YOR029W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR029W / YOR029W

Click on Significant Values for Screen Details ID:SGTC_76|Compound:0433-0009|FD-Score:-3.00|P-value:6.36E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.20|P-value:1.69E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.15|P-value:3.51E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:4.73|P-value:7.05E-8 ID:SGTC_833|Compound:3852-0053|FD-Score:3.71|P-value:1.72E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:-3.61|P-value:5.03E-5 ID:SGTC_999|Compound:4022-0066|FD-Score:-3.17|P-value:3.35E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-3.42|P-value:1.15E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.25|P-value:1.36E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:2.97|P-value:4.27E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.67|P-value:2.06E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:-3.31|P-value:1.86E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.57|P-value:3.33E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:-3.77|P-value:2.42E-5 ID:SGTC_1632|Compound:st005650|FD-Score:-3.52|P-value:7.36E-5 ID:SGTC_1699|Compound:st031318|FD-Score:-2.88|P-value:9.93E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.16|P-value:1.94E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.40|P-value:6.93E-5 ID:SGTC_1784|Compound:st039334|FD-Score:4.81|P-value:4.25E-8 ID:SGTC_2237|Compound:6667747|FD-Score:3.27|P-value:1.25E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.15|P-value:2.03E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.71|P-value:1.69E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.72|P-value:1.60E-5 ID:SGTC_2431|Compound:5490079|FD-Score:-3.06|P-value:5.05E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:2.90|P-value:5.51E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.56|P-value:3.14E-10 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.26|P-value:1.30E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.13|P-value:2.24E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:2.77|P-value:9.30E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.71|P-value:1.67E-5 ID:SGTC_2972|Compound:9093619|FD-Score:-4.74|P-value:1.47E-7 ID:SGTC_2973|Compound:9094665|FD-Score:3.10|P-value:2.57E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.10|P-value:2.57E-4 ID:SGTC_3006|Compound:9075424|FD-Score:-3.14|P-value:3.70E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:-3.00|P-value:6.36E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.20|P-value:1.69E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.15|P-value:3.51E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:4.73|P-value:7.05E-8 ID:SGTC_833|Compound:3852-0053|FD-Score:3.71|P-value:1.72E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:-3.61|P-value:5.03E-5 ID:SGTC_999|Compound:4022-0066|FD-Score:-3.17|P-value:3.35E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-3.42|P-value:1.15E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.25|P-value:1.36E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:2.97|P-value:4.27E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.67|P-value:2.06E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:-3.31|P-value:1.86E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.57|P-value:3.33E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:-3.77|P-value:2.42E-5 ID:SGTC_1632|Compound:st005650|FD-Score:-3.52|P-value:7.36E-5 ID:SGTC_1699|Compound:st031318|FD-Score:-2.88|P-value:9.93E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.16|P-value:1.94E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.40|P-value:6.93E-5 ID:SGTC_1784|Compound:st039334|FD-Score:4.81|P-value:4.25E-8 ID:SGTC_2237|Compound:6667747|FD-Score:3.27|P-value:1.25E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.15|P-value:2.03E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.71|P-value:1.69E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.72|P-value:1.60E-5 ID:SGTC_2431|Compound:5490079|FD-Score:-3.06|P-value:5.05E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:2.90|P-value:5.51E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.56|P-value:3.14E-10 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.26|P-value:1.30E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.13|P-value:2.24E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:2.77|P-value:9.30E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.71|P-value:1.67E-5 ID:SGTC_2972|Compound:9093619|FD-Score:-4.74|P-value:1.47E-7 ID:SGTC_2973|Compound:9094665|FD-Score:3.10|P-value:2.57E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.10|P-value:2.57E-4 ID:SGTC_3006|Compound:9075424|FD-Score:-3.14|P-value:3.70E-4

Top fitness defect scores for YOR029W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2567 aureobasidin a 5.56 60.0 nM 3.14E-10 48 1.31E-8
2 SGTC_1784 st039334 4.81 36.3 µM 4.25E-8 8 7.49E-7
3 SGTC_628 1636-0253 4.73 16.0 µM 7.05E-8 sphingolipid biosynthesis & PDR1 20 1.14E-6
4 SGTC_2407 paclitaxel 3.72 400.0 µM 1.60E-5 45 9.94E-5
5 SGTC_2933 9026794 3.71 32.5 µM 1.67E-5 26 1.03E-4
6 SGTC_2382 9035899 3.71 200.0 µM 1.69E-5 60S ribosome export 21 1.04E-4
7 SGTC_833 3852-0053 3.71 558.0 µM 1.72E-5 18 1.05E-4
8 SGTC_1335 1486-0900 3.67 202.0 µM 2.06E-5 33 1.22E-4
9 SGTC_1377 2944-0135 3.57 198.0 µM 3.33E-5 calcium & mitochondrial duress 49 1.82E-4
10 SGTC_1783 st039459 3.40 87.5 µM 6.93E-5 Golgi 36 3.32E-4
11 SGTC_2237 6667747 3.27 47.2 µM 1.25E-4 30 5.40E-4
12 SGTC_2572 astragaloside iv 3.26 100.0 µM 1.30E-4 58 5.57E-4
13 SGTC_1216 1165-0504 3.25 9.7 µM 1.36E-4 37 5.80E-4
14 SGTC_178 4092-0806 3.20 87.5 µM 1.69E-4 ergosterol depletion effects on membrane 140 6.92E-4
15 SGTC_1736 st036774 3.16 51.0 µM 1.94E-4 65 7.76E-4
16 SGTC_2246 7293507 3.15 91.6 µM 2.03E-4 68 8.07E-4
17 SGTC_2574 2',4'-dihydroxychalcone 3.13 14.6 µM 2.24E-4 51 8.75E-4
18 SGTC_2986 9022445 3.10 71.4 µM 2.57E-4 43 9.78E-4
19 SGTC_2973 9094665 3.10 18.0 µM 2.57E-4 NEO1 72 9.79E-4
20 SGTC_1332 1480-0653 2.97 17.5 µM 4.27E-4 TSC3-RPN4 54 0.00149

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.260 5.67E-53 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.175 2.07E-24 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.133 9.43E-15 YDR340W_d YDR340W_d hom Putative protein of unknown function
0.129 5.57E-14 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.124 4.97E-13 YBR024W SCO2 hom Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication
0.121 2.21E-12 YHR164C DNA2 het Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress
0.114 4.14E-11 YMR028W TAP42 het Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits
0.113 5.34E-11 YBR110W ALG1 het Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog
0.109 2.25E-10 YDR501W PLM2 hom Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication
0.107 5.94E-10 YIR028W DAL4 hom Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
0.103 2.21E-9 YER139C RTR1 hom CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication
0.102 3.17E-9 YBR056W YBR056W hom Putative glycoside hydrolase of the mitochondrial intermembrane space
0.102 3.45E-9 YMR211W DML1 het Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
0.101 4.26E-9 YGL169W SUA5 het Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family
0.099 7.87E-9 YER157W COG3 het Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments