HIPHOP chemogenomics database

YOR037W / CYC2

Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)

Zygosity: Homozygous strain

fixedexpanded
Profile for YOR037W / CYC2

Click on Significant Values for Screen Details

Top fitness defect scores for YOR037W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_996	3970-0799	12.00	1.8 µM	3.70E-44		10	2.83E-33
2	SGTC_669	0108-0021	7.70	26.2 µM	1.78E-19	fatty acid desaturase (OLE1)	13	6.85E-15
3	SGTC_1635	st007035	5.25	42.4 µM	4.91E-10		158	7.58E-8
4	SGTC_998	3996-0085	4.02	177.0 µM	1.40E-6		17	2.92E-5
5	SGTC_1256	0570-0116	3.91	285.0 µM	2.51E-6		21	4.53E-5
6	SGTC_790	1575-0012	3.73	79.1 µM	6.68E-6	TSC3-RPN4	35	9.45E-5
7	SGTC_2076	5212012	3.73	200.0 µM	6.73E-6		7	9.51E-5
8	SGTC_1916	st067606	3.70	49.2 µM	7.93E-6		49	1.08E-4
9	SGTC_968	1309-0633	3.66	340.0 µM	9.65E-6		19	1.25E-4
10	SGTC_3313	9133968	3.47	57.0 µM	2.56E-5		12	2.59E-4
11	SGTC_355	1311-2252	3.41	105.0 µM	3.47E-5		41	3.26E-4
12	SGTC_953	1188-0045	3.24	9.7 µM	7.67E-5	60S ribosome export	56	5.92E-4
13	SGTC_2831	7999036	3.18	19.5 µM	1.04E-4		89	7.45E-4
14	SGTC_1346	1488-2224	2.98	62.4 µM	2.45E-4		53	0.00142
15	SGTC_1257	0669-0121	2.93	16.0 µM	3.10E-4		82	0.00170
16	SGTC_1630	st005209	2.93	31.3 µM	3.11E-4		86	0.00170
17	SGTC_2795	7780010	2.90	54.5 µM	3.54E-4		83	0.00188
18	SGTC_1913	st060213	2.89	96.1 µM	3.70E-4		107	0.00194
19	SGTC_2162	5663267	2.84	200.0 µM	4.54E-4		53	0.00226
20	SGTC_1110	3-hydroxy-3'-methoxyflavone	2.81	1.2 µM	5.07E-4	iron homeostasis	117	0.00246

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.541	2.46E-254	YML118W	NGL3	hom	3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.431	1.59E-151	YDR505C	PSP1	hom	Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.403	2.04E-131	YGL222C	EDC1	hom	RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.398	1.55E-127	YDL099W	BUG1	hom	Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.397	6.57E-127	YGL205W	POX1	hom	Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.363	5.63E-105	YGL096W	TOS8	hom	Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.344	7.42E-94	YGL040C	HEM2	het	Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.337	8.71E-90	YBR084W	MIS1	hom	Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
0.326	5.68E-84	YDL177C_p	YDL177C_p	hom	Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
0.314	7.99E-78	YGR025W_d	YGR025W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.306	1.85E-73	YBR083W	TEC1	hom	Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.298	1.36E-69	YML084W_d	YML084W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.292	8.72E-67	YGL083W	SCY1	hom	Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.281	6.41E-62	YBR207W	FTH1	hom	Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.280	2.30E-61	YBR067C	TIP1	hom	Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins