HIPHOP chemogenomics database

YOR063W / RPL3

Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; involved in the replication and maintenance of killer double stranded RNA virus

Zygosity: Heterozygous strain

fixedexpanded
Profile for YOR063W / RPL3

Click on Significant Values for Screen Details

Top fitness defect scores for YOR063W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_2781	5567276	6.06	71.4 µM	1.83E-11		1	6.61E-10	0.64
2	SGTC_3199	9111318	5.22	49.5 µM	6.14E-9		5	9.19E-8	0.01
3	SGTC_955	1216-0110	4.82	33.0 µM	6.92E-8	sphingolipid biosynthesis & PDR1	3	7.17E-7	0.54
4	SGTC_2285	7945142	4.63	200.0 µM	2.09E-7		6	1.83E-6	0.06
5	SGTC_1242	0402-0103	4.57	60.1 µM	2.95E-7		4	2.46E-6	0.07
6	SGTC_1976	st070609	4.48	63.5 µM	4.85E-7		1	3.75E-6	0.46
7	SGTC_1275	0867-0008	4.17	21.1 µM	2.56E-6		4	1.54E-5	0.30
8	SGTC_1314	1222-0010	4.01	41.1 µM	5.68E-6		1	3.03E-5	0.41
9	SGTC_2113	5491891	3.89	107.0 µM	1.05E-5	TSC3-RPN4	7	5.11E-5	0.10
10	SGTC_39	0986-0283	3.85	58.4 µM	1.23E-5	calcium & mitochondrial duress	9	5.83E-5	0.08
11	SGTC_891	0929-0073	3.73	133.0 µM	2.17E-5		3	9.46E-5	0.47
12	SGTC_2462	5162487	3.73	171.8 µM	2.20E-5		5	9.58E-5	0.12
13	SGTC_2008	4012253	3.73	172.0 µM	2.22E-5		15	9.64E-5	0.36
14	SGTC_2286	7945697	3.72	125.0 µM	2.29E-5		13	9.91E-5	0.01
15	SGTC_958	1222-0007	3.70	33.0 µM	2.55E-5		6	1.08E-4	0.01
16	SGTC_710	3448-4187	3.68	58.0 µM	2.73E-5	fatty acid desaturase (OLE1)	13	1.15E-4	0.41
17	SGTC_1318	1280-3875	3.58	124.0 µM	4.34E-5		8	1.70E-4	0.17
18	SGTC_3332	9141069	3.42	11.2 µM	8.82E-5		3	3.11E-4	0.06
19	SGTC_3101	9120531	3.41	49.5 µM	9.22E-5		8	3.23E-4	0.00
20	SGTC_2456	5770359	3.39	74.5 µM	9.92E-5		8	3.44E-4	0.05

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.180	9.27E-26	YJL174W	KRE9	het	Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects
0.125	3.18E-13	YBL004W	UTP20	het	Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.121	1.91E-12	YDR021W	FAL1	het	Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases
0.108	3.26E-10	YNL161W	CBK1	het	Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.107	5.61E-10	YLR195C	NMT1	het	N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.104	1.77E-9	YBR155W	CNS1	het	TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.102	3.44E-9	YKL152C	GPM1	het	Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
0.101	4.19E-9	YDL153C	SAS10	het	Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.101	4.77E-9	YDR235W	PRP42	het	U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
0.099	9.58E-9	YER147C	SCC4	het	Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
0.098	1.08E-8	YML054C-A_p	YML054C-A_p	hom	Putative protein of unknown function
0.098	1.15E-8	YER043C	SAH1	het	S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.096	2.66E-8	YCR068W	ATG15	hom	Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
0.094	4.45E-8	YOL050C_d	YOL050C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.089	2.60E-7	YKL088W	CAB3	het	Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC