YOR081C / TGL5

Bifunctional enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity; involved in triacylglycerol mobilization; localizes to lipid particles; potential Cdc28p substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR081C / TGL5

Click on Significant Values for Screen Details ID:SGTC_114|Compound:0364-0001|FD-Score:3.43|P-value:9.38E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:3.02|P-value:5.00E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:3.44|P-value:8.86E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:3.39|P-value:1.11E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.21|P-value:2.37E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:2.89|P-value:8.24E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:4.12|P-value:3.55E-6 ID:SGTC_356|Compound:1634-0012|FD-Score:3.10|P-value:3.63E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:-3.62|P-value:3.99E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:-3.49|P-value:7.06E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.08|P-value:4.03E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.02|P-value:4.96E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:2.90|P-value:7.88E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:-2.88|P-value:8.39E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.70|P-value:2.74E-5 ID:SGTC_1187|Compound:1391-0724|FD-Score:-4.41|P-value:7.83E-7 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.49|P-value:7.29E-5 ID:SGTC_1210|Compound:3013-0140|FD-Score:2.92|P-value:7.38E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.33|P-value:1.42E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.34|P-value:1.37E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.58|P-value:4.92E-5 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.91|P-value:1.03E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:-3.20|P-value:2.45E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:7.49|P-value:1.65E-16 ID:SGTC_1373|Compound:2887-0003|FD-Score:-3.19|P-value:2.55E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:4.88|P-value:5.33E-8 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.15|P-value:3.03E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.40|P-value:1.06E-4 ID:SGTC_1657|Compound:st012939|FD-Score:4.52|P-value:4.28E-7 ID:SGTC_1779|Compound:st039427|FD-Score:2.97|P-value:6.10E-4 ID:SGTC_1848|Compound:st056003|FD-Score:3.13|P-value:3.21E-4 ID:SGTC_1859|Compound:st055998|FD-Score:4.15|P-value:3.01E-6 ID:SGTC_2110|Compound:5483698|FD-Score:3.13|P-value:3.25E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-2.87|P-value:8.76E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.15|P-value:3.05E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.53|P-value:6.06E-5 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:-2.91|P-value:7.71E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:-4.10|P-value:3.88E-6 ID:SGTC_2670|Compound:beta-carotene|FD-Score:3.54|P-value:5.77E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.20|P-value:2.46E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.59|P-value:4.69E-5 ID:SGTC_2950|Compound:9072895|FD-Score:-3.80|P-value:1.78E-5 ID:SGTC_3010|Compound:9080089|FD-Score:3.40|P-value:1.08E-4 ID:SGTC_3186|Compound:9110464|FD-Score:2.93|P-value:7.05E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.01|P-value:5.26E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-2.84|P-value:9.76E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.43|P-value:9.38E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:3.02|P-value:5.00E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:3.44|P-value:8.86E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:3.39|P-value:1.11E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.21|P-value:2.37E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:2.89|P-value:8.24E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:4.12|P-value:3.55E-6 ID:SGTC_356|Compound:1634-0012|FD-Score:3.10|P-value:3.63E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:-3.62|P-value:3.99E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:-3.49|P-value:7.06E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.08|P-value:4.03E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.02|P-value:4.96E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:2.90|P-value:7.88E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:-2.88|P-value:8.39E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.70|P-value:2.74E-5 ID:SGTC_1187|Compound:1391-0724|FD-Score:-4.41|P-value:7.83E-7 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.49|P-value:7.29E-5 ID:SGTC_1210|Compound:3013-0140|FD-Score:2.92|P-value:7.38E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.33|P-value:1.42E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.34|P-value:1.37E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.58|P-value:4.92E-5 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.91|P-value:1.03E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:-3.20|P-value:2.45E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:7.49|P-value:1.65E-16 ID:SGTC_1373|Compound:2887-0003|FD-Score:-3.19|P-value:2.55E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:4.88|P-value:5.33E-8 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.15|P-value:3.03E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.40|P-value:1.06E-4 ID:SGTC_1657|Compound:st012939|FD-Score:4.52|P-value:4.28E-7 ID:SGTC_1779|Compound:st039427|FD-Score:2.97|P-value:6.10E-4 ID:SGTC_1848|Compound:st056003|FD-Score:3.13|P-value:3.21E-4 ID:SGTC_1859|Compound:st055998|FD-Score:4.15|P-value:3.01E-6 ID:SGTC_2110|Compound:5483698|FD-Score:3.13|P-value:3.25E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-2.87|P-value:8.76E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.15|P-value:3.05E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.53|P-value:6.06E-5 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:-2.91|P-value:7.71E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:-4.10|P-value:3.88E-6 ID:SGTC_2670|Compound:beta-carotene|FD-Score:3.54|P-value:5.77E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.20|P-value:2.46E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.59|P-value:4.69E-5 ID:SGTC_2950|Compound:9072895|FD-Score:-3.80|P-value:1.78E-5 ID:SGTC_3010|Compound:9080089|FD-Score:3.40|P-value:1.08E-4 ID:SGTC_3186|Compound:9110464|FD-Score:2.93|P-value:7.05E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.01|P-value:5.26E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-2.84|P-value:9.76E-4

Top fitness defect scores for YOR081C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1372 2752-0194 7.49 270.0 µM 1.65E-16 2 3.38E-14
2 SGTC_1382 3002-2117 4.88 298.0 µM 5.33E-8 4 5.32E-7
3 SGTC_1657 st012939 4.52 43.4 µM 4.28E-7 6 3.11E-6
4 SGTC_1859 st055998 4.15 20.0 µM 3.01E-6 18 1.63E-5
5 SGTC_353 1988-1175 4.12 58.3 µM 3.55E-6 unfolded protein response 23 1.87E-5
6 SGTC_2884 9058502 3.59 52.0 µM 4.69E-5 38 1.68E-4
7 SGTC_1320 1313-0481 3.58 95.3 µM 4.92E-5 35 1.75E-4
8 SGTC_2670 beta-carotene 3.54 100.0 µM 5.77E-5 4 2.00E-4
9 SGTC_2445 5742597 3.53 35.6 µM 6.06E-5 49 2.09E-4
10 SGTC_132 0417-1715 3.44 25.8 µM 8.86E-5 RPP1 & pyrimidine depletion 34 2.88E-4
11 SGTC_114 0364-0001 3.43 490.3 µM 9.38E-5 69 3.03E-4
12 SGTC_1527 coumarin 3.40 137.0 µM 1.06E-4 41 3.36E-4
13 SGTC_3010 9080089 3.40 71.4 µM 1.08E-4 32 3.42E-4
14 SGTC_133 0724-0033 3.39 378.9 µM 1.11E-4 44 3.48E-4
15 SGTC_1253 0550-0034 3.34 176.0 µM 1.37E-4 37 4.19E-4
16 SGTC_1245 0418-0076 3.33 17.2 µM 1.42E-4 ERG2 51 4.32E-4
17 SGTC_2768 sulfasalazine 3.20 50.2 µM 2.46E-4 43 6.88E-4
18 SGTC_1456 k015-0012 3.15 13.0 µM 3.03E-4 66 8.23E-4
19 SGTC_2376 9072922 3.15 81.3 µM 3.05E-4 70 8.26E-4
20 SGTC_1848 st056003 3.13 16.4 µM 3.21E-4 40 8.63E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.183 9.87E-27 YDR088C SLU7 het RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
0.120 2.73E-12 YBR263W SHM1 hom Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine
0.113 5.33E-11 YNL042W BOP3 hom Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury
0.112 9.61E-11 YOR020W-A_p YOR020W-A_p hom Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.106 8.28E-10 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.104 1.42E-9 YOR245C DGA1 hom Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles
0.104 1.70E-9 YKL100C_p YKL100C_p hom Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene
0.102 2.93E-9 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.099 8.69E-9 YLR306W UBC12 hom Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes
0.096 2.73E-8 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.096 2.87E-8 YMR149W SWP1 het Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum
0.093 5.87E-8 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.092 1.11E-7 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.091 1.24E-7 YKL006C-A SFT1 het Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment
0.089 2.10E-7 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p