284|Compound:0988-0104|FD-Score:-5.67|P-value:2.73E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.79|P-value:6.13E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:-4.41|P-value:1.99E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:4.78|P-value:7.61E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:-5.29|P-value:1.09E-5 ID:SGTC_398|Compound:bronopol|FD-Score:6.41|P-value:1.85E-7 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-4.30|P-value:2.76E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.68|P-value:8.56E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:6.63|P-value:7.10E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.39|P-value:2.11E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:9.88|P-value:2.07E-15 ID:SGTC_462|Compound:ag-879|FD-Score:4.98|P-value:3.95E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:8.42|P-value:1.14E-11 ID:SGTC_524|Compound:r073-0010|FD-Score:9.79|P-value:3.48E-15 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.98|P-value:6.88E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:4.50|P-value:1.83E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:14.00|P-value:2.77E-29 ID:SGTC_584|Compound:0986-0246|FD-Score:-4.27|P-value:3.01E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:12.30|P-value:8.77E-23 ID:SGTC_778|Compound:3456-2434|FD-Score:-6.87|P-value:1.89E-8 ID:SGTC_788|Compound:1182-0090|FD-Score:8.14|P-value:5.04E-11 ID:SGTC_795|Compound:0685-0265|FD-Score:9.12|P-value:2.12E-13 ID:SGTC_808|Compound:0711-0032|FD-Score:6.90|P-value:2.16E-8 ID:SGTC_851|Compound:0394-0702|FD-Score:4.79|P-value:7.27E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:4.09|P-value:6.02E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:7.42|P-value:1.89E-9 ID:SGTC_955|Compound:1216-0110|FD-Score:-4.25|P-value:3.23E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:13.10|P-value:7.61E-26 ID:SGTC_1057|Compound:3448-5381|FD-Score:5.63|P-value:4.05E-6 ID:SGTC_1127|Compound:asiatic acid|FD-Score:5.26|P-value:1.51E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:8.78|P-value:1.51E-12 ID:SGTC_1230|Compound:0170-0365|FD-Score:10.70|P-value:8.24E-18 ID:SGTC_1247|Compound:0448-0043|FD-Score:5.19|P-value:1.93E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.97|P-value:4.13E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:10.40|P-value:7.26E-17 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.81|P-value:6.98E-5 ID:SGTC_1478|Compound:0453-0656|FD-Score:4.46|P-value:2.09E-4 ID:SGTC_1522|Compound:st012842|FD-Score:4.33|P-value:2.99E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.94|P-value:9.23E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-6.17|P-value:3.78E-7 ID:SGTC_1573|Compound:oleylamine|FD-Score:-4.04|P-value:5.89E-4 ID:SGTC_1616|Compound:st002734|FD-Score:-5.95|P-value:9.13E-7 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:6.76|P-value:4.09E-8 ID:SGTC_1754|Compound:st042065|FD-Score:9.33|P-value:5.95E-14 ID:SGTC_1786|Compound:berberine|FD-Score:6.66|P-value:6.12E-8 ID:SGTC_1800|Compound:st050079|FD-Score:5.70|P-value:3.05E-6 ID:SGTC_1801|Compound:st050089|FD-Score:6.40|P-value:1.92E-7 ID:SGTC_1803|Compound:st050068|FD-Score:10.20|P-value:2.92E-16 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.34|P-value:2.42E-4 ID:SGTC_1853|Compound:st056710|FD-Score:4.91|P-value:5.02E-5 ID:SGTC_1962|Compound:st076595|FD-Score:4.29|P-value:3.37E-4 