YOR105W_p

Protein of unknown function; expressed at both mRNA and protein levels

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR105W / YOR105W

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:3.11|P-value:8.97E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:-3.56|P-value:2.18E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.60|P-value:1.50E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.20|P-value:6.49E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:3.11|P-value:8.95E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.69|P-value:1.07E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.20|P-value:6.56E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:5.55|P-value:1.35E-8 ID:SGTC_869|Compound:0564-0080|FD-Score:4.70|P-value:1.23E-6 ID:SGTC_874|Compound:0599-0792|FD-Score:5.40|P-value:3.23E-8 ID:SGTC_1031|Compound:k035-0009|FD-Score:4.09|P-value:2.08E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:-4.15|P-value:1.95E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.21|P-value:1.19E-5 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.29|P-value:4.75E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.21|P-value:6.38E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.09|P-value:9.41E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.47|P-value:2.20E-8 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.56|P-value:1.73E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.78|P-value:7.53E-5 ID:SGTC_1740|Compound:st038286|FD-Score:-13.30|P-value:4.17E-40 ID:SGTC_1747|Compound:st037496|FD-Score:-3.57|P-value:2.05E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-5.92|P-value:2.12E-9 ID:SGTC_1750|Compound:st081859|FD-Score:5.29|P-value:5.95E-8 ID:SGTC_1804|Compound:st050076|FD-Score:4.33|P-value:7.20E-6 ID:SGTC_1846|Compound:st056244|FD-Score:3.74|P-value:8.64E-5 ID:SGTC_1910|Compound:st062352|FD-Score:4.00|P-value:3.02E-5 ID:SGTC_2024|Compound:5144227|FD-Score:-4.14|P-value:2.05E-5 ID:SGTC_2123|Compound:5259487|FD-Score:4.12|P-value:1.81E-5 ID:SGTC_2144|Compound:5628481|FD-Score:4.00|P-value:3.03E-5 ID:SGTC_2146|Compound:5545642|FD-Score:-4.15|P-value:2.01E-5 ID:SGTC_2166|Compound:5933061|FD-Score:-4.12|P-value:2.21E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-6.30|P-value:2.05E-10 ID:SGTC_2295|Compound:7971645|FD-Score:8.33|P-value:4.18E-17 ID:SGTC_2297|Compound:7971671|FD-Score:-3.96|P-value:4.40E-5 ID:SGTC_2300|Compound:7976697|FD-Score:-7.35|P-value:1.40E-13 ID:SGTC_2302|Compound:7771753|FD-Score:10.10|P-value:4.54E-24 ID:SGTC_2312|Compound:7706453|FD-Score:3.38|P-value:3.42E-4 ID:SGTC_2327|Compound:6189656|FD-Score:-3.40|P-value:3.92E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.12|P-value:8.44E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.92|P-value:4.26E-5 ID:SGTC_2455|Compound:5377712|FD-Score:3.48|P-value:2.39E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.92|P-value:4.22E-5 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.31|P-value:4.41E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:4.14|P-value:1.62E-5 ID:SGTC_2560|Compound:caryophyllene|FD-Score:4.52|P-value:2.94E-6 ID:SGTC_2623|Compound:humulene|FD-Score:3.66|P-value:1.17E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.40|P-value:3.20E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:5.01|P-value:2.62E-7 ID:SGTC_2829|Compound:7992743|FD-Score:7.05|P-value:8.82E-13 ID:SGTC_2833|Compound:9001315|FD-Score:-3.58|P-value:2.02E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.61|P-value:1.78E-4 ID:SGTC_2925|Compound:9010536|FD-Score:4.01|P-value:2.83E-5 ID:SGTC_3201|Compound:9113999|FD-Score:-4.33|P-value:8.82E-6 ID:SGTC_3206|Compound:9114350|FD-Score:-3.31|P-value:5.26E-4 ID:SGTC_3209|Compound:9113616|FD-Score:5.80|P-value:3.17E-9 ID:SGTC_3215|Compound:9129942|FD-Score:3.52|P-value:2.06E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.12|P-value:8.53E-4 ID:SGTC_3279|Compound:9140807|FD-Score:-3.25|P-value:6.62E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-4.07|P-value:2.78E-5 ID:SGTC_3341|Compound:9147222|FD-Score:3.11|P-value:9.01E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:3.11|P-value:8.97E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:-3.56|P-value:2.18E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.60|P-value:1.50E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.20|P-value:6.49E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:3.11|P-value:8.95E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.69|P-value:1.07E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.20|P-value:6.56E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:5.55|P-value:1.35E-8 ID:SGTC_869|Compound:0564-0080|FD-Score:4.70|P-value:1.23E-6 ID:SGTC_874|Compound:0599-0792|FD-Score:5.40|P-value:3.23E-8 ID:SGTC_1031|Compound:k035-0009|FD-Score:4.09|P-value:2.08E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:-4.15|P-value:1.95E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.21|P-value:1.19E-5 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.29|P-value:4.75E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.21|P-value:6.38E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.09|P-value:9.41E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.47|P-value:2.20E-8 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.56|P-value:1.73E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.78|P-value:7.53E-5 ID:SGTC_1740|Compound:st038286|FD-Score:-13.30|P-value:4.17E-40 ID:SGTC_1747|Compound:st037496|FD-Score:-3.57|P-value:2.05E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-5.92|P-value:2.12E-9 ID:SGTC_1750|Compound:st081859|FD-Score:5.29|P-value:5.95E-8 ID:SGTC_1804|Compound:st050076|FD-Score:4.33|P-value:7.20E-6 ID:SGTC_1846|Compound:st056244|FD-Score:3.74|P-value:8.64E-5 ID:SGTC_1910|Compound:st062352|FD-Score:4.00|P-value:3.02E-5 ID:SGTC_2024|Compound:5144227|FD-Score:-4.14|P-value:2.05E-5 ID:SGTC_2123|Compound:5259487|FD-Score:4.12|P-value:1.81E-5 ID:SGTC_2144|Compound:5628481|FD-Score:4.00|P-value:3.03E-5 ID:SGTC_2146|Compound:5545642|FD-Score:-4.15|P-value:2.01E-5 ID:SGTC_2166|Compound:5933061|FD-Score:-4.12|P-value:2.21E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-6.30|P-value:2.05E-10 ID:SGTC_2295|Compound:7971645|FD-Score:8.33|P-value:4.18E-17 ID:SGTC_2297|Compound:7971671|FD-Score:-3.96|P-value:4.40E-5 ID:SGTC_2300|Compound:7976697|FD-Score:-7.35|P-value:1.40E-13 ID:SGTC_2302|Compound:7771753|FD-Score:10.10|P-value:4.54E-24 ID:SGTC_2312|Compound:7706453|FD-Score:3.38|P-value:3.42E-4 ID:SGTC_2327|Compound:6189656|FD-Score:-3.40|P-value:3.92E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.12|P-value:8.44E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.92|P-value:4.26E-5 ID:SGTC_2455|Compound:5377712|FD-Score:3.48|P-value:2.39E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.92|P-value:4.22E-5 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.31|P-value:4.41E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:4.14|P-value:1.62E-5 ID:SGTC_2560|Compound:caryophyllene|FD-Score:4.52|P-value:2.94E-6 ID:SGTC_2623|Compound:humulene|FD-Score:3.66|P-value:1.17E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.40|P-value:3.20E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:5.01|P-value:2.62E-7 ID:SGTC_2829|Compound:7992743|FD-Score:7.05|P-value:8.82E-13 ID:SGTC_2833|Compound:9001315|FD-Score:-3.58|P-value:2.02E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.61|P-value:1.78E-4 ID:SGTC_2925|Compound:9010536|FD-Score:4.01|P-value:2.83E-5 ID:SGTC_3201|Compound:9113999|FD-Score:-4.33|P-value:8.82E-6 ID:SGTC_3206|Compound:9114350|FD-Score:-3.31|P-value:5.26E-4 ID:SGTC_3209|Compound:9113616|FD-Score:5.80|P-value:3.17E-9 ID:SGTC_3215|Compound:9129942|FD-Score:3.52|P-value:2.06E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.12|P-value:8.53E-4 ID:SGTC_3279|Compound:9140807|FD-Score:-3.25|P-value:6.62E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-4.07|P-value:2.78E-5 ID:SGTC_3341|Compound:9147222|FD-Score:3.11|P-value:9.01E-4

Top fitness defect scores for YOR105W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2302 7771753 10.10 200.0 µM 4.54E-24 1 4.22E-24
2 SGTC_2295 7971645 8.33 200.0 µM 4.18E-17 2 4.12E-17
3 SGTC_2829 7992743 7.05 58.4 µM 8.82E-13 2 8.99E-13
4 SGTC_3209 9113616 5.80 49.5 µM 3.17E-9 1 3.30E-9
5 SGTC_807 1315-0151 5.55 48.0 µM 1.35E-8 8 1.41E-8
6 SGTC_1495 4469-0029 5.47 237.0 µM 2.20E-8 64 2.30E-8
7 SGTC_874 0599-0792 5.40 117.0 µM 3.23E-8 10 3.38E-8
8 SGTC_1750 st081859 5.29 2.4 µM 5.95E-8 endomembrane recycling 126 6.23E-8
9 SGTC_2773 thioridazine 5.01 9.1 µM 2.62E-7 4 2.75E-7
10 SGTC_869 0564-0080 4.70 44.1 µM 1.23E-6 10 1.29E-6
11 SGTC_2560 caryophyllene 4.52 100.0 µM 2.94E-6 8 3.10E-6
12 SGTC_1804 st050076 4.33 49.1 µM 7.20E-6 7 7.60E-6
13 SGTC_1363 1636-0063 4.21 10.4 µM 1.19E-5 Golgi 20 1.26E-5
14 SGTC_2557 derrustone 4.14 83.8 µM 1.62E-5 26 1.71E-5
15 SGTC_2123 5259487 4.12 200.0 µM 1.81E-5 16 1.91E-5
16 SGTC_1031 k035-0009 4.09 16.0 µM 2.08E-5 21 2.19E-5
17 SGTC_2925 9010536 4.01 32.5 µM 2.83E-5 azole & statin 47 2.99E-5
18 SGTC_1910 st062352 4.00 60.4 µM 3.02E-5 35 3.19E-5
19 SGTC_2144 5628481 4.00 200.0 µM 3.03E-5 ERG2 20 3.19E-5
20 SGTC_2460 5552655 3.92 174.2 µM 4.22E-5 amide catabolism 32 4.46E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 1.32E-14 YJL109C UTP10 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance
0.129 5.93E-14 YKL099C UTP11 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.118 6.35E-12 YEL066W HPA3 hom D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
0.109 2.18E-10 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.107 5.53E-10 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.105 1.26E-9 YPR153W YPR153W hom Putative protein of unknown function
0.104 1.59E-9 YBR165W UBS1 hom Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity
0.102 3.82E-9 YAL045C_d YAL045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A
0.099 1.06E-8 YMR073C IRC21 hom Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study
0.099 1.04E-8 YMR312W ELP6 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
0.097 1.61E-8 YML043C RRN11 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.093 7.15E-8 YGR138C TPO2 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication
0.091 1.12E-7 YEL026W SNU13 het RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein
0.091 1.37E-7 YJL208C NUC1 hom Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy
0.090 1.66E-7 YKL143W LTV1 hom Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature