YOR084W / LPX1

Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR084W / LPX1

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:-3.50|P-value:2.61E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:4.66|P-value:3.32E-8 ID:SGTC_40|Compound:0327-0103|FD-Score:-2.96|P-value:3.19E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.27|P-value:7.46E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.14|P-value:1.43E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-2.72|P-value:8.36E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:2.75|P-value:6.96E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.21|P-value:9.87E-5 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:2.94|P-value:3.19E-4 ID:SGTC_448|Compound:monastrol|FD-Score:-2.86|P-value:4.85E-4 ID:SGTC_719|Compound:2810-4230|FD-Score:-2.79|P-value:6.41E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.14|P-value:1.32E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:2.73|P-value:7.55E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.55|P-value:1.89E-5 ID:SGTC_828|Compound:2074-0507|FD-Score:3.15|P-value:1.27E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:2.67|P-value:9.51E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.43|P-value:3.40E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:2.89|P-value:3.89E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:2.70|P-value:8.50E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:-2.99|P-value:2.76E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:2.78|P-value:6.35E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.26|P-value:7.72E-5 ID:SGTC_1677|Compound:st019204|FD-Score:2.68|P-value:9.21E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-2.98|P-value:2.89E-4 ID:SGTC_2031|Compound:5180455|FD-Score:-2.74|P-value:7.88E-4 ID:SGTC_2071|Compound:5230951|FD-Score:-3.13|P-value:1.53E-4 ID:SGTC_2096|Compound:5468907|FD-Score:5.18|P-value:9.28E-10 ID:SGTC_2101|Compound:5377231|FD-Score:2.72|P-value:7.81E-4 ID:SGTC_2103|Compound:5378138|FD-Score:2.96|P-value:3.00E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.84|P-value:4.87E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.16|P-value:1.32E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.72|P-value:2.27E-8 ID:SGTC_2795|Compound:7780010|FD-Score:-5.37|P-value:2.65E-10 ID:SGTC_37|Compound:0566-0070|FD-Score:-3.50|P-value:2.61E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:4.66|P-value:3.32E-8 ID:SGTC_40|Compound:0327-0103|FD-Score:-2.96|P-value:3.19E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.27|P-value:7.46E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.14|P-value:1.43E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-2.72|P-value:8.36E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:2.75|P-value:6.96E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.21|P-value:9.87E-5 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:2.94|P-value:3.19E-4 ID:SGTC_448|Compound:monastrol|FD-Score:-2.86|P-value:4.85E-4 ID:SGTC_719|Compound:2810-4230|FD-Score:-2.79|P-value:6.41E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.14|P-value:1.32E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:2.73|P-value:7.55E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.55|P-value:1.89E-5 ID:SGTC_828|Compound:2074-0507|FD-Score:3.15|P-value:1.27E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:2.67|P-value:9.51E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.43|P-value:3.40E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:2.89|P-value:3.89E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:2.70|P-value:8.50E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:-2.99|P-value:2.76E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:2.78|P-value:6.35E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.26|P-value:7.72E-5 ID:SGTC_1677|Compound:st019204|FD-Score:2.68|P-value:9.21E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-2.98|P-value:2.89E-4 ID:SGTC_2031|Compound:5180455|FD-Score:-2.74|P-value:7.88E-4 ID:SGTC_2071|Compound:5230951|FD-Score:-3.13|P-value:1.53E-4 ID:SGTC_2096|Compound:5468907|FD-Score:5.18|P-value:9.28E-10 ID:SGTC_2101|Compound:5377231|FD-Score:2.72|P-value:7.81E-4 ID:SGTC_2103|Compound:5378138|FD-Score:2.96|P-value:3.00E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.84|P-value:4.87E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.16|P-value:1.32E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.72|P-value:2.27E-8 ID:SGTC_2795|Compound:7780010|FD-Score:-5.37|P-value:2.65E-10

Top fitness defect scores for YOR084W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2096 5468907 5.18 200.0 µM 9.28E-10 2 1.09E-7
2 SGTC_2794 7785382 4.72 27.3 µM 2.27E-8 12 1.21E-6
3 SGTC_38 0929-0051 4.66 58.3 µM 3.32E-8 11 1.60E-6
4 SGTC_822 1487-0950 3.55 154.0 µM 1.89E-5 24 1.92E-4
5 SGTC_1004 4084-0029 3.43 199.0 µM 3.40E-5 34 2.99E-4
6 SGTC_46 0329-0187a 3.27 2.2 µM 7.46E-5 107 5.43E-4
7 SGTC_1203 3992-3522 3.26 103.0 µM 7.72E-5 67 5.57E-4
8 SGTC_360 0957-0399 3.21 1.0 µM 9.87E-5 cell wall 79 6.71E-4
9 SGTC_828 2074-0507 3.15 139.0 µM 1.27E-4 RPP1 & pyrimidine depletion 55 8.13E-4
10 SGTC_737 1950-0117 3.14 57.9 µM 1.32E-4 50 8.37E-4
11 SGTC_2103 5378138 2.96 10.0 µM 3.00E-4 62 0.00156
12 SGTC_415 dibenzyl ketone 2.94 100.0 µM 3.19E-4 45 0.00163
13 SGTC_1007 4101-0031 2.89 70.0 µM 3.89E-4 59 0.00190
14 SGTC_2126 5251174 2.84 33.9 µM 4.87E-4 118 0.00226
15 SGTC_1202 1988-0068 2.78 29.6 µM 6.35E-4 RNA processing & uracil transport 93 0.00276
16 SGTC_310 1273-0058 2.75 1.1 µM 6.96E-4 mitochondrial stress 387 0.00296
17 SGTC_753 1322-0200 2.73 289.0 µM 7.55E-4 87 0.00315
18 SGTC_2101 5377231 2.72 179.2 µM 7.81E-4 53 0.00323
19 SGTC_1128 3448-9350 2.70 235.0 µM 8.50E-4 93 0.00345
20 SGTC_1677 st019204 2.68 53.9 µM 9.21E-4 95 0.00366

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.185 3.85E-27 YER051W JHD1 hom JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe
0.149 3.28E-18 YDR534C FIT1 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.139 7.32E-16 YDR359C EAF1 hom Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1
0.138 1.14E-15 YHL010C ETP1 hom Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences
0.130 4.18E-14 YFL009W CDC4 het F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p
0.129 6.05E-14 YOL139C CDC33 het mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth
0.129 6.29E-14 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.129 6.69E-14 YOR293C-A_p YOR293C-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.128 1.05E-13 YGL098W USE1 het Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p
0.127 1.84E-13 YOL082W ATG19 hom Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles
0.125 4.44E-13 YLR410W VIP1 hom Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1
0.118 6.34E-12 YGL164C YRB30 hom RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes
0.114 4.49E-11 YMR132C_p JLP2_p hom Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
0.113 5.20E-11 YLL056C_p YLL056C_p hom Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin
0.113 6.83E-11 YGR174W-A_p YGR174W-A_p hom Putative protein of unknown function; predicted to have a role in cell budding based on computational guilt by association analysis