YOR093C_p

Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR093C / YOR093C

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.89|P-value:2.57E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:-2.77|P-value:7.61E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:2.68|P-value:8.03E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:2.67|P-value:8.38E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:-3.14|P-value:1.56E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.24|P-value:4.61E-10 ID:SGTC_545|Compound:4218-0007|FD-Score:3.06|P-value:1.66E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:2.85|P-value:4.01E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-6.29|P-value:2.02E-13 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.38|P-value:2.25E-7 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:-2.82|P-value:6.03E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.05|P-value:1.05E-6 ID:SGTC_1382|Compound:3002-2117|FD-Score:2.72|P-value:6.84E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.10|P-value:1.40E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.14|P-value:1.15E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-2.76|P-value:7.82E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.21|P-value:1.16E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.00|P-value:2.16E-4 ID:SGTC_1691|Compound:st019933|FD-Score:2.85|P-value:4.14E-4 ID:SGTC_1695|Compound:st026914|FD-Score:-2.82|P-value:6.24E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.00|P-value:2.17E-4 ID:SGTC_1993|Compound:st073995|FD-Score:-3.96|P-value:2.60E-6 ID:SGTC_2052|Compound:5265182|FD-Score:2.71|P-value:7.34E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.06|P-value:2.19E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.29|P-value:5.72E-5 ID:SGTC_2806|Compound:7952793|FD-Score:-2.74|P-value:8.47E-4 ID:SGTC_2903|Compound:5923464|FD-Score:-2.86|P-value:5.27E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-2.81|P-value:6.42E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.18|P-value:9.69E-5 ID:SGTC_3154|Compound:9100113|FD-Score:-2.84|P-value:5.60E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.89|P-value:2.57E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:-2.77|P-value:7.61E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:2.68|P-value:8.03E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:2.67|P-value:8.38E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:-3.14|P-value:1.56E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.24|P-value:4.61E-10 ID:SGTC_545|Compound:4218-0007|FD-Score:3.06|P-value:1.66E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:2.85|P-value:4.01E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-6.29|P-value:2.02E-13 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.38|P-value:2.25E-7 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:-2.82|P-value:6.03E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.05|P-value:1.05E-6 ID:SGTC_1382|Compound:3002-2117|FD-Score:2.72|P-value:6.84E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.10|P-value:1.40E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.14|P-value:1.15E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-2.76|P-value:7.82E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.21|P-value:1.16E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.00|P-value:2.16E-4 ID:SGTC_1691|Compound:st019933|FD-Score:2.85|P-value:4.14E-4 ID:SGTC_1695|Compound:st026914|FD-Score:-2.82|P-value:6.24E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.00|P-value:2.17E-4 ID:SGTC_1993|Compound:st073995|FD-Score:-3.96|P-value:2.60E-6 ID:SGTC_2052|Compound:5265182|FD-Score:2.71|P-value:7.34E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.06|P-value:2.19E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.29|P-value:5.72E-5 ID:SGTC_2806|Compound:7952793|FD-Score:-2.74|P-value:8.47E-4 ID:SGTC_2903|Compound:5923464|FD-Score:-2.86|P-value:5.27E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-2.81|P-value:6.42E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.18|P-value:9.69E-5 ID:SGTC_3154|Compound:9100113|FD-Score:-2.84|P-value:5.60E-4

Top fitness defect scores for YOR093C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 5.24 1.1 µM 4.61E-10 mitochondrial stress 173 7.96E-8
2 SGTC_1212 0520-0165 4.05 585.0 µM 1.05E-6 28 2.53E-5
3 SGTC_58 0957-0393 3.89 9.0 µM 2.57E-6 cell wall 379 4.92E-5
4 SGTC_2788 5282734 3.29 71.4 µM 5.72E-5 82 5.00E-4
5 SGTC_2970 9090938 3.18 41.9 µM 9.69E-5 RNA processing & uracil transport 88 7.43E-4
6 SGTC_1470 k295-0292 3.14 231.0 µM 1.15E-4 45 8.43E-4
7 SGTC_1383 3049-0032 3.10 20.7 µM 1.40E-4 60S ribosome export 48 9.80E-4
8 SGTC_545 4218-0007 3.06 221.0 µM 1.66E-4 65 0.00111
9 SGTC_1658 st012944 3.00 20.0 µM 2.16E-4 iron homeostasis 116 0.00135
10 SGTC_1726 st035556 3.00 14.6 µM 2.17E-4 93 0.00136
11 SGTC_610 4215-0184 2.85 155.0 µM 4.01E-4 exosome 61 0.00215
12 SGTC_1691 st019933 2.85 84.6 µM 4.14E-4 61 0.00221
13 SGTC_1382 3002-2117 2.72 298.0 µM 6.84E-4 63 0.00322
14 SGTC_2052 5265182 2.71 7.1 µM 7.34E-4 97 0.00340
15 SGTC_255 tunicamycin 2.68 200.5 nM 8.03E-4 unfolded protein response 175 0.00363
16 SGTC_284 0988-0104 2.67 32.6 µM 8.38E-4 heme requiring 64 0.00375
17 SGTC_1251 0490-5699 2.61 265.0 µM 0.00106 128 0.00447
18 SGTC_1145 3546-0597 2.61 10.2 µM 0.00107 mitochondrial processes 120 0.00450
19 SGTC_1172 0370-0043 2.58 85.0 µM 0.00119 99 0.00488
20 SGTC_1732 st034308 2.54 51.8 µM 0.00143 117 0.00562

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.267 7.91E-56 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.240 3.63E-45 YNR039C ZRG17 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency
0.215 1.46E-36 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.212 2.69E-35 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.209 2.24E-34 YGL134W PCL10 hom Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate
0.206 1.99E-33 YLR412W BER1 hom Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene
0.199 1.91E-31 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.195 4.43E-30 YDL189W RBS1 hom Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain
0.194 8.14E-30 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.193 1.59E-29 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.193 2.04E-29 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.193 2.24E-29 YNL291C MID1 hom N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
0.185 4.05E-27 YDR239C YDR239C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.184 6.68E-27 YOL053W AIM39 hom Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss
0.181 3.86E-26 YDL224C WHI4 hom Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication