YOR053W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR053W / YOR053W

Click on Significant Values for Screen Details ID:SGTC_34|Compound:0469-0683|FD-Score:3.05|P-value:5.89E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.12|P-value:5.34E-6 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.61|P-value:5.72E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:4.04|P-value:8.38E-6 ID:SGTC_269|Compound:exalamide|FD-Score:3.00|P-value:6.92E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.69|P-value:4.24E-5 ID:SGTC_433|Compound:pimozide|FD-Score:5.88|P-value:1.83E-10 ID:SGTC_621|Compound:3584-0052|FD-Score:2.92|P-value:9.42E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:-3.35|P-value:1.71E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:5.17|P-value:1.79E-8 ID:SGTC_670|Compound:4204-0025|FD-Score:3.90|P-value:1.60E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:5.49|P-value:2.47E-9 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.48|P-value:9.17E-7 ID:SGTC_1268|Compound:0828-0275|FD-Score:-3.39|P-value:1.42E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.45|P-value:1.18E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.24|P-value:2.76E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.72|P-value:3.77E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.18|P-value:3.51E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:4.00|P-value:1.01E-5 ID:SGTC_1571|Compound:st070080|FD-Score:4.01|P-value:9.69E-6 ID:SGTC_1591|Compound:genipin|FD-Score:3.84|P-value:2.13E-5 ID:SGTC_1724|Compound:st037281|FD-Score:3.19|P-value:3.47E-4 ID:SGTC_1885|Compound:st057546|FD-Score:4.11|P-value:5.91E-6 ID:SGTC_2002|Compound:4023503|FD-Score:4.26|P-value:2.91E-6 ID:SGTC_2009|Compound:4012297|FD-Score:3.38|P-value:1.61E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.55|P-value:7.72E-5 ID:SGTC_2053|Compound:5265679|FD-Score:3.31|P-value:2.10E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.25|P-value:2.72E-4 ID:SGTC_2282|Compound:7944268|FD-Score:2.92|P-value:9.48E-4 ID:SGTC_2300|Compound:7976697|FD-Score:3.64|P-value:5.25E-5 ID:SGTC_2394|Compound:5221648|FD-Score:3.53|P-value:8.45E-5 ID:SGTC_2395|Compound:5646831|FD-Score:3.09|P-value:5.10E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.75|P-value:3.00E-5 ID:SGTC_2413|Compound:inermin|FD-Score:-2.94|P-value:8.29E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-4.39|P-value:1.35E-6 ID:SGTC_2415|Compound:st077333|FD-Score:4.40|P-value:1.42E-6 ID:SGTC_2593|Compound:nobiletin|FD-Score:5.71|P-value:5.78E-10 ID:SGTC_2610|Compound:ononetin|FD-Score:-4.16|P-value:4.38E-6 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.60|P-value:5.89E-5 ID:SGTC_2700|Compound:st077718|FD-Score:4.44|P-value:1.11E-6 ID:SGTC_2704|Compound:st078022|FD-Score:-3.19|P-value:3.20E-4 ID:SGTC_2708|Compound:st078559|FD-Score:3.68|P-value:4.35E-5 ID:SGTC_2837|Compound:9008476|FD-Score:3.45|P-value:1.18E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.12|P-value:4.46E-4 ID:SGTC_2851|Compound:9015922|FD-Score:5.80|P-value:3.18E-10 ID:SGTC_2855|Compound:9016525|FD-Score:3.03|P-value:6.40E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-5.00|P-value:4.69E-8 ID:SGTC_2928|Compound:9011484|FD-Score:4.68|P-value:3.05E-7 ID:SGTC_2970|Compound:9090938|FD-Score:3.02|P-value:6.62E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.67|P-value:4.70E-5 ID:SGTC_3017|Compound:9080681|FD-Score:3.11|P-value:4.72E-4 ID:SGTC_3090|Compound:9117696|FD-Score:-3.12|P-value:4.31E-4 