YOR090C / PTC5

Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR090C / PTC5

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:-3.11|P-value:8.77E-4 ID:SGTC_224|Compound:benfluorex|FD-Score:3.21|P-value:7.06E-4 ID:SGTC_230|Compound:MPP+|FD-Score:-3.13|P-value:8.12E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.35|P-value:4.24E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.75|P-value:9.23E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.25|P-value:5.39E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.22|P-value:5.99E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.18|P-value:7.72E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:3.27|P-value:5.77E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:-3.34|P-value:3.85E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:-3.11|P-value:8.69E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.12|P-value:8.41E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:4.04|P-value:2.89E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:-5.21|P-value:8.07E-8 ID:SGTC_1234|Compound:0326-0494|FD-Score:4.12|P-value:2.05E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:4.31|P-value:8.91E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.55|P-value:1.77E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.88|P-value:5.49E-5 ID:SGTC_1634|Compound:st006576|FD-Score:3.48|P-value:2.61E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.65|P-value:1.37E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.27|P-value:5.77E-4 ID:SGTC_1893|Compound:st059353|FD-Score:-3.50|P-value:2.15E-4 ID:SGTC_2011|Compound:4012611|FD-Score:-5.11|P-value:1.40E-7 ID:SGTC_2014|Compound:4013930|FD-Score:3.73|P-value:1.02E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.68|P-value:1.22E-4 ID:SGTC_2023|Compound:5144124|FD-Score:5.39|P-value:3.79E-8 ID:SGTC_2078|Compound:5212016|FD-Score:3.59|P-value:1.73E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.48|P-value:2.70E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.47|P-value:2.37E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.81|P-value:6.33E-5 ID:SGTC_2829|Compound:7992743|FD-Score:-9.61|P-value:2.61E-22 ID:SGTC_2831|Compound:7999036|FD-Score:4.01|P-value:3.17E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-8.02|P-value:4.24E-16 ID:SGTC_2958|Compound:9077254|FD-Score:3.91|P-value:4.96E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.29|P-value:5.25E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-3.38|P-value:3.33E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.80|P-value:6.56E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-3.99|P-value:2.98E-5 ID:SGTC_3284|Compound:9108171|FD-Score:-3.41|P-value:3.00E-4 ID:SGTC_3335|Compound:9143315|FD-Score:-3.43|P-value:2.73E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:-3.11|P-value:8.77E-4 ID:SGTC_224|Compound:benfluorex|FD-Score:3.21|P-value:7.06E-4 ID:SGTC_230|Compound:MPP+|FD-Score:-3.13|P-value:8.12E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.35|P-value:4.24E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.75|P-value:9.23E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.25|P-value:5.39E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.22|P-value:5.99E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.18|P-value:7.72E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:3.27|P-value:5.77E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:-3.34|P-value:3.85E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:-3.11|P-value:8.69E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.12|P-value:8.41E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:4.04|P-value:2.89E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:-5.21|P-value:8.07E-8 ID:SGTC_1234|Compound:0326-0494|FD-Score:4.12|P-value:2.05E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:4.31|P-value:8.91E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.55|P-value:1.77E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.88|P-value:5.49E-5 ID:SGTC_1634|Compound:st006576|FD-Score:3.48|P-value:2.61E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.65|P-value:1.37E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.27|P-value:5.77E-4 ID:SGTC_1893|Compound:st059353|FD-Score:-3.50|P-value:2.15E-4 ID:SGTC_2011|Compound:4012611|FD-Score:-5.11|P-value:1.40E-7 ID:SGTC_2014|Compound:4013930|FD-Score:3.73|P-value:1.02E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.68|P-value:1.22E-4 ID:SGTC_2023|Compound:5144124|FD-Score:5.39|P-value:3.79E-8 ID:SGTC_2078|Compound:5212016|FD-Score:3.59|P-value:1.73E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.48|P-value:2.70E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.47|P-value:2.37E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.81|P-value:6.33E-5 ID:SGTC_2829|Compound:7992743|FD-Score:-9.61|P-value:2.61E-22 ID:SGTC_2831|Compound:7999036|FD-Score:4.01|P-value:3.17E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-8.02|P-value:4.24E-16 ID:SGTC_2958|Compound:9077254|FD-Score:3.91|P-value:4.96E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.29|P-value:5.25E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-3.38|P-value:3.33E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.80|P-value:6.56E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-3.99|P-value:2.98E-5 ID:SGTC_3284|Compound:9108171|FD-Score:-3.41|P-value:3.00E-4 ID:SGTC_3335|Compound:9143315|FD-Score:-3.43|P-value:2.73E-4

Top fitness defect scores for YOR090C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2023 5144124 5.39 124.0 µM 3.79E-8 3 3.52E-8
2 SGTC_1378 2093-0007 4.31 380.0 nM 8.91E-6 14 8.35E-6
3 SGTC_1234 0326-0494 4.12 15.5 µM 2.05E-5 12 1.92E-5
4 SGTC_1146 3579-1023 4.04 7.0 µM 2.89E-5 13 2.71E-5
5 SGTC_2831 7999036 4.01 19.5 µM 3.17E-5 45 2.98E-5
6 SGTC_2958 9077254 3.91 16.7 µM 4.96E-5 32 4.67E-5
7 SGTC_1628 st004252 3.88 77.7 µM 5.49E-5 22 5.16E-5
8 SGTC_350 k064-0020 3.75 19.8 µM 9.23E-5 heme requiring 31 8.69E-5
9 SGTC_2014 4013930 3.73 200.0 µM 1.02E-4 43 9.64E-5
10 SGTC_2020 4017018 3.68 200.0 µM 1.22E-4 29 1.15E-4
11 SGTC_1842 st055362 3.65 61.2 µM 1.37E-4 19 1.30E-4
12 SGTC_2078 5212016 3.59 200.0 µM 1.73E-4 60S ribosome export 24 1.63E-4
13 SGTC_1634 st006576 3.48 41.0 µM 2.61E-4 TSC3-RPN4 32 2.47E-4
14 SGTC_2100 5377183 3.48 190.0 µM 2.70E-4 60S ribosome export 20 2.55E-4
15 SGTC_245 methotrexate 3.35 289.6 µM 4.24E-4 64 4.01E-4
16 SGTC_2963 9082507 3.29 9.0 µM 5.25E-4 50 4.96E-4
17 SGTC_1887 st057648 3.27 70.8 µM 5.77E-4 36 5.46E-4
18 SGTC_523 1934-0222 3.27 13.7 µM 5.77E-4 56 5.46E-4
19 SGTC_224 benfluorex 3.21 43.9 µM 7.06E-4 20 6.68E-4
20 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 3.18 150.0 µM 7.72E-4 Golgi 71 7.31E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.203 1.66E-32 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.202 3.70E-32 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.142 1.27E-16 YDR094W_d YDR094W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
0.131 2.90E-14 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.130 3.44E-14 YOR267C HRK1 hom Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress
0.128 1.14E-13 YAL037C-A_p YAL037C-A_p hom Putative protein of unknown function
0.114 3.59E-11 YKR094C RPL40B hom Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication
0.114 4.22E-11 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.112 8.58E-11 YGL166W CUP2 hom Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication
0.111 1.22E-10 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
0.109 2.67E-10 YIL056W VHR1 hom Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication
0.108 3.03E-10 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.106 7.72E-10 YDR089W YDR089W hom Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.106 7.86E-10 YGL137W SEC27 het Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP
0.105 9.13E-10 YER024W YAT2 hom Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane