YOR009W / TIR4

Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR009W / TIR4

Click on Significant Values for Screen Details ID:SGTC_136|Compound:0097-0015|FD-Score:3.81|P-value:9.83E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:4.84|P-value:1.17E-6 ID:SGTC_305|Compound:1682-2595|FD-Score:4.05|P-value:3.83E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:4.34|P-value:1.12E-5 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.18|P-value:9.12E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.41|P-value:4.18E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:-4.16|P-value:3.10E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:-3.39|P-value:5.62E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.26|P-value:7.11E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.39|P-value:9.20E-6 ID:SGTC_1063|Compound:disulfiram|FD-Score:-3.24|P-value:9.34E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.23|P-value:7.82E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.31|P-value:6.02E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.93|P-value:6.08E-5 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.27|P-value:6.88E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.46|P-value:3.52E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.75|P-value:1.23E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.63|P-value:1.92E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.88|P-value:7.33E-5 ID:SGTC_2148|Compound:5546263|FD-Score:3.90|P-value:6.91E-5 ID:SGTC_2314|Compound:7727897|FD-Score:-4.17|P-value:2.96E-5 ID:SGTC_2560|Compound:caryophyllene|FD-Score:4.40|P-value:8.56E-6 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.94|P-value:5.97E-5 ID:SGTC_2625|Compound:euphol|FD-Score:-3.27|P-value:8.60E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-5.51|P-value:5.59E-8 ID:SGTC_2717|Compound:st081029|FD-Score:3.28|P-value:6.53E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.53|P-value:2.81E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:-3.31|P-value:7.37E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-3.29|P-value:7.97E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.70|P-value:1.47E-4 ID:SGTC_3213|Compound:9129884|FD-Score:5.13|P-value:2.76E-7 ID:SGTC_3224|Compound:9130643|FD-Score:3.56|P-value:2.48E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.81|P-value:9.83E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:4.84|P-value:1.17E-6 ID:SGTC_305|Compound:1682-2595|FD-Score:4.05|P-value:3.83E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:4.34|P-value:1.12E-5 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.18|P-value:9.12E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.41|P-value:4.18E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:-4.16|P-value:3.10E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:-3.39|P-value:5.62E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.26|P-value:7.11E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.39|P-value:9.20E-6 ID:SGTC_1063|Compound:disulfiram|FD-Score:-3.24|P-value:9.34E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.23|P-value:7.82E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.31|P-value:6.02E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.93|P-value:6.08E-5 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.27|P-value:6.88E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.46|P-value:3.52E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.75|P-value:1.23E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.63|P-value:1.92E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.88|P-value:7.33E-5 ID:SGTC_2148|Compound:5546263|FD-Score:3.90|P-value:6.91E-5 ID:SGTC_2314|Compound:7727897|FD-Score:-4.17|P-value:2.96E-5 ID:SGTC_2560|Compound:caryophyllene|FD-Score:4.40|P-value:8.56E-6 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.94|P-value:5.97E-5 ID:SGTC_2625|Compound:euphol|FD-Score:-3.27|P-value:8.60E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-5.51|P-value:5.59E-8 ID:SGTC_2717|Compound:st081029|FD-Score:3.28|P-value:6.53E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.53|P-value:2.81E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:-3.31|P-value:7.37E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-3.29|P-value:7.97E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.70|P-value:1.47E-4 ID:SGTC_3213|Compound:9129884|FD-Score:5.13|P-value:2.76E-7 ID:SGTC_3224|Compound:9130643|FD-Score:3.56|P-value:2.48E-4

Top fitness defect scores for YOR009W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3213 9129884 5.13 49.5 µM 2.76E-7 5 1.42E-7
2 SGTC_146 3448-8650 4.84 53.1 µM 1.17E-6 NEO1-PIK1 91 6.54E-7
3 SGTC_2560 caryophyllene 4.40 100.0 µM 8.56E-6 9 5.34E-6
4 SGTC_1053 3366-3204 4.39 134.0 µM 9.20E-6 cell wall 25 5.76E-6
5 SGTC_346 4513-0042 4.34 7.2 µM 1.12E-5 azole & statin 32 7.08E-6
6 SGTC_305 1682-2595 4.05 20.8 µM 3.83E-5 RNA processing & uracil transport 21 2.59E-5
7 SGTC_2588 indole-3-carbinol 3.94 100.0 µM 5.97E-5 45 4.13E-5
8 SGTC_1083 didemethylchlorpromazine sulfoxide 3.93 707.4 nM 6.08E-5 redox potentiating 83 4.21E-5
9 SGTC_2148 5546263 3.90 113.6 µM 6.91E-5 20 4.82E-5
10 SGTC_2135 5326629 3.88 150.4 µM 7.33E-5 RPP1 & pyrimidine depletion 28 5.13E-5
11 SGTC_136 0097-0015 3.81 404.5 µM 9.83E-5 60S ribosome export 19 6.99E-5
12 SGTC_1930 st074634 3.75 34.3 µM 1.23E-4 RNA pol III & RNase P/MRP 43 8.85E-5
13 SGTC_3149 9097855 3.70 49.5 µM 1.47E-4 Golgi 33 1.07E-4
14 SGTC_1965 Pectolinarigenin 3.63 58.4 µM 1.92E-4 RPP1 & pyrimidine depletion 17 1.42E-4
15 SGTC_3224 9130643 3.56 49.5 µM 2.48E-4 RPP1 & pyrimidine depletion 40 1.85E-4
16 SGTC_2742 clothiapine 3.53 36.3 µM 2.81E-4 NEO1 21 2.11E-4
17 SGTC_1592 4',5'-dihydroxyflavone 3.46 8.8 µM 3.52E-4 60S ribosome export 27 2.67E-4
18 SGTC_682 0kpi-0099 3.41 17.0 µM 4.18E-4 93 3.20E-4
19 SGTC_1075 aripiprazole 3.31 15.2 µM 6.02E-4 62 4.70E-4
20 SGTC_2717 st081029 3.28 62.3 µM 6.53E-4 32 5.12E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.37E-16 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.118 6.62E-12 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.118 7.94E-12 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.116 1.85E-11 YPR126C_d YPR126C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.113 5.87E-11 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.090 2.07E-7 YNR026C SEC12 het Guanine nucleotide exchange factor (GEF), activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER
0.087 5.05E-7 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.085 7.18E-7 YHR167W THP2 hom Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance
0.085 8.31E-7 YPL239W YAR1 hom Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock
0.084 1.00E-6 YJL072C PSF2 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.077 7.95E-6 YJR093C FIP1 het Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p
0.076 9.81E-6 YMR234W RNH1 hom Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201)
0.074 1.62E-5 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.073 2.17E-5 YCR033W SNT1 hom Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance
0.071 4.05E-5 YLR171W_d YLR171W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data