HIPHOP chemogenomics database
YOR083W / WHI5 
Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YOR083W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.186 | 2.09E-27 | YDR487C | RIB3 | het | 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration |
| 0.181 | 5.76E-26 | YEL004W | YEA4 | hom | Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER |
| 0.171 | 1.94E-23 | YKL140W | TGL1 | hom | Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes |
| 0.162 | 2.86E-21 | YKR023W_p | YKR023W_p | hom | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| 0.148 | 8.16E-18 | YBR118W | TEF2 | hom | Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication |
| 0.145 | 2.74E-17 | YGL243W | TAD1 | hom | tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala |
| 0.142 | 1.10E-16 | YLR016C | PML1 | hom | Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p |
| 0.141 | 2.27E-16 | YHR003C | YHR003C | hom | Protein of unknown function, localized to the mitochondrial outer membrane |
| 0.140 | 3.61E-16 | YKL179C | COY1 | hom | Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function |
| 0.135 | 3.82E-15 | YMR164C | MSS11 | hom | Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals |
| 0.133 | 1.32E-14 | YOR298C-A | MBF1 | hom | Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress |
| 0.132 | 1.92E-14 | YGR093W_p | YGR093W_p | hom | Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus |
| 0.130 | 3.56E-14 | YLR205C | HMX1 | hom | ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants |
| 0.130 | 3.65E-14 | YBL036C | YBL036C | hom | Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS |
| 0.127 | 1.28E-13 | YEL049W | PAU2 | hom | Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme |