Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YOR084W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.185 | 3.85E-27 | YER051W | JHD1 | hom | JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe |
0.149 | 3.28E-18 | YDR534C | FIT1 | hom | Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall |
0.139 | 7.32E-16 | YDR359C | EAF1 | hom | Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1 |
0.138 | 1.14E-15 | YHL010C | ETP1 | hom | Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences |
0.130 | 4.18E-14 | YFL009W | CDC4 | het | F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p |
0.129 | 6.05E-14 | YOL139C | CDC33 | het | mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth |
0.129 | 6.29E-14 | YLR117C | CLF1 | het | Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins |
0.129 | 6.69E-14 | YOR293C-A_p | YOR293C-A_p | hom | Putative protein of unknown function; identified by expression profiling and mass spectrometry |
0.128 | 1.05E-13 | YGL098W | USE1 | het | Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p |
0.127 | 1.84E-13 | YOL082W | ATG19 | hom | Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles |
0.125 | 4.44E-13 | YLR410W | VIP1 | hom | Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1 |
0.118 | 6.34E-12 | YGL164C | YRB30 | hom | RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes |
0.114 | 4.49E-11 | YMR132C_p | JLP2_p | hom | Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein) |
0.113 | 5.20E-11 | YLL056C_p | YLL056C_p | hom | Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin |
0.113 | 6.83E-11 | YGR174W-A_p | YGR174W-A_p | hom | Putative protein of unknown function; predicted to have a role in cell budding based on computational guilt by association analysis |