YOR016C / ERP4

Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR016C / ERP4

Click on Significant Values for Screen Details ID:SGTC_146|Compound:3448-8650|FD-Score:4.95|P-value:4.70E-8 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.10|P-value:3.71E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.34|P-value:1.40E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-2.89|P-value:8.37E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:-3.11|P-value:3.60E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.01|P-value:5.99E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.07|P-value:4.25E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.16|P-value:3.26E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.93|P-value:5.24E-8 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.96|P-value:7.06E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.25|P-value:2.08E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.05|P-value:5.00E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.09|P-value:4.38E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.03|P-value:5.57E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.44|P-value:1.07E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-3.03|P-value:4.98E-4 ID:SGTC_1655|Compound:st012546|FD-Score:-2.92|P-value:7.43E-4 ID:SGTC_1704|Compound:st028805|FD-Score:3.41|P-value:1.19E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.00|P-value:5.52E-4 ID:SGTC_1953|Compound:st076800|FD-Score:4.00|P-value:7.99E-6 ID:SGTC_2015|Compound:5119600|FD-Score:4.64|P-value:2.81E-7 ID:SGTC_2016|Compound:5121758|FD-Score:-4.11|P-value:3.94E-6 ID:SGTC_2073|Compound:5212005|FD-Score:3.01|P-value:5.86E-4 ID:SGTC_2078|Compound:5212016|FD-Score:3.28|P-value:2.05E-4 ID:SGTC_2092|Compound:5303694|FD-Score:-2.87|P-value:8.98E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.35|P-value:1.53E-4 ID:SGTC_2220|Compound:6782180|FD-Score:3.05|P-value:5.06E-4 ID:SGTC_2383|Compound:9036125|FD-Score:-2.88|P-value:8.74E-4 ID:SGTC_2386|Compound:9075165|FD-Score:-2.88|P-value:8.61E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.04|P-value:4.73E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.40|P-value:1.22E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.06|P-value:6.07E-6 ID:SGTC_2869|Compound:9037858|FD-Score:-2.99|P-value:5.75E-4 ID:SGTC_2998|Compound:9066762|FD-Score:2.98|P-value:6.63E-4 ID:SGTC_3040|Compound:9091894|FD-Score:2.98|P-value:6.66E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:4.95|P-value:4.70E-8 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.10|P-value:3.71E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.34|P-value:1.40E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-2.89|P-value:8.37E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:-3.11|P-value:3.60E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.01|P-value:5.99E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.07|P-value:4.25E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.16|P-value:3.26E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.93|P-value:5.24E-8 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.96|P-value:7.06E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.25|P-value:2.08E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.05|P-value:5.00E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.09|P-value:4.38E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.03|P-value:5.57E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.44|P-value:1.07E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-3.03|P-value:4.98E-4 ID:SGTC_1655|Compound:st012546|FD-Score:-2.92|P-value:7.43E-4 ID:SGTC_1704|Compound:st028805|FD-Score:3.41|P-value:1.19E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.00|P-value:5.52E-4 ID:SGTC_1953|Compound:st076800|FD-Score:4.00|P-value:7.99E-6 ID:SGTC_2015|Compound:5119600|FD-Score:4.64|P-value:2.81E-7 ID:SGTC_2016|Compound:5121758|FD-Score:-4.11|P-value:3.94E-6 ID:SGTC_2073|Compound:5212005|FD-Score:3.01|P-value:5.86E-4 ID:SGTC_2078|Compound:5212016|FD-Score:3.28|P-value:2.05E-4 ID:SGTC_2092|Compound:5303694|FD-Score:-2.87|P-value:8.98E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.35|P-value:1.53E-4 ID:SGTC_2220|Compound:6782180|FD-Score:3.05|P-value:5.06E-4 ID:SGTC_2383|Compound:9036125|FD-Score:-2.88|P-value:8.74E-4 ID:SGTC_2386|Compound:9075165|FD-Score:-2.88|P-value:8.61E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.04|P-value:4.73E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.40|P-value:1.22E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.06|P-value:6.07E-6 ID:SGTC_2869|Compound:9037858|FD-Score:-2.99|P-value:5.75E-4 ID:SGTC_2998|Compound:9066762|FD-Score:2.98|P-value:6.63E-4 ID:SGTC_3040|Compound:9091894|FD-Score:2.98|P-value:6.66E-4

Top fitness defect scores for YOR016C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_146 3448-8650 4.95 53.1 µM 4.70E-8 NEO1-PIK1 87 3.78E-7
2 SGTC_1226 3909-7979 4.93 35.4 µM 5.24E-8 24 4.15E-7
3 SGTC_2015 5119600 4.64 184.0 µM 2.81E-7 20 1.76E-6
4 SGTC_2794 7785382 4.06 27.3 µM 6.07E-6 33 2.49E-5
5 SGTC_1953 st076800 4.00 12.1 µM 7.99E-6 47 3.15E-5
6 SGTC_1606 st000094 3.44 49.2 µM 1.07E-4 60S ribosome export 32 2.95E-4
7 SGTC_1704 st028805 3.41 70.8 µM 1.19E-4 22 3.24E-4
8 SGTC_2601 securinine 3.40 100.0 µM 1.22E-4 47 3.33E-4
9 SGTC_2102 5377816 3.35 72.8 µM 1.53E-4 39 4.03E-4
10 SGTC_2078 5212016 3.28 200.0 µM 2.05E-4 60S ribosome export 31 5.21E-4
11 SGTC_1216 1165-0504 3.16 9.7 µM 3.26E-4 40 7.78E-4
12 SGTC_1359 1582-0056 3.09 520.0 nM 4.38E-4 54 0.00100
13 SGTC_1280 0880-0253 3.05 10.1 µM 5.00E-4 51 0.00113
14 SGTC_2220 6782180 3.05 200.0 µM 5.06E-4 RNA processing & uracil transport 22 0.00114
15 SGTC_1519 esterone 3.03 74.0 µM 5.57E-4 DNA intercalators 62 0.00124
16 SGTC_2073 5212005 3.01 126.0 µM 5.86E-4 25 0.00129
17 SGTC_773 4358-1457 3.01 44.6 µM 5.99E-4 88 0.00132
18 SGTC_2998 9066762 2.98 71.4 µM 6.63E-4 RPP1 & pyrimidine depletion 76 0.00144
19 SGTC_3040 9091894 2.98 49.5 µM 6.66E-4 DNA intercalators 47 0.00144
20 SGTC_1230 0170-0365 2.96 3.8 µM 7.06E-4 endomembrane recycling 143 0.00152

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.211 3.27E-35 YDL080C THI3 hom Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis
0.204 9.49E-33 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.151 1.38E-18 YDR501W PLM2 hom Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication
0.122 1.59E-12 YOR010C TIR2 hom Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
0.118 5.71E-12 YCR095C_p OCA4_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.115 2.19E-11 YKL082C RRP14 het Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family
0.114 3.57E-11 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.112 8.22E-11 YNL032W SIW14 hom Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm
0.108 2.93E-10 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.106 8.60E-10 YBR068C BAP2 hom High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.105 9.33E-10 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.104 1.63E-9 YOR004W UTP23 het Component of the small subunit processome, involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein
0.099 8.10E-9 YHL020C OPI1 hom Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance
0.098 1.21E-8 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.098 1.31E-8 YNL209W SSB2 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication