YOL164W-A_p

Putative protein of unknown function; identified by fungal homology and RT-PCR

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL164W-A / YOL164W-A

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-3.59|P-value:2.74E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:4.27|P-value:8.63E-7 ID:SGTC_74|Compound:000s-0487|FD-Score:-6.79|P-value:1.19E-14 ID:SGTC_94|Compound:0334-0113|FD-Score:2.87|P-value:6.48E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.12|P-value:2.26E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.87|P-value:2.22E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:3.26|P-value:1.32E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:-3.00|P-value:3.71E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:2.96|P-value:4.63E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.98|P-value:4.11E-6 ID:SGTC_564|Compound:3555-0129|FD-Score:3.74|P-value:1.38E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:2.87|P-value:6.58E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:3.65|P-value:2.24E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.79|P-value:8.46E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-4.37|P-value:4.39E-7 ID:SGTC_769|Compound:0302-0231|FD-Score:2.79|P-value:9.01E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:-3.03|P-value:3.27E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.79|P-value:1.13E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:4.87|P-value:2.48E-8 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.08|P-value:2.83E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:5.47|P-value:4.51E-10 ID:SGTC_1367|Compound:1812-0510|FD-Score:2.87|P-value:6.55E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.11|P-value:2.11E-6 ID:SGTC_1635|Compound:st007035|FD-Score:3.43|P-value:6.07E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.78|P-value:1.16E-5 ID:SGTC_1741|Compound:st038134|FD-Score:4.46|P-value:2.97E-7 ID:SGTC_1745|Compound:st081495|FD-Score:3.98|P-value:4.13E-6 ID:SGTC_1747|Compound:st037496|FD-Score:-3.42|P-value:6.12E-5 ID:SGTC_1804|Compound:st050076|FD-Score:2.77|P-value:9.80E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.13|P-value:2.29E-4 ID:SGTC_1814|Compound:st052110|FD-Score:2.91|P-value:5.70E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.37|P-value:8.03E-5 ID:SGTC_1847|Compound:st056231|FD-Score:-5.82|P-value:3.11E-11 ID:SGTC_1848|Compound:st056003|FD-Score:-3.94|P-value:4.73E-6 ID:SGTC_1849|Compound:st056239|FD-Score:-2.78|P-value:8.70E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-4.59|P-value:1.24E-7 ID:SGTC_1860|Compound:st056228|FD-Score:-7.22|P-value:2.57E-16 ID:SGTC_1922|Compound:5578187|FD-Score:5.70|P-value:8.33E-11 ID:SGTC_1924|Compound:st058459|FD-Score:4.26|P-value:8.98E-7 ID:SGTC_1927|Compound:st060202|FD-Score:5.48|P-value:4.24E-10 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:5.33|P-value:1.19E-9 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-2.85|P-value:6.83E-4 ID:SGTC_1990|Compound:st072050|FD-Score:3.13|P-value:2.29E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.57|P-value:3.19E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-2.95|P-value:4.52E-4 ID:SGTC_2107|Compound:5363541|FD-Score:2.98|P-value:4.25E-4 ID:SGTC_2277|Compound:7947813|FD-Score:-5.08|P-value:5.59E-9 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:2.97|P-value:4.45E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-4.38|P-value:4.37E-7 ID:SGTC_2934|Compound:9036370|FD-Score:3.00|P-value:3.96E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.59|P-value:2.74E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:4.27|P-value:8.63E-7 ID:SGTC_74|Compound:000s-0487|FD-Score:-6.79|P-value:1.19E-14 ID:SGTC_94|Compound:0334-0113|FD-Score:2.87|P-value:6.48E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.12|P-value:2.26E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.87|P-value:2.22E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:3.26|P-value:1.32E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:-3.00|P-value:3.71E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:2.96|P-value:4.63E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.98|P-value:4.11E-6 ID:SGTC_564|Compound:3555-0129|FD-Score:3.74|P-value:1.38E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:2.87|P-value:6.58E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:3.65|P-value:2.24E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.79|P-value:8.46E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-4.37|P-value:4.39E-7 ID:SGTC_769|Compound:0302-0231|FD-Score:2.79|P-value:9.01E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:-3.03|P-value:3.27E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.79|P-value:1.13E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:4.87|P-value:2.48E-8 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.08|P-value:2.83E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:5.47|P-value:4.51E-10 ID:SGTC_1367|Compound:1812-0510|FD-Score:2.87|P-value:6.55E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.11|P-value:2.11E-6 ID:SGTC_1635|Compound:st007035|FD-Score:3.43|P-value:6.07E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.78|P-value:1.16E-5 ID:SGTC_1741|Compound:st038134|FD-Score:4.46|P-value:2.97E-7 ID:SGTC_1745|Compound:st081495|FD-Score:3.98|P-value:4.13E-6 ID:SGTC_1747|Compound:st037496|FD-Score:-3.42|P-value:6.12E-5 ID:SGTC_1804|Compound:st050076|FD-Score:2.77|P-value:9.80E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.13|P-value:2.29E-4 ID:SGTC_1814|Compound:st052110|FD-Score:2.91|P-value:5.70E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.37|P-value:8.03E-5 ID:SGTC_1847|Compound:st056231|FD-Score:-5.82|P-value:3.11E-11 ID:SGTC_1848|Compound:st056003|FD-Score:-3.94|P-value:4.73E-6 ID:SGTC_1849|Compound:st056239|FD-Score:-2.78|P-value:8.70E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-4.59|P-value:1.24E-7 ID:SGTC_1860|Compound:st056228|FD-Score:-7.22|P-value:2.57E-16 ID:SGTC_1922|Compound:5578187|FD-Score:5.70|P-value:8.33E-11 ID:SGTC_1924|Compound:st058459|FD-Score:4.26|P-value:8.98E-7 ID:SGTC_1927|Compound:st060202|FD-Score:5.48|P-value:4.24E-10 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:5.33|P-value:1.19E-9 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-2.85|P-value:6.83E-4 ID:SGTC_1990|Compound:st072050|FD-Score:3.13|P-value:2.29E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.57|P-value:3.19E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-2.95|P-value:4.52E-4 ID:SGTC_2107|Compound:5363541|FD-Score:2.98|P-value:4.25E-4 ID:SGTC_2277|Compound:7947813|FD-Score:-5.08|P-value:5.59E-9 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:2.97|P-value:4.45E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-4.38|P-value:4.37E-7 ID:SGTC_2934|Compound:9036370|FD-Score:3.00|P-value:3.96E-4

Top fitness defect scores for YOL164W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1922 5578187 5.70 25.0 µM 8.33E-11 TRP & mitochondrial translation 6 5.91E-9
2 SGTC_1927 st060202 5.48 13.8 µM 4.24E-10 5 2.17E-8
3 SGTC_1341 1486-1360 5.47 280.0 µM 4.51E-10 4 2.28E-8
4 SGTC_1929 genistein trimethyl ether 5.33 50.5 µM 1.19E-9 4 4.96E-8
5 SGTC_1126 isoteolin 4.87 1.0 µM 2.48E-8 12 5.64E-7
6 SGTC_1741 st038134 4.46 10.2 µM 2.97E-7 20 4.14E-6
7 SGTC_68 0986-0284 4.27 82.8 µM 8.63E-7 53 9.74E-6
8 SGTC_1924 st058459 4.26 75.1 µM 8.98E-7 3 1.01E-5
9 SGTC_1370 2001-0092 4.11 44.6 µM 2.11E-6 25 2.00E-5
10 SGTC_505 gw-5074 3.98 63.9 µM 4.11E-6 56 3.41E-5
11 SGTC_1745 st081495 3.98 74.0 µM 4.13E-6 RNA processing & uracil transport 73 3.43E-5
12 SGTC_786 4544-0069 3.79 423.0 µM 1.13E-5 40 7.69E-5
13 SGTC_1679 4130-1276 3.78 6.7 µM 1.16E-5 Golgi 73 7.88E-5
14 SGTC_564 3555-0129 3.74 330.0 µM 1.38E-5 6 9.02E-5
15 SGTC_591 4299-0174 3.65 154.0 µM 2.24E-5 13 1.34E-4
16 SGTC_2014 4013930 3.57 200.0 µM 3.19E-5 58 1.78E-4
17 SGTC_1635 st007035 3.43 42.4 µM 6.07E-5 254 2.98E-4
18 SGTC_1830 st055982 3.37 50.3 µM 8.03E-5 42 3.74E-4
19 SGTC_236 1509-0011 3.26 5.3 µM 1.32E-4 442 5.59E-4
20 SGTC_1990 st072050 3.13 59.8 µM 2.29E-4 42 8.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.172 1.46E-23 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.162 3.27E-21 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.151 1.60E-18 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.148 9.01E-18 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.146 2.30E-17 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.145 2.60E-17 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.139 5.53E-16 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.138 1.02E-15 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.136 2.78E-15 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.133 1.07E-14 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.129 5.52E-14 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.129 5.57E-14 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.129 7.21E-14 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.128 1.02E-13 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.128 1.20E-13 YGR174C CBP4 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex