HIPHOP chemogenomics database

YOR012W_p

Putative protein of unknown function

Zygosity: Homozygous strain

fixedexpanded
Profile for YOR012W / YOR012W

Click on Significant Values for Screen Details

Top fitness defect scores for YOR012W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2950	9072895	4.49	21.5 µM	5.84E-8		25	3.63E-6
2	SGTC_6	0844-0013	4.31	19.8 µM	1.79E-7		63	8.25E-6
3	SGTC_3192	9110362	3.38	49.5 µM	3.06E-5	mitochondrial processes	23	3.60E-4
4	SGTC_2303	7774051	3.37	200.0 µM	3.22E-5		42	3.74E-4
5	SGTC_1235	benzylparaben	3.37	21.5 µM	3.27E-5		24	3.78E-4
6	SGTC_3330	9141424	3.37	71.4 µM	3.28E-5	amide catabolism	34	3.79E-4
7	SGTC_2804	7954240	3.33	19.5 µM	3.90E-5		59	4.29E-4
8	SGTC_2990	9074105	3.28	71.4 µM	4.95E-5		22	5.12E-4
9	SGTC_2922	7999257	3.23	32.5 µM	6.56E-5		26	6.30E-4
10	SGTC_1630	st005209	3.17	31.3 µM	8.51E-5		62	7.63E-4
11	SGTC_774	k060-0086	3.07	136.0 µM	1.36E-4		52	0.00108
12	SGTC_2984	9022109	3.03	39.0 µM	1.60E-4		32	0.00122
13	SGTC_780	0109-0199	3.02	192.0 µM	1.69E-4		60	0.00126
14	SGTC_3298	9116858	2.83	71.4 µM	3.92E-4		54	0.00235
15	SGTC_2494	18-aminoabieta-8,11,13-triene sulfate	2.79	3.7 µM	4.55E-4		248	0.00263
16	SGTC_1068	loratadine	2.79	26.9 µM	4.61E-4		83	0.00265
17	SGTC_3161	9100388	2.76	49.5 µM	5.26E-4	iron homeostasis	47	0.00292
18	SGTC_3079	9117512	2.73	49.5 µM	5.89E-4		23	0.00318
19	SGTC_73	0327-0325	2.66	16.2 µM	7.72E-4	DNA damage response	160	0.00388
20	SGTC_2023	5144124	2.62	124.0 µM	8.99E-4		88	0.00434

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.243	2.68E-46	YBL036C	YBL036C	hom	Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.236	8.53E-44	YLR401C	DUS3	hom	Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.232	3.92E-42	YLR205C	HMX1	hom	ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.226	3.11E-40	YER064C	VHR2	hom	Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.220	7.23E-38	YKL164C	PIR1	hom	O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication
0.213	1.30E-35	YDR051C	DET1	hom	Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.207	1.25E-33	YER067C-A_d	YER067C-A_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.200	1.45E-31	YAL068C	PAU8	hom	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions
0.200	1.55E-31	YHR003C	YHR003C	hom	Protein of unknown function, localized to the mitochondrial outer membrane
0.195	6.32E-30	YDR110W	FOB1	hom	Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases
0.193	1.46E-29	YGR097W	ASK10	hom	Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.191	8.46E-29	YCL035C	GRX1	hom	Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.188	3.90E-28	YGR025W_d	YGR025W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.187	8.57E-28	YBR262C	AIM5	hom	Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.186	1.68E-27	YKR023W_p	YKR023W_p	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies