YOR047C / STD1

Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR047C / STD1

Click on Significant Values for Screen Details ID:SGTC_27|Compound:0485-0001|FD-Score:3.16|P-value:6.76E-4 ID:SGTC_202|Compound:3594-0513|FD-Score:-3.59|P-value:1.01E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.34|P-value:3.56E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.66|P-value:7.63E-5 ID:SGTC_389|Compound:tpck|FD-Score:4.32|P-value:5.78E-6 ID:SGTC_397|Compound:arbidol|FD-Score:3.13|P-value:7.53E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.17|P-value:6.68E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.36|P-value:3.23E-4 ID:SGTC_448|Compound:monastrol|FD-Score:-3.72|P-value:5.98E-5 ID:SGTC_455|Compound:paf C-16|FD-Score:-3.33|P-value:2.84E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:14.90|P-value:1.65E-52 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:3.18|P-value:6.31E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:4.36|P-value:4.75E-6 ID:SGTC_664|Compound:1222-0054|FD-Score:3.14|P-value:7.33E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:4.63|P-value:1.23E-6 ID:SGTC_993|Compound:3909-8757|FD-Score:3.16|P-value:6.86E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.58|P-value:1.43E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.91|P-value:3.54E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.07|P-value:9.29E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:6.40|P-value:3.40E-11 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.26|P-value:4.69E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.22|P-value:5.43E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:-3.24|P-value:3.91E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:4.25|P-value:7.85E-6 ID:SGTC_1554|Compound:st069299|FD-Score:3.13|P-value:7.60E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-4.68|P-value:6.71E-7 ID:SGTC_1773|Compound:st048542|FD-Score:3.28|P-value:4.48E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.27|P-value:4.56E-4 ID:SGTC_2134|Compound:5324836|FD-Score:-4.06|P-value:1.33E-5 ID:SGTC_2276|Compound:7947513|FD-Score:-3.33|P-value:2.85E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-3.42|P-value:2.00E-4 ID:SGTC_2434|Compound:5670830|FD-Score:-4.79|P-value:3.74E-7 ID:SGTC_2451|Compound:5856223|FD-Score:-3.17|P-value:5.14E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.44|P-value:2.43E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.29|P-value:4.25E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.15|P-value:5.42E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.61|P-value:1.24E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.46|P-value:2.23E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-4.12|P-value:1.03E-5 ID:SGTC_2822|Compound:7994718|FD-Score:-4.69|P-value:6.31E-7 ID:SGTC_2826|Compound:7992541|FD-Score:-5.08|P-value:8.05E-8 ID:SGTC_2862|Compound:9027634|FD-Score:3.35|P-value:3.36E-4 ID:SGTC_2863|Compound:9028737|FD-Score:4.43|P-value:3.42E-6 ID:SGTC_2864|Compound:9034755|FD-Score:-5.08|P-value:7.94E-8 ID:SGTC_2876|Compound:9059903|FD-Score:3.23|P-value:5.39E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-3.01|P-value:8.90E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-4.41|P-value:2.62E-6 ID:SGTC_2965|Compound:9082772|FD-Score:3.17|P-value:6.53E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.28|P-value:3.32E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.60|P-value:1.31E-4 ID:SGTC_3188|Compound:9110789|FD-Score:4.57|P-value:1.69E-6 ID:SGTC_27|Compound:0485-0001|FD-Score:3.16|P-value:6.76E-4 ID:SGTC_202|Compound:3594-0513|FD-Score:-3.59|P-value:1.01E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.34|P-value:3.56E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.66|P-value:7.63E-5 ID:SGTC_389|Compound:tpck|FD-Score:4.32|P-value:5.78E-6 ID:SGTC_397|Compound:arbidol|FD-Score:3.13|P-value:7.53E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.17|P-value:6.68E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.36|P-value:3.23E-4 ID:SGTC_448|Compound:monastrol|FD-Score:-3.72|P-value:5.98E-5 ID:SGTC_455|Compound:paf C-16|FD-Score:-3.33|P-value:2.84E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:14.90|P-value:1.65E-52 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:3.18|P-value:6.31E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:4.36|P-value:4.75E-6 ID:SGTC_664|Compound:1222-0054|FD-Score:3.14|P-value:7.33E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:4.63|P-value:1.23E-6 ID:SGTC_993|Compound:3909-8757|FD-Score:3.16|P-value:6.86E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.58|P-value:1.43E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.91|P-value:3.54E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.07|P-value:9.29E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:6.40|P-value:3.40E-11 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.26|P-value:4.69E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.22|P-value:5.43E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:-3.24|P-value:3.91E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:4.25|P-value:7.85E-6 ID:SGTC_1554|Compound:st069299|FD-Score:3.13|P-value:7.60E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-4.68|P-value:6.71E-7 ID:SGTC_1773|Compound:st048542|FD-Score:3.28|P-value:4.48E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.27|P-value:4.56E-4 ID:SGTC_2134|Compound:5324836|FD-Score:-4.06|P-value:1.33E-5 ID:SGTC_2276|Compound:7947513|FD-Score:-3.33|P-value:2.85E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-3.42|P-value:2.00E-4 ID:SGTC_2434|Compound:5670830|FD-Score:-4.79|P-value:3.74E-7 ID:SGTC_2451|Compound:5856223|FD-Score:-3.17|P-value:5.14E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.44|P-value:2.43E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.29|P-value:4.25E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.15|P-value:5.42E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.61|P-value:1.24E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.46|P-value:2.23E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-4.12|P-value:1.03E-5 ID:SGTC_2822|Compound:7994718|FD-Score:-4.69|P-value:6.31E-7 ID:SGTC_2826|Compound:7992541|FD-Score:-5.08|P-value:8.05E-8 ID:SGTC_2862|Compound:9027634|FD-Score:3.35|P-value:3.36E-4 ID:SGTC_2863|Compound:9028737|FD-Score:4.43|P-value:3.42E-6 ID:SGTC_2864|Compound:9034755|FD-Score:-5.08|P-value:7.94E-8 ID:SGTC_2876|Compound:9059903|FD-Score:3.23|P-value:5.39E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-3.01|P-value:8.90E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-4.41|P-value:2.62E-6 ID:SGTC_2965|Compound:9082772|FD-Score:3.17|P-value:6.53E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.28|P-value:3.32E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.60|P-value:1.31E-4 ID:SGTC_3188|Compound:9110789|FD-Score:4.57|P-value:1.69E-6

Top fitness defect scores for YOR047C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_457 grayanotoxin iii 14.90 135.0 µM 1.65E-52 1 2.48E-50
2 SGTC_1233 0325-0408 6.40 14.2 µM 3.40E-11 3 7.61E-11
3 SGTC_899 1083-0020 4.63 478.0 µM 1.23E-6 13 1.80E-6
4 SGTC_3188 9110789 4.57 49.5 µM 1.69E-6 iron homeostasis 11 2.43E-6
5 SGTC_2863 9028737 4.43 58.4 µM 3.42E-6 2 4.81E-6
6 SGTC_495 decylubiquinone 4.36 155.0 µM 4.75E-6 copper-dependent oxidative stress 16 6.58E-6
7 SGTC_389 tpck 4.32 16.7 µM 5.78E-6 23 7.95E-6
8 SGTC_1409 3909-8004 4.25 61.9 µM 7.85E-6 8 1.07E-5
9 SGTC_1182 1222-0449 3.91 220.0 µM 3.54E-5 18 4.54E-5
10 SGTC_2698 st077697 3.61 67.5 µM 1.24E-4 23 1.52E-4
11 SGTC_2985 9022375 3.60 71.4 µM 1.31E-4 RPP1 & pyrimidine depletion 44 1.60E-4
12 SGTC_1069 diphenylcyclopropenone 3.58 8.5 µM 1.43E-4 42 1.75E-4
13 SGTC_2760 etidronate 3.46 98.0 µM 2.23E-4 44 2.68E-4
14 SGTC_2521 angolensin 3.44 13.4 µM 2.43E-4 19 2.90E-4
15 SGTC_432 NS 1619 3.36 61.3 µM 3.23E-4 48 3.83E-4
16 SGTC_2862 9027634 3.35 71.4 µM 3.36E-4 ERG2 51 3.97E-4
17 SGTC_266 formosanin C 3.34 406.0 nM 3.56E-4 sphingolipid biosynthesis & PDR1 89 4.20E-4
18 SGTC_2584 androsterone 3.29 48.7 µM 4.25E-4 cell wall 176 4.98E-4
19 SGTC_1773 st048542 3.28 73.6 µM 4.48E-4 76 5.24E-4
20 SGTC_1891 st059073 3.27 26.2 µM 4.56E-4 TSC3-RPN4 42 5.33E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.274 1.19E-58 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.246 2.23E-47 YJL134W LCB3 hom Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication
0.179 1.19E-25 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.163 2.04E-21 YDR042C_p YDR042C_p hom Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
0.158 3.37E-20 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.143 6.77E-17 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.136 2.59E-15 YOR171C LCB4 hom Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes
0.133 9.66E-15 YML114C TAF8 het TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.131 2.51E-14 YDR420W HKR1 hom Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection
0.124 5.94E-13 YDR262W_p YDR262W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment
0.122 1.23E-12 YDL050C_d YDL050C_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.120 2.84E-12 YML028W TSA1 hom Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.117 1.09E-11 YDR278C_d YDR278C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.116 1.81E-11 YOR170W_d YOR170W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4
0.116 1.93E-11 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together