YOL154W / ZPS1

Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL154W / ZPS1

Click on Significant Values for Screen Details ID:SGTC_164|Compound:4100-3994|FD-Score:3.36|P-value:8.22E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.23|P-value:1.49E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:2.96|P-value:4.34E-4 ID:SGTC_397|Compound:arbidol|FD-Score:-2.90|P-value:6.00E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.58|P-value:3.13E-5 ID:SGTC_606|Compound:k015-0008|FD-Score:3.59|P-value:2.81E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:2.80|P-value:8.33E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:2.99|P-value:3.93E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.16|P-value:1.97E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:-3.59|P-value:2.91E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:2.99|P-value:3.98E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.07|P-value:2.77E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:-2.95|P-value:4.83E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.44|P-value:5.87E-5 ID:SGTC_2037|Compound:5169046|FD-Score:2.86|P-value:6.46E-4 ID:SGTC_2146|Compound:5545642|FD-Score:2.82|P-value:7.81E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-2.97|P-value:4.43E-4 ID:SGTC_2451|Compound:5856223|FD-Score:-3.32|P-value:1.04E-4 ID:SGTC_2481|Compound:5478948|FD-Score:2.95|P-value:4.51E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.13|P-value:2.22E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.02|P-value:3.21E-6 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.56|P-value:3.38E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.43|P-value:6.28E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:-5.38|P-value:8.49E-10 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-2.85|P-value:7.14E-4 ID:SGTC_2692|Compound:st077426|FD-Score:2.95|P-value:4.57E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.06|P-value:2.95E-4 ID:SGTC_2822|Compound:7994718|FD-Score:-3.50|P-value:4.52E-5 ID:SGTC_3007|Compound:9078383|FD-Score:-3.21|P-value:1.66E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.08|P-value:2.75E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-3.84|P-value:8.65E-6 ID:SGTC_3312|Compound:9133330|FD-Score:2.96|P-value:4.50E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.36|P-value:8.22E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.23|P-value:1.49E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:2.96|P-value:4.34E-4 ID:SGTC_397|Compound:arbidol|FD-Score:-2.90|P-value:6.00E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.58|P-value:3.13E-5 ID:SGTC_606|Compound:k015-0008|FD-Score:3.59|P-value:2.81E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:2.80|P-value:8.33E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:2.99|P-value:3.93E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.16|P-value:1.97E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:-3.59|P-value:2.91E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:2.99|P-value:3.98E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.07|P-value:2.77E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:-2.95|P-value:4.83E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.44|P-value:5.87E-5 ID:SGTC_2037|Compound:5169046|FD-Score:2.86|P-value:6.46E-4 ID:SGTC_2146|Compound:5545642|FD-Score:2.82|P-value:7.81E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-2.97|P-value:4.43E-4 ID:SGTC_2451|Compound:5856223|FD-Score:-3.32|P-value:1.04E-4 ID:SGTC_2481|Compound:5478948|FD-Score:2.95|P-value:4.51E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.13|P-value:2.22E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.02|P-value:3.21E-6 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.56|P-value:3.38E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.43|P-value:6.28E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:-5.38|P-value:8.49E-10 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-2.85|P-value:7.14E-4 ID:SGTC_2692|Compound:st077426|FD-Score:2.95|P-value:4.57E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.06|P-value:2.95E-4 ID:SGTC_2822|Compound:7994718|FD-Score:-3.50|P-value:4.52E-5 ID:SGTC_3007|Compound:9078383|FD-Score:-3.21|P-value:1.66E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.08|P-value:2.75E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-3.84|P-value:8.65E-6 ID:SGTC_3312|Compound:9133330|FD-Score:2.96|P-value:4.50E-4

Top fitness defect scores for YOL154W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2568 diosmetin 4.02 100.0 µM 3.21E-6 23 2.92E-5
2 SGTC_606 k015-0008 3.59 38.6 µM 2.81E-5 26 1.67E-4
3 SGTC_164 4100-3994 3.36 89.6 µM 8.22E-5 58 3.96E-4
4 SGTC_996 3970-0799 3.16 1.8 µM 1.97E-4 140 8.02E-4
5 SGTC_2482 5981709 3.13 142.7 µM 2.22E-4 PDR1 78 8.84E-4
6 SGTC_3047 9092122 3.08 49.5 µM 2.75E-4 54 0.00105
7 SGTC_1311 1190-0148 3.07 100.0 µM 2.77E-4 azole & statin 63 0.00106
8 SGTC_2821 7996764 3.06 71.4 µM 2.95E-4 94 0.00111
9 SGTC_737 1950-0117 2.99 57.9 µM 3.93E-4 59 0.00140
10 SGTC_1211 1056-0033 2.99 32.3 µM 3.98E-4 32 0.00141
11 SGTC_310 1273-0058 2.96 1.1 µM 4.34E-4 mitochondrial stress 353 0.00152
12 SGTC_3312 9133330 2.96 71.4 µM 4.50E-4 32 0.00156
13 SGTC_2481 5478948 2.95 45.2 µM 4.51E-4 PDR1 96 0.00156
14 SGTC_2692 st077426 2.95 47.7 µM 4.57E-4 70 0.00158
15 SGTC_2037 5169046 2.86 200.0 µM 6.46E-4 60S ribosome export 51 0.00209
16 SGTC_2146 5545642 2.82 200.0 µM 7.81E-4 73 0.00244
17 SGTC_660 4031-1742 2.80 102.0 µM 8.33E-4 redox potentiating 119 0.00257
18 SGTC_1090 efavirenz 2.74 20.7 µM 0.00103 86 0.00305
19 SGTC_2894 9048625 2.73 32.5 µM 0.00108 63 0.00318
20 SGTC_922 1866-0035 2.72 480.0 µM 0.00112 excess fatty acid 152 0.00325

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.195 4.39E-30 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.176 9.20E-25 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.155 1.54E-19 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.149 4.64E-18 YBR084W MIS1 hom Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
0.137 1.55E-15 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.136 3.27E-15 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.127 1.62E-13 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.124 6.36E-13 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.117 1.13E-11 YDR339C FCF1 het Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p
0.117 1.20E-11 YOR345C_d YOR345C_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
0.115 2.59E-11 YAL060W BDH1 hom NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
0.115 2.77E-11 YGR295C COS6 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.111 1.22E-10 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.110 1.98E-10 YLR390W-A CCW14 hom Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
0.109 2.44E-10 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress