YOR010C / TIR2

Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR010C / TIR2

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:3.45|P-value:7.13E-5 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.45|P-value:9.12E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.72|P-value:2.33E-10 ID:SGTC_917|Compound:harmaline|FD-Score:3.53|P-value:4.89E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.06|P-value:4.51E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.72|P-value:2.04E-5 ID:SGTC_1478|Compound:0453-0656|FD-Score:-4.15|P-value:3.16E-6 ID:SGTC_1485|Compound:3909-9022|FD-Score:-3.07|P-value:4.29E-4 ID:SGTC_1684|Compound:st024538|FD-Score:-4.64|P-value:2.25E-7 ID:SGTC_1704|Compound:st028805|FD-Score:3.64|P-value:3.06E-5 ID:SGTC_1736|Compound:st036774|FD-Score:3.72|P-value:2.05E-5 ID:SGTC_1905|Compound:st060207|FD-Score:-3.01|P-value:5.59E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.37|P-value:1.28E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-2.87|P-value:9.24E-4 ID:SGTC_2368|Compound:9071271|FD-Score:-3.23|P-value:2.30E-4 ID:SGTC_2446|Compound:5162541|FD-Score:-3.03|P-value:5.20E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:3.01|P-value:4.52E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.62|P-value:3.37E-5 ID:SGTC_2711|Compound:st079103|FD-Score:3.41|P-value:8.52E-5 ID:SGTC_2793|Compound:7325131|FD-Score:-2.93|P-value:7.50E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.45|P-value:6.97E-5 ID:SGTC_2918|Compound:7977171|FD-Score:2.80|P-value:9.90E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.45|P-value:7.13E-5 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.45|P-value:9.12E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.72|P-value:2.33E-10 ID:SGTC_917|Compound:harmaline|FD-Score:3.53|P-value:4.89E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.06|P-value:4.51E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.72|P-value:2.04E-5 ID:SGTC_1478|Compound:0453-0656|FD-Score:-4.15|P-value:3.16E-6 ID:SGTC_1485|Compound:3909-9022|FD-Score:-3.07|P-value:4.29E-4 ID:SGTC_1684|Compound:st024538|FD-Score:-4.64|P-value:2.25E-7 ID:SGTC_1704|Compound:st028805|FD-Score:3.64|P-value:3.06E-5 ID:SGTC_1736|Compound:st036774|FD-Score:3.72|P-value:2.05E-5 ID:SGTC_1905|Compound:st060207|FD-Score:-3.01|P-value:5.59E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.37|P-value:1.28E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-2.87|P-value:9.24E-4 ID:SGTC_2368|Compound:9071271|FD-Score:-3.23|P-value:2.30E-4 ID:SGTC_2446|Compound:5162541|FD-Score:-3.03|P-value:5.20E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:3.01|P-value:4.52E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.62|P-value:3.37E-5 ID:SGTC_2711|Compound:st079103|FD-Score:3.41|P-value:8.52E-5 ID:SGTC_2793|Compound:7325131|FD-Score:-2.93|P-value:7.50E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.45|P-value:6.97E-5 ID:SGTC_2918|Compound:7977171|FD-Score:2.80|P-value:9.90E-4

Top fitness defect scores for YOR010C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1138 3761-0006 3.72 1.0 µM 2.04E-5 8 9.84E-5
2 SGTC_1736 st036774 3.72 51.0 µM 2.05E-5 42 9.89E-5
3 SGTC_1704 st028805 3.64 70.8 µM 3.06E-5 16 1.38E-4
4 SGTC_2605 digitonin 3.62 300.0 nM 3.37E-5 43 1.50E-4
5 SGTC_917 harmaline 3.53 728.1 nM 4.89E-5 ergosterol biosynthesis 43 2.05E-4
6 SGTC_2794 7785382 3.45 27.3 µM 6.97E-5 53 2.75E-4
7 SGTC_39 0986-0283 3.45 58.4 µM 7.13E-5 calcium & mitochondrial duress 55 2.81E-4
8 SGTC_2711 st079103 3.41 59.1 µM 8.52E-5 16 3.26E-4
9 SGTC_2491 paeonol 3.01 100.0 µM 4.52E-4 23 0.00132
10 SGTC_2918 7977171 2.80 22.1 µM 9.90E-4 73 0.00255
11 SGTC_65 0798-0905 2.78 35.0 µM 0.00108 calcium & mitochondrial duress 185 0.00274
12 SGTC_1029 k015-0030 2.74 64.7 µM 0.00124 104 0.00308
13 SGTC_798 1287-0182 2.73 476.0 µM 0.00130 93 0.00321
14 SGTC_1498 4478-3555 2.69 97.6 µM 0.00147 36 0.00355
15 SGTC_3086 9117350 2.69 49.5 µM 0.00147 32 0.00356
16 SGTC_968 1309-0633 2.65 340.0 µM 0.00169 71 0.00400
17 SGTC_2360 9040895 2.62 200.0 µM 0.00188 RPP1 & pyrimidine depletion 97 0.00437
18 SGTC_739 1486-1183 2.59 203.0 µM 0.00207 84 0.00475
19 SGTC_2807 7945238 2.58 52.0 µM 0.00216 138 0.00493
20 SGTC_41 0478-0632 2.56 82.6 µM 0.00232 137 0.00523

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.243 3.87E-46 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.238 1.45E-44 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.233 1.21E-42 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.217 3.50E-37 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.213 1.30E-35 YLR023C IZH3 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.206 1.45E-33 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.206 1.76E-33 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.202 3.52E-32 YLL046C RNP1 hom Ribonucleoprotein that contains two RNA recognition motifs (RRM)
0.200 1.35E-31 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.195 3.08E-30 YKL001C MET14 hom Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
0.194 1.06E-29 YLR223C IFH1 het Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
0.189 2.34E-28 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.186 1.72E-27 YCR072C RSA4 het WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus
0.180 9.54E-26 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.177 4.84E-25 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function