YOR023C / AHC1

Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR023C / AHC1

Click on Significant Values for Screen Details ID:SGTC_148|Compound:3253-0744|FD-Score:-3.22|P-value:4.25E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.96|P-value:1.54E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:5.05|P-value:5.54E-8 ID:SGTC_165|Compound:k038-0023|FD-Score:12.00|P-value:1.38E-36 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.58|P-value:9.63E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.67|P-value:6.78E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.16|P-value:5.21E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:-3.70|P-value:6.19E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:3.56|P-value:8.72E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:4.42|P-value:1.65E-6 ID:SGTC_886|Compound:0866-0150|FD-Score:3.51|P-value:1.10E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:5.20|P-value:2.35E-8 ID:SGTC_971|Compound:1315-0384|FD-Score:-3.16|P-value:5.18E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-4.42|P-value:2.21E-6 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.26|P-value:3.58E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:-3.55|P-value:1.16E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:4.32|P-value:2.83E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:-3.65|P-value:7.58E-5 ID:SGTC_1152|Compound:3909-8331|FD-Score:-3.08|P-value:7.13E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.57|P-value:8.41E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:4.17|P-value:5.75E-6 ID:SGTC_1380|Compound:2291-0730|FD-Score:-4.00|P-value:1.65E-5 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:-3.48|P-value:1.54E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.12|P-value:5.96E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.09|P-value:5.72E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.43|P-value:1.84E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.04|P-value:6.78E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.32|P-value:2.80E-4 ID:SGTC_1624|Compound:st003710|FD-Score:3.30|P-value:2.51E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.88|P-value:2.18E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.56|P-value:1.10E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.08|P-value:5.87E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.49|P-value:1.17E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.32|P-value:2.32E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-3.15|P-value:5.46E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.34|P-value:2.54E-6 ID:SGTC_2174|Compound:5790901|FD-Score:3.66|P-value:5.94E-5 ID:SGTC_2307|Compound:7538926|FD-Score:-3.75|P-value:4.90E-5 ID:SGTC_2334|Compound:9017922|FD-Score:3.15|P-value:4.52E-4 ID:SGTC_2360|Compound:9040895|FD-Score:-4.51|P-value:1.40E-6 ID:SGTC_2369|Compound:9071472|FD-Score:3.62|P-value:6.87E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.05|P-value:7.76E-4 ID:SGTC_2472|Compound:5377652|FD-Score:-3.08|P-value:7.11E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.14|P-value:4.72E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.22|P-value:3.46E-4 ID:SGTC_2670|Compound:beta-carotene|FD-Score:3.29|P-value:2.65E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-2.99|P-value:9.76E-4 ID:SGTC_3016|Compound:9080866|FD-Score:-3.07|P-value:7.38E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.18|P-value:5.42E-6 ID:SGTC_3122|Compound:9126309|FD-Score:-3.34|P-value:2.63E-4 ID:SGTC_3126|Compound:9127922|FD-Score:2.96|P-value:9.07E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.72|P-value:4.56E-5 ID:SGTC_3264|Compound:9137442|FD-Score:3.09|P-value:5.68E-4 ID:SGTC_3265|Compound:9137266|FD-Score:4.22|P-value:4.58E-6 ID:SGTC_3283|Compound:9109332|FD-Score:-3.60|P-value:9.34E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.22|P-value:4.25E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.96|P-value:1.54E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:5.05|P-value:5.54E-8 ID:SGTC_165|Compound:k038-0023|FD-Score:12.00|P-value:1.38E-36 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.58|P-value:9.63E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.67|P-value:6.78E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.16|P-value:5.21E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:-3.70|P-value:6.19E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:3.56|P-value:8.72E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:4.42|P-value:1.65E-6 ID:SGTC_886|Compound:0866-0150|FD-Score:3.51|P-value:1.10E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:5.20|P-value:2.35E-8 ID:SGTC_971|Compound:1315-0384|FD-Score:-3.16|P-value:5.18E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-4.42|P-value:2.21E-6 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.26|P-value:3.58E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:-3.55|P-value:1.16E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:4.32|P-value:2.83E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:-3.65|P-value:7.58E-5 ID:SGTC_1152|Compound:3909-8331|FD-Score:-3.08|P-value:7.13E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.57|P-value:8.41E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:4.17|P-value:5.75E-6 ID:SGTC_1380|Compound:2291-0730|FD-Score:-4.00|P-value:1.65E-5 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:-3.48|P-value:1.54E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.12|P-value:5.96E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.09|P-value:5.72E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.43|P-value:1.84E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.04|P-value:6.78E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.32|P-value:2.80E-4 ID:SGTC_1624|Compound:st003710|FD-Score:3.30|P-value:2.51E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.88|P-value:2.18E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.56|P-value:1.10E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.08|P-value:5.87E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.49|P-value:1.17E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.32|P-value:2.32E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-3.15|P-value:5.46E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.34|P-value:2.54E-6 ID:SGTC_2174|Compound:5790901|FD-Score:3.66|P-value:5.94E-5 ID:SGTC_2307|Compound:7538926|FD-Score:-3.75|P-value:4.90E-5 ID:SGTC_2334|Compound:9017922|FD-Score:3.15|P-value:4.52E-4 ID:SGTC_2360|Compound:9040895|FD-Score:-4.51|P-value:1.40E-6 ID:SGTC_2369|Compound:9071472|FD-Score:3.62|P-value:6.87E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.05|P-value:7.76E-4 ID:SGTC_2472|Compound:5377652|FD-Score:-3.08|P-value:7.11E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.14|P-value:4.72E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.22|P-value:3.46E-4 ID:SGTC_2670|Compound:beta-carotene|FD-Score:3.29|P-value:2.65E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-2.99|P-value:9.76E-4 ID:SGTC_3016|Compound:9080866|FD-Score:-3.07|P-value:7.38E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.18|P-value:5.42E-6 ID:SGTC_3122|Compound:9126309|FD-Score:-3.34|P-value:2.63E-4 ID:SGTC_3126|Compound:9127922|FD-Score:2.96|P-value:9.07E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.72|P-value:4.56E-5 ID:SGTC_3264|Compound:9137442|FD-Score:3.09|P-value:5.68E-4 ID:SGTC_3265|Compound:9137266|FD-Score:4.22|P-value:4.58E-6 ID:SGTC_3283|Compound:9109332|FD-Score:-3.60|P-value:9.34E-5

Top fitness defect scores for YOR023C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_165 k038-0023 12.00 64.4 µM 1.38E-36 ubiquinone biosynthesis & proteasome 4 1.69E-33
2 SGTC_904 1141-0088 5.20 396.0 µM 2.35E-8 5 1.00E-7
3 SGTC_159 3970-0959 5.05 50.0 µM 5.54E-8 40 2.20E-7
4 SGTC_813 k007-0158 4.42 173.0 µM 1.65E-6 fatty acid desaturase (OLE1) 31 4.87E-6
5 SGTC_2128 5255449 4.34 168.5 µM 2.54E-6 25 7.22E-6
6 SGTC_1068 loratadine 4.32 26.9 µM 2.83E-6 15 7.96E-6
7 SGTC_3265 9137266 4.22 49.5 µM 4.58E-6 5 1.24E-5
8 SGTC_3037 9091026 4.18 49.5 µM 5.42E-6 NEO1-PIK1 112 1.44E-5
9 SGTC_1261 0712-0010 4.17 12.7 µM 5.75E-6 RNA processing & uracil transport 18 1.52E-5
10 SGTC_158 k038-0087 3.96 26.4 µM 1.54E-5 ubiquinone biosynthesis & proteasome 137 3.75E-5
11 SGTC_1712 st032288 3.88 53.4 µM 2.18E-5 calcium & mitochondrial duress 190 5.15E-5
12 SGTC_3263 9137018 3.72 49.5 µM 4.56E-5 23 1.01E-4
13 SGTC_2174 5790901 3.66 200.0 µM 5.94E-5 tubulin folding & SWR complex 42 1.28E-4
14 SGTC_2369 9071472 3.62 200.0 µM 6.87E-5 24 1.47E-4
15 SGTC_1161 k007-0610 3.57 110.0 µM 8.41E-5 ERAD & cell cycle 140 1.76E-4
16 SGTC_697 0508-1955 3.56 564.0 µM 8.72E-5 51 1.82E-4
17 SGTC_886 0866-0150 3.51 153.0 µM 1.10E-4 34 2.25E-4
18 SGTC_2021 4019055 3.49 173.0 µM 1.17E-4 endomembrane recycling 157 2.39E-4
19 SGTC_2061 5245884 3.32 81.0 µM 2.32E-4 tubulin folding & SWR complex 45 4.47E-4
20 SGTC_1624 st003710 3.30 6.2 µM 2.51E-4 calcium & mitochondrial duress 66 4.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.174 2.89E-24 YGL073W HSF1 het Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated
0.165 5.72E-22 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.155 1.41E-19 YLR028C ADE16 hom Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine
0.150 1.82E-18 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.141 2.67E-16 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.135 4.09E-15 YML041C VPS71 hom Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.133 1.08E-14 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.128 1.02E-13 YFL051C_p YFL051C_p hom Putative protein of unknown function; YFL051C is not an essential gene
0.125 4.08E-13 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.122 1.13E-12 YGR289C MAL11 hom Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization
0.120 2.90E-12 YLR316C TAD3 het Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs
0.119 3.99E-12 YOR316C COT1 hom Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication
0.117 9.77E-12 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.117 1.28E-11 YLR130C ZRT2 hom Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor
0.116 1.87E-11 YJL169W_d YJL169W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2