YOR055W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR055W / YOR055W

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:3.01|P-value:5.92E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:4.37|P-value:1.26E-6 ID:SGTC_130|Compound:0136-0219|FD-Score:-2.87|P-value:9.82E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:4.55|P-value:4.82E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:3.64|P-value:4.47E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:3.10|P-value:4.19E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.26|P-value:2.25E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-3.75|P-value:2.62E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:2.91|P-value:8.70E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.75|P-value:1.57E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.06|P-value:2.56E-8 ID:SGTC_692|Compound:k241-0027|FD-Score:3.32|P-value:1.80E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.02|P-value:5.76E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:2.92|P-value:8.52E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:3.24|P-value:2.43E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:2.96|P-value:7.33E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.71|P-value:3.25E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.06|P-value:5.04E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.45|P-value:1.01E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.65|P-value:4.22E-5 ID:SGTC_1236|Compound:0330-0013|FD-Score:2.94|P-value:7.87E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.20|P-value:2.87E-4 ID:SGTC_1741|Compound:st038134|FD-Score:-4.56|P-value:4.30E-7 ID:SGTC_1747|Compound:st037496|FD-Score:-4.11|P-value:4.71E-6 ID:SGTC_1786|Compound:berberine|FD-Score:2.96|P-value:7.17E-4 ID:SGTC_1950|Compound:st077106|FD-Score:2.99|P-value:6.57E-4 ID:SGTC_2128|Compound:5255449|FD-Score:5.40|P-value:3.13E-9 ID:SGTC_2239|Compound:6685329|FD-Score:4.32|P-value:1.69E-6 ID:SGTC_2289|Compound:7946404|FD-Score:3.42|P-value:1.16E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.35|P-value:1.56E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.34|P-value:1.63E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.20|P-value:2.87E-4 ID:SGTC_2655|Compound:perillic acid|FD-Score:2.97|P-value:6.89E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.06|P-value:4.90E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.10|P-value:4.30E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-3.19|P-value:2.89E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.21|P-value:2.79E-4 ID:SGTC_2871|Compound:9038510|FD-Score:-2.94|P-value:7.45E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.44|P-value:1.06E-4 ID:SGTC_3028|Compound:9087778|FD-Score:3.23|P-value:2.55E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.28|P-value:2.04E-4 ID:SGTC_3199|Compound:9111318|FD-Score:2.90|P-value:8.88E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.56|P-value:6.32E-5 ID:SGTC_3212|Compound:9128307|FD-Score:6.66|P-value:3.69E-13 ID:SGTC_49|Compound:0717-0965|FD-Score:3.01|P-value:5.92E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:4.37|P-value:1.26E-6 ID:SGTC_130|Compound:0136-0219|FD-Score:-2.87|P-value:9.82E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:4.55|P-value:4.82E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:3.64|P-value:4.47E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:3.10|P-value:4.19E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.26|P-value:2.25E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-3.75|P-value:2.62E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:2.91|P-value:8.70E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.75|P-value:1.57E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.06|P-value:2.56E-8 ID:SGTC_692|Compound:k241-0027|FD-Score:3.32|P-value:1.80E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.02|P-value:5.76E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:2.92|P-value:8.52E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:3.24|P-value:2.43E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:2.96|P-value:7.33E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.71|P-value:3.25E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.06|P-value:5.04E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.45|P-value:1.01E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.65|P-value:4.22E-5 