ID:SGTC_3100|Compound:9120536|FD-Score:3.28|P-value:2.43E-4 ID:SGTC_3113|Compound:9123498|FD-Score:3.05|P-value:5.84E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.00|P-value:7.01E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.98|P-value:1.13E-5 ID:SGTC_3181|Compound:9108277|FD-Score:3.23|P-value:2.96E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.06|P-value:5.68E-4 ID:SGTC_3213|Compound:9129884|FD-Score:3.11|P-value:4.73E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:3.05|P-value:5.89E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.12|P-value:5.34E-6 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.61|P-value:5.72E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:4.04|P-value:8.38E-6 ID:SGTC_269|Compound:exalamide|FD-Score:3.00|P-value:6.92E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.69|P-value:4.24E-5 ID:SGTC_433|Compound:pimozide|FD-Score:5.88|P-value:1.83E-10 ID:SGTC_621|Compound:3584-0052|FD-Score:2.92|P-value:9.42E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:-3.35|P-value:1.71E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:5.17|P-value:1.79E-8 ID:SGTC_670|Compound:4204-0025|FD-Score:3.90|P-value:1.60E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:5.49|P-value:2.47E-9 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.48|P-value:9.17E-7 ID:SGTC_1268|Compound:0828-0275|FD-Score:-3.39|P-value:1.42E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.45|P-value:1.18E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.24|P-value:2.76E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.72|P-value:3.77E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.18|P-value:3.51E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:4.00|P-value:1.01E-5 ID:SGTC_1571|Compound:st070080|FD-Score:4.01|P-value:9.69E-6 ID:SGTC_1591|Compound:genipin|FD-Score:3.84|P-value:2.13E-5 ID:SGTC_1724|Compound:st037281|FD-Score:3.19|P-value:3.47E-4 ID:SGTC_1885|Compound:st057546|FD-Score:4.11|P-value:5.91E-6 ID:SGTC_2002|Compound:4023503|FD-Score:4.26|P-value:2.91E-6 ID:SGTC_2009|Compound:4012297|FD-Score:3.38|P-value:1.61E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.55|P-value:7.72E-5 ID:SGTC_2053|Compound:5265679|FD-Score:3.31|P-value:2.10E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.25|P-value:2.72E-4 ID:SGTC_2282|Compound:7944268|FD-Score:2.92|P-value:9.48E-4 ID:SGTC_2300|Compound:7976697|FD-Score:3.64|P-value:5.25E-5 ID:SGTC_2394|Compound:5221648|FD-Score:3.53|P-value:8.45E-5 ID:SGTC_2395|Compound:5646831|FD-Score:3.09|P-value:5.10E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.75|P-value:3.00E-5 ID:SGTC_2413|Compound:inermin|FD-Score:-2.94|P-value:8.29E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-4.39|P-value:1.35E-6 ID:SGTC_2415|Compound:st077333|FD-Score:4.40|P-value:1.42E-6 ID:SGTC_2593|Compound:nobiletin|FD-Score:5.71|P-value:5.78E-10 ID:SGTC_2610|Compound:ononetin|FD-Score:-4.16|P-value:4.38E-6 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.60|P-value:5.89E-5 ID:SGTC_2700|Compound:st077718|FD-Score:4.44|P-value:1.11E-6 ID:SGTC_2704|Compound:st078022|FD-Score:-3.19|P-value:3.20E-4 ID:SGTC_2708|Compound:st078559|FD-Score:3.68|P-value:4.35E-5 ID:SGTC_2837|Compound:9008476|FD-Score:3.45|P-value:1.18E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.12|P-value:4.46E-4 ID:SGTC_2851|Compound:9015922|FD-Score:5.80|P-value:3.18E-10 ID:SGTC_2855|Compound:9016525|FD-Score:3.03|P-value:6.40E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-5.00|P-value:4.69E-8 ID:SGTC_2928|Compound:9011484|FD-Score:4.68|P-value:3.05E-7 ID:SGTC_2970|Compound:9090938|FD-Score:3.02|P-value:6.62E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.67|P-value:4.70E-5 ID:SGTC_3017|Compound:9080681|FD-Score:3.11|P-value:4.72E-4 ID:SGTC_3090|Compound:9117696|FD-Score:-3.12|P-value:4.31E-4 ID:SGTC_3100|Compound:9120536|FD-Score:3.28|P-value:2.43E-4 ID:SGTC_3113|Compound:9123498|FD-Score:3.05|P-value:5.84E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.00|P-value:7.01E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.98|P-value:1.13E-5 ID:SGTC_3181|Compound:9108277|FD-Score:3.23|P-value:2.96E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.06|P-value:5.68E-4 ID:SGTC_3213|Compound:9129884|FD-Score:3.11|P-value:4.73E-4

Top fitness defect scores for YOR053W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_433 pimozide 5.88 108.0 µM 1.83E-10 4 2.04E-9
2 SGTC_2851 9015922 5.80 71.4 µM 3.18E-10 8 3.32E-9
3 SGTC_2593 nobiletin 5.71 86.2 µM 5.78E-10 7 5.62E-9
4 SGTC_674 0498-0004 5.49 451.0 µM 2.47E-9 heme requiring 5 2.03E-8
5 SGTC_665 3914-0008 5.17 307.0 µM 1.79E-8 4 1.16E-7
6 SGTC_2928 9011484 4.68 9.8 µM 3.05E-7 heme biosynthesis & mitochondrial translocase 25 1.42E-6
7 SGTC_1042 0350-0096 4.48 82.0 µM 9.17E-7 TSC3-RPN4 13 3.76E-6
8 SGTC_2700 st077718 4.44 96.8 µM 1.11E-6 8 4.45E-6
9 SGTC_2415 st077333 4.40 57.7 µM 1.42E-6 32 5.53E-6
10 SGTC_2002 4023503 4.26 131.0 µM 2.91E-6 mitochondrial processes 23 1.04E-5
11 SGTC_1885 st057546 4.11 99.9 µM 5.91E-6 16 1.96E-5
12 SGTC_170 4197-0004 4.04 226.0 µM 8.38E-6 15 2.66E-5
13 SGTC_1571 st070080 4.01 73.4 µM 9.69E-6 14 3.03E-5
14 SGTC_1427 4048-4900 4.00 550.0 nM 1.01E-5 24 3.14E-5
15 SGTC_3173 9105693 3.98 49.5 µM 1.13E-5 21 3.48E-5
16 SGTC_670 4204-0025 3.90 119.0 µM 1.60E-5 copper-dependent oxidative stress 33 4.71E-5
17 SGTC_1591 genipin 3.84 88.4 µM 2.13E-5 mitochondrial processes 17 6.08E-5
18 SGTC_1374 2889-5571 3.72 141.0 µM 3.77E-5 RSC complex & mRNA processing 47 1.01E-4
19 SGTC_366 0181-0206 3.69 4.3 µM 4.24E-5 Golgi 50 1.12E-4
20 SGTC_2708 st078559 3.68 56.0 µM 4.35E-5 10 1.15E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.098 1.54E-8 YGR107W_d YGR107W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.094 5.05E-8 YMR196W_p YMR196W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene
0.093 6.51E-8 YDL217C TIM22 het Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported
0.087 4.74E-7 YMR025W CSI1 hom Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome
0.087 5.15E-7 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.086 5.57E-7 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.082 1.93E-6 YFR012W DCV1 hom Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication
0.082 2.04E-6 YJR147W HMS2 hom Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication
0.080 3.43E-6 YML003W_p YML003W_p hom Putative protein of unknown function
0.080 3.97E-6 YCR004C YCP4 hom Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.079 4.15E-6 YAL022C FUN26 hom Vacuolar membrane transporter with broad nucleoside selectivity; may regulate balance of nicotinamide riboside (NmR) levels between cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis
0.079 5.08E-6 YPL150W_p YPL150W_p hom Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study
0.077 8.25E-6 YKL222C YKL222C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine
0.077 8.56E-6 YKR017C HEL1 hom RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU)
0.076 1.02E-5 YOL117W RRI2 hom Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response