HIPHOP chemogenomics database

YOL154W / ZPS1

Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH

Zygosity: Homozygous strain

fixedexpanded
Profile for YOL154W / ZPS1

Click on Significant Values for Screen Details

Top fitness defect scores for YOL154W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2568	diosmetin	4.02	100.0 µM	3.21E-6		23	2.92E-5
2	SGTC_606	k015-0008	3.59	38.6 µM	2.81E-5		26	1.67E-4
3	SGTC_164	4100-3994	3.36	89.6 µM	8.22E-5		58	3.96E-4
4	SGTC_996	3970-0799	3.16	1.8 µM	1.97E-4		140	8.02E-4
5	SGTC_2482	5981709	3.13	142.7 µM	2.22E-4	PDR1	78	8.84E-4
6	SGTC_3047	9092122	3.08	49.5 µM	2.75E-4		54	0.00105
7	SGTC_1311	1190-0148	3.07	100.0 µM	2.77E-4	azole & statin	63	0.00106
8	SGTC_2821	7996764	3.06	71.4 µM	2.95E-4		94	0.00111
9	SGTC_737	1950-0117	2.99	57.9 µM	3.93E-4		59	0.00140
10	SGTC_1211	1056-0033	2.99	32.3 µM	3.98E-4		32	0.00141
11	SGTC_310	1273-0058	2.96	1.1 µM	4.34E-4	mitochondrial stress	353	0.00152
12	SGTC_3312	9133330	2.96	71.4 µM	4.50E-4		32	0.00156
13	SGTC_2481	5478948	2.95	45.2 µM	4.51E-4	PDR1	96	0.00156
14	SGTC_2692	st077426	2.95	47.7 µM	4.57E-4		70	0.00158
15	SGTC_2037	5169046	2.86	200.0 µM	6.46E-4	60S ribosome export	51	0.00209
16	SGTC_2146	5545642	2.82	200.0 µM	7.81E-4		73	0.00244
17	SGTC_660	4031-1742	2.80	102.0 µM	8.33E-4	redox potentiating	119	0.00257
18	SGTC_1090	efavirenz	2.74	20.7 µM	0.00103		86	0.00305
19	SGTC_2894	9048625	2.73	32.5 µM	0.00108		63	0.00318
20	SGTC_922	1866-0035	2.72	480.0 µM	0.00112	excess fatty acid	152	0.00325

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.195	4.39E-30	YML118W	NGL3	hom	3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.176	9.20E-25	YGL205W	POX1	hom	Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.155	1.54E-19	YDL099W	BUG1	hom	Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.149	4.64E-18	YBR084W	MIS1	hom	Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
0.137	1.55E-15	YDR505C	PSP1	hom	Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.136	3.27E-15	YDL086W_p	YDL086W_p	hom	Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.127	1.62E-13	YGL222C	EDC1	hom	RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.124	6.36E-13	YOR037W	CYC2	hom	Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.117	1.13E-11	YDR339C	FCF1	het	Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p
0.117	1.20E-11	YOR345C_d	YOR345C_d	hom	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
0.115	2.59E-11	YAL060W	BDH1	hom	NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
0.115	2.77E-11	YGR295C	COS6	hom	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.111	1.22E-10	YBR067C	TIP1	hom	Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.110	1.98E-10	YLR390W-A	CCW14	hom	Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
0.109	2.44E-10	YNR033W	ABZ1	hom	Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress