YOR082C_d

Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR082C / YOR082C

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:3.09|P-value:5.12E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.39|P-value:1.57E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.45|P-value:1.09E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.24|P-value:2.94E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:-3.85|P-value:1.85E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.08|P-value:4.77E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:3.94|P-value:1.40E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:3.46|P-value:1.17E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.96|P-value:1.28E-5 ID:SGTC_554|Compound:4483-2211|FD-Score:-3.09|P-value:4.59E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:3.67|P-value:4.82E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:2.99|P-value:7.54E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.47|P-value:1.13E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.16|P-value:3.40E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-4.54|P-value:5.60E-7 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.52|P-value:9.26E-5 ID:SGTC_1100|Compound:amiodarone|FD-Score:4.45|P-value:1.13E-6 ID:SGTC_1101|Compound:ebselen|FD-Score:5.91|P-value:1.53E-10 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.14|P-value:4.29E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-9.51|P-value:1.30E-24 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.12|P-value:4.12E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:4.64|P-value:4.09E-7 ID:SGTC_1280|Compound:0880-0253|FD-Score:-3.10|P-value:4.34E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.29|P-value:2.40E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:-2.97|P-value:7.08E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.13|P-value:5.66E-6 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.58|P-value:6.13E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:2.99|P-value:7.62E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.16|P-value:3.93E-4 ID:SGTC_1644|Compound:st010134|FD-Score:4.98|P-value:5.74E-8 ID:SGTC_1669|Compound:st015249|FD-Score:-4.09|P-value:5.92E-6 ID:SGTC_1783|Compound:st039459|FD-Score:3.00|P-value:7.27E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.23|P-value:3.00E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-2.93|P-value:8.24E-4 ID:SGTC_1904|Compound:st060225|FD-Score:-2.90|P-value:9.12E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.77|P-value:3.14E-10 ID:SGTC_1933|Compound:st074711|FD-Score:-3.20|P-value:3.00E-4 ID:SGTC_2096|Compound:5468907|FD-Score:3.57|P-value:7.52E-5 ID:SGTC_2173|Compound:5763948|FD-Score:-3.52|P-value:7.85E-5 ID:SGTC_2175|Compound:5807670|FD-Score:4.06|P-value:7.85E-6 ID:SGTC_2176|Compound:5809774|FD-Score:3.72|P-value:3.85E-5 ID:SGTC_2178|Compound:5812956|FD-Score:-4.42|P-value:1.11E-6 ID:SGTC_2179|Compound:6298986|FD-Score:2.97|P-value:8.17E-4 ID:SGTC_2248|Compound:tofa|FD-Score:2.92|P-value:9.72E-4 ID:SGTC_2352|Compound:9027995|FD-Score:-3.85|P-value:1.86E-5 ID:SGTC_2399|Compound:5884133|FD-Score:-3.16|P-value:3.48E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.47|P-value:9.69E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:5.09|P-value:3.12E-8 ID:SGTC_2661|Compound:dactinomycin|FD-Score:-2.96|P-value:7.49E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.02|P-value:6.01E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.41|P-value:1.24E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.36|P-value:1.56E-4 ID:SGTC_2855|Compound:9016525|FD-Score:3.36|P-value:1.78E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.61|P-value:5.36E-5 ID:SGTC_2993|Compound:9054257|FD-Score:-3.14|P-value:3.72E-4 ID:SGTC_3069|Compound:9117009|FD-Score:2.99|P-value:7.60E-4 ID:SGTC_3074|Compound:9116018|FD-Score:-3.35|P-value:1.63E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-2.94|P-value:7.92E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.27|P-value:2.62E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.46|P-value:1.03E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:3.09|P-value:5.12E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.39|P-value:1.57E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.45|P-value:1.09E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.24|P-value:2.94E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:-3.85|P-value:1.85E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.08|P-value:4.77E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:3.94|P-value:1.40E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:3.46|P-value:1.17E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.96|P-value:1.28E-5 ID:SGTC_554|Compound:4483-2211|FD-Score:-3.09|P-value:4.59E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:3.67|P-value:4.82E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:2.99|P-value:7.54E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.47|P-value:1.13E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.16|P-value:3.40E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-4.54|P-value:5.60E-7 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.52|P-value:9.26E-5 ID:SGTC_1100|Compound:amiodarone|FD-Score:4.45|P-value:1.13E-6 ID:SGTC_1101|Compound:ebselen|FD-Score:5.91|P-value:1.53E-10 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.14|P-value:4.29E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-9.51|P-value:1.30E-24 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.12|P-value:4.12E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:4.64|P-value:4.09E-7 ID:SGTC_1280|Compound:0880-0253|FD-Score:-3.10|P-value:4.34E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.29|P-value:2.40E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:-2.97|P-value:7.08E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.13|P-value:5.66E-6 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.58|P-value:6.13E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:2.99|P-value:7.62E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.16|P-value:3.93E-4 ID:SGTC_1644|Compound:st010134|FD-Score:4.98|P-value:5.74E-8 ID:SGTC_1669|Compound:st015249|FD-Score:-4.09|P-value:5.92E-6 ID:SGTC_1783|Compound:st039459|FD-Score:3.00|P-value:7.27E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.23|P-value:3.00E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-2.93|P-value:8.24E-4 ID:SGTC_1904|Compound:st060225|FD-Score:-2.90|P-value:9.12E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.77|P-value:3.14E-10 ID:SGTC_1933|Compound:st074711|FD-Score:-3.20|P-value:3.00E-4 ID:SGTC_2096|Compound:5468907|FD-Score:3.57|P-value:7.52E-5 ID:SGTC_2173|Compound:5763948|FD-Score:-3.52|P-value:7.85E-5 ID:SGTC_2175|Compound:5807670|FD-Score:4.06|P-value:7.85E-6 ID:SGTC_2176|Compound:5809774|FD-Score:3.72|P-value:3.85E-5 ID:SGTC_2178|Compound:5812956|FD-Score:-4.42|P-value:1.11E-6 ID:SGTC_2179|Compound:6298986|FD-Score:2.97|P-value:8.17E-4 ID:SGTC_2248|Compound:tofa|FD-Score:2.92|P-value:9.72E-4 ID:SGTC_2352|Compound:9027995|FD-Score:-3.85|P-value:1.86E-5 ID:SGTC_2399|Compound:5884133|FD-Score:-3.16|P-value:3.48E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.47|P-value:9.69E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:5.09|P-value:3.12E-8 ID:SGTC_2661|Compound:dactinomycin|FD-Score:-2.96|P-value:7.49E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.02|P-value:6.01E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.41|P-value:1.24E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.36|P-value:1.56E-4 ID:SGTC_2855|Compound:9016525|FD-Score:3.36|P-value:1.78E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.61|P-value:5.36E-5 ID:SGTC_2993|Compound:9054257|FD-Score:-3.14|P-value:3.72E-4 ID:SGTC_3069|Compound:9117009|FD-Score:2.99|P-value:7.60E-4 ID:SGTC_3074|Compound:9116018|FD-Score:-3.35|P-value:1.63E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-2.94|P-value:7.92E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.27|P-value:2.62E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.46|P-value:1.03E-4