ID:SGTC_2006|Compound:4011487|FD-Score:9.51|P-value:2.07E-14 ID:SGTC_2021|Compound:4019055|FD-Score:13.20|P-value:5.26E-26 ID:SGTC_2036|Compound:5160441|FD-Score:8.79|P-value:1.45E-12 ID:SGTC_2044|Compound:5102272|FD-Score:5.76|P-value:2.47E-6 ID:SGTC_2050|Compound:5263056|FD-Score:4.30|P-value:3.31E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-5.21|P-value:1.46E-5 ID:SGTC_2066|Compound:5222451|FD-Score:4.63|P-value:1.23E-4 ID:SGTC_2118|Compound:5526350|FD-Score:4.07|P-value:6.47E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-4.02|P-value:6.25E-4 ID:SGTC_2183|Compound:6420625|FD-Score:12.00|P-value:8.70E-22 ID:SGTC_2223|Compound:6903751|FD-Score:5.04|P-value:3.23E-5 ID:SGTC_2257|Compound:7960413|FD-Score:10.80|P-value:5.94E-18 ID:SGTC_2286|Compound:7945697|FD-Score:-4.40|P-value:2.04E-4 ID:SGTC_2290|Compound:7904846|FD-Score:4.48|P-value:1.93E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.27|P-value:3.63E-4 ID:SGTC_2336|Compound:9001819|FD-Score:11.00|P-value:8.83E-19 ID:SGTC_2368|Compound:9071271|FD-Score:3.91|P-value:9.78E-4 ID:SGTC_2378|Compound:9074213|FD-Score:4.46|P-value:2.05E-4 ID:SGTC_2398|Compound:5228213|FD-Score:9.20|P-value:1.35E-13 ID:SGTC_2399|Compound:5884133|FD-Score:7.29|P-value:3.55E-9 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.89|P-value:8.94E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:5.33|P-value:1.19E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.95|P-value:8.85E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:4.61|P-value:1.30E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.79|P-value:7.47E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.54|P-value:1.62E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.91|P-value:4.03E-5 ID:SGTC_2838|Compound:9002687|FD-Score:5.51|P-value:6.18E-6 ID:SGTC_2868|Compound:9035608|FD-Score:4.32|P-value:3.13E-4 ID:SGTC_2880|Compound:9042983|FD-Score:6.41|P-value:1.83E-7 ID:SGTC_2887|Compound:9044784|FD-Score:5.11|P-value:2.55E-5 ID:SGTC_2896|Compound:9052656|FD-Score:7.86|P-value:2.10E-10 ID:SGTC_2916|Compound:7875993|FD-Score:-4.25|P-value:3.17E-4 ID:SGTC_2928|Compound:9011484|FD-Score:5.39|P-value:9.72E-6 ID:SGTC_2943|Compound:9068529|FD-Score:7.66|P-value:5.89E-10 ID:SGTC_2993|Compound:9054257|FD-Score:12.80|P-value:1.08E-24 ID:SGTC_3037|Compound:9091026|FD-Score:4.37|P-value:2.66E-4 ID:SGTC_3081|Compound:9117243|FD-Score:6.75|P-value:4.20E-8 ID:SGTC_3091|Compound:9116372|FD-Score:4.14|P-value:5.21E-4 ID:SGTC_3126|Compound:9127922|FD-Score:4.42|P-value:2.34E-4 ID:SGTC_3181|Compound:9108277|FD-Score:4.43|P-value:2.23E-4 ID:SGTC_3198|Compound:9112019|FD-Score:4.55|P-value:1.55E-4 ID:SGTC_3214|Compound:9129694|FD-Score:4.24|P-value:3.96E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-4.78|P-value:6.32E-5 ID:SGTC_3295|Compound:9122362|FD-Score:5.01|P-value:3.64E-5 ID:SGTC_3334|Compound:9142812|FD-Score:4.22|P-value:4.13E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:5.54|P-value:5.55E-6 ID:SGTC_15|Compound:0266-0086|FD-Score:5.84|P-value:1.80E-6 ID:SGTC_50|Compound:0929-0078|FD-Score:-4.88|P-value:4.56E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:10.10|P-value:4.59E-16 ID:SGTC_63|Compound:0099-0242|FD-Score:8.22|P-value:3.36E-11 ID:SGTC_64|Compound:000l-0018|FD-Score:4.06|P-value:6.65E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:12.30|P-value:4.81E-23 ID:SGTC_70|Compound:0141-0289|FD-Score:6.69|P-value:5.39E-8 ID:SGTC_86|Compound:0417-1630|FD-Score:5.11|P-value:2.58E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:7.02|P-value:1.23E-8 ID:SGTC_116|Compound:0155-0182|FD-Score:-5.50|P-value:5.15E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:-3.88|P-value:9.05E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:8.05|P-value:7.90E-11 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:5.74|P-value:2.66E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:9.00|P-value:4.17E-13 ID:SGTC_150|Compound:3970-0969|FD-Score:4.44|P-value:2.17E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-5.89|P-value:1.19E-6 ID:SGTC_194|Compound:1486-1323|FD-Score:4.21|P-value:4.32E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:4.96|P-value:4.28E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:13.10|P-value:8.59E-26 ID:SGTC_284|Compound:0988-0104|FD-Score:-5.67|P-value:2.73E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.79|P-value:6.13E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:-4.41|P-value:1.99E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:4.78|P-value:7.61E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:-5.29|P-value:1.09E-5 ID:SGTC_398|Compound:bronopol|FD-Score:6.41|P-value:1.85E-7 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-4.30|P-value:2.76E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.68|P-value:8.56E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:6.63|P-value:7.10E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.39|P-value:2.11E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:9.88|P-value:2.07E-15 ID:SGTC_462|Compound:ag-879|FD-Score:4.98|P-value:3.95E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:8.42|P-value:1.14E-11 ID:SGTC_524|Compound:r073-0010|FD-Score:9.79|P-value:3.48E-15 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.98|P-value:6.88E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:4.50|P-value:1.83E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:14.00|P-value:2.77E-29 ID:SGTC_584|Compound:0986-0246|FD-Score:-4.27|P-value:3.01E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:12.30|P-value:8.77E-23 ID:SGTC_778|Compound:3456-2434|FD-Score:-6.87|P-value:1.89E-8 ID:SGTC_788|Compound:1182-0090|FD-Score:8.14|P-value:5.04E-11 ID:SGTC_795|Compound:0685-0265|FD-Score:9.12|P-value:2.12E-13 ID:SGTC_808|Compound:0711-0032|FD-Score:6.90|P-value:2.16E-8 ID:SGTC_851|Compound:0394-0702|FD-Score:4.79|P-value:7.27E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:4.09|P-value:6.02E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:7.42|P-value:1.89E-9 ID:SGTC_955|Compound:1216-0110|FD-Score:-4.25|P-value:3.23E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:13.10|P-value:7.61E-26 ID:SGTC_1057|Compound:3448-5381|FD-Score:5.63|P-value:4.05E-6 ID:SGTC_1127|Compound:asiatic acid|FD-Score:5.26|P-value:1.51E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:8.78|P-value:1.51E-12 ID:SGTC_1230|Compound:0170-0365|FD-Score:10.70|P-value:8.24E-18 ID:SGTC_1247|Compound:0448-0043|FD-Score:5.19|P-value:1.93E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.97|P-value:4.13E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:10.40|P-value:7.26E-17 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.81|P-value:6.98E-5 ID:SGTC_1478|Compound:0453-0656|FD-Score:4.46|P-value:2.09E-4 ID:SGTC_1522|Compound:st012842|FD-Score:4.33|P-value:2.99E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.94|P-value:9.23E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-6.17|P-value:3.78E-7 ID:SGTC_1573|Compound:oleylamine|FD-Score:-4.04|P-value:5.89E-4 ID:SGTC_1616|Compound:st002734|FD-Score:-5.95|P-value:9.13E-7 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:6.76|P-value:4.09E-8 ID:SGTC_1754|Compound:st042065|FD-Score:9.33|P-value:5.95E-14 ID:SGTC_1786|Compound:berberine|FD-Score:6.66|P-value:6.12E-8 ID:SGTC_1800|Compound:st050079|FD-Score:5.70|P-value:3.05E-6 ID:SGTC_1801|Compound:st050089|FD-Score:6.40|P-value:1.92E-7 ID:SGTC_1803|Compound:st050068|FD-Score:10.20|P-value:2.92E-16 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.34|P-value:2.42E-4 ID:SGTC_1853|Compound:st056710|FD-Score:4.91|P-value:5.02E-5 ID:SGTC_1962|Compound:st076595|FD-Score:4.29|P-value:3.37E-4 ID:SGTC_2006|Compound:4011487|FD-Score:9.51|P-value:2.07E-14 ID:SGTC_2021|Compound:4019055|FD-Score:13.20|P-value:5.26E-26 ID:SGTC_2036|Compound:5160441|FD-Score:8.79|P-value:1.45E-12 ID:SGTC_2044|Compound:5102272|FD-Score:5.76|P-value:2.47E-6 ID:SGTC_2050|Compound:5263056|FD-Score:4.30|P-value:3.31E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-5.21|P-value:1.46E-5 ID:SGTC_2066|Compound:5222451|FD-Score:4.63|P-value:1.23E-4 ID:SGTC_2118|Compound:5526350|FD-Score:4.07|P-value:6.47E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-4.02|P-value:6.25E-4 ID:SGTC_2183|Compound:6420625|FD-Score:12.00|P-value:8.70E-22 ID:SGTC_2223|Compound:6903751|FD-Score:5.04|P-value:3.23E-5 ID:SGTC_2257|Compound:7960413|FD-Score:10.80|P-value:5.94E-18 ID:SGTC_2286|Compound:7945697|FD-Score:-4.40|P-value:2.04E-4 ID:SGTC_2290|Compound:7904846|FD-Score:4.48|P-value:1.93E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.27|P-value:3.63E-4 ID:SGTC_2336|Compound:9001819|FD-Score:11.00|P-value:8.83E-19 ID:SGTC_2368|Compound:9071271|FD-Score:3.91|P-value:9.78E-4 ID:SGTC_2378|Compound:9074213|FD-Score:4.46|P-value:2.05E-4 ID:SGTC_2398|Compound:5228213|FD-Score:9.20|P-value:1.35E-13 ID:SGTC_2399|Compound:5884133|FD-Score:7.29|P-value:3.55E-9 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.89|P-value:8.94E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:5.33|P-value:1.19E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.95|P-value:8.85E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:4.61|P-value:1.30E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.79|P-value:7.47E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.54|P-value:1.62E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.91|P-value:4.03E-5 ID:SGTC_2838|Compound:9002687|FD-Score:5.51|P-value:6.18E-6 ID:SGTC_2868|Compound:9035608|FD-Score:4.32|P-value:3.13E-4 ID:SGTC_2880|Compound:9042983|FD-Score:6.41|P-value:1.83E-7 ID:SGTC_2887|Compound:9044784|FD-Score:5.11|P-value:2.55E-5 ID:SGTC_2896|Compound:9052656|FD-Score:7.86|P-value:2.10E-10 ID:SGTC_2916|Compound:7875993|FD-Score:-4.25|P-value:3.17E-4 ID:SGTC_2928|Compound:9011484|FD-Score:5.39|P-value:9.72E-6 ID:SGTC_2943|Compound:9068529|FD-Score:7.66|P-value:5.89E-10 ID:SGTC_2993|Compound:9054257|FD-Score:12.80|P-value:1.08E-24 ID:SGTC_3037|Compound:9091026|FD-Score:4.37|P-value:2.66E-4 ID:SGTC_3081|Compound:9117243|FD-Score:6.75|P-value:4.20E-8 ID:SGTC_3091|Compound:9116372|FD-Score:4.14|P-value:5.21E-4 ID:SGTC_3126|Compound:9127922|FD-Score:4.42|P-value:2.34E-4 ID:SGTC_3181|Compound:9108277|FD-Score:4.43|P-value:2.23E-4 ID:SGTC_3198|Compound:9112019|FD-Score:4.55|P-value:1.55E-4 ID:SGTC_3214|Compound:9129694|FD-Score:4.24|P-value:3.96E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-4.78|P-value:6.32E-5 ID:SGTC_3295|Compound:9122362|FD-Score:5.01|P-value:3.64E-5 ID:SGTC_3334|Compound:9142812|FD-Score:4.22|P-value:4.13E-4

Top fitness defect scores for YOL144W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_568 1193-0097 14.00 7.5 µM 2.77E-29 ERAD & cell cycle 3 4.33E-45 1.92
2 SGTC_2021 4019055 13.20 173.0 µM 5.26E-26 endomembrane recycling 3 6.14E-40 0.71
3 SGTC_969 1313-0238 13.10 134.0 µM 7.61E-26 mitochondrial processes 1 1.10E-39 2.95
4 SGTC_221 trifluoperazine 13.10 10.3 µM 8.59E-26 NEO1-PIK1 5 1.33E-39 3.82
5 SGTC_2993 9054257 12.80 71.4 µM 1.08E-24 fatty acid desaturase (OLE1) 2 7.07E-38 2.24
6 SGTC_69 0096-0274 12.30 206.7 µM 4.81E-23 mitochondrial processes 2 2.76E-35 1.83
7 SGTC_730 1436-0052 12.30 41.2 µM 8.77E-23 mitochondrial processes 4 7.09E-35 6.09
8 SGTC_2183 6420625 12.00 130.5 µM 8.70E-22 mitochondrial processes 1 2.60E-33 2.17
9 SGTC_2336 9001819 11.00 198.7 µM 8.83E-19 heme biosynthesis & mitochondrial translocase 7 1.37E-28 0.70
10 SGTC_2257 7960413 10.80 200.0 µM 5.94E-18 NEO1-PIK1 3 2.72E-27 2.42
11 SGTC_1230 0170-0365 10.70 3.8 µM 8.24E-18 endomembrane recycling 6 4.55E-27 1.11
12 SGTC_1308 1187-1617 10.40 41.4 µM 7.26E-17 fatty acid desaturase (OLE1) 1 1.39E-25 3.24
13 SGTC_1803 st050068 10.20 52.4 µM 2.92E-16 NEO1-PIK1 4 1.23E-24 3.09
14 SGTC_58 0957-0393 10.10 9.0 µM 4.59E-16 cell wall 9 2.51E-24 1.45
15 SGTC_457 grayanotoxin iii 9.88 135.0 µM 2.07E-15 3 2.65E-23 2.41
16 SGTC_524 r073-0010 9.79 27.8 µM 3.48E-15 2 5.99E-23 1.00
17 SGTC_2006 4011487 9.51 200.0 µM 2.07E-14 endomembrane recycling 5 9.80E-22 1.49
18 SGTC_1754 st042065 9.33 16.1 µM 5.95E-14 NEO1-PIK1 6 5.15E-21 1.10
19 SGTC_2398 5228213 9.20 48.8 µM 1.35E-13 iron homeostasis 3 1.86E-20 1.96
20 SGTC_795 0685-0265 9.12 78.0 µM 2.12E-13 excess fatty acid 1 3.78E-20 2.56

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.558 1.64E-273 YJL086C_d YJL086C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1
0.338 4.40E-90 YCR035C RRP43 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8); protein abundance increases in response to DNA replication stress
0.330 8.70E-86 YCR052W RSC6 het Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p
0.296 1.70E-68 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.288 7.29E-65 YDR317W HIM1 hom Protein of unknown function involved in DNA repair
0.272 5.15E-58 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.267 1.24E-55 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.252 9.08E-50 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.235 4.35E-43 YMR134W ERG29 het Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
0.231 1.15E-41 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.230 2.76E-41 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.226 4.70E-40 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.226 6.96E-40 YCR079W PTC6 hom Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase
0.224 1.84E-39 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.219 8.57E-38 YGR060W ERG25 het C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol