YOR071C / NRT1

High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR071C / NRT1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.19|P-value:4.16E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:9.88|P-value:2.65E-25 ID:SGTC_119|Compound:0121-0043|FD-Score:4.97|P-value:9.63E-8 ID:SGTC_121|Compound:0557-0495|FD-Score:4.42|P-value:1.88E-6 ID:SGTC_122|Compound:0236-0016|FD-Score:3.43|P-value:1.60E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.29|P-value:2.89E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.24|P-value:3.39E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:4.59|P-value:7.58E-7 ID:SGTC_344|Compound:k064-0035|FD-Score:-4.07|P-value:1.12E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:3.22|P-value:3.76E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:3.11|P-value:5.55E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:-3.31|P-value:2.84E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:-5.00|P-value:9.12E-8 ID:SGTC_723|Compound:4182-0001|FD-Score:-5.09|P-value:5.43E-8 ID:SGTC_727|Compound:3032-0951|FD-Score:3.17|P-value:4.49E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.55|P-value:9.82E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:-3.07|P-value:6.83E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:-3.05|P-value:7.42E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.99|P-value:1.47E-5 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.16|P-value:4.69E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:5.31|P-value:1.40E-8 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.61|P-value:7.82E-5 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.26|P-value:3.24E-4 ID:SGTC_1642|Compound:st009582|FD-Score:-2.99|P-value:9.24E-4 ID:SGTC_1647|Compound:st011722|FD-Score:-3.03|P-value:7.85E-4 ID:SGTC_1655|Compound:st012546|FD-Score:-4.02|P-value:1.39E-5 ID:SGTC_1700|Compound:st030840|FD-Score:-3.36|P-value:2.36E-4 ID:SGTC_1755|Compound:st041960|FD-Score:-4.51|P-value:1.27E-6 ID:SGTC_1761|Compound:st044296|FD-Score:3.94|P-value:1.84E-5 ID:SGTC_1779|Compound:st039427|FD-Score:5.00|P-value:8.18E-8 ID:SGTC_2035|Compound:5154463|FD-Score:3.45|P-value:1.51E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-5.45|P-value:6.42E-9 ID:SGTC_2413|Compound:inermin|FD-Score:3.41|P-value:1.79E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.09|P-value:6.53E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-4.71|P-value:4.44E-7 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.18|P-value:4.66E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:7.10|P-value:5.52E-14 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.32|P-value:3.05E-6 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-6.12|P-value:8.85E-11 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.07|P-value:6.82E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:-2.99|P-value:9.32E-4 ID:SGTC_2746|Compound:daunorubicin|FD-Score:3.07|P-value:6.58E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.16|P-value:4.56E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-3.64|P-value:7.31E-5 ID:SGTC_2966|Compound:9084041|FD-Score:-3.97|P-value:1.72E-5 ID:SGTC_2972|Compound:9093619|FD-Score:5.38|P-value:9.23E-9 ID:SGTC_3032|Compound:9089427|FD-Score:-3.05|P-value:7.53E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-3.04|P-value:7.71E-4 ID:SGTC_3065|Compound:9113888|FD-Score:3.16|P-value:4.72E-4 ID:SGTC_3067|Compound:9117431|FD-Score:-3.02|P-value:8.38E-4 ID:SGTC_3125|Compound:9127534|FD-Score:4.26|P-value:4.05E-6 ID:SGTC_3154|Compound:9100113|FD-Score:-3.40|P-value:2.00E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.19|P-value:4.18E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-3.12|P-value:5.67E-4 ID:SGTC_3329|Compound:9141233|FD-Score:-3.29|P-value:3.02E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.19|P-value:4.16E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:9.88|P-value:2.65E-25 ID:SGTC_119|Compound:0121-0043|FD-Score:4.97|P-value:9.63E-8 ID:SGTC_121|Compound:0557-0495|FD-Score:4.42|P-value:1.88E-6 ID:SGTC_122|Compound:0236-0016|FD-Score:3.43|P-value:1.60E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.29|P-value:2.89E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.24|P-value:3.39E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:4.59|P-value:7.58E-7 ID:SGTC_344|Compound:k064-0035|FD-Score:-4.07|P-value:1.12E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:3.22|P-value:3.76E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:3.11|P-value:5.55E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:-3.31|P-value:2.84E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:-5.00|P-value:9.12E-8 ID:SGTC_723|Compound:4182-0001|FD-Score:-5.09|P-value:5.43E-8 ID:SGTC_727|Compound:3032-0951|FD-Score:3.17|P-value:4.49E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.55|P-value:9.82E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:-3.07|P-value:6.83E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:-3.05|P-value:7.42E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.99|P-value:1.47E-5 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.16|P-value:4.69E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:5.31|P-value:1.40E-8 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.61|P-value:7.82E-5 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.26|P-value:3.24E-4 ID:SGTC_1642|Compound:st009582|FD-Score:-2.99|P-value:9.24E-4 ID:SGTC_1647|Compound:st011722|FD-Score:-3.03|P-value:7.85E-4 ID:SGTC_1655|Compound:st012546|FD-Score:-4.02|P-value:1.39E-5 ID:SGTC_1700|Compound:st030840|FD-Score:-3.36|P-value:2.36E-4 ID:SGTC_1755|Compound:st041960|FD-Score:-4.51|P-value:1.27E-6 ID:SGTC_1761|Compound:st044296|FD-Score:3.94|P-value:1.84E-5 ID:SGTC_1779|Compound:st039427|FD-Score:5.00|P-value:8.18E-8 ID:SGTC_2035|Compound:5154463|FD-Score:3.45|P-value:1.51E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-5.45|P-value:6.42E-9 ID:SGTC_2413|Compound:inermin|FD-Score:3.41|P-value:1.79E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.09|P-value:6.53E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-4.71|P-value:4.44E-7 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.18|P-value:4.66E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:7.10|P-value:5.52E-14 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.32|P-value:3.05E-6 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-6.12|P-value:8.85E-11 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.07|P-value:6.82E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:-2.99|P-value:9.32E-4 ID:SGTC_2746|Compound:daunorubicin|FD-Score:3.07|P-value:6.58E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.16|P-value:4.56E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-3.64|P-value:7.31E-5 ID:SGTC_2966|Compound:9084041|FD-Score:-3.97|P-value:1.72E-5 ID:SGTC_2972|Compound:9093619|FD-Score:5.38|P-value:9.23E-9 ID:SGTC_3032|Compound:9089427|FD-Score:-3.05|P-value:7.53E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-3.04|P-value:7.71E-4 ID:SGTC_3065|Compound:9113888|FD-Score:3.16|P-value:4.72E-4 ID:SGTC_3067|Compound:9117431|FD-Score:-3.02|P-value:8.38E-4 ID:SGTC_3125|Compound:9127534|FD-Score:4.26|P-value:4.05E-6 ID:SGTC_3154|Compound:9100113|FD-Score:-3.40|P-value:2.00E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.19|P-value:4.18E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-3.12|P-value:5.67E-4 ID:SGTC_3329|Compound:9141233|FD-Score:-3.29|P-value:3.02E-4

Top fitness defect scores for YOR071C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_65 0798-0905 9.88 35.0 µM 2.65E-25 calcium & mitochondrial duress 10 2.66E-23
2 SGTC_2594 a-mangostin 7.10 100.0 µM 5.52E-14 4 6.22E-13
3 SGTC_2972 9093619 5.38 59.9 µM 9.23E-9 3 3.81E-8
4 SGTC_1286 0929-0070 5.31 131.0 µM 1.40E-8 8 5.60E-8
5 SGTC_1779 st039427 5.00 55.0 µM 8.18E-8 6 2.82E-7
6 SGTC_119 0121-0043 4.97 24.8 µM 9.63E-8 mitochondrial stress 56 3.28E-7
7 SGTC_343 4130-2827 4.59 29.8 µM 7.58E-7 19 2.18E-6
8 SGTC_121 0557-0495 4.42 61.3 µM 1.88E-6 calcium & mitochondrial duress 46 4.99E-6
9 SGTC_2596 sinensetin 4.32 100.0 µM 3.05E-6 22 7.79E-6
10 SGTC_3125 9127534 4.26 49.5 µM 4.05E-6 10 1.01E-5
11 SGTC_1011 4112-3381 3.99 17.4 µM 1.47E-5 42 3.31E-5
12 SGTC_1761 st044296 3.94 37.0 µM 1.84E-5 16 4.06E-5
13 SGTC_1400 3771-8998 3.61 51.5 µM 7.82E-5 14 1.53E-4
14 SGTC_769 0302-0231 3.55 76.0 µM 9.82E-5 61 1.89E-4
15 SGTC_2035 5154463 3.45 94.6 µM 1.51E-4 28 2.82E-4
16 SGTC_122 0236-0016 3.43 402.4 µM 1.60E-4 RNA processing & uracil transport 58 2.96E-4
17 SGTC_2413 inermin 3.41 26.1 µM 1.79E-4 79 3.29E-4
18 SGTC_288 1315-0019 3.29 35.1 µM 2.89E-4 RSC & ERG11 44 5.10E-4
19 SGTC_1437 4092-1038 3.26 11.6 µM 3.24E-4 37 5.66E-4
20 SGTC_310 1273-0058 3.24 1.1 µM 3.39E-4 mitochondrial stress 317 5.90E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.200 1.37E-31 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.175 1.89E-24 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.164 9.73E-22 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.150 2.60E-18 YMR118C_p SHH3_p hom Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase
0.140 3.99E-16 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.130 4.55E-14 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.123 7.52E-13 YGR138C TPO2 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication
0.122 1.19E-12 YGR234W YHB1 hom Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.120 3.02E-12 YNL086W_p SNN1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes
0.120 3.08E-12 YPL027W SMA1 hom Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p
0.118 6.15E-12 YKL187C FAT3 hom Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
0.118 6.95E-12 YOR268C_p YOR268C_p hom Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
0.114 3.22E-11 YJL150W_d YJL150W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.112 7.95E-11 YJR099W YUH1 hom Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p
0.110 1.95E-10 YMR017W SPO20 hom Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog