YOR037W / CYC2

Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR037W / CYC2

Click on Significant Values for Screen Details ID:SGTC_26|Compound:0302-0163|FD-Score:2.80|P-value:5.37E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.25|P-value:9.39E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:2.70|P-value:8.07E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.41|P-value:3.47E-5 ID:SGTC_433|Compound:pimozide|FD-Score:-2.70|P-value:9.54E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:2.67|P-value:8.98E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:-2.81|P-value:6.12E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:2.72|P-value:7.28E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:7.70|P-value:1.78E-19 ID:SGTC_789|Compound:1309-1135|FD-Score:-2.79|P-value:6.89E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:3.73|P-value:6.68E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:2.68|P-value:8.70E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.24|P-value:7.67E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:-4.09|P-value:1.21E-6 ID:SGTC_968|Compound:1309-0633|FD-Score:3.66|P-value:9.65E-6 ID:SGTC_996|Compound:3970-0799|FD-Score:12.00|P-value:3.70E-44 ID:SGTC_998|Compound:3996-0085|FD-Score:4.02|P-value:1.40E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.32|P-value:4.36E-10 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:2.81|P-value:5.07E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.91|P-value:2.51E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:2.93|P-value:3.10E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:2.98|P-value:2.45E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.13|P-value:1.61E-4 ID:SGTC_1630|Compound:st005209|FD-Score:2.93|P-value:3.11E-4 ID:SGTC_1634|Compound:st006576|FD-Score:2.71|P-value:7.77E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.25|P-value:4.91E-10 ID:SGTC_1913|Compound:st060213|FD-Score:2.89|P-value:3.70E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.70|P-value:7.93E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.68|P-value:1.13E-5 ID:SGTC_2061|Compound:5245884|FD-Score:2.73|P-value:7.09E-4 ID:SGTC_2076|Compound:5212012|FD-Score:3.73|P-value:6.73E-6 ID:SGTC_2146|Compound:5545642|FD-Score:-2.99|P-value:2.93E-4 ID:SGTC_2162|Compound:5663267|FD-Score:2.84|P-value:4.54E-4 ID:SGTC_2164|Compound:5685496|FD-Score:-2.75|P-value:7.90E-4 ID:SGTC_2276|Compound:7947513|FD-Score:-3.34|P-value:6.13E-5 ID:SGTC_2795|Compound:7780010|FD-Score:2.90|P-value:3.54E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.18|P-value:1.04E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-2.81|P-value:6.30E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-2.88|P-value:4.65E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-2.98|P-value:3.13E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.47|P-value:2.56E-5 ID:SGTC_26|Compound:0302-0163|FD-Score:2.80|P-value:5.37E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.25|P-value:9.39E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:2.70|P-value:8.07E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.41|P-value:3.47E-5 ID:SGTC_433|Compound:pimozide|FD-Score:-2.70|P-value:9.54E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:2.67|P-value:8.98E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:-2.81|P-value:6.12E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:2.72|P-value:7.28E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:7.70|P-value:1.78E-19 ID:SGTC_789|Compound:1309-1135|FD-Score:-2.79|P-value:6.89E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:3.73|P-value:6.68E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:2.68|P-value:8.70E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.24|P-value:7.67E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:-4.09|P-value:1.21E-6 ID:SGTC_968|Compound:1309-0633|FD-Score:3.66|P-value:9.65E-6 ID:SGTC_996|Compound:3970-0799|FD-Score:12.00|P-value:3.70E-44 ID:SGTC_998|Compound:3996-0085|FD-Score:4.02|P-value:1.40E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.32|P-value:4.36E-10 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:2.81|P-value:5.07E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.91|P-value:2.51E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:2.93|P-value:3.10E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:2.98|P-value:2.45E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.13|P-value:1.61E-4 ID:SGTC_1630|Compound:st005209|FD-Score:2.93|P-value:3.11E-4 ID:SGTC_1634|Compound:st006576|FD-Score:2.71|P-value:7.77E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.25|P-value:4.91E-10 ID:SGTC_1913|Compound:st060213|FD-Score:2.89|P-value:3.70E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.70|P-value:7.93E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.68|P-value:1.13E-5 ID:SGTC_2061|Compound:5245884|FD-Score:2.73|P-value:7.09E-4 ID:SGTC_2076|Compound:5212012|FD-Score:3.73|P-value:6.73E-6 ID:SGTC_2146|Compound:5545642|FD-Score:-2.99|P-value:2.93E-4 ID:SGTC_2162|Compound:5663267|FD-Score:2.84|P-value:4.54E-4 ID:SGTC_2164|Compound:5685496|FD-Score:-2.75|P-value:7.90E-4 ID:SGTC_2276|Compound:7947513|FD-Score:-3.34|P-value:6.13E-5 ID:SGTC_2795|Compound:7780010|FD-Score:2.90|P-value:3.54E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.18|P-value:1.04E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-2.81|P-value:6.30E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-2.88|P-value:4.65E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-2.98|P-value:3.13E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.47|P-value:2.56E-5

Top fitness defect scores for YOR037W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_996 3970-0799 12.00 1.8 µM 3.70E-44 10 2.83E-33
2 SGTC_669 0108-0021 7.70 26.2 µM 1.78E-19 fatty acid desaturase (OLE1) 13 6.85E-15
3 SGTC_1635 st007035 5.25 42.4 µM 4.91E-10 158 7.58E-8
4 SGTC_998 3996-0085 4.02 177.0 µM 1.40E-6 17 2.92E-5
5 SGTC_1256 0570-0116 3.91 285.0 µM 2.51E-6 21 4.53E-5
6 SGTC_790 1575-0012 3.73 79.1 µM 6.68E-6 TSC3-RPN4 35 9.45E-5
7 SGTC_2076 5212012 3.73 200.0 µM 6.73E-6 7 9.51E-5
8 SGTC_1916 st067606 3.70 49.2 µM 7.93E-6 49 1.08E-4
9 SGTC_968 1309-0633 3.66 340.0 µM 9.65E-6 19 1.25E-4
10 SGTC_3313 9133968 3.47 57.0 µM 2.56E-5 12 2.59E-4
11 SGTC_355 1311-2252 3.41 105.0 µM 3.47E-5 41 3.26E-4
12 SGTC_953 1188-0045 3.24 9.7 µM 7.67E-5 60S ribosome export 56 5.92E-4
13 SGTC_2831 7999036 3.18 19.5 µM 1.04E-4 89 7.45E-4
14 SGTC_1346 1488-2224 2.98 62.4 µM 2.45E-4 53 0.00142
15 SGTC_1257 0669-0121 2.93 16.0 µM 3.10E-4 82 0.00170
16 SGTC_1630 st005209 2.93 31.3 µM 3.11E-4 86 0.00170
17 SGTC_2795 7780010 2.90 54.5 µM 3.54E-4 83 0.00188
18 SGTC_1913 st060213 2.89 96.1 µM 3.70E-4 107 0.00194
19 SGTC_2162 5663267 2.84 200.0 µM 4.54E-4 53 0.00226
20 SGTC_1110 3-hydroxy-3'-methoxyflavone 2.81 1.2 µM 5.07E-4 iron homeostasis 117 0.00246

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.541 2.46E-254 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.431 1.59E-151 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.403 2.04E-131 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.398 1.55E-127 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.397 6.57E-127 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.363 5.63E-105 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.344 7.42E-94 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.337 8.71E-90 YBR084W MIS1 hom Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
0.326 5.68E-84 YDL177C_p YDL177C_p hom Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
0.314 7.99E-78 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.306 1.85E-73 YBR083W TEC1 hom Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.298 1.36E-69 YML084W_d YML084W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.292 8.72E-67 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.281 6.41E-62 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.280 2.30E-61 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins