YOR001W / RRP6

Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR001W / RRP6

Click on Significant Values for Screen Details ID:SGTC_101|Compound:0490-5701|FD-Score:4.12|P-value:8.55E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:3.06|P-value:1.62E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-4.15|P-value:3.17E-6 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.41|P-value:1.62E-7 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.96|P-value:4.87E-9 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:5.86|P-value:7.90E-12 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:6.53|P-value:3.23E-14 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.13|P-value:8.14E-7 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.16|P-value:6.90E-7 ID:SGTC_292|Compound:k038-0015|FD-Score:-3.07|P-value:4.73E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.07|P-value:4.85E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.07|P-value:4.73E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:2.86|P-value:3.78E-4 ID:SGTC_401|Compound:neomycin|FD-Score:3.07|P-value:1.58E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.61|P-value:4.63E-8 ID:SGTC_598|Compound:3937-0236|FD-Score:3.20|P-value:8.72E-5 ID:SGTC_627|Compound:1391-0720|FD-Score:-3.08|P-value:4.61E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.56|P-value:1.60E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:2.78|P-value:5.26E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:-2.99|P-value:6.50E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.08|P-value:1.47E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.79|P-value:5.10E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.53|P-value:6.74E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:2.68|P-value:7.69E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.04|P-value:1.80E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:2.86|P-value:3.85E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.00|P-value:2.13E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:2.62|P-value:9.73E-4 ID:SGTC_1683|Compound:st010134|FD-Score:2.89|P-value:3.37E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.91|P-value:2.73E-6 ID:SGTC_1958|Compound:st076513|FD-Score:2.95|P-value:2.56E-4 ID:SGTC_1968|Compound:st069590|FD-Score:-3.46|P-value:9.18E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.24|P-value:7.30E-5 ID:SGTC_2112|Compound:5488546|FD-Score:2.72|P-value:6.73E-4 ID:SGTC_2162|Compound:5663267|FD-Score:-2.97|P-value:7.20E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-3.03|P-value:5.69E-4 ID:SGTC_2279|Compound:7948423|FD-Score:-2.96|P-value:7.26E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.45|P-value:2.81E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:2.98|P-value:2.26E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-2.95|P-value:7.51E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.24|P-value:4.35E-7 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-2.93|P-value:8.16E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.04|P-value:1.76E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:-2.89|P-value:9.54E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.40|P-value:1.20E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-3.41|P-value:1.14E-4 ID:SGTC_2840|Compound:9008771|FD-Score:-3.20|P-value:2.81E-4 ID:SGTC_2853|Compound:9015042|FD-Score:2.63|P-value:9.28E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.22|P-value:8.21E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.84|P-value:1.54E-5 ID:SGTC_2932|Compound:9016711|FD-Score:7.19|P-value:8.67E-17 ID:SGTC_2933|Compound:9026794|FD-Score:4.16|P-value:6.61E-7 ID:SGTC_2938|Compound:9059746|FD-Score:-3.83|P-value:1.57E-5 ID:SGTC_3046|Compound:9092212|FD-Score:3.07|P-value:1.60E-4 ID:SGTC_3095|Compound:9117207|FD-Score:2.85|P-value:3.96E-4 ID:SGTC_3148|Compound:9097893|FD-Score:7.49|P-value:4.70E-18 ID:SGTC_3152|Compound:9099253|FD-Score:-6.17|P-value:5.66E-12 ID:SGTC_3197|Compound:9113331|FD-Score:-2.98|P-value:6.77E-4 ID:SGTC_3240|Compound:9133527|FD-Score:3.64|P-value:1.10E-5 ID:SGTC_3337|Compound:9144342|FD-Score:8.39|P-value:4.37E-22 ID:SGTC_3342|Compound:9147791|FD-Score:3.17|P-value:1.03E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:4.12|P-value:8.55E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:3.06|P-value:1.62E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-4.15|P-value:3.17E-6 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.41|P-value:1.62E-7 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.96|P-value:4.87E-9 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:5.86|P-value:7.90E-12 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:6.53|P-value:3.23E-14 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.13|P-value:8.14E-7 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.16|P-value:6.90E-7 ID:SGTC_292|Compound:k038-0015|FD-Score:-3.07|P-value:4.73E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.07|P-value:4.85E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.07|P-value:4.73E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:2.86|P-value:3.78E-4 ID:SGTC_401|Compound:neomycin|FD-Score:3.07|P-value:1.58E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.61|P-value:4.63E-8 ID:SGTC_598|Compound:3937-0236|FD-Score:3.20|P-value:8.72E-5 ID:SGTC_627|Compound:1391-0720|FD-Score:-3.08|P-value:4.61E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.56|P-value:1.60E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:2.78|P-value:5.26E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:-2.99|P-value:6.50E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.08|P-value:1.47E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.79|P-value:5.10E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.53|P-value:6.74E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:2.68|P-value:7.69E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.04|P-value:1.80E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:2.86|P-value:3.85E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.00|P-value:2.13E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:2.62|P-value:9.73E-4 ID:SGTC_1683|Compound:st010134|FD-Score:2.89|P-value:3.37E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.91|P-value:2.73E-6 ID:SGTC_1958|Compound:st076513|FD-Score:2.95|P-value:2.56E-4 ID:SGTC_1968|Compound:st069590|FD-Score:-3.46|P-value:9.18E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.24|P-value:7.30E-5 ID:SGTC_2112|Compound:5488546|FD-Score:2.72|P-value:6.73E-4 ID:SGTC_2162|Compound:5663267|FD-Score:-2.97|P-value:7.20E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-3.03|P-value:5.69E-4 ID:SGTC_2279|Compound:7948423|FD-Score:-2.96|P-value:7.26E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.45|P-value:2.81E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:2.98|P-value:2.26E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-2.95|P-value:7.51E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.24|P-value:4.35E-7 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-2.93|P-value:8.16E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.04|P-value:1.76E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:-2.89|P-value:9.54E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.40|P-value:1.20E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-3.41|P-value:1.14E-4 ID:SGTC_2840|Compound:9008771|FD-Score:-3.20|P-value:2.81E-4 ID:SGTC_2853|Compound:9015042|FD-Score:2.63|P-value:9.28E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.22|P-value:8.21E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.84|P-value:1.54E-5 ID:SGTC_2932|Compound:9016711|FD-Score:7.19|P-value:8.67E-17 ID:SGTC_2933|Compound:9026794|FD-Score:4.16|P-value:6.61E-7 ID:SGTC_2938|Compound:9059746|FD-Score:-3.83|P-value:1.57E-5 ID:SGTC_3046|Compound:9092212|FD-Score:3.07|P-value:1.60E-4 ID:SGTC_3095|Compound:9117207|FD-Score:2.85|P-value:3.96E-4 ID:SGTC_3148|Compound:9097893|FD-Score:7.49|P-value:4.70E-18 ID:SGTC_3152|Compound:9099253|FD-Score:-6.17|P-value:5.66E-12 ID:SGTC_3197|Compound:9113331|FD-Score:-2.98|P-value:6.77E-4 ID:SGTC_3240|Compound:9133527|FD-Score:3.64|P-value:1.10E-5 ID:SGTC_3337|Compound:9144342|FD-Score:8.39|P-value:4.37E-22 ID:SGTC_3342|Compound:9147791|FD-Score:3.17|P-value:1.03E-4

Top fitness defect scores for YOR001W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3337 9144342 8.39 33.5 µM 4.37E-22 8 2.42E-17
2 SGTC_3148 9097893 7.49 49.5 µM 4.70E-18 7 3.36E-14
3 SGTC_2932 9016711 7.19 44.5 µM 8.67E-17 10 3.26E-13
4 SGTC_241 5hr heat shock (37°C) + cantharidin 6.53 155.4 µM 3.23E-14 cell wall signaling 27 3.27E-11
5 SGTC_240 5hr heat shock (37°C) + Streptovitacin 5.86 300.0 µM 7.90E-12 heat shock/prefoldin 18 2.35E-9
6 SGTC_239 5hr heat shock (37°C) + mitomycin C 4.96 819.4 µM 4.87E-9 heat shock/prefoldin 19 3.46E-7
7 SGTC_582 0987-0078 4.61 156.0 µM 4.63E-8 calcium & mitochondrial duress 42 1.98E-6
8 SGTC_238 5hr heat shock (37°C) + nsc-638432 4.41 8.9 µM 1.62E-7 heat shock/prefoldin 28 5.23E-6
9 SGTC_2603 homopterocarpin 4.24 100.0 µM 4.35E-7 25 1.13E-5
10 SGTC_2933 9026794 4.16 32.5 µM 6.61E-7 12 1.56E-5
11 SGTC_243 5hr heat shock (37°C) + splitomicin 4.16 1.0 µM 6.90E-7 heat shock/prefoldin 46 1.61E-5
12 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.13 4.6 µM 8.14E-7 heat shock/prefoldin 32 1.83E-5
13 SGTC_101 0490-5701 4.12 117.5 µM 8.55E-7 11 1.90E-5
14 SGTC_1792 st045773 3.91 43.6 µM 2.73E-6 27 4.66E-5
15 SGTC_1137 ixabepilone 3.79 100.0 µM 5.10E-6 32 7.57E-5
16 SGTC_3240 9133527 3.64 49.5 µM 1.10E-5 17 1.38E-4
17 SGTC_667 1498-1044 3.56 59.0 µM 1.60E-5 RPP1 & pyrimidine depletion 29 1.83E-4
18 SGTC_2325 6158266 3.45 200.0 µM 2.81E-5 43 2.84E-4
19 SGTC_2057 5236571 3.24 38.3 µM 7.30E-5 RPP1 & pyrimidine depletion 70 5.94E-4
20 SGTC_2881 9058953 3.22 52.0 µM 8.21E-5 51 6.50E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.359 1.78E-102 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.348 6.11E-96 YDR457W TOM1 hom E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.330 4.70E-86 YDR260C SWM1 hom Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
0.284 2.09E-63 YCR063W BUD31 hom Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis
0.279 9.36E-61 YNL140C_p YNL140C_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C
0.219 1.21E-37 YLR200W YKE2 hom Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
0.200 2.01E-31 YDR433W_d YDR433W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.192 3.18E-29 YDR069C DOA4 hom Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
0.172 8.79E-24 YNL098C RAS2 hom GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes
0.169 8.57E-23 YHR041C SRB2 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
0.165 7.18E-22 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.163 2.68E-21 YCR077C PAT1 hom Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress
0.152 8.77E-19 YKR024C DBP7 hom Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions
0.149 4.11E-18 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.145 2.56E-17 YLL045C RPL8B hom Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication