YOR038C / HIR2

Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR038C / HIR2

Click on Significant Values for Screen Details ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.10|P-value:6.55E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.85|P-value:3.33E-5 ID:SGTC_444|Compound:curcumin|FD-Score:3.72|P-value:5.79E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:2.99|P-value:9.74E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.52|P-value:1.33E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.78|P-value:4.35E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:3.87|P-value:3.06E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:-3.36|P-value:2.52E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.49|P-value:1.49E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.17|P-value:5.08E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:4.18|P-value:7.41E-6 ID:SGTC_918|Compound:glabranin|FD-Score:5.90|P-value:4.76E-10 ID:SGTC_991|Compound:3996-0057|FD-Score:-3.64|P-value:7.89E-5 ID:SGTC_1208|Compound:2323-2347|FD-Score:4.07|P-value:1.24E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:-4.23|P-value:5.88E-6 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.25|P-value:3.79E-4 ID:SGTC_1757|Compound:st041620|FD-Score:-4.06|P-value:1.26E-5 ID:SGTC_1791|Compound:st048313|FD-Score:4.43|P-value:2.21E-6 ID:SGTC_1825|Compound:st052143|FD-Score:3.00|P-value:9.47E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.27|P-value:3.47E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-6.06|P-value:1.70E-10 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.31|P-value:3.98E-6 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.05|P-value:7.92E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.53|P-value:1.27E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.26|P-value:3.63E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.27|P-value:3.48E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.52|P-value:1.34E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.29|P-value:3.19E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.58|P-value:1.02E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.25|P-value:3.70E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.54|P-value:1.23E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-4.45|P-value:1.98E-6 ID:SGTC_2878|Compound:9043973|FD-Score:-3.36|P-value:2.45E-4 ID:SGTC_2884|Compound:9058502|FD-Score:4.27|P-value:4.87E-6 ID:SGTC_2890|Compound:9046729|FD-Score:5.48|P-value:6.85E-9 ID:SGTC_2896|Compound:9052656|FD-Score:4.61|P-value:8.60E-7 ID:SGTC_2981|Compound:9013952|FD-Score:3.49|P-value:1.50E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.25|P-value:3.75E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.46|P-value:1.64E-4 ID:SGTC_3032|Compound:9089427|FD-Score:3.29|P-value:3.28E-4 ID:SGTC_3058|Compound:9093861|FD-Score:-3.72|P-value:5.71E-5 ID:SGTC_3185|Compound:9108267|FD-Score:3.33|P-value:2.81E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.80|P-value:4.03E-5 ID:SGTC_3209|Compound:9113616|FD-Score:-3.44|P-value:1.78E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.28|P-value:3.34E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.23|P-value:3.99E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.10|P-value:6.55E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.85|P-value:3.33E-5 ID:SGTC_444|Compound:curcumin|FD-Score:3.72|P-value:5.79E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:2.99|P-value:9.74E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.52|P-value:1.33E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.78|P-value:4.35E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:3.87|P-value:3.06E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:-3.36|P-value:2.52E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.49|P-value:1.49E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.17|P-value:5.08E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:4.18|P-value:7.41E-6 ID:SGTC_918|Compound:glabranin|FD-Score:5.90|P-value:4.76E-10 ID:SGTC_991|Compound:3996-0057|FD-Score:-3.64|P-value:7.89E-5 ID:SGTC_1208|Compound:2323-2347|FD-Score:4.07|P-value:1.24E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:-4.23|P-value:5.88E-6 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.25|P-value:3.79E-4 ID:SGTC_1757|Compound:st041620|FD-Score:-4.06|P-value:1.26E-5 ID:SGTC_1791|Compound:st048313|FD-Score:4.43|P-value:2.21E-6 ID:SGTC_1825|Compound:st052143|FD-Score:3.00|P-value:9.47E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.27|P-value:3.47E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-6.06|P-value:1.70E-10 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.31|P-value:3.98E-6 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.05|P-value:7.92E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.53|P-value:1.27E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.26|P-value:3.63E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.27|P-value:3.48E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.52|P-value:1.34E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.29|P-value:3.19E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.58|P-value:1.02E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.25|P-value:3.70E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.54|P-value:1.23E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-4.45|P-value:1.98E-6 ID:SGTC_2878|Compound:9043973|FD-Score:-3.36|P-value:2.45E-4 ID:SGTC_2884|Compound:9058502|FD-Score:4.27|P-value:4.87E-6 ID:SGTC_2890|Compound:9046729|FD-Score:5.48|P-value:6.85E-9 ID:SGTC_2896|Compound:9052656|FD-Score:4.61|P-value:8.60E-7 ID:SGTC_2981|Compound:9013952|FD-Score:3.49|P-value:1.50E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.25|P-value:3.75E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.46|P-value:1.64E-4 ID:SGTC_3032|Compound:9089427|FD-Score:3.29|P-value:3.28E-4 ID:SGTC_3058|Compound:9093861|FD-Score:-3.72|P-value:5.71E-5 ID:SGTC_3185|Compound:9108267|FD-Score:3.33|P-value:2.81E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.80|P-value:4.03E-5 ID:SGTC_3209|Compound:9113616|FD-Score:-3.44|P-value:1.78E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.28|P-value:3.34E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.23|P-value:3.99E-4

Top fitness defect scores for YOR038C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_918 glabranin 5.90 770.7 nM 4.76E-10 5 1.81E-9
2 SGTC_2890 9046729 5.48 58.4 µM 6.85E-9 Golgi 9 2.18E-8
3 SGTC_2896 9052656 4.61 71.4 µM 8.60E-7 endomembrane recycling 77 1.97E-6
4 SGTC_1791 st048313 4.43 56.1 µM 2.21E-6 7 4.76E-6
5 SGTC_2884 9058502 4.27 52.0 µM 4.87E-6 21 9.94E-6
6 SGTC_914 3820-6779 4.18 408.0 µM 7.41E-6 19 1.47E-5
7 SGTC_1208 2323-2347 4.07 50.3 µM 1.24E-5 5 2.39E-5
8 SGTC_609 0986-0026 3.87 86.3 µM 3.06E-5 calcium & mitochondrial duress 34 5.53E-5
9 SGTC_475 α-linolenic acid 3.78 10.0 µM 4.35E-5 excess fatty acid 22 7.69E-5
10 SGTC_444 curcumin 3.72 90.4 µM 5.79E-5 iron homeostasis 34 1.00E-4
11 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 3.58 70.0 µM 1.02E-4 redox potentiating 89 1.71E-4
12 SGTC_2779 methotrexate 3.54 400.0 µM 1.23E-4 37 2.02E-4
13 SGTC_2472 5377652 3.53 49.4 µM 1.27E-4 TRP & mitochondrial translation 78 2.09E-4
14 SGTC_2575 plumbagin 3.52 510.0 nM 1.34E-4 superoxide 60 2.19E-4
15 SGTC_635 k038-0028 3.49 24.7 µM 1.49E-4 ubiquinone biosynthesis & proteasome 60 2.43E-4
16 SGTC_2981 9013952 3.49 39.0 µM 1.50E-4 60 2.44E-4
17 SGTC_2999 9069765 3.46 71.4 µM 1.64E-4 amide catabolism 49 2.65E-4
18 SGTC_3185 9108267 3.33 49.5 µM 2.81E-4 60S ribosome export 44 4.40E-4
19 SGTC_3032 9089427 3.29 49.5 µM 3.28E-4 60S ribosome export 28 5.07E-4
20 SGTC_3222 9128301 3.28 49.5 µM 3.34E-4 60S ribosome export 47 5.16E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 1.89E-12 YOR304W ISW2 hom ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth
0.112 7.86E-11 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.110 1.94E-10 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.098 1.56E-8 YAL030W SNC1 hom Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication
0.096 2.17E-8 YOR074C CDC21 het Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
0.092 9.19E-8 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.089 2.43E-7 YLR209C PNP1 hom Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway
0.086 6.28E-7 YMR135W-A_d YMR135W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.086 6.89E-7 YER152C YER152C hom Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene
0.085 8.96E-7 YGR071C ENV11 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.084 1.25E-6 YOR077W RTS2 het Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication
0.082 1.90E-6 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.080 3.45E-6 YDR267C CIA1 het Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein
0.079 4.39E-6 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.079 4.57E-6 YKR027W BCH2 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BCH2 has a paralog, CHS6, that arose from the whole genome duplication