Top fitness defect scores for YOR082C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1101 ebselen 5.91 5.3 µM 1.53E-10 6 1.67E-9
2 SGTC_2584 androsterone 5.09 48.7 µM 3.12E-8 cell wall 80 1.82E-7
3 SGTC_1644 st010134 4.98 20.9 µM 5.74E-8 mitochondrial processes 3 3.13E-7
4 SGTC_1233 0325-0408 4.64 14.2 µM 4.09E-7 11 1.78E-6
5 SGTC_1100 amiodarone 4.45 5.1 µM 1.13E-6 9 4.38E-6
6 SGTC_1333 1482-0047 4.13 286.0 µM 5.66E-6 14 1.82E-5
7 SGTC_2175 5807670 4.06 165.3 µM 7.85E-6 20 2.43E-5
8 SGTC_549 1661-1316 3.96 519.0 µM 1.28E-5 18 3.76E-5
9 SGTC_486 niguldipine 3.94 82.0 µM 1.40E-5 amide catabolism 15 4.06E-5
10 SGTC_2176 5809774 3.72 34.0 µM 3.85E-5 mitochondrial processes 18 9.94E-5
11 SGTC_561 1550-0330 3.67 72.9 µM 4.82E-5 12 1.21E-4
12 SGTC_2096 5468907 3.57 200.0 µM 7.52E-5 16 1.80E-4
13 SGTC_1096 rimcazole 3.52 32.2 µM 9.26E-5 19 2.17E-4
14 SGTC_732 3970-1727 3.47 52.7 µM 1.13E-4 15 2.58E-4
15 SGTC_529 4076-0302 3.46 30.3 µM 1.17E-4 mitochondrial processes 27 2.66E-4
16 SGTC_159 3970-0959 3.39 50.0 µM 1.57E-4 117 3.45E-4
17 SGTC_2855 9016525 3.36 58.4 µM 1.78E-4 42 3.86E-4
18 SGTC_1296 1068-0102 3.29 11.9 µM 2.40E-4 22 5.04E-4
19 SGTC_3315 9136395 3.27 68.5 µM 2.62E-4 25 5.46E-4
20 SGTC_384 k007-0144 3.24 5.2 µM 2.94E-4 ERAD & cell cycle 91 6.04E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.219 1.07E-37 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.217 4.85E-37 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.211 3.54E-35 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.210 8.40E-35 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.206 1.28E-33 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.187 6.74E-28 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
0.183 1.19E-26 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.175 1.53E-24 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.174 2.39E-24 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.173 7.17E-24 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.172 8.47E-24 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
0.171 2.59E-23 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.166 4.23E-22 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.165 7.25E-22 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.165 7.88E-22 YAL061W_p BDH2_p hom Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3