HIPHOP chemogenomics database

YOR084W / LPX1

Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction

Zygosity: Homozygous strain

fixedexpanded
Profile for YOR084W / LPX1

Click on Significant Values for Screen Details

Top fitness defect scores for YOR084W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2096	5468907	5.18	200.0 µM	9.28E-10		2	1.09E-7
2	SGTC_2794	7785382	4.72	27.3 µM	2.27E-8		12	1.21E-6
3	SGTC_38	0929-0051	4.66	58.3 µM	3.32E-8		11	1.60E-6
4	SGTC_822	1487-0950	3.55	154.0 µM	1.89E-5		24	1.92E-4
5	SGTC_1004	4084-0029	3.43	199.0 µM	3.40E-5		34	2.99E-4
6	SGTC_46	0329-0187a	3.27	2.2 µM	7.46E-5		107	5.43E-4
7	SGTC_1203	3992-3522	3.26	103.0 µM	7.72E-5		67	5.57E-4
8	SGTC_360	0957-0399	3.21	1.0 µM	9.87E-5	cell wall	79	6.71E-4
9	SGTC_828	2074-0507	3.15	139.0 µM	1.27E-4	RPP1 & pyrimidine depletion	55	8.13E-4
10	SGTC_737	1950-0117	3.14	57.9 µM	1.32E-4		50	8.37E-4
11	SGTC_2103	5378138	2.96	10.0 µM	3.00E-4		62	0.00156
12	SGTC_415	dibenzyl ketone	2.94	100.0 µM	3.19E-4		45	0.00163
13	SGTC_1007	4101-0031	2.89	70.0 µM	3.89E-4		59	0.00190
14	SGTC_2126	5251174	2.84	33.9 µM	4.87E-4		118	0.00226
15	SGTC_1202	1988-0068	2.78	29.6 µM	6.35E-4	RNA processing & uracil transport	93	0.00276
16	SGTC_310	1273-0058	2.75	1.1 µM	6.96E-4	mitochondrial stress	387	0.00296
17	SGTC_753	1322-0200	2.73	289.0 µM	7.55E-4		87	0.00315
18	SGTC_2101	5377231	2.72	179.2 µM	7.81E-4		53	0.00323
19	SGTC_1128	3448-9350	2.70	235.0 µM	8.50E-4		93	0.00345
20	SGTC_1677	st019204	2.68	53.9 µM	9.21E-4		95	0.00366

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.185	3.85E-27	YER051W	JHD1	hom	JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe
0.149	3.28E-18	YDR534C	FIT1	hom	Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.139	7.32E-16	YDR359C	EAF1	hom	Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1
0.138	1.14E-15	YHL010C	ETP1	hom	Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences
0.130	4.18E-14	YFL009W	CDC4	het	F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p
0.129	6.05E-14	YOL139C	CDC33	het	mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth
0.129	6.29E-14	YLR117C	CLF1	het	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.129	6.69E-14	YOR293C-A_p	YOR293C-A_p	hom	Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.128	1.05E-13	YGL098W	USE1	het	Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p
0.127	1.84E-13	YOL082W	ATG19	hom	Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles
0.125	4.44E-13	YLR410W	VIP1	hom	Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1
0.118	6.34E-12	YGL164C	YRB30	hom	RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes
0.114	4.49E-11	YMR132C_p	JLP2_p	hom	Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
0.113	5.20E-11	YLL056C_p	YLL056C_p	hom	Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin
0.113	6.83E-11	YGR174W-A_p	YGR174W-A_p	hom	Putative protein of unknown function; predicted to have a role in cell budding based on computational guilt by association analysis