ID:SGTC_1236|Compound:0330-0013|FD-Score:2.94|P-value:7.87E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.20|P-value:2.87E-4 ID:SGTC_1741|Compound:st038134|FD-Score:-4.56|P-value:4.30E-7 ID:SGTC_1747|Compound:st037496|FD-Score:-4.11|P-value:4.71E-6 ID:SGTC_1786|Compound:berberine|FD-Score:2.96|P-value:7.17E-4 ID:SGTC_1950|Compound:st077106|FD-Score:2.99|P-value:6.57E-4 ID:SGTC_2128|Compound:5255449|FD-Score:5.40|P-value:3.13E-9 ID:SGTC_2239|Compound:6685329|FD-Score:4.32|P-value:1.69E-6 ID:SGTC_2289|Compound:7946404|FD-Score:3.42|P-value:1.16E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.35|P-value:1.56E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.34|P-value:1.63E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.20|P-value:2.87E-4 ID:SGTC_2655|Compound:perillic acid|FD-Score:2.97|P-value:6.89E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.06|P-value:4.90E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.10|P-value:4.30E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-3.19|P-value:2.89E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.21|P-value:2.79E-4 ID:SGTC_2871|Compound:9038510|FD-Score:-2.94|P-value:7.45E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.44|P-value:1.06E-4 ID:SGTC_3028|Compound:9087778|FD-Score:3.23|P-value:2.55E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.28|P-value:2.04E-4 ID:SGTC_3199|Compound:9111318|FD-Score:2.90|P-value:8.88E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.56|P-value:6.32E-5 ID:SGTC_3212|Compound:9128307|FD-Score:6.66|P-value:3.69E-13

Top fitness defect scores for YOR055W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3212 9128307 6.66 49.5 µM 3.69E-13 10 1.36E-11
2 SGTC_2128 5255449 5.40 168.5 µM 3.13E-9 7 3.40E-8
3 SGTC_453 enantio-paf c16 5.06 10.0 µM 2.56E-8 85 2.10E-7
4 SGTC_449 xestospongin c 4.75 11.2 µM 1.57E-7 NEO1-PIK1 39 1.01E-6
5 SGTC_136 0097-0015 4.55 404.5 µM 4.82E-7 60S ribosome export 7 2.67E-6
6 SGTC_77 0828-0286 4.37 12.5 µM 1.26E-6 TSC3-RPN4 26 6.13E-6
7 SGTC_2239 6685329 4.32 187.6 µM 1.69E-6 21 7.94E-6
8 SGTC_1096 rimcazole 3.71 32.2 µM 3.25E-5 16 1.03E-4
9 SGTC_1223 0764-0573 3.65 147.0 µM 4.22E-5 30 1.30E-4
10 SGTC_178 4092-0806 3.64 87.5 µM 4.47E-5 ergosterol depletion effects on membrane 112 1.36E-4
11 SGTC_3201 9113999 3.56 49.5 µM 6.32E-5 52 1.84E-4
12 SGTC_1166 k206-0078 3.45 225.0 µM 1.01E-4 37 2.78E-4
13 SGTC_2951 9072950 3.44 58.1 µM 1.06E-4 ERG2 39 2.89E-4
14 SGTC_2289 7946404 3.42 165.1 µM 1.16E-4 115 3.12E-4
15 SGTC_2466 5983409 3.35 37.1 µM 1.56E-4 37 4.04E-4
16 SGTC_2555 cholic acid 3.34 100.0 µM 1.63E-4 33 4.20E-4
17 SGTC_692 k241-0027 3.32 77.8 µM 1.80E-4 23 4.58E-4
18 SGTC_3126 9127922 3.28 49.5 µM 2.04E-4 fatty acid desaturase (OLE1) 62 5.11E-4
19 SGTC_271 rotenone 3.26 740.0 µM 2.25E-4 55 5.55E-4
20 SGTC_904 1141-0088 3.24 396.0 µM 2.43E-4 39 5.93E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.196 3.19E-30 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.173 6.80E-24 YPL167C REV3 hom Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
0.152 6.59E-19 YHR130C_d YHR130C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.141 1.83E-16 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.107 5.59E-10 YML002W_p YML002W_p hom Putative protein of unknown function; expression induced by heat and by calcium shortage
0.102 3.10E-9 YMR214W SCJ1 hom One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
0.101 4.06E-9 YMR099C YMR099C hom Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
0.100 6.61E-9 YDR349C YPS7 hom Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum
0.098 1.33E-8 YOL072W THP1 hom Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding
0.098 1.47E-8 YNL200C YNL200C hom NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.094 5.02E-8 YLR318W EST2 hom Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia
0.094 5.53E-8 YDR218C SPR28 hom Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation
0.094 5.72E-8 YLR342W FKS1 hom Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling
0.093 6.93E-8 YDR407C TRS120 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.090 1.52E-7 YJR107W_p YJR107W_p hom Putative lipase