YOR012W_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR012W / YOR012W

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.31|P-value:1.79E-7 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.63|P-value:1.40E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:2.66|P-value:7.72E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.76|P-value:7.10E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:-2.96|P-value:3.32E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-4.30|P-value:3.19E-7 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.49|P-value:2.85E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.94|P-value:2.64E-6 ID:SGTC_774|Compound:k060-0086|FD-Score:3.07|P-value:1.36E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.02|P-value:1.69E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:-3.23|P-value:9.92E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:-2.69|P-value:9.79E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:2.79|P-value:4.61E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-2.74|P-value:8.15E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.70|P-value:3.51E-15 ID:SGTC_1220|Compound:1838-0075|FD-Score:-4.71|P-value:2.50E-8 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.37|P-value:3.27E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:-2.77|P-value:7.09E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.95|P-value:3.35E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-4.86|P-value:9.30E-9 ID:SGTC_1355|Compound:1499-0035|FD-Score:2.62|P-value:9.32E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.04|P-value:2.36E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.20|P-value:1.11E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-4.22|P-value:5.38E-7 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.14|P-value:1.46E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.17|P-value:8.51E-5 ID:SGTC_1721|Compound:st082152|FD-Score:-4.72|P-value:2.28E-8 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.29|P-value:7.29E-5 ID:SGTC_2023|Compound:5144124|FD-Score:2.62|P-value:8.99E-4 ID:SGTC_2078|Compound:5212016|FD-Score:2.61|P-value:9.34E-4 ID:SGTC_2296|Compound:7971656|FD-Score:-5.10|P-value:1.75E-9 ID:SGTC_2303|Compound:7774051|FD-Score:3.37|P-value:3.22E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:2.79|P-value:4.55E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.23|P-value:9.59E-5 ID:SGTC_2804|Compound:7954240|FD-Score:3.33|P-value:3.90E-5 ID:SGTC_2855|Compound:9016525|FD-Score:-3.19|P-value:1.17E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.06|P-value:2.09E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.23|P-value:6.56E-5 ID:SGTC_2950|Compound:9072895|FD-Score:4.49|P-value:5.84E-8 ID:SGTC_2981|Compound:9013952|FD-Score:-2.98|P-value:3.05E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.03|P-value:1.60E-4 ID:SGTC_2990|Compound:9074105|FD-Score:3.28|P-value:4.95E-5 ID:SGTC_2999|Compound:9069765|FD-Score:-3.33|P-value:6.23E-5 ID:SGTC_3079|Compound:9117512|FD-Score:2.73|P-value:5.89E-4 ID:SGTC_3161|Compound:9100388|FD-Score:2.76|P-value:5.26E-4 ID:SGTC_3192|Compound:9110362|FD-Score:3.38|P-value:3.06E-5 ID:SGTC_3236|Compound:9132701|FD-Score:-2.74|P-value:8.28E-4 ID:SGTC_3240|Compound:9133527|FD-Score:-3.45|P-value:3.35E-5 ID:SGTC_3269|Compound:9137823|FD-Score:-3.41|P-value:4.09E-5 ID:SGTC_3270|Compound:9137563|FD-Score:-4.10|P-value:1.07E-6 ID:SGTC_3272|Compound:9137413|FD-Score:-2.93|P-value:3.79E-4 ID:SGTC_3277|Compound:9138724|FD-Score:-3.79|P-value:6.12E-6 ID:SGTC_3278|Compound:9139605|FD-Score:-6.18|P-value:3.78E-13 ID:SGTC_3283|Compound:9109332|FD-Score:-3.45|P-value:3.35E-5 ID:SGTC_3284|Compound:9108171|FD-Score:-2.96|P-value:3.31E-4 ID:SGTC_3292|Compound:9120825|FD-Score:2.62|P-value:9.24E-4 ID:SGTC_3298|Compound:9116858|FD-Score:2.83|P-value:3.92E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.37|P-value:3.28E-5 ID:SGTC_3332|Compound:9141069|FD-Score:-3.00|P-value:2.73E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-2.82|P-value:6.00E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:4.31|P-value:1.79E-7 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.63|P-value:1.40E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:2.66|P-value:7.72E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.76|P-value:7.10E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:-2.96|P-value:3.32E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-4.30|P-value:3.19E-7 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.49|P-value:2.85E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.94|P-value:2.64E-6 ID:SGTC_774|Compound:k060-0086|FD-Score:3.07|P-value:1.36E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.02|P-value:1.69E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:-3.23|P-value:9.92E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:-2.69|P-value:9.79E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:2.79|P-value:4.61E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-2.74|P-value:8.15E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.70|P-value:3.51E-15 ID:SGTC_1220|Compound:1838-0075|FD-Score:-4.71|P-value:2.50E-8 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.37|P-value:3.27E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:-2.77|P-value:7.09E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.95|P-value:3.35E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-4.86|P-value:9.30E-9 ID:SGTC_1355|Compound:1499-0035|FD-Score:2.62|P-value:9.32E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.04|P-value:2.36E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.20|P-value:1.11E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-4.22|P-value:5.38E-7 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.14|P-value:1.46E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.17|P-value:8.51E-5 ID:SGTC_1721|Compound:st082152|FD-Score:-4.72|P-value:2.28E-8 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.29|P-value:7.29E-5 ID:SGTC_2023|Compound:5144124|FD-Score:2.62|P-value:8.99E-4 ID:SGTC_2078|Compound:5212016|FD-Score:2.61|P-value:9.34E-4 ID:SGTC_2296|Compound:7971656|FD-Score:-5.10|P-value:1.75E-9 ID:SGTC_2303|Compound:7774051|FD-Score:3.37|P-value:3.22E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:2.79|P-value:4.55E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.23|P-value:9.59E-5 ID:SGTC_2804|Compound:7954240|FD-Score:3.33|P-value:3.90E-5 ID:SGTC_2855|Compound:9016525|FD-Score:-3.19|P-value:1.17E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.06|P-value:2.09E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.23|P-value:6.56E-5 ID:SGTC_2950|Compound:9072895|FD-Score:4.49|P-value:5.84E-8 ID:SGTC_2981|Compound:9013952|FD-Score:-2.98|P-value:3.05E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.03|P-value:1.60E-4 ID:SGTC_2990|Compound:9074105|FD-Score:3.28|P-value:4.95E-5 ID:SGTC_2999|Compound:9069765|FD-Score:-3.33|P-value:6.23E-5 ID:SGTC_3079|Compound:9117512|FD-Score:2.73|P-value:5.89E-4 ID:SGTC_3161|Compound:9100388|FD-Score:2.76|P-value:5.26E-4 ID:SGTC_3192|Compound:9110362|FD-Score:3.38|P-value:3.06E-5 ID:SGTC_3236|Compound:9132701|FD-Score:-2.74|P-value:8.28E-4 ID:SGTC_3240|Compound:9133527|FD-Score:-3.45|P-value:3.35E-5 ID:SGTC_3269|Compound:9137823|FD-Score:-3.41|P-value:4.09E-5 ID:SGTC_3270|Compound:9137563|FD-Score:-4.10|P-value:1.07E-6 ID:SGTC_3272|Compound:9137413|FD-Score:-2.93|P-value:3.79E-4 ID:SGTC_3277|Compound:9138724|FD-Score:-3.79|P-value:6.12E-6 ID:SGTC_3278|Compound:9139605|FD-Score:-6.18|P-value:3.78E-13 ID:SGTC_3283|Compound:9109332|FD-Score:-3.45|P-value:3.35E-5 ID:SGTC_3284|Compound:9108171|FD-Score:-2.96|P-value:3.31E-4 ID:SGTC_3292|Compound:9120825|FD-Score:2.62|P-value:9.24E-4 ID:SGTC_3298|Compound:9116858|FD-Score:2.83|P-value:3.92E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.37|P-value:3.28E-5 ID:SGTC_3332|Compound:9141069|FD-Score:-3.00|P-value:2.73E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-2.82|P-value:6.00E-4

Top fitness defect scores for YOR012W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2950 9072895 4.49 21.5 µM 5.84E-8 25 3.63E-6
2 SGTC_6 0844-0013 4.31 19.8 µM 1.79E-7 63 8.25E-6
3 SGTC_3192 9110362 3.38 49.5 µM 3.06E-5 mitochondrial processes 23 3.60E-4
4 SGTC_2303 7774051 3.37 200.0 µM 3.22E-5 42 3.74E-4
5 SGTC_1235 benzylparaben 3.37 21.5 µM 3.27E-5 24 3.78E-4
6 SGTC_3330 9141424 3.37 71.4 µM 3.28E-5 amide catabolism 34 3.79E-4
7 SGTC_2804 7954240 3.33 19.5 µM 3.90E-5 59 4.29E-4
8 SGTC_2990 9074105 3.28 71.4 µM 4.95E-5 22 5.12E-4
9 SGTC_2922 7999257 3.23 32.5 µM 6.56E-5 26 6.30E-4
10 SGTC_1630 st005209 3.17 31.3 µM 8.51E-5 62 7.63E-4
11 SGTC_774 k060-0086 3.07 136.0 µM 1.36E-4 52 0.00108
12 SGTC_2984 9022109 3.03 39.0 µM 1.60E-4 32 0.00122
13 SGTC_780 0109-0199 3.02 192.0 µM 1.69E-4 60 0.00126
14 SGTC_3298 9116858 2.83 71.4 µM 3.92E-4 54 0.00235
15 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 2.79 3.7 µM 4.55E-4 248 0.00263
16 SGTC_1068 loratadine 2.79 26.9 µM 4.61E-4 83 0.00265
17 SGTC_3161 9100388 2.76 49.5 µM 5.26E-4 iron homeostasis 47 0.00292
18 SGTC_3079 9117512 2.73 49.5 µM 5.89E-4 23 0.00318
19 SGTC_73 0327-0325 2.66 16.2 µM 7.72E-4 DNA damage response 160 0.00388
20 SGTC_2023 5144124 2.62 124.0 µM 8.99E-4 88 0.00434

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.243 2.68E-46 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.236 8.53E-44 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.232 3.92E-42 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.226 3.11E-40 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.220 7.23E-38 YKL164C PIR1 hom O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication
0.213 1.30E-35 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.207 1.25E-33 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.200 1.45E-31 YAL068C PAU8 hom Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions
0.200 1.55E-31 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.195 6.32E-30 YDR110W FOB1 hom Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases
0.193 1.46E-29 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.191 8.46E-29 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.188 3.90E-28 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.187 8.57E-28 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.186 1.68E-27 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies