HIPHOP chemogenomics database
YOR098C / NUP1 
FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YOR098C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.111 | 1.30E-10 | YLR063W_p | YLR063W_p | hom | Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene |
| 0.109 | 2.85E-10 | YHR040W | BCD1 | het | Essential protein required for the accumulation of box C/D snoRNA |
| 0.108 | 2.97E-10 | YEL068C_p | YEL068C_p | hom | Protein of unknown function; expressed at both mRNA and protein levels |
| 0.107 | 4.35E-10 | YJR008W | MHO1 | hom | Protein of unknown function; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility |
| 0.104 | 1.72E-9 | YBR153W | RIB7 | het | Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway |
| 0.104 | 1.76E-9 | YLR247C | IRC20 | hom | Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci |
| 0.103 | 2.68E-9 | YNL145W | MFA2 | hom | Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1 |
| 0.102 | 3.49E-9 | YLR216C | CPR6 | hom | Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress |
| 0.100 | 7.02E-9 | YLR001C_p | YLR001C_p | hom | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated |
| 0.097 | 2.05E-8 | YDR479C | PEX29 | hom | Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress |
| 0.094 | 5.68E-8 | YBR054W | YRO2 | hom | Protein of unknown function with similarity to archaeal rhodopsins; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p; YRO2 has a paralog, MRH1, that arose from the whole genome duplication |
| 0.092 | 8.36E-8 | YIL024C_p | YIL024C_p | hom | Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p |
| 0.084 | 1.17E-6 | YLR350W | ORM2 | hom | Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress |
| 0.083 | 1.47E-6 | YAL014C | SYN8 | hom | Endosomal SNARE related to mammalian syntaxin 8 |
| 0.083 | 1.60E-6 | YIR019C | FLO11 | hom | GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); required for the formation of fibrous interconnections between cells in a colony of a wild S. cerevisiae strain |