YOR083W / WHI5

Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR083W / WHI5

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:2.91|P-value:5.80E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:2.98|P-value:4.42E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.06|P-value:3.19E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.00|P-value:4.17E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:4.48|P-value:2.86E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:2.96|P-value:4.83E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.87|P-value:6.78E-6 ID:SGTC_590|Compound:k048-0076|FD-Score:2.85|P-value:7.43E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.83|P-value:7.10E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:2.78|P-value:9.67E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.38|P-value:7.29E-5 ID:SGTC_803|Compound:4488-1585|FD-Score:3.07|P-value:3.15E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.56|P-value:3.11E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:-8.78|P-value:3.35E-23 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.72|P-value:6.72E-8 ID:SGTC_1241|Compound:0364-0022|FD-Score:-2.88|P-value:6.01E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.27|P-value:1.31E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.92|P-value:6.13E-6 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.38|P-value:8.17E-5 ID:SGTC_1619|Compound:st003326|FD-Score:3.47|P-value:5.53E-5 ID:SGTC_1765|Compound:st044815|FD-Score:-2.93|P-value:4.92E-4 ID:SGTC_1794|Compound:st048918|FD-Score:3.00|P-value:4.05E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.10|P-value:2.69E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-3.24|P-value:1.35E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:2.99|P-value:4.34E-4 ID:SGTC_2476|Compound:5806916|FD-Score:4.52|P-value:2.26E-7 ID:SGTC_2605|Compound:digitonin|FD-Score:3.70|P-value:1.78E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.03|P-value:3.59E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-2.88|P-value:5.91E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:2.99|P-value:4.23E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.09|P-value:2.85E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-4.24|P-value:9.57E-7 ID:SGTC_2791|Compound:5663188|FD-Score:4.96|P-value:1.50E-8 ID:SGTC_2810|Compound:7959871|FD-Score:-3.09|P-value:2.58E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-3.59|P-value:2.66E-5 ID:SGTC_3013|Compound:9080133|FD-Score:3.18|P-value:1.98E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:2.91|P-value:5.80E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:2.98|P-value:4.42E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.06|P-value:3.19E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.00|P-value:4.17E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:4.48|P-value:2.86E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:2.96|P-value:4.83E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.87|P-value:6.78E-6 ID:SGTC_590|Compound:k048-0076|FD-Score:2.85|P-value:7.43E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.83|P-value:7.10E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:2.78|P-value:9.67E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.38|P-value:7.29E-5 ID:SGTC_803|Compound:4488-1585|FD-Score:3.07|P-value:3.15E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.56|P-value:3.11E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:-8.78|P-value:3.35E-23 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.72|P-value:6.72E-8 ID:SGTC_1241|Compound:0364-0022|FD-Score:-2.88|P-value:6.01E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.27|P-value:1.31E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.92|P-value:6.13E-6 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.38|P-value:8.17E-5 ID:SGTC_1619|Compound:st003326|FD-Score:3.47|P-value:5.53E-5 ID:SGTC_1765|Compound:st044815|FD-Score:-2.93|P-value:4.92E-4 ID:SGTC_1794|Compound:st048918|FD-Score:3.00|P-value:4.05E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.10|P-value:2.69E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-3.24|P-value:1.35E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:2.99|P-value:4.34E-4 ID:SGTC_2476|Compound:5806916|FD-Score:4.52|P-value:2.26E-7 ID:SGTC_2605|Compound:digitonin|FD-Score:3.70|P-value:1.78E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.03|P-value:3.59E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-2.88|P-value:5.91E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:2.99|P-value:4.23E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.09|P-value:2.85E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-4.24|P-value:9.57E-7 ID:SGTC_2791|Compound:5663188|FD-Score:4.96|P-value:1.50E-8 ID:SGTC_2810|Compound:7959871|FD-Score:-3.09|P-value:2.58E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-3.59|P-value:2.66E-5 ID:SGTC_3013|Compound:9080133|FD-Score:3.18|P-value:1.98E-4

Top fitness defect scores for YOR083W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2791 5663188 4.96 71.4 µM 1.50E-8 RPP1 & pyrimidine depletion 4 3.51E-7
2 SGTC_1134 3477-0009 4.72 42.5 µM 6.72E-8 26 1.17E-6
3 SGTC_2476 5806916 4.52 10.5 µM 2.26E-7 7 3.12E-6
4 SGTC_452 diindolylmethane 4.48 8.0 µM 2.86E-7 RNA processing & uracil transport 6 3.77E-6
5 SGTC_1306 1185-0270 3.92 9.0 µM 6.13E-6 Golgi 52 4.47E-5
6 SGTC_2605 digitonin 3.70 300.0 nM 1.78E-5 39 1.06E-4
7 SGTC_1619 st003326 3.47 88.7 µM 5.53E-5 60S ribosome export 30 2.65E-4
8 SGTC_1331 1472-0049 3.38 76.2 µM 8.17E-5 48 3.63E-4
9 SGTC_1296 1068-0102 3.27 11.9 µM 1.31E-4 23 5.31E-4
10 SGTC_3013 9080133 3.18 71.4 µM 1.98E-4 57 7.44E-4
11 SGTC_2063 5246145 3.10 200.0 µM 2.69E-4 57 9.57E-4
12 SGTC_2639 lactacystin 3.09 53.0 µM 2.85E-4 69 0.00100
13 SGTC_803 4488-1585 3.07 147.0 µM 3.15E-4 41 0.00109
14 SGTC_159 3970-0959 3.06 50.0 µM 3.19E-4 158 0.00110
15 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 3.03 70.0 µM 3.59E-4 redox potentiating 134 0.00121
16 SGTC_1794 st048918 3.00 76.9 µM 4.05E-4 28 0.00133
17 SGTC_312 4092-0653 3.00 6.8 µM 4.17E-4 ergosterol depletion effects on membrane 138 0.00136
18 SGTC_2629 bisabolol 2.99 100.0 µM 4.23E-4 69 0.00138
19 SGTC_2407 paclitaxel 2.99 400.0 µM 4.34E-4 85 0.00141
20 SGTC_86 0417-1630 2.98 471.9 µM 4.42E-4 ubiquinone biosynthesis & proteasome 226 0.00143

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.186 2.09E-27 YDR487C RIB3 het 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration
0.181 5.76E-26 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.171 1.94E-23 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.162 2.86E-21 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.148 8.16E-18 YBR118W TEF2 hom Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication
0.145 2.74E-17 YGL243W TAD1 hom tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala
0.142 1.10E-16 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.141 2.27E-16 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.140 3.61E-16 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.135 3.82E-15 YMR164C MSS11 hom Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals
0.133 1.32E-14 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.132 1.92E-14 YGR093W_p YGR093W_p hom Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.130 3.56E-14 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.130 3.65E-14 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.127 1.28E-13 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme