YOR007C / SGT2

Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR007C / SGT2

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:-2.98|P-value:6.25E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.43|P-value:1.02E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.39|P-value:1.18E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:2.94|P-value:7.28E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.27|P-value:1.94E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:-3.51|P-value:7.21E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.30|P-value:1.74E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:4.39|P-value:1.01E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:3.30|P-value:1.82E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.72|P-value:2.84E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:4.46|P-value:6.88E-7 ID:SGTC_743|Compound:1275-0778|FD-Score:3.27|P-value:2.02E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.19|P-value:2.72E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:-3.81|P-value:1.86E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:6.02|P-value:3.58E-11 ID:SGTC_926|Compound:2268-1401|FD-Score:3.87|P-value:1.39E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:3.05|P-value:4.88E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.04|P-value:4.89E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:5.89|P-value:9.06E-11 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.00|P-value:7.58E-6 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.61|P-value:3.06E-7 ID:SGTC_1521|Compound:st012942|FD-Score:-3.27|P-value:1.93E-4 ID:SGTC_1554|Compound:st069299|FD-Score:2.90|P-value:8.49E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.12|P-value:3.66E-4 ID:SGTC_1621|Compound:st003705|FD-Score:-3.26|P-value:2.04E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.17|P-value:2.98E-4 ID:SGTC_1943|Compound:st076331|FD-Score:-2.95|P-value:6.83E-4 ID:SGTC_2049|Compound:5262831|FD-Score:5.03|P-value:2.63E-8 ID:SGTC_2072|Compound:5231554|FD-Score:-3.49|P-value:7.70E-5 ID:SGTC_2178|Compound:5812956|FD-Score:-3.47|P-value:8.33E-5 ID:SGTC_2292|Compound:7671323|FD-Score:2.98|P-value:6.34E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.27|P-value:2.06E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.11|P-value:3.69E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.73|P-value:2.73E-5 ID:SGTC_2534|Compound:helenine|FD-Score:5.21|P-value:8.84E-9 ID:SGTC_2537|Compound:larixol|FD-Score:3.22|P-value:2.50E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.80|P-value:1.93E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:4.36|P-value:1.17E-6 ID:SGTC_2611|Compound:pyromycin|FD-Score:-2.90|P-value:8.33E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:4.02|P-value:6.81E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.47|P-value:8.64E-5 ID:SGTC_2722|Compound:naftopidil|FD-Score:2.99|P-value:5.99E-4 ID:SGTC_2831|Compound:7999036|FD-Score:4.30|P-value:1.65E-6 ID:SGTC_2833|Compound:9001315|FD-Score:-2.98|P-value:6.13E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.62|P-value:4.55E-5 ID:SGTC_2967|Compound:9089538|FD-Score:3.62|P-value:4.59E-5 ID:SGTC_2976|Compound:9009005|FD-Score:3.42|P-value:1.07E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-2.98|P-value:6.20E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:-2.98|P-value:6.25E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.43|P-value:1.02E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.39|P-value:1.18E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:2.94|P-value:7.28E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.27|P-value:1.94E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:-3.51|P-value:7.21E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.30|P-value:1.74E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:4.39|P-value:1.01E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:3.30|P-value:1.82E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.72|P-value:2.84E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:4.46|P-value:6.88E-7 ID:SGTC_743|Compound:1275-0778|FD-Score:3.27|P-value:2.02E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.19|P-value:2.72E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:-3.81|P-value:1.86E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:6.02|P-value:3.58E-11 ID:SGTC_926|Compound:2268-1401|FD-Score:3.87|P-value:1.39E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:3.05|P-value:4.88E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.04|P-value:4.89E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:5.89|P-value:9.06E-11 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.00|P-value:7.58E-6 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.61|P-value:3.06E-7 ID:SGTC_1521|Compound:st012942|FD-Score:-3.27|P-value:1.93E-4 ID:SGTC_1554|Compound:st069299|FD-Score:2.90|P-value:8.49E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.12|P-value:3.66E-4 ID:SGTC_1621|Compound:st003705|FD-Score:-3.26|P-value:2.04E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.17|P-value:2.98E-4 ID:SGTC_1943|Compound:st076331|FD-Score:-2.95|P-value:6.83E-4 ID:SGTC_2049|Compound:5262831|FD-Score:5.03|P-value:2.63E-8 ID:SGTC_2072|Compound:5231554|FD-Score:-3.49|P-value:7.70E-5 ID:SGTC_2178|Compound:5812956|FD-Score:-3.47|P-value:8.33E-5 ID:SGTC_2292|Compound:7671323|FD-Score:2.98|P-value:6.34E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.27|P-value:2.06E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.11|P-value:3.69E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.73|P-value:2.73E-5 ID:SGTC_2534|Compound:helenine|FD-Score:5.21|P-value:8.84E-9 ID:SGTC_2537|Compound:larixol|FD-Score:3.22|P-value:2.50E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.80|P-value:1.93E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:4.36|P-value:1.17E-6 ID:SGTC_2611|Compound:pyromycin|FD-Score:-2.90|P-value:8.33E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:4.02|P-value:6.81E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.47|P-value:8.64E-5 ID:SGTC_2722|Compound:naftopidil|FD-Score:2.99|P-value:5.99E-4 ID:SGTC_2831|Compound:7999036|FD-Score:4.30|P-value:1.65E-6 ID:SGTC_2833|Compound:9001315|FD-Score:-2.98|P-value:6.13E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.62|P-value:4.55E-5 ID:SGTC_2967|Compound:9089538|FD-Score:3.62|P-value:4.59E-5 ID:SGTC_2976|Compound:9009005|FD-Score:3.42|P-value:1.07E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-2.98|P-value:6.20E-4

Top fitness defect scores for YOR007C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_922 1866-0035 6.02 480.0 µM 3.58E-11 excess fatty acid 19 8.62E-10
2 SGTC_1129 3453-1384 5.89 223.0 µM 9.06E-11 12 1.91E-9
3 SGTC_2534 helenine 5.21 20.1 µM 8.84E-9 RSC complex & mRNA processing 8 9.66E-8
4 SGTC_2049 5262831 5.03 67.2 µM 2.63E-8 11 2.46E-7
5 SGTC_1255 0566-0045 4.61 221.0 µM 3.06E-7 excess fatty acid 17 2.02E-6
6 SGTC_660 4031-1742 4.46 102.0 µM 6.88E-7 redox potentiating 32 4.06E-6
7 SGTC_640 3381-0960 4.39 37.1 µM 1.01E-6 5 5.64E-6
8 SGTC_2605 digitonin 4.36 300.0 nM 1.17E-6 18 6.39E-6
9 SGTC_2831 7999036 4.30 19.5 µM 1.65E-6 33 8.59E-6
10 SGTC_2660 2',4'-dihydroxychalcone 4.02 17.1 µM 6.81E-6 16 2.91E-5
11 SGTC_1130 3454-2858 4.00 15.9 µM 7.58E-6 NEO1 89 3.19E-5
12 SGTC_926 2268-1401 3.87 59.4 µM 1.39E-5 TSC3-RPN4 32 5.36E-5
13 SGTC_2510 benzyl isothiocyanate 3.73 8.3 µM 2.73E-5 21 9.58E-5
14 SGTC_650 1328-0195 3.72 38.0 µM 2.84E-5 22 9.93E-5
15 SGTC_2836 9010338 3.62 19.5 µM 4.55E-5 RPP1 & pyrimidine depletion 41 1.49E-4
16 SGTC_2967 9089538 3.62 49.9 µM 4.59E-5 46 1.50E-4
17 SGTC_25 0118-0223 3.43 35.7 µM 1.02E-4 33 2.99E-4
18 SGTC_2976 9009005 3.42 19.5 µM 1.07E-4 45 3.11E-4
19 SGTC_649 1123-0311 3.30 367.0 µM 1.82E-4 endomembrane recycling 112 4.91E-4
20 SGTC_743 1275-0778 3.27 158.0 µM 2.02E-4 excess fatty acid 67 5.39E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.262 5.87E-54 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.165 6.65E-22 YLR324W PEX30 hom Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
0.150 2.73E-18 YGL184C STR3 hom Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p
0.131 2.65E-14 YBR086C IST2 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process
0.127 1.76E-13 YDL100C GET3 hom Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress
0.126 2.36E-13 YJL035C TAD2 het Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs
0.120 2.94E-12 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.117 1.07E-11 YGL132W_d YGL132W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C
0.109 2.20E-10 YLL001W DNM1 hom Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
0.108 3.20E-10 YOR062C_p YOR062C_p hom Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.103 2.43E-9 YHR110W ERP5 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.101 5.24E-9 YMR063W RIM9 hom Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;
0.101 5.43E-9 YNR008W LRO1 hom Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
0.100 7.63E-9 YDL180W_p YDL180W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.099 9.62E-9 YDR329C PEX3 hom Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p