YOR020W-A_p

Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR020W-A / YOR020W-A

Click on Significant Values for Screen Details ID:SGTC_141|Compound:0443-0274|FD-Score:-3.64|P-value:2.44E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:3.06|P-value:4.01E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:3.06|P-value:4.11E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-2.87|P-value:6.50E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.07|P-value:2.81E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:2.91|P-value:7.28E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.21|P-value:2.24E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:-3.17|P-value:1.98E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:2.91|P-value:7.24E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.31|P-value:1.47E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.77|P-value:9.66E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.60|P-value:3.95E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:3.51|P-value:5.91E-5 ID:SGTC_818|Compound:4072-2707|FD-Score:-4.40|P-value:4.80E-7 ID:SGTC_822|Compound:1487-0950|FD-Score:3.09|P-value:3.62E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.54|P-value:3.92E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:2.88|P-value:8.17E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.05|P-value:4.30E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.21|P-value:1.65E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:2.98|P-value:5.59E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.81|P-value:1.43E-5 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.30|P-value:1.49E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:2.96|P-value:5.90E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.11|P-value:3.35E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:-2.79|P-value:8.86E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-2.90|P-value:5.89E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-2.82|P-value:8.06E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-2.78|P-value:9.39E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-2.94|P-value:5.04E-4 ID:SGTC_1752|Compound:st044819|FD-Score:-2.84|P-value:7.48E-4 ID:SGTC_1761|Compound:st044296|FD-Score:-3.05|P-value:3.27E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.89|P-value:6.04E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.61|P-value:2.85E-5 ID:SGTC_1989|Compound:st071868|FD-Score:2.98|P-value:5.66E-4 ID:SGTC_1995|Compound:st072814|FD-Score:-3.25|P-value:1.43E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-3.25|P-value:1.39E-4 ID:SGTC_2309|Compound:7664088|FD-Score:2.86|P-value:8.70E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.06|P-value:3.08E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.60|P-value:4.00E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.01|P-value:4.88E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.70|P-value:2.53E-5 ID:SGTC_2693|Compound:st077581|FD-Score:3.47|P-value:7.03E-5 ID:SGTC_2695|Compound:st077686|FD-Score:-4.55|P-value:1.94E-7 ID:SGTC_2798|Compound:7813637|FD-Score:3.29|P-value:1.58E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.64|P-value:2.44E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:3.06|P-value:4.01E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:3.06|P-value:4.11E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-2.87|P-value:6.50E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.07|P-value:2.81E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:2.91|P-value:7.28E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.21|P-value:2.24E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:-3.17|P-value:1.98E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:2.91|P-value:7.24E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.31|P-value:1.47E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.77|P-value:9.66E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.60|P-value:3.95E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:3.51|P-value:5.91E-5 ID:SGTC_818|Compound:4072-2707|FD-Score:-4.40|P-value:4.80E-7 ID:SGTC_822|Compound:1487-0950|FD-Score:3.09|P-value:3.62E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.54|P-value:3.92E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:2.88|P-value:8.17E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.05|P-value:4.30E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.21|P-value:1.65E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:2.98|P-value:5.59E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.81|P-value:1.43E-5 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.30|P-value:1.49E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:2.96|P-value:5.90E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.11|P-value:3.35E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:-2.79|P-value:8.86E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-2.90|P-value:5.89E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-2.82|P-value:8.06E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-2.78|P-value:9.39E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-2.94|P-value:5.04E-4 ID:SGTC_1752|Compound:st044819|FD-Score:-2.84|P-value:7.48E-4 ID:SGTC_1761|Compound:st044296|FD-Score:-3.05|P-value:3.27E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.89|P-value:6.04E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.61|P-value:2.85E-5 ID:SGTC_1989|Compound:st071868|FD-Score:2.98|P-value:5.66E-4 ID:SGTC_1995|Compound:st072814|FD-Score:-3.25|P-value:1.43E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-3.25|P-value:1.39E-4 ID:SGTC_2309|Compound:7664088|FD-Score:2.86|P-value:8.70E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.06|P-value:3.08E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.60|P-value:4.00E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.01|P-value:4.88E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.70|P-value:2.53E-5 ID:SGTC_2693|Compound:st077581|FD-Score:3.47|P-value:7.03E-5 ID:SGTC_2695|Compound:st077686|FD-Score:-4.55|P-value:1.94E-7 ID:SGTC_2798|Compound:7813637|FD-Score:3.29|P-value:1.58E-4

Top fitness defect scores for YOR020W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1298 1079-1278 3.81 263.0 µM 1.43E-5 DNA damage response 19 6.82E-5
2 SGTC_2692 st077426 3.70 47.7 µM 2.53E-5 27 1.09E-4
3 SGTC_759 3486-0358 3.60 89.3 µM 3.95E-5 28 1.58E-4
4 SGTC_2536 dehydroabietamide 3.60 32.0 µM 4.00E-5 49 1.60E-4
5 SGTC_763 3453-1109 3.51 128.0 µM 5.91E-5 33 2.22E-4
6 SGTC_2693 st077581 3.47 40.7 µM 7.03E-5 57 2.56E-4
7 SGTC_537 1334-0398 3.31 209.0 µM 1.47E-4 51 4.75E-4
8 SGTC_1382 3002-2117 3.30 298.0 µM 1.49E-4 27 4.81E-4
9 SGTC_2798 7813637 3.29 45.5 µM 1.58E-4 58 5.04E-4
10 SGTC_399 oxolinic acid 3.21 75.0 µM 2.24E-4 23 6.72E-4
11 SGTC_1434 4073-0095 3.11 163.0 µM 3.35E-4 39 9.43E-4
12 SGTC_822 1487-0950 3.09 154.0 µM 3.62E-4 46 0.00101
13 SGTC_169 k015-0017 3.06 16.0 µM 4.01E-4 47 0.00110
14 SGTC_174 3553-0389 3.06 74.3 µM 4.11E-4 52 0.00112
15 SGTC_1061 3448-9325 3.05 110.0 µM 4.30E-4 52 0.00116
16 SGTC_2567 aureobasidin a 3.01 60.0 nM 4.88E-4 158 0.00129
17 SGTC_1144 3486-0183 2.98 12.5 µM 5.59E-4 67 0.00145
18 SGTC_1989 st071868 2.98 50.2 µM 5.66E-4 43 0.00146
19 SGTC_1405 3909-7894 2.96 12.0 µM 5.90E-4 60S ribosome export 47 0.00151
20 SGTC_507 nimesulide 2.91 162.0 µM 7.24E-4 60 0.00180

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.210 1.22E-34 YDR088C SLU7 het RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
0.194 9.30E-30 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.190 1.03E-28 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.172 9.61E-24 YGR207C CIR1 hom Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response
0.163 2.04E-21 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.151 1.46E-18 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.145 2.49E-17 YAL034W-A MTW1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
0.142 1.56E-16 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.141 1.75E-16 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.131 2.38E-14 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.126 2.70E-13 YML081C-A ATP18 hom Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
0.123 8.78E-13 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.123 1.03E-12 YJR092W BUD4 hom Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p
0.122 1.59E-12 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.120 2.82E-12 YDR139C RUB1 hom